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Medications for Nocturnal Leg Cramps

Other names: Night Cramps; Night Leg Cramps

About Nocturnal Leg Cramps

Nocturnal leg cramps are sudden, painful squeezes in the calf (lower leg) or thigh (upper leg) muscles, occurring at night. The muscle may twitch under the skin or feel hard.

Drugs used to treat Nocturnal Leg Cramps

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
vitamin e 9.0 1 review
Rx/OTC C N

Generic name: vitamin e systemic

Brand names:  Alpha E, E-400 Clear, Aqua-E, Aqua Gem-E, Aquasol E, Aquavite-E, E-600, E Pherol, E-Gems …show all

Drug class: vitamins

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Natural Product Monographs

Soma Off-label 9.1 11 reviews
Rx C 4 X

Generic name: carisoprodol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off-label: Yes

carisoprodol Off-label 9.0 14 reviews
Rx C 4 X

Generic name: carisoprodol systemic

Brand name:  Soma

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

verapamil Off-label 9.0 2 reviews
Rx C N X

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Alpha E Rate Add review
Rx/OTC C N

Generic name: vitamin e systemic

Drug class: vitamins

For consumers: dosage, interactions, side effects

E-400 Clear Rate Add review
Rx/OTC C N

Generic name: vitamin e systemic

Drug class: vitamins

For consumers: dosage, interactions, side effects

Aqua-E Rate Add review
Rx/OTC C N

Generic name: vitamin e systemic

Drug class: vitamins

For consumers: dosage, interactions, side effects

Aqua Gem-E Rate Add review
Rx/OTC C N

Generic name: vitamin e systemic

Drug class: vitamins

For consumers: dosage, interactions, side effects

Aquasol E Rate Add review
Rx/OTC C N

Generic name: vitamin e systemic

Drug class: vitamins

For consumers: dosage, interactions, side effects

Aquavite-E Rate Add review
Rx/OTC C N

Generic name: vitamin e systemic

Drug class: vitamins

For consumers: dosage, interactions, side effects

E-600 Rate Add review
Rx/OTC C N

Generic name: vitamin e systemic

Drug class: vitamins

For consumers: dosage, interactions, side effects

E Pherol Rate Add review
Rx/OTC C N

Generic name: vitamin e systemic

Drug class: vitamins

For consumers: dosage, interactions, side effects

E-Gems Rate Add review
Rx/OTC C N

Generic name: vitamin e systemic

Drug class: vitamins

For consumers: dosage, interactions, side effects

Alternative treatments for Nocturnal Leg Cramps

The following products are considered to be alternative treatments or natural remedies for Nocturnal Leg Cramps. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Nocturnal Leg Cramps.

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.