Aleve PM Interactions
There are 795 drugs known to interact with Aleve PM (diphenhydramine/naproxen), along with 19 disease interactions, and 4 alcohol/food interactions. Of the total drug interactions, 114 are major, 661 are moderate, and 20 are minor.
- View all 795 medications that may interact with Aleve PM
- View Aleve PM alcohol/food interactions (4)
- View Aleve PM disease interactions (19)
Most frequently checked interactions
View interaction reports for Aleve PM (diphenhydramine / naproxen) and the medicines listed below.
- Aleve (naproxen)
- amlodipine
- aspirin
- atorvastatin
- Benadryl (diphenhydramine)
- benzonatate
- CoQ10 (ubiquinone)
- cyclobenzaprine
- famotidine
- Fish Oil (omega-3 polyunsaturated fatty acids)
- gabapentin
- hydrochlorothiazide
- ibuprofen
- levothyroxine
- lisinopril
- losartan
- melatonin
- meloxicam
- metformin
- naproxen
- omeprazole
- pantoprazole
- prednisone
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Tylenol PM (acetaminophen / diphenhydramine)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
Aleve PM alcohol/food interactions
There are 4 alcohol/food interactions with Aleve PM (diphenhydramine / naproxen).
Aleve PM disease interactions
There are 19 disease interactions with Aleve PM (diphenhydramine / naproxen) which include:
- depression
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- sodium
- anemia
- hepatotoxicity
- hyperkalemia
- platelet aggregation inhibition
Report options
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More about Aleve PM (diphenhydramine / naproxen)
- Aleve PM consumer information
- Compare alternatives
- Reviews (42)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: analgesic combinations
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
