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Aspirin / Caffeine Dosage

Applies to the following strength(s): 400 mg-32 mg ; 845 mg-65 mg ; 500 mg-32 mg ; 1000 mg-65 mg ; 421 mg-32 mg ; 500 mg-32.5 mg ; 500 mg-65 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Fever

Aspirin 500 mg - caffeine 65 mg effervescent tablets:
2 tablets orally every 6 hours as needed. Maximum 8 tablets per 24 hours. Dissolve each tablet in 4 ounces of water before taking.

Aspirin 500 mg - caffeine 32 mg and aspirin 400 mg - caffeine 32 mg:
2 tablets orally every 6 hours as needed. Maximum 8 tablets per 24 hours. Take each dose with a full glass of water.

Aspirin 421 mg - caffeine 32 mg:
2 tablets initially, followed by 1 tablet every 3 hours as needed. Maximum 9 tablets per 24 hours. Take each dose with a full glass of water.

Aspirin 845 mg - caffeine 65 mg and aspirin 1000 mg - caffeine 65 mg:
1 powder on tongue every 6 hours as needed with a full glass of water or stir powder into a glass of water or other liquid
Maximum dose: 4 powders in 24 hours

Aspirin 500 mg - caffeine 32.5 mg:
Recommended dose: 2 caplets orally every 6 hours with a full glass of water
Maximum dose: 8 caplets in 24 hours

Usual Adult Dose for Pain

Aspirin 500 mg - caffeine 65 mg effervescent tablets:
2 tablets orally every 6 hours as needed. Maximum 8 tablets per 24 hours. Dissolve each tablet in 4 ounces of water before taking.

Aspirin 500 mg - caffeine 32 mg and aspirin 400 mg - caffeine 32 mg:
2 tablets orally every 6 hours as needed. Maximum 8 tablets per 24 hours. Take each dose with a full glass of water.

Aspirin 421 mg - caffeine 32 mg:
2 tablets initially, followed by 1 tablet every 3 hours as needed. Maximum 9 tablets per 24 hours. Take each dose with a full glass of water.

Aspirin 845 mg - caffeine 65 mg and aspirin 1000 mg - caffeine 65 mg:
1 powder on tongue every 6 hours as needed with a full glass of water or stir powder into a glass of water or other liquid
Maximum dose: 4 powders in 24 hours

Aspirin 500 mg - caffeine 32.5 mg:
Recommended dose: 2 caplets orally every 6 hours with a full glass of water
Maximum dose: 8 caplets in 24 hours

Usual Geriatric Dose for Fever

Aspirin 500 mg - caffeine 65 mg effervescent tablets:
2 tablets every 6 hours as needed. Maximum 4 tablets per 24 hours. Dissolve each tablet in 4 ounces of water before taking.

Aspirin 845 mg - caffeine 65 mg and aspirin 1000 mg - caffeine 65 mg:
1 powder on tongue every 6 hours as needed with a full glass of water or stir powder into a glass of water or other liquid
Maximum dose: 4 powders in 24 hours

Aspirin 500 mg - caffeine 32.5 mg:
Recommended dose: 2 caplets orally every 6 hours with a full glass of water
Maximum dose: 8 caplets in 24 hours

Usual Geriatric Dose for Pain

Aspirin 500 mg - caffeine 65 mg effervescent tablets:
2 tablets every 6 hours as needed. Maximum 4 tablets per 24 hours. Dissolve each tablet in 4 ounces of water before taking.

Aspirin 845 mg - caffeine 65 mg and aspirin 1000 mg - caffeine 65 mg:
1 powder on tongue every 6 hours as needed with a full glass of water or stir powder into a glass of water or other liquid
Maximum dose: 4 powders in 24 hours

Aspirin 500 mg - caffeine 32.5 mg:
Recommended dose: 2 caplets orally every 6 hours with a full glass of water
Maximum dose: 8 caplets in 24 hours

Usual Pediatric Dose for Fever

12 years or greater:

Aspirin 500 mg - caffeine 65 mg effervescent tablets:
2 tablets orally every 6 hours as needed. Maximum 8 tablets per 24 hours. Dissolve each tablet in 4 ounces of water before taking.

Aspirin 500 mg - caffeine 32 mg and aspirin 400 mg - caffeine 32 mg:
2 tablets orally every 6 hours as needed. Maximum 8 tablets per 24 hours. Take each dose with a full glass of water.

Aspirin 421 mg - caffeine 32 mg:
2 tablets initially, followed by 1 tablet every 3 hours as needed. Maximum 9 tablets per 24 hours. Take each dose with a full glass of water.

Aspirin 845 mg - caffeine 65 mg and aspirin 1000 mg - caffeine 65 mg:
1 powder on tongue every 6 hours as needed with a full glass of water or stir powder into a glass of water or other liquid
Maximum dose: 4 powders in 24 hours

Aspirin 500 mg - caffeine 32.5 mg:
Recommended dose: 2 caplets orally every 6 hours with a full glass of water
Maximum dose: 8 caplets in 24 hours

Usual Pediatric Dose for Pain

12 years or greater:

Aspirin 500 mg - caffeine 65 mg effervescent tablets:
2 tablets orally every 6 hours as needed. Maximum 8 tablets per 24 hours. Dissolve each tablet in 4 ounces of water before taking.

Aspirin 500 mg - caffeine 32 mg and aspirin 400 mg - caffeine 32 mg:
2 tablets orally every 6 hours as needed. Maximum 8 tablets per 24 hours. Take each dose with a full glass of water.

Aspirin 421 mg - caffeine 32 mg:
2 tablets initially, followed by 1 tablet every 3 hours as needed. Maximum 9 tablets per 24 hours. Take each dose with a full glass of water.

Aspirin 845 mg - caffeine 65 mg and aspirin 1000 mg - caffeine 65 mg:
1 powder on tongue every 6 hours as needed with a full glass of water or stir powder into a glass of water or other liquid
Maximum dose: 4 powders in 24 hours

Aspirin 500 mg - caffeine 32.5 mg:
Recommended dose: 2 caplets orally every 6 hours with a full glass of water
Maximum dose: 8 caplets in 24 hours

Renal Dose Adjustments

Detailed information concerning the pharmacokinetic disposition of aspirin and/or caffeine in patients with renal dysfunction or is not available. Aspirin should be used with caution in chronic renal insufficiency, since it may cause a transient decrease in renal function. The use of aspirin in patients with severe renal impairment (CrCl less than 10 mL/minute) is not recommended due to the potential for increased risk of salicylate toxicity.

Liver Dose Adjustments

The use of aspirin in patients with severe hepatic impairment is not recommended due to the potential for increased risk of clinically significant bleeding and other adverse effects.

Precautions

Each effervescent aspirin 500 mg- caffeine 65 mg tablet contains 9 mg phenylalanine and 410 mg sodium.

Aspirin has been associated with Reyes syndrome; therefore, this drug should not be taken by children and teenagers with the chicken pox or flu.

Aspirin is contraindicated in patients with severe bleeding, coagulation or primary hemostasis disorders, nasal polyps associated with asthma, peptic ulcer, serious GI lesions, or on anticoagulant therapy.

Aspirin should be discontinued 5 days before surgery.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Detailed information concerning the removal of aspirin and/or caffeine by hemodialysis is not available. Some investigators have suggested that aspirin and/or salicylate may be removed by hemodialysis and that aspirin dosing should follow dialysis sessions.

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