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What's the difference between aspirin and ibuprofen?

Medically reviewed by Carmen Pope, BPharm. Last updated on Aug 13, 2024.

Official Answer by Drugs.com

Even though aspirin and Ibuprofen are both NSAIDs (nonsteroidal anti-inflammatory drugs) and work similarly, that is by blocking the body’s production of prostaglandins which relieves pain and inflammation, there are several differences between the two drugs and they are not considered interchangeable.

The main differences between aspirin and ibuprofen are:

Other points to note include:

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Important Guidance

When taking any NSAID, the following guidance is given:

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Aspirin Overdose: Symptoms, Diagnosis, Emergency Treatment

An aspirin overdose can occur after a single large dose (this is called an acute overdose) or develop gradually after taking lower doses for a long time (this is called a chronic overdose). An acute aspirin overdose may be accidental or intentional. A toxic dose of aspirin for a human adult is considered to be 200 to 300 milligrams per kilogram of body weight (works out to be 13,600 to 20,400mg of aspirin for a person who weighs 68 kg [approximately 150 pounds]). A dose of 500 milligrams per kilogram of body weight (34,000mg for a 68kg person) is considered a potentially lethal dose of aspirin, and could result in death. Continue reading

Does aspirin lower blood pressure?

No, aspirin does not appear to affect blood pressure. The effects of aspirin on blood pressure have been studied at doses even higher than 1,500 mg per day, as well as low doses for an average of 4 years. These studies showed that aspirin does not have an effect on blood pressure. Continue reading

Can I give Aspirin to my dog or cat?

DO NOT give aspirin to cats; it can be deadly to your cat. Cats lack the enzyme needed for metabolizing salicylic acid properly, and aspirin can build up and be extremely toxic. Many vets do not recommend aspirin use in dogs anymore due to stomach ulcers and the possibility of bleeding. Continue reading

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