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Medications for Pain

About Pain:  An unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage.

Drugs Used to Treat Pain

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Activity
Nucynta ER C 2 X 68 reviews 7.2

Generic name: tapentadol systemic

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Sprix C N X 50 reviews 7.2

Generic name: ketorolac systemic

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

acetaminophen / tramadol C 4 X 54 reviews 7.1

Generic name: acetaminophen / tramadol systemic

Brand names:  Ultracet, Tramapap

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

Aleve C N X 22 reviews 7.1

Generic name: naproxen systemic

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions, side effects

duloxetine Off Label C N X 79 reviews 7.1

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Flector Patch C N 82 reviews 7.1

Generic name: diclofenac topical

Drug class: topical non-steroidal anti-inflammatories

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

naloxone / pentazocine C 4 X 16 reviews 7.1

Generic name: naloxone / pentazocine systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

celecoxib C N 99 reviews 7.0

Generic name: celecoxib systemic

Brand name:  Celebrex

Drug class: cox-2 inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

choline salicylate / magnesium salicylate C N X 1 review 7.0

Generic name: choline salicylate / magnesium salicylate systemic

Brand name:  Choline Magnesium Trisalicylate

Drug class: salicylates

For consumers: interactions,

For professionals: Prescribing Information

Tylenol Arthritis Pain C N X 3 reviews 7.0

Generic name: acetaminophen systemic

Drug class: miscellaneous analgesics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

acetaminophen / hydrocodone C 2 X 620 reviews 6.9

Generic name: acetaminophen / hydrocodone systemic

Brand names:  Norco, Lortab, Anexsia, Hycet, Lorcet Plus, Co-Gesic, Lorcet, Theracodophen Low 90, Verdrocet, Xodol, Zyfrel …show all

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

acetaminophen C N X 43 reviews 6.9

Generic name: acetaminophen systemic

Brand names:  Tylenol, Paracetamol, Tylenol Arthritis Pain, Tylenol 8 Hour, 7T Gummy ES Chewable Tablets, Abenol, Acephen, Actamin, Actimol Children's, Actimol Infant, Altenol, Aminofen, Anacin Aspirin Free, Apra, Arthritis Pain Relief, Atasol, Aurophen, Cetafen, Children's Silapap, Children's Tylenol, Dolono, Equaline Pain Relief, Febrol Solution, Feverall, Genapap, Genebs, Infant's Tylenol, Jr. Tylenol, M-Pap, Mapap, Mapap Arthritis Pain, Nortemp Children's, Ofirmev, Pharbetol, Silapap Childrens, Tactinal, Tempra Quicklets, Topcare 8 Hour Pain Relief, Topcare Arthritis Pain Relief, Tycolene, Tylophen, Vitapap …show all

Drug class: miscellaneous analgesics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Norco C 2 X 178 reviews 6.9

Generic name: acetaminophen / hydrocodone systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

trolamine salicylate N N 26 reviews 6.9

Generic name: trolamine salicylate topical

Brand names:  Arthricream, Asper-Flex, Myoflex, Tru-micin, Ultracin T …show all

Drug class: topical rubefacient

For consumers: dosage,

Embeda C 2 X 15 reviews 6.8

Generic name: morphine / naltrexone systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

ketorolac C N X 323 reviews 6.8

Generic name: ketorolac systemic

Brand name:  Sprix

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

menthol N N 11 reviews 6.8

Generic name: menthol topical

Brand names:  Biofreeze, Aspercreme Max No Mess Roll-On, Aspercreme Pain Relieving Heat Gel, Bengay Cold Therapy Gel, Bengay Ultra Strength Pain Relieving Patch, BENGAY Vanishing Scent, Bengay Zero Degrees, Berri-Freez Spray, Blue-Emu Maximum Strength Arthritis, Muscle & Joint Pain Relief, Blue Gel, Cold Spot Point Relief, Cool 'n Heat Patch, Fast Freeze Naturally Cool, Flexall, Gold Bond Medicated Maximum Strength Foot, Icy Hot Advanced Relief Pain Relief Patch, Icy Hot Medicated Spray, Icy Hot Vanishing Scent Pain Relieving Gel, Mineral Freez Gel, Mineral Ice, Perform Pain Relieving Spray, Sombra Cool Therapy, Stopain, Therapeutic Ice, Therapeutic Menthol …show all

Drug class: topical rubefacient

For consumers: dosage,

For professionals: Prescribing Information

morphine / naltrexone C 2 X 15 reviews 6.8

Generic name: morphine / naltrexone systemic

Brand name:  Embeda

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts

nortriptyline Off Label N N X 107 reviews 6.8

Generic name: nortriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Tylenol C N X 12 reviews 6.8

Generic name: acetaminophen systemic

Drug class: miscellaneous analgesics

For consumers: dosage, interactions, side effects

Children's Motrin C N X 3 reviews 6.7

Generic name: ibuprofen systemic

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions, side effects

pregabalin Off Label C 5 X 140 reviews 6.7

Generic name: pregabalin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Butrans C 3 X 74 reviews 6.6

Generic name: buprenorphine systemic

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Indocin C N X 5 reviews 6.6

Generic name: indomethacin systemic

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

ketamine Off Label N 3 X 27 reviews 6.6

Generic name: ketamine systemic

Drug class: general anesthetics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Topics under Pain

Alternative treatments for Pain

The following products are considered to be alternative treatments or natural remedies for Pain. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Pain.

Legend

Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Off Label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.