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Percodan Side Effects

Generic name: aspirin / oxycodone

Medically reviewed by Drugs.com. Last updated on Aug 14, 2024.

Note: This document provides detailed information about Percodan Side Effects associated with aspirin / oxycodone. Some dosage forms listed on this page may not apply specifically to the brand name Percodan.

Applies to aspirin / oxycodone: oral tablet.

Important warnings This medicine can cause some serious health issues

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects may occur if you use also use alcohol or other drugs that cause drowsiness or slow breathing.

Get emergency medical help if you have signs of an allergic reaction: hives, rash; fever, difficulty breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Managing side effects (general information)

For healthcare professionals

Applies to aspirin / oxycodone: oral tablet.

General adverse events

The most commonly reported adverse events have included lightheadedness, dizziness, drowsiness, sedation, nausea, and vomiting.[Ref]

Gastrointestinal

Oxycodone-Aspirin:

Aspirin:

Nervous system

Opioids:

Renal

Hematologic

Oxycodone-aspirin:

Aspirin:

Hypersensitivity

Cardiovascular

Metabolic

Other

Hepatic

Oxycodone-aspirin:

Aspirin:

Psychiatric

Dermatologic

Musculoskeletal

Ocular

Genitourinary

Respiratory

Endocrine

Opioids:

Adrenal insufficiency and androgen deficiency have been reported with opioid use, most often with chronic use.

References

1. Leow KP, Smith MT, Watt JA, Williams BE, Cramond T (1992) "Comparative oxycodone pharmacokinetics in humans after intravenous, oral, and rectal administration." Ther Drug Monit, 14, p. 479-84

2. (2016) "Product Information. Percodan (aspirin-oxycodone)." Endo Laboratories LLC, SUPPL-49

3. Bergmann JF, Chassany O, Geneve J, Abiteboul M, Caulin C, Segrestaa JM (1992) "Endoscopic evaluation of the effect of ketoprofen, ibuprofen and aspirin on the gastroduodenal mucosa." Eur J Clin Pharmacol, 42, p. 685-8

4. Leow KP, Smith MT, Williams B, Cramond T (1992) "Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer." Clin Pharmacol Ther, 52, p. 487-95

5. Glare P, Walsh D (1991) "Dose-ranging study of oxycodone for advanced cancer pain (meeting abstract)." Proc Annu Meet Am Soc Clin Oncol, 10, a1201

6. Mehta S, Dasarathy S, Tandon RK, Mathur M, Malaviya AN (1992) "A prospective randomized study of the injurious effects of aspirin and naproxen on the gastroduodenal mucosa in patients with rheumatoid arthritis." Am J Gastroenterol, 87, p. 996-1000

7. Naschitz JE, Yeshurun D, Odeh M, Bassan H, Rosner I, Stermer E, Levy N (1990) "Overt gastrointestinal bleeding in the course of chronic low-dose aspirin administration for secondary prevention of arterial occlusive disease." Am J Gastroenterol, 85, p. 408-11

8. Sabesin SM, Boyce HW Jr, King CE, Mann JA, Ruoff G, Wall E (1988) "Comparative evaluation of gastrointestinal intolerance produced by plain and tri-buffered aspirin tablets." Am J Gastroenterol, 83, p. 1220-5

9. Graham DY, Smith JL (1986) "Aspirin and the stomach." Ann Intern Med, 104, p. 390-8

10. Levy M, Miller DR, Kaufman DW, Siskind V, Schwingl P, Rosenberg L, Strom B, Shapiro S (1988) "Major upper gastrointestinal tract bleeding. Relation to the use of aspirin and other nonnarcotic analgesics." Arch Intern Med, 148, p. 281-5

11. Prichard PJ, Kitchingman GK, Walt RP, Daneshmend TK, Hawkey CJ (1989) "Human gastric mucosal bleeding induced by low dose aspirin, but not warfarin." BMJ, 298, p. 493-6

12. Roderick PJ, Wilkes HC, Meade TW (1993) "The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials." Br J Clin Pharmacol, 35, p. 219-26

13. Glare PA, Walsh TD (1993) "Dose-ranging study of oxycodone for chronic pain in advanced cancer." J Clin Oncol, 11, p. 973-8

14. Sunshine A, Olson NZ, Zighelboim I, Decastro A (1993) "Ketoprofen, acetaminophen plus oxycodone, and acetaminophen in the relief of postoperative pain." Clin Pharmacol Ther, 54, p. 546-55

15. Wilcox CM, Shalek KA, Cotsonis G (1994) "Striking prevalence of over-the-counter nonsteroidal anti- inflammatory drug use in patients with upper gastrointestinal hemorrhage." Arch Intern Med, 154, p. 42-6

16. Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K (1993) "Adverse effects of low-dose aspirin in a healthy elderly population." Clin Pharmacol Ther, 54, p. 84-9

17. Thirlby RC (1993) "More problems with aspirin: it may cause appendicitis." Gastroenterology, 104, p. 1571-3

18. D'Haens G, Breysem Y, Rutgeerts P, van Besien B, Geboes K, Ponette E, Vantrappen G (1993) "Proctitis and rectal stenosis induced by nonsteroidal antiinflammatory suppositories." J Clin Gastroenterol, 17, p. 207-12

19. Halla JT, Hardin JG (1988) "Salicylate ototoxicity in patients with rheumatoid arthritis: a controlled study." Ann Rheum Dis, 47, p. 134-7

20. Boettcher FA, Salvi RJ (1991) "Salicylate ototoxicity: review and synthesis." Am J Otolaryngol, 12, p. 33-47

21. Carlyon RP, Butt M (1993) "Effects of aspirin on human auditory filters." Hear Res, 66, p. 233-44

22. Kimberly RP, Plotz PH (1977) "Aspirin-induced depression of renal function." N Engl J Med, 296, p. 418-24

23. Riegger GA, Kahles HW, Elsner D, Kromer EP, Kochsiek K (1991) "Effects of acetylsalicylic acid on renal function in patients with chronic heart failure." Am J Med, 90, p. 571-5

24. Carmichael J, Shankel SW (1985) "Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function." Am J Med, 78, p. 992-1000

25. Wen SF, Parthasarathy R, Iliopoulos O, Oberley TD (1992) "Acute renal failure following binge drinking and nonsteroidal antiinflammatory drugs." Am J Kidney Dis, 20, p. 281-5

26. Maher JF (1984) "Analgesic nephropathy. Observations, interpretations, and perspective on the low incidence in America." Am J Med, 76, p. 345-8

27. Muther RS, Potter DM, Bennett WM (1981) "Aspirin-induced depression of glomerular filtration rate in normal humans: role of sodium balance." Ann Intern Med, 94, p. 317-21

28. Sutor AH (1973) "Thrombocyturia after aspirin." N Engl J Med, 288, p. 794-5

29. Moroz LA (1977) "Increased blood fibrinolytic activity after aspirin ingestion." N Engl J Med, 296, p. 525-9

30. Barrow MV, Quick DT, Cunningham RW (1967) "Salicylate hypoprothrombinemia in rheumatoid arthritis with liver disease. Report of two cases." Arch Intern Med, 120, p. 620-4

31. Wijnja L, Snijder JA, Nieweg HO (1966) "Acetylsalicylic acid as a cause of pancytopenia from bone-marrow damage." Lancet, 2, p. 768-70

32. Williams JO, Mengel CE, Sullivan LW, Haq AS (1969) "Megaloblastic anemia associated with chronic ingestion of an analgesic." N Engl J Med, 280, p. 312-3

33. Eldar M, Aderka D, Shoenfeld Y, Livni E, Pinkhas J (1979) "Aspirin-induced aplastic anaemia." S Afr Med J, 55, p. 318

34. Fausa O (1970) "Salicylate-induced hypoprothrombinemia: a report of four cases." Acta Med Scand, 188, p. 403-8

35. Lee TH (1993) "Mechanism of bronchospasm in aspirin-sensitive asthma." Am Rev Respir Dis, 148, p. 1442-3

36. Israel E, Fischer AR, Rosenberg MA, Lilly CM, Callery JC, Shapiro J, Cohn J, Rubin P, Drazen JM (1993) "The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin." Am Rev Respir Dis, 148, p. 1447-51

37. Kowalski ML, Sliwinska-Kowalska M, Igarashi Y, White MV, Wojciechowska B, Brayton P, Kaulbach H, Rozniecki J, Kaliner MA (1993) "Nasal secretions in response to acetylsalicylic acid." J Allergy Clin Immunol, 91, p. 580-98

38. Katz Y, Goldberg N, Kivity S (1993) "Localized periorbital edema induced by aspirin." Allergy, 48, p. 366-9

39. Al-Abbasi AH (1983) "Salicylate-induced variant angina." Am Heart J, 106, p. 1450

40. Mukerji V, Alpert MA, Flaker GC, Beach CL, Weber RD (1986) "Cardiac conduction abnormalities and atrial arrhythmias associated with salicylate toxicity." Pharmacotherapy, 6, p. 41-3

41. Berg KJ (1977) "Acute acetylsalicylic acid poisoning: treatment with forced alkaline diuresis and diuretics." Eur J Clin Pharmacol, 12, p. 111-6

42. David DS, Steere AC Jr, Pi-Sunyer XF, Sakai S, Clark SB (1971) "Aspirin-induced hypoglycaemia in a patient on haemodialysis." Lancet, 2, p. 1092-3

43. Gardos G (1977) "Dyskinesia after discountinuation of compound analgesic containing oxycodone ." Lancet, 1, p. 759-60

44. Fishbain DA, Goldberg M, Rosomoff RS, Rosomoff H (1988) "Atypical withdrawal syndrome (organic delusional syndrome) secondary to oxycodone detoxification ." J Clin Psychopharmacol, 8, p. 441-2

45. Peters LJ, Wiener GJ, Gilliam J, Van Noord G, Geisinger KR, Roach ES (1986) "Reye's syndrome in adults. A case report and review of the literature." Arch Intern Med, 146, p. 2401-3

46. Epidemiology Office, Divisiion of Viral and Rickettsial Diseasses, Center for Infectious Diseases, Centers for Disease Control. (1989) "Leads from the MMWR. Reye syndrome surveillance--United States, 1987 and 1988." JAMA, 261, 3520,

47. Seaman WE, Ishak KG, Plotz PH (1974) "Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus." Ann Intern Med, 80, p. 1-8

48. Wolfe JD, Metzger AL, Goldstein RC (1974) "Aspirin hepatitis." Ann Intern Med, 80, p. 74-6

49. Sbarbaro JA, Bennett RM (1977) "Aspirin hepatotoxicity and disseminated intravascular coagulation." Ann Intern Med, 86, p. 183-5

50. Pearson RE, Salter FJ (1970) "Drug interaction? Orphenadrine with propoxyphene." N Engl J Med, 282, p. 1215

51. Bharija SC, Belhaj MS (1988) "Acetylsalicylic acid may induce a lichenoid eruption." Dermatologica, 177, p. 19

52. Analysis of Reports to the Spontaneous Reporting System of the Gruppo Italiano Studi Epidemiiologici in Dermatologia. (1993) "Cutaneous reactions to analgesic-antipyretics and nonsteroidal anti- inflammatory drugs." Dermatology, 186, p. 164-9

Further information

Percodan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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