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Medications for Depression

About Depression:  Feelings of depression may be described as feeling sad, blue, unhappy, miserable, or down in the dumps. Most of us feel this way at one time or another for short periods. But true clinical depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for an extended period of time.

Drugs Used to Treat Depression

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Viibryd C N X 445 reviews
6.0

Generic name: vilazodone systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

alprazolam D 4 X 88 reviews
8.0

Generic name: alprazolam systemic

Brand names:  Xanax, Alprazolam Intensol, Niravam

Drug class: benzodiazepines

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

amitriptyline C N X 68 reviews
7.0

Generic name: amitriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Seroquel XR C N X 46 reviews
7.0

Generic name: quetiapine systemic

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

lamotrigine Off Label C N X 79 reviews
7.0

Generic name: lamotrigine systemic

Drug class: triazine anticonvulsants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Deplin N N 67 reviews
7.0

Generic name: l-methylfolate systemic

Drug class: vitamins

For consumers: dosage, side effects

Zyprexa C N X 42 reviews
6.0

Generic name: olanzapine systemic

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

aripiprazole C N X 228 reviews
6.0

Generic name: aripiprazole systemic

Brand names:  Abilify, Abilify MyCite

Drug class: atypical antipsychotics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

nortriptyline N N X 34 reviews
6.0

Generic name: nortriptyline systemic

Brand names:  Pamelor, Aventyl Hydrochloride

Drug class: tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

quetiapine C N X 126 reviews
7.0

Generic name: quetiapine systemic

Brand name:  Seroquel XR

Drug class: atypical antipsychotics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

tramadol Off Label C 4 X 85 reviews
9.0

Generic name: tramadol systemic

Drug class: narcotic analgesics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Desyrel C N X 3 reviews
7.0

Generic name: trazodone systemic

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Fetzima C N X 63 reviews
4.0

Generic name: levomilnacipran systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Trintellix C N X 379 reviews
6.0

Generic name: vortioxetine systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Alprazolam Intensol D 4 X Add review
10

Generic name: alprazolam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Budeprion XL C N X 15 reviews
6.0

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Oleptro C N X 5 reviews
7.0

Generic name: trazodone systemic

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Aplenzin C N X 8 reviews
7.0

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Budeprion SR C N X 7 reviews
8.0

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

desvenlafaxine C N X 648 reviews
7.0

Generic name: desvenlafaxine systemic

Brand names:  Pristiq, Khedezla

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Desyrel Dividose C N X Add review Rate

Generic name: trazodone systemic

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions, side effects

doxepin N N X 18 reviews
6.0

Generic name: doxepin systemic

Brand name:  Sinequan

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Forfivo XL C N X 1 review
10

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

lithium Off Label D N X 22 reviews
6.0

Generic name: lithium systemic

Drug class: miscellaneous antipsychotic agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

methylphenidate C 2 X 39 reviews
8.0

Generic name: methylphenidate systemic

Brand name:  Methylin ER

Drug class: CNS stimulants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

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Topics under Depression

Alternative treatments for Depression

The following products are considered to be alternative treatments or natural remedies for Depression. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Depression.

Learn more about Depression

Micromedex® Care Notes

Symptoms and treatments

Drugs.com Health Center

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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