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Could you or a loved one be experiencing depression?

Medications for Depression

What is Depression:  Feelings of depression may be described as feeling sad, blue, unhappy, miserable, or down in the dumps. Most of us feel this way at one time or another for short periods. But true clinical depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for an extended period of time.

Medications to treat Depression

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Prozac Weekly C N X 1 review
8.0

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
risperidone Off Label C N X 23 reviews
6.0

Generic name: risperidone systemic

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Serzone C N X 10 reviews
9.0

Generic name: nefazodone systemic

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
imipramine N N X 12 reviews
7.0

Generic name: imipramine systemic

Brand names:  Tofranil, Tofranil-PM

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
lithium Off Label D N X 20 reviews
6.0

Generic name: lithium systemic

Drug class: miscellaneous antipsychotic agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Rapiflux C N X Add review Rate

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

 
Asendin C N X 2 reviews
10

Generic name: amoxapine systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

 
desipramine N N X 12 reviews
9.0

Generic name: desipramine systemic

Brand name:  Norpramin

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
desvenlafaxine C N X 614 reviews
7.0

Generic name: desvenlafaxine systemic

Brand names:  Pristiq, Khedezla

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Emsam C N 24 reviews
8.0

Generic name: selegiline systemic

Drug class: monoamine oxidase inhibitors, dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Irenka C N X Add review Rate

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
l-methylfolate N N 85 reviews
8.0

Generic name: l-methylfolate systemic

Brand names:  Deplin, L-Methylfolate Formula, L-Methylfolate Forte, XaQuil XR

Drug class: vitamins

For consumers: dosage, side effects

 
Methylin ER C 2 X 2 reviews
9.0

Generic name: methylphenidate systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

 
methylphenidate C 2 X 33 reviews
9.0

Generic name: methylphenidate systemic

Brand name:  Methylin ER

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Nardil C N X 37 reviews
8.0

Generic name: phenelzine systemic

Drug class: monoamine oxidase inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
nefazodone C N X 25 reviews
8.0

Generic name: nefazodone systemic

Brand name:  Serzone

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
niacin Off Label C N X 23 reviews
9.0

Generic name: niacin systemic

Drug class: vitamins, miscellaneous antihyperlipidemic agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Pamelor N N X 4 reviews
5.0

Generic name: nortriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Parnate N N X 49 reviews
9.0

Generic name: tranylcypromine systemic

Drug class: monoamine oxidase inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Pexeva D N X Add review
8.0

Generic name: paroxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Remeron SolTab C N X 5 reviews
8.0

Generic name: mirtazapine systemic

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Sinequan N N X 3 reviews
9.0

Generic name: doxepin systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Symbyax C N X 16 reviews
9.0

Generic name: fluoxetine / olanzapine systemic

Drug class: psychotherapeutic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
vortioxetine C N X 496 reviews
6.0

Generic name: vortioxetine systemic

Brand name:  Trintellix

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
amitriptyline / chlordiazepoxide N 4 X 4 reviews
9.0

Generic name: amitriptyline / chlordiazepoxide systemic

Brand names:  Limbitrol, Limbitrol DS

Drug class: psychotherapeutic combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
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Topics under Depression

Alternative treatments for Depression

The following products are considered to be alternative treatments or natural remedies for Depression. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Depression.

Learn more about Depression

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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