L-Methylfolate Dosage

Medically reviewed on July 9, 2018.

Usual Adult Dose for Folic Acid Deficiency

L-methylfolate (in the 7.5 mg or 15 mg strength marketed as Deplin tablets) is used for the distinct nutritional requirements of individuals who have suboptimal L-methylfolate levels in the cerebrospinal fluid, plasma, and/or red blood cells and have major depressive disorder (MDD) with particular emphasis as adjunctive support for individuals who are on an antidepressant.
Dose: 7.5 mg or 15 mg orally once daily

L-methylfolate (in the 7.5 mg or 15 mg strength marketed as Deplin tablets) is also used for the distinct nutritional requirements of individuals who have suboptimal L-methylfolate levels in the cerebrospinal fluid, plasma, and/or red blood cells and have schizophrenia who present with negative symptoms and/or cognitive impairment, with particular emphasis as an adjunctive support for individuals who have stabilized on antipsychotics.
Dose: 7.5 mg or 15 mg orally once daily

L-methylfolate (in a 1 mg strength marketed as Zervalx tablets) is used as an orally administered prescription medical food for the dietary management of:
1) intermediate to higher risk pregnancies which require an increased dietary folate intake
2) hemolytic, megaloblastic, and/or sickle cell anemia complicated by folate deficiency
Dose: 1 mg orally once daily

Usual Adult Dose for Hyperhomocysteinemia

L-methylfolate (in a 1 mg strength marketed as Zervalx tablets) is used as an orally administered prescription medical food for the dietary management of:
1) preconception hyperhomocysteinemia
2) methotrexate induced plasma hyperhomocysteinemia
Dose: 1 mg orally once daily

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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