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User Reviews for L-methylfolate

Also known as: Deplin, Elfolate, L-Methylfolate Forte, Duleek-DP, Denovo XaQuil XR

L-methylfolate has an average rating of 7.8 out of 10 from a total of 144 ratings on Drugs.com. 75% of those users who reviewed L-methylfolate reported a positive effect, while 15% reported a negative effect.

Condition Avg. Rating Reviews Compare
Depression  
7.8
125 reviews 78 medications
Folic Acid Deficiency  
7.8
16 reviews 10 medications
Borderline Personality Disorder  Off-label
9.0
2 reviews 28 medications
Hyperhomocysteinemia  
10.0
1 reviews 61 medications
Summary of L-methylfolate reviews 7.8 144 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for L-methylfolate

KQ · Taken for 1 to 6 months May 5, 2021

Deplin (l-methylfolate) for Depression: “My child has been on antidepressants for three years. I read about MTHFR gene mutations and felt this might be the case with my daughter. Her psychiatrist recommended a trial of Deplin rather than testing since Deplin would be the treatment. The results are nothing short of amazing. I have my daughter back!”

10 / 10
Anonymous · Taken for 1 to 6 months April 7, 2021

For Folic Acid Deficiency: “Life changing. After 3 years of trying different SSRI’s that didn’t work for my Depression or Severe Anxiety, I finally did a gene test and not only found 5 medications that were suitable for me, but they saw that I had the homozygous C667T MTHFR mutation, meaning my folic acid conversion was pretty much non existent. This made so, so much sense for a lot of things that happened to me, and I began taking 75mg of Pristiq (SNRI), and 15 mg of L-methylfolate supplements. After several months of these meds, therapy sessions, and even starting exercise again, I am a changed person. The hamster wheels in my head have finally slowed down, I’m not seeing darkness (figuratively) all the time anymore, and I haven’t had a panic attack in months. These results and these capsules have saved me.”

10 / 10
Blewee0813 · Taken for 1 to 2 years February 10, 2021

For Depression: “Very good supplement for the treatment of depression. It's definitely good as an add-on to prescription antidepressants. Most people with mental health issues are lacking in folic acid and l-methylfolate is the most potent kind of folate.”

7 / 10
Kendall April 21, 2019

Deplin (l-methylfolate) for Depression: “Deplin has changed my life. My doc did genetic testing for my severe anxiety and panic disorder and found I have the MTHFR gene mutation where I don’t break down folate. He prescribed me this with my antidepressant and it’s been a miracle. I’m no longer anxious, I do not have panic attacks, my depersonalization and derealization is completely gone. I praise the Lord in how good and healed I feel. I’m a RN and I suggest all those who are suffering to give this a try. Hang in there, God is with you. There is hope. You will feel better. Praying for all who read this post.”

10 / 10
johnny734 · Taken for 2 to 5 years April 20, 2013

Deplin (l-methylfolate) for Depression: “I want to I really say people should wait at least 3 months before they rate Deplin or any psychiatric medicine, unless you have some major horrible reaction. Deplin gave me a kick start the first week I took it for some reason but then the effects disappeared. I talked to the P-doc and he said it takes something like 6 weeks to build up in your system. Well after about 6 weeks or so I started to notice the effects. It gave my Wellbutrin a huge boost and my energy level rose through the roof. People rating a medicine after 2 days is just ridiculous and annoying. Even the SSRI's take a couple weeks to work. Stop it people.”

8 / 10
Tina August 30, 2019

Deplin (l-methylfolate) for Depression: “I’m a psychiatric nurse and have seen many medications work and many not. For me, Deplin has worked quite well. I’ve stopped taking it before with a marked increase in depression. With Deplin I feel genuine happiness and want to smile. We all know people with depression are pros at the “fake smile” but my smile is from the heart. At the risk of sounding like a marketer for Deplin, there have been a few times I’ve tear up because I’m afraid the happiness will go away. I enjoy being well and don’t take what I have right now for granted. I know the studies aren’t great concerning Deplin but for the people who do respond well to it, Deplin can be a life changer and a life saver.”

MsRinkyDink · Taken for 2 to 5 years June 16, 2019

Deplin (l-methylfolate) for Depression: “I was being treated for a mood disorder and the meds were kind of helping but many days I still felt ‘disconnected’, rarely having a day where I felt great. I assumed it was normal for me to feel that way. My doctor decided to prescribe Deplin. This was years ago. Anyway, one day, after having been taking it for about 3 weeks, I woke up and realized I felt GREAT! Like the fog had lifted. I have so many great days now. I’ve been on it for years now and it really has changed the quality of my life.”

10 / 10
The Man with a Plan · Taken for 10 years or more June 27, 2020

Deplin (l-methylfolate) for Depression: “This is a follow up from a post years ago. I tried every med possible both antidepressants as well as benzos for panic, depression and anxiety. Nothing every worked and the meds had intolerable side effects. In 2009, I took Deplin for the first time and my life changed. Yes I am Heterozygous with the C667T mutation and 11 years later, I am still loving my Deplin. I am off benzos completely, after a long taper, and have lowered my SSRI to a very small dose.”

10 / 10
Mark D February 4, 2019

Deplin (l-methylfolate) for Depression: “I am a 50 year old medical professional and have struggled with mostly moderate depression for most of my life. I had struggled with, and eventually refused, taking anti-depressants because the side effects were worse than the cure. Eventually, a counsellor convinced me to try Deplin. After a few weeks, there was a noticeable shift in my mood. It was like a curtain had been lifted and I felt normal. A few months later, I ran out of the Deplin but didn't want to spend the money to get it refilled. Approximately two weeks later, wham!, the curtain dropped and the depression was back. Lesson learned.”

9 / 10
ladyKR December 14, 2013

Deplin (l-methylfolate) for Depression: “In 28 years, after dozens of antidepressants, add on's, ECT's...I've never felt so full of life. Ever. An absolute miracle this was. I was absolutely lifeless. I feel sorrow for having gone so long miserable, but blessed to have been lucky enough to have a doctor try this with me.”

10 / 10
Color Love · Taken for less than 1 month November 6, 2016

Deplin (l-methylfolate) for Depression: “Deplin has saved my life. For two years I have struggled with debilitating depression and anxiety. I have been on every anti-depressant and anti-psychotic, and went through sixteen sessions of ECT. A fourth visit in the hospital landed me under the care of a psychiatrist who finally ordered genetic testing for me, and we learned I have the gene-mutation that impairs folate production. Started Deplin 15 mg eight days ago and I feel absolutely wonderful. Mood is great, anxiety has improved significantly, and I feel so peaceful. My energy level is up, and I feel hopeful and full of life again. I am so relieved and happy I could cry.”

10 / 10
I feel like a puppy May 10, 2015

Deplin (l-methylfolate) for Depression: “My sister was tested and has the MTHFR mutation. I have struggled with depression, anxiety, ADHD, and bowel problems since childhood. I have only been on Deplin for five days but I have never been so energized and just generally happy in my life. Finally I have hope for the future. Before I was unsure how long I could last because I knew all of my symptoms were slowly worsening. Now I feel like a little kid again. All I want to do is dance around and do handstands. Everything and everyone makes me laugh and life has never been so good. My ADHD, depression(obviously) and IBS have dissipated, I have increased sex drive and metabolism and even my liver is detoxing again. THANK YOU DEPLIN”

10 / 10
Raylee · Taken for less than 1 month November 12, 2018

Deplin (l-methylfolate) for Depression: “Deplin ! What can I say, changed my life!. I had been dealing with treatment-resistant depression for over a year. My psychiatrist finally gave me deplin and in just days I felt better than I had in a long time!I also starting taking L-carnitine which if youve been depressed for a long time you are probably deficient in it. But I know it was the deplin. You have nothing to lose please try it! I had absolutely no side effects. I have more energy but mainly the horrible painful depression lifted in 3 days! I am beyond thrilled and would pay any amount of money per month to keep this medicine. Please give it a try.”

10 / 10
Margaret · Taken for 1 to 6 months April 2, 2019

Deplin (l-methylfolate) for Depression: “Like many, I have been clinically depressed since my 20’s. (30 years). Cymbalta has helped me the most, but I still get hit with very dark times. Last month, my doctor gave me Deplin samples. I took them, but with very low expectations. Three weeks into it, I began to notice a change...normalcy! It crept up on me. I stopped needing a 2 hour nap, I feel clear minded. My mind doesn’t feel like a Los Angeles freeway. I am calm and feel content. I can’t wait to tell my doctor tomorrow. I also needed a D3 prescription. I am sure my father could have felt so much better with these food meds.”

8 / 10
Mark2112 Deplin works for me. · Taken for 6 months to 1 year January 5, 2013

Deplin (l-methylfolate) for Depression: “Deplin worked for me but is not for everybody. I have the genetic mutation which others on this website have talked about, which keeps the body from processing folic acid into L-methylfolate which is needed by the brain for the other neurotransmitters to work properly. A blood test ($280) proved this. Before Deplin I was was on Bipolar meds (including Seroquel which was miserable) and antidepressants. Now I am only on Deplin and Clonazepam for chronic anxiety and am feeling re-energized.”

10 / 10
So this is what I used to feel like! May 10, 2011

Deplin (l-methylfolate) for Depression: “Just turned 50 and I've fought with Bipolar Disorder and Depression my entire life. I've been taking 300mg of Lamictal to control mood swings and 1.5mg of Klonopin to treat chronic anxiety. Depression was still so overwhelming that I asked for an anti-depressant. The MD prescribed 200mg of Wellbutrin SR which had a positive effect, yet did not get rid of the underlying thoughts of death and dying; many of you will understand that I'm talking about a coping mechanism not actually wanting harm myself. A pharmacist told me to ask my MD about Deplin and that was the best medical advice I've ever received! I've been taking 15mg daily for over two months and have not felt this "normal" for many years! Thanks for reading my opinion.”

10 / 10
Jeanne Beanie June 12, 2016

Deplin (l-methylfolate) for Depression: “I have suffered with depression since I was a child but of course I didn't know it then. Alcohol and drugs became my only salvation. Eventually I had to get sober. Still depressed. Had a relapse that lasted 4 years. Sobered up again. 18 years sober and still suffering that back cloud with anxiety on top. Tried Depli 3 months ago. I didn't expect good results since I've taken so many antidepressants over the years. I felt better the first day. I feel like normal people feel. I have hope, motivation, freedom. I am completely happy. I know this has not been everyone's experience, but it's mine, and for that; I'm eternally grateful. If your insurance doesn't cover it file an appeal. If you can pay cash it's only $178 for 3 months or pay monthly”

10 / 10
Mucky · Taken for 1 to 6 months August 30, 2018

Deplin (l-methylfolate) for Depression: “I have suffered from depression, anxiety and PTSD for years . I tried most of the SRI’s &SNRI’s . The best medicine for me was Lexapro and klonopin. However, after 10 years on Lexapro, it lost its efficacy. My psychiatrist suggested Deplin. It took about 9 weeks for it to work . I hung in there because of him, and posts like this . It has reduced my depression and , surprisingly my anxiety. I am thrilled . Deplin is a true blessing . Don’t give up if it does work for you quickly. I’ve read it can talk much longer for some people ; even 10 weeks . Have patience ; it’s worth it !!”

10 / 10
Anonymous · Taken for 6 months to 1 year September 12, 2012

Deplin (l-methylfolate) for Folic Acid Deficiency: “I was tested for MTHFR genetic mutations after several years of fibromyalgia/chronic fatigue type symptoms. BINGO! I have compound heterozygous mutations. Which can cause whole host of health issues, many I have been experiencing since youth. Once I started 7.5mg of Deplin with Methyl b12 my aches, brain fog, and unrelenting fatigue started to diminish..this is a life changer!”

10 / 10
Karin, Kissimmee, FL October 20, 2016

Deplin (l-methylfolate) for Depression: “I have struggled with depression almost all my life and have been on Zoloft for more than 20 years. I recently told my doctor that in addition to being overwhelmed with devastating family health issues, I had been becoming more and more fearful of losing my career because I couldn't seem to remember even the simplest of tasks. I was literally losing my mind!!!! He prescribed DEPLIN. I've been on it for roughly four months. SUCCESS!! My memory and mind is as sharp as it's ever been. Thank God for DEPLIN. Additionally, my overall mood has improved and I have a calm outlook on life and now take everything in stride. It's been years since I've been able to just "go with the flow". I FEEL LIKE A NEW PERSON. THANK YOU, DEPLIN!!”

10 / 10
SadRich February 5, 2009

Deplin (l-methylfolate) for Depression: “I'm 47 and have had serious, treatment resistant depression since my early 20s. Antidepressants have offered me some relief, though it has been far from complete. Although I have remained consistently on antidepressants since Prozac was released, my depression has been bad. I've been muddling along on Pristiq and Welbutrin. Recently my doctor had me on Ritalin as well, to give me the energy just to make it through the day. She put me on Deplin a week ago and its effect on me was felt the next day. After a night of extremely colorful dreams, I woke up feeling great. I took my medicine as usual and it was suddenly as if my brain could feel all the antidepressants for the first time. I spent a trippy weekend, got in touch with my doctor on Monday, immediately discontinued Ritalin. I'm still feeling great, full of energy, and still feeling over medicated. I suspect the next step might be to reduce, if not discontinue, the Pristiq and Welbutrin. This is the first time I've ever actually thought I may have found a "cure" for lifelong depression. It's only been about a week now, but I remain cautiously optimistic.”

Suzeeh April 13, 2012

Deplin (l-methylfolate) for Depression: “I lost my only child four years ago and have battled grief and depression. I was put on Deplin and it made a huge difference in my frame of mind. I went off of it a month ago because I started a new job and basically just forgot to get it filled. Big mistake. I have been extremely sad and depressed. I will be getting that prescription filled tomorrow. It was a lifesaver.”

10 / 10
WhoCares(: February 22, 2012

Deplin (l-methylfolate) for Depression: “I have had depression for 8 years and nothing has ever pleased me.. I just had a baby 5 weeks ago and my depression like doubled! I felt so lost and I really thought I was losing my mind!! I just wanted to end my life! I told my OBGYN and he gave me this medicine and I really haven't felt this good in years! It makes me feel relaxed and do nothing but laugh! My mom said she hasn't seen me this way in years! I was pushing my sons dad away because of how I been feeling but I just been so happy around him now! I can handle the baby's crying better and most of all myself! I just feel alive again. Thank you Deplin!”

8 / 10
Cheryl2280 · Taken for 1 to 6 months March 30, 2019

Deplin (l-methylfolate) for Depression: “I take l-methylfolate (this medical food )once a day with my anti depressant for my anxiety and panic disorder and I feel great. I am always very positive and I never have anxiety. My panic triggers are gone, it is amazing. Definitely recommend to anyone having depression. It works. It's not expensive. 58 a month. Worth it for me. Also helps my folate deficiency. 100% awesome med. Never want to be without it.”

10 / 10
glbrosnan · Taken for less than 1 month April 9, 2015

Deplin (l-methylfolate) for Depression: “Because this is a food/medicine, there is no way it can cause side effects. I have only been on it for a little over a week, but I am thrilled!! I do not feel depressed, and I am feeling energized and better than I have in years! I have taken every kind of antidepressant there is, I think. I weaned off the last one, and right now I am not on anything but Deplin. I am amazed.”

10 / 10
Anxious like crazy · Taken for less than 1 month January 16, 2015

Deplin (l-methylfolate) for Depression: “I have been taking Citalopram and Clonazepam (for panic attack only) for MONTHS. My anxiety level, even on these medicines, was completely out of control. To the point where my muscles were twitching non stop all day long (as well as other physical symptoms). I added the Deplin to my 20mg Citalopram at the request of my doctor. Within a few days I felt like a completely new person! Better than I have felt in years. My muscle twitching completely went away and I no longer have obsessive thoughts. I highly recommend this medicine for anyone suffering with severe anxiety or Generalized Anxiety Disorder. It is life changer. Well worth the $60 a month.”

10 / 10
Neties December 24, 2010

Deplin (l-methylfolate) for Depression: “I have suffered with Major Depressive Disorder, Generalized Anxiety Disorder, and Obsessive Compulsive Disorder for over twenty-years. I have been on many types of anti-depressants with moderate success. I started taking Deplin 7.5mg once a day and I can't believe the results. I feel "normal." My idea of normal is to go through a day without having feelings of hopelessness and wanting to stay out of social situations. I feel great. I started feeling the effects of Deplin on the second day. I am a mental health counselor (graduate student). I have learned how to survive and muddle through all that I want to accomplish in life. Deplin has given me new hope for the future.”

10 / 10
RNGeorgia September 23, 2015

Deplin (l-methylfolate) for Depression: “Within just days of my first dose, I could fell a huge, positive difference. My mind and speech were clearer, my anxiety was nearly unrecognizable, and I was just plain happy. I admit that the cost has been somewhat limiting at times. When I have chosen to delay filling a prescription for a week or two, not only can I feel the difference, but my coworkers, family and friends quickly point out the changes. It's an amazing supplement and worth every penny (when I have it to spare). Plan to stay on it from now on!”

9 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.