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User Reviews for L-methylfolate

Also known as: Deplin, Duleek-DP, Elfolate, L-Methylfolate Formula, Vilofane-DP, XaQuil XR, Zervalx

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about L-methylfolate.

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Condition DownUp Reviews Compare Avg. Ratings DownUp
Folic Acid Deficiency 5 reviews 9 medications
   
10
Depression 66 reviews 79 medications
   
8.0
Borderline Personality Disorder 2 reviews 0 medications
   
6.3
Summary of L-methylfolate reviews 73 reviews 8.1

Reviews for L-methylfolate

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Deplin (l-methylfolate) for : "Prescribed for my young daughter with Autism and epilepsy, anxiety- hair pulling , but the dose was too high and caused even more anxiety, so found reducing it from every day, to once a week, and sometimes just twice a month, makes a huge difference for her to receive the benefit without the heightened anxiety. I muscle test for the amount and timing, and notice when she is pulling her eyelashes, hair or eyebrows."

   
6.0

LURee August 9, 2016

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Deplin (l-methylfolate) for Depression: "It has helped me quite a bit, although it doesn't seem to have antidepressant effects. It's definitely helping me "think" better - I'm not confused anymore."

   
8.0

Stonecrab (taken for 1 to 6 months) July 29, 2016

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Deplin (l-methylfolate) for Depression: "Long history of medication resistant recurrent major depression. Tried Deplin 15 mg daily for 6 months. No improvement at all seen with Deplin. Total waste of money for me."

   
1.0

Rich Dock (taken for 6 months to 1 year) July 21, 2016

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For Depression: "Normally I only peruse these listings, but this time I thought I owed it to all my fellow readers to give a detailed review. I began taking 10mg methyfolate around 10 days ago at the urging of my father, who, for obvious reasons, shares a very similar genetic predisposition toward depression and anxiety. The results? All I can say is wow. Within 1 day, I felt like my internal motor that had been idling along at a 5 out of 10 had been turned up to a 10 for the first time in a long time. I had more energy, clearer thoughts, happier disposition, appetite and libido returned full force. My only regret is not trying this stuff sooner. If it feels like nothing has ever really solved the problem before, please try this. It's a miracle."

   
10

Former Skeptic (taken for less than 1 month) July 11, 2016

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Deplin (l-methylfolate) for Folic Acid Deficiency: "MTHFR with some bipolar, previous ADHD and OCD diagnoses. Started taking Deplin with B12 (methyl folate)- be sure to take both - and seeing great results. Mood improved greatly and performance overall. Couldn't imagine life without it!"

   
10

MedStudent91 July 11, 2016

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Deplin (l-methylfolate) for Depression: "Terrible! I was on it 3 days while also on Viibryd and it caused me SEVERE anxiety. I was found to have a compound heterozygous gene mutation and the psychiatrist thought this should help. Wrong. I also found out through the gene test I cannot take SSRI's. Viibryd is a hydrid SSRI. The combination was bad news for me and I had to stop the AD cold turkey bc the blast of Deplin apparently caused me serotonin overload. Still struggling 4 weeks later. From what I've researched, l-methyl folate should be started at SMALL doses, like 400mg, NOT 15mg (Deplin).... Lord!"

   
1.0

Lskmjk (taken for less than 1 month) July 10, 2016

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For Depression: "2 weeks after starting 15 mg I started having insomnia, increased anxiety, and aggitation. Apparently these can be rare side effects. I am stopping the medication."

   
2.0

Sndallas July 3, 2016

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Deplin (l-methylfolate) for Depression: "I started Deplin 8 months ago. I thought it was helping but I didnt notice drastic effects. I stopped taking it for 2 weeks due to the cost and quickly realized it had been working.I started feeling lethargic and unmotivated. Since I have been taking it daily I am much more active, energetic, less moody, and I am happier. I think it is a subtle change but over time it is drastic."

   
10

Ajade2003 June 29, 2016

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Deplin (l-methylfolate) for Depression: "I have suffered with depression since I was a child but of course I didn't know it then. Alcohol and drugs became my only salvation. Eventually I had to get sober. Still depressed. Had a relapse that lasted 4 years. Sobered up again. 18 years sober and still suffering that back cloud with anxiety on top. Tried Depli 3 months ago. I didn't expect good results since I've taken so many antidepressants over the years. I felt better the first day. I feel like normal people feel. I have hope, motivation, freedom. I am completely happy. I know this has not been everyone's experience, but it's mine, and for that; I'm eternally grateful. If your insurance doesn't cover it file an appeal. If you can pay cash it's only $178 for 3 months or pay monthly"

   
10

Jeanne Beanie June 12, 2016

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For Depression: "I have suffered from anxiety and depression for the better part of 60 years. Anxiety was normal for me until a friend told me about Deplin's L-methylfolate. She explained that severe anxiety could be from an inability to absorb folate. I asked my Dr for an Rx and he said it wouldn't hurt to try this it was a medical food and not a drug. I was on Ativan, Prozac, Doxepin and Trazadone and still had anxiety 24/7. Within one week of taking L-methylfolate, I had absolutely NO anxiety. It was so quiet in my soul that I almost felt anxiety about not having anxiety! It was foreign to me; the steady drip, drip, drip of adrenalin rushing through my system was shut off. Within six months I was off all other medications. This was a miracle for me."

   
10

usagranny June 11, 2016

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Deplin (l-methylfolate) for Depression: "I have been on Deplin 15mg for about 3.5 months. I have the mutation and was hopeful that this would help. I noticed no change whatsoever in my anxiety or depression. I also started having severe joint pain and nothing had changed but adding Deplin. My doctor recommended that I stop the Deplin. I have been off for 3 days and continue to have joint pain. Would love to hear from others with a similar experience."

   
1.0

CK1210 May 26, 2016

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Deplin (l-methylfolate) for Depression: "Not worked for my depression. Zero effect."

   
1.0

mikoy (taken for 1 to 6 months) May 25, 2016

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Deplin (l-methylfolate) for Depression: "I'm just starting deplin I need energy I been taking Wellburtion for two yrs now 100 mg 3 times daily I pray it work for my energy level."

joy2016 (taken for less than 1 month) April 19, 2016

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Deplin (l-methylfolate) for Depression: "I have suffered with depression as long as I can remember, high school and since. I'm 30 years old. I've tried everything to help my depression. Paxil lexpril prozac HTP5 WELBUTRIN and now celexa. Celexa did help more than the other antidepressants bUT still I was suffering from depression. I lost my baby girl doggie who was only 3 years old and was just like my child. My world fell apart and my depression became severe at the worst I ve ever experienced. I went to the doctor to talk about options as the severity of depression was overruling my life. Doc gave me 30 deplin 15 mg capsules samples. In 2 days I felt alive again. I am so grateful. Look up brand direct health and have you dr send your script to them. Much cheaper. 65 $ for 30cap"

   
10

MyleeJ14 (taken for 1 to 6 months) October 14, 2015

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Deplin (l-methylfolate) for Depression: "Within just days of my first dose, I could fell a huge, positive difference. My mind and speech were clearer, my anxiety was nearly unrecognizable, and I was just plain happy. I admit that the cost has been somewhat limiting at times. When I have chosen to delay filling a prescription for a week or two, not only can I feel the difference, but my coworkers, family and friends quickly point out the changes. It's an amazing supplement and worth every penny (when I have it to spare). Plan to stay on it from now on!"

   
9.0

RNGeorgia September 23, 2015

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Deplin (l-methylfolate) for Depression: "I was born with Spina Bifida L4-5 s1-2 along wt a myleomingeocole. My Birth issues were due to LowFolate. Through life I have struggled wt Depression always being told it was due to the Spina Bifida. I fought through a major depression my senior year in college. When I became employed following college and had insurance I sought counseling & medication taking imipramine. When Prozac became available I began it. After a decline in my health from a stoke at 33 My depression became worse requiring hospitalization. Five years ago I returned to my hometown & sought medical care from my high school friend. He tested me for L methyofolate deficiency. I was deficient he put me on Deplin 15mg wt Zoloft 100mg. I am finally emotionally healthy"

   
10

Terriwriter September 4, 2015

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For Depression: "Deplin has helped to clear my thinking and has improved my memory, big difference noted when stoped. Continued right away after stopping!"

   
10

CrystalJx August 21, 2015

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Deplin (l-methylfolate) for Depression: "I have been taking Paxil/Paroxetine for approx.15 years. About 2 years ago, I mentioned to my psychiatrist that I had long been very sensitive to noise. I would get really upset (angry) by the sound of the doorbell, or even my young daughter's playfulness. My Dr. recommended Deplin as an additional "medicine". After a couple of weeks of taking Deplin,,my sensitivity improved greatly. I did not feel any different, nor have any side-effects. I stopped for a couple of weeks, thinking that it didn't really do anything, and I DID notice a big difference. Although it is expensive, I will continue to take my 15mg every day (along with my Paxil) It works!, My husband agrees! "

   
9.0

StaceyaS August 8, 2015

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Deplin (l-methylfolate) for Depression: "I started taking Deplin 2 months ago in addition to the 300 mg. of Wellbutrin I had already been taking for several years. I was experiencing a very low level of chronic depression but generally okay. The doctor recommended I try Deplin to see whether it would increase my level of well-being. I could swear I feel a lot MORE depressed with the Deplin. Nothing has changed in terms of life style over the past few months, so I can't think of any other explanation. Needless to say, I'm going to stop taking it. I had no idea it might worsen my symptoms."

   
1.0

Haystackneedle (taken for 1 to 6 months) August 1, 2015

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Deplin (l-methylfolate) for Depression: "My sister was tested and has the MTHFR mutation. I have struggled with depression, anxiety, ADHD, and bowel problems since childhood. I have only been on Deplin for five days but I have never been so energized and just generally happy in my life. Finally I have hope for the future. Before I was unsure how long I could last because I knew all of my symptoms were slowly worsening. Now I feel like a little kid again. All I want to do is dance around and do handstands. Everything and everyone makes me laugh and life has never been so good. My ADHD, depression(obviously) and IBS have dissipated, I have increased sex drive and metabolism and even my liver is detoxing again. THANK YOU DEPLIN"

   
10

I feel like a puppy May 10, 2015

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Deplin (l-methylfolate) for Depression: "Because this is a food/medicine, there is no way it can cause side effects. I have only been on it for a little over a week, but I am thrilled!! I do not feel depressed, and I am feeling energized and better than I have in years! I have taken every kind of antidepressant there is, I think. I weaned off the last one, and right now I am not on anything but Deplin. I am amazed."

   
10

glbrosnan (taken for less than 1 month) April 9, 2015

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For Depression: "Depression sufferer my whole life. On Deplin for last year and my lows vanished within first week on 15mg/day. It's all I'm taking and the benefit is absolutely profound. Zero side effects. Most psychiatrists downplay the lack of studies but it definitely works for me better than anything else I've tried. Good luck."

   
10

Male, 46 yrs old (taken for 1 to 2 years) February 15, 2015

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Deplin (l-methylfolate) for Depression: "I've been using antidepressants for quite a few years now. I seem to have gone through the entire list of antidepressants. My latest script is Escitalopram Tabs, 10mg. We recently added Abilify and this Deplin Caps, 15mg. I've been feeling a bit better. One of these two give me an awful case of Heartburn! Painful it is. I'll mention it during my next appointment. Now, as before, I can't watch anything with intense emotions as I'll breakdown and start crying. At age 52 I find it a bit annoying. Before I added these last two medicines I found myself crying more frequent than not. The movie "UP" really freaked me out. Anyway I'm disabled with intractable pain. That's what started all the depression stuff."

   
7.0

stgecko (taken for less than 1 month) February 4, 2015

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Deplin (l-methylfolate) for Depression: "I have been taking Citalopram and Clonazepam (for panic attack only) for MONTHS. My anxiety level, even on these medicines, was completely out of control. To the point where my muscles were twitching non stop all day long (as well as other physical symptoms). I added the Deplin to my 20mg Citalopram at the request of my doctor. Within a few days I felt like a completely new person! Better than I have felt in years. My muscle twitching completely went away and I no longer have obsessive thoughts. I highly recommend this medicine for anyone suffering with severe anxiety or Generalized Anxiety Disorder. It is life changer. Well worth the $60 a month."

   
10

Anxious like crazy (taken for less than 1 month) January 16, 2015

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For Depression: "After YEARS of depression & anxiety I'd been on countless combinations of medicines. The past few years severe health problems (open heart surgery @ 37 and a bowel resection @ 39 over 200 days in hospital) have contributed to the lowest lows of my life. I've spent the vast majority of the past two years in pajamas. EVERYTHING felt overwhelming. Living a normal life again seemed impossible. I had absolutely NO energy & believed I'd feel tired forever which made me sad all the time. After adding Deplin to the Celexa I've been taking for years, I am amazed by the results. It's been like flipping a switch in my brain. The darkness has been flooded with light. I have the motivation to live life again. Deplin is nothing short of a miracle!"

   
10

JDmom2four (taken for 1 to 6 months) January 12, 2015

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