L-methylfolate User Reviews & Ratings (Page 4)

• spr...
• December 15, 2010

L-methylfolate for Depression "I started taking Deplin yesterday and recently tapered myself off of Cymbalta and Wellbutrin. I still have the Cymbalta withdrawal 'brain zaps,' but have regained my crying reflex that I lose every time I get back on medication. I have been pregnant several times and needed to come off all medications for the duration. Today I had more natural energy than I've had in a long time. I had been taking Hydroxycut just to get myself moving and to the gym as I had reached my maximum weight of 188 last week. Now I don't feel like I need it anymore. My OCD is almost non-existent now. I can complete multiple tasks without spending an eternity detailing every aspect of a small task. This is how I feel after day 2, hopeful this will continue."

• Els...
• February 24, 2012

For Depression "I have suffered from depression for about 30 years, crippling depression with anxiety since 1992. I am 62. I have taken nearly every antidepressant, and none really worked. I read this forum about four months ago and decided to order 5-MTHF, 10 mg. After about three weeks, I realized I was coming up from the deep depression. I was taking 20 mg of Lexapro and cut that down to 10 mg a day. I am excited that this might be what I need, but will wait a while before foregoing with the Lexapro because I'm not ready to enter that deep depression if this doesn't work by itself. I am so excited even if I do have to continue the Lexapro. To feel like getting out of bed, doing normal things, and feeling good is great. I will post updates."

• JDm...
• Taken for 1 to 6 months
• January 12, 2015

For Depression "After years of depression and anxiety, I'd been on countless combinations of medicines. The past few years, severe health problems (open heart surgery at 37 and a bowel resection at 39, over 200 days in the hospital) have contributed to the lowest lows of my life. I've spent the vast majority of the past two years in pajamas. Everything felt overwhelming. Living a normal life again seemed impossible. I had absolutely no energy and believed I'd feel tired forever, which made me sad all the time. After adding Deplin to the Celexa I've been taking for years, I am amazed by the results. It's been like flipping a switch in my brain. The darkness has been flooded with light. I have the motivation to live life again. Deplin is nothing short of a miracle!"

• jus...
• March 26, 2014

L-methylfolate for Depression "I thought I would share my experience, as it may be helpful to others. I have been on this for over 2 years now... and depression-wise (which is what I'm basing my rating off of because that is what this rating is supposed to pertain to), it hasn't done anything for me at all. At least nothing at all that I have ever noticed. I have stayed on the medication because of the fact it does help bring down my homocysteine levels. I have a condition referred to as MTHFR. Basically, it's a liver enzyme condition that makes it so the body doesn't convert proteins/peptides very well. Common condition (1/10 Americans) but rarely tested for. The lab had to look up what to do for drawing blood and testing for it."

• Jin...
• Taken for 1 to 6 months
• August 23, 2023

L-methylfolate for Depression "I have a genetic mutation which lowers my body's ability to convert folic acid into its active form, but had never been prescribed Deplin for my bouts with depression and lifelong insomnia. This spring, my mood started to decline and my sleep was worse. At one point, I was taking three medications for sleep. I told my new psychiatrist about my old genetic test results regarding folic acid, and he thought I should try 15 mg of Deplin. Within two weeks, my sleep improved dramatically - I was able to discontinue a sleeping medication, and within 3-4 weeks, my mood also became much more stable and consistent. I've now been taking Deplin for almost six months and have been able to discontinue another sleep medication (I still take one for sleep). Although I still get short bouts of lower moods, they are nothing compared to what they were prior to Deplin. I tried at least five add-on antidepressants prior to Deplin with no results. I had no side effects, and it's very easy to take - a real lifesaver!"

• CK1...
• May 26, 2016

L-methylfolate for Depression "I have been on Deplin 15 mg for about 3.5 months. I have the mutation and was hopeful that this would help. I noticed no change whatsoever in my anxiety or depression. I also started having severe joint pain, and nothing had changed but adding Deplin. My doctor recommended that I stop the Deplin. I have been off for 3 days and continue to have joint pain. Would love to hear from others with a similar experience."

• pja...
• Taken for 1 to 6 months
• September 19, 2018

L-methylfolate for Folate Deficiency "I started taking Klonopin after several years of depression, two bouts of major depression, and tension myositis syndrome (TMS). It helped the TMS a great deal, but after about a year, symptoms of major depression and anxiety returned. The psychiatrist wanted to prescribe more Klonopin, and when I declined that, she recommended Deplin. Deplin has helped. I now am able to wake up in the morning, and the speed of thought is almost normal. I still have mood instability, but symptoms have decreased. I also have been able to significantly reduce the use of Klonopin and hope to be off it completely as Deplin therapy continues."

• Zar...
• Taken for less than 1 month
• March 1, 2018

L-methylfolate for Depression "I had the swab genetic test done. I lack the MTHFR gene that creates the enzyme that breaks down folic acid to folate. Without folate, depression is very likely. My doctor prescribed Deplin, as it would take 60 bottles of over-the-counter folate to equate to the convenient orange capsule. The first three weeks, my depression and anxiety got worse. My doctor wasn't helpful, but I kept taking it. I’m around week 5, and I am able to see my compulsive eating as not good for me, as I am morbidly obese. I don't feel overly happy, but more in control in a chaotic world and able to focus more. I'll chat with my doctor about getting off Lamictal once I've had a couple of months on Deplin. I am far less paranoid and explosive, but I have routine scary dreams being out of control. I can't put my finger on it, but I think I am better off with Deplin and apprehensive to go off it. This is not the placebo effect talking. I think I can lose weight and get off the bipolar meds. I pay $160 for a three-month supply."

• Pay...
• April 21, 2017

For Depression "As mentioned in other reviews, Deplin is designed to augment other medications to increase their efficacy. All Deplin is is L-methylfolate packaged as a prescription medication by drug manufacturers to make money on a supplement that is readily available for much less cost. If you are paying more than $30/month, check out other brands. It sells L-Methylfolate 15 mg, 30 capsules for $30. They also have 7.5 mg capsules. Methylpro is not a generic Deplin. Methylpro is L-methylfolate. Deplin is L-Methylfolate. No difference. Naturopaths and savvy doctors (not the medication-only white coats) have been using L-methylfolate years and years before it was packaged as an expensive prescription 'drug.' Do your homework, save money, and stick it to the man."

• Jul...
• October 24, 2019

For Depression "So, I've been on a litany of meds for 40 years. I have BPD1, major depressive disorder with psychotic features. I sometimes have delusions and hallucinations. Both suicidal and homicidal ideations. This has been utterly unbearable because no antidepressants or antipsychotics have ever helped me. The antidepressants cause me to feel suicidal. About a year ago, a doctor gave me Deplin. I take it when I need to, and it works. Just 3 days ago, I felt suicidal and was hearing the voices inside my head. Day 3 of Deplin, and I feel better again. I only use Deplin and nothing else. Yes, it's tough managing the other symptoms by myself, but they're nothing next to my depressive episodes. All I can say is that L-methylfolate is helping me. It is the only thing that has ever helped. There are some side effects like palpitations, insomnia, and some restlessness, but I don't care."

• sti...
• September 29, 2009

L-methylfolate for Depression "I have had a partial response to my antidepressant. I have had a hard time finding one as my chemistry responds unfavorably to many drugs. Deplin was advised by my doctor, who has actually participated in clinical trials. She had seen no adverse effects and thought it would work great for me. On the 3rd day, I felt like my old self for the first time in 1 year. Unfortunately, that night I had auditory hallucinations... first time in my life... and a very restless night. Went off and slept okay. Tried just doing folic acid and Vitamin B6 and had the same response, only worse. Didn't sleep the whole night. Both my psychiatrist and psychologist say I am the only person who they have ever seen have a negative reaction. Like I said, I felt great. Good luck."

• Cin...
• July 14, 2009

L-methylfolate for Depression "I've been on Deplin for 20 days now, along with Zoloft. I had great success with Cymbalta, but it messed badly with my blood pressure (going from 112/65 to 175/100), so I had to go off it. I was put on Zoloft as a stopgap, but have tried it in the past without much success, as with all the others. They say it can take 4-6 weeks before Deplin has its full effect. I'm still hopeful, but I do so wish I'd seen the overnight change like others."

• Ros...
• Taken for 1 to 6 months
• August 14, 2018

For Depression "I’ve been on so many antidepressants. None made me feel great. Improved the depression for a while, then pooped out. Or the dose was raised, and I had no emotions at all. I started Enlyte. I’m in month 3. It’s subtle and gradual for me. But I’m napping less. Back to reading and doing artwork again. I feel much less of the 'ugh, this is too hard.' I’m putting one foot in front of the other on automatic instead of such a forced effort. Well worth the $30 a month. I don’t miss any work, as work is less of a drag, so it pays for itself. I’m living my life for the first time since I was a teenager. At age 60!"

• Lau...
• Taken for 1 to 6 months
• May 31, 2017

L-methylfolate for Depression "I started this supplement with high hopes. I was given it to boost the effectiveness of the Pristiq I'm taking. After using it for over a month, I'm disappointed. Really have experienced no change. I'll keep searching for the right combination of meds."

• Luc...
• October 24, 2019

L-methylfolate for Folate Deficiency "I am 66 years old and have suffered from ADD, depression, brain fog, fatigue, and extreme anxiety all my life. 30 years ago, I was put on dextroamphetamine 3-4 times a day, and it was a miracle. I came to life, both physically and especially mentally, and I slept wonderfully. Now that drug has little to no effect on me. My doctor, after doing a genetic test on me, says I have a gene mutation and prescribed Deplin for me. At first, I felt nothing, now, 2 months later, I feel a difference. Not a huge difference."

• See...
• Taken for less than 1 month
• December 16, 2017

L-methylfolate for Depression "MUST take Deplin and not a generic and definitely not over-the-counter folic acid or folate! These can make things worse! My C spinal fluid showed that I have a less prominent type of folate abnormality. Wasn't detected in a gene swab test. Anyway, just started taking 15 mg as an antidepressant add-on. Made my depression & anxiety worse!!! I would stop taking it, but my doc has me taking a lower dose as she recognizes that Deplin can cause a worsening of symptoms in certain folks. It just needs to be started low and gradually increased. So, please start with a low dose if it makes you MORE anxious/depressed at 15 mg. Too early to say it helps, but the lower dose is needed to start, for some. And it may take many months to work--for some!"

• Agi...
• Taken for less than 1 month
• May 20, 2014

L-methylfolate "I finished the 6-day trial, and I must say I felt so good on the last 2-3 days on Deplin. I didn't experience the crazy lows I had in the last few months. I don't truly have depression, more like bipolar II, and on no medications. I love my emotions and want to work with them, so my naturopath suggested we try Deplin. I will be seeing her again next week, and I will ask her to continue it."

• Abl...
• Taken for less than 1 month
• April 27, 2018

For Depression "I've had depression for most of my life and have been suffering from premenstrual dysphoric disorder (PMDD) the last five. I was prescribed l-methylfolate by my psychiatrist to go along with my anti-depressants a year ago, but for some reason I didn't take them. If only I knew! I took those and noticed a difference right away, but when I ran out, my insurance wouldn't cover it (different insurance company at the time), so I had to go OTC. I have felt so much better since taking the MethylPro at 10mg. I am actually happy, content, and I laugh. My PMDD is calming down. I've only been on it about two weeks consistently. Yesterday, I woke up and exercised! I've been doing some type of exercise the past week almost every day: yoga, dance, kickboxing (not actual kickboxing, but as exercise). It's amazing how much energy I have, but it isn't that caffeine-driven energy feeling, if that makes sense. I haven't been tested for the gene mutation and am going to inquire about it when I speak with my doctor next."

• sky...
• Taken for less than 1 month
• June 5, 2017

L-methylfolate for Depression "Like many others, I took the Genomind test, which told me that SSRIs were not optimal and that SNRIs were a better choice. After 16 years and 20 different meds, I have had much better success with SSRIs than SNRIs. The test results also said that I was deficient in what Deplin could provide. I have been taking 15 mg of Deplin for almost 3 weeks now and have been experiencing some of the lowest depression that I have ever felt. Today, I woke up feeling just as miserable as I have been for the past 3 weeks, so I decided not to take Deplin. As I slumped through the morning, I started to feel a wave of happiness and excitement for life come over me around 10:30 am, and I still feel great. I feel like 'my' normal self again. $60 wasted!"

• Jon...
• Taken for 2 to 5 years
• February 26, 2020

L-methylfolate for Depression "I took this for a while at the recommendation of my psychiatrist. I have the double MTHFR mutation. It did nothing for me and is prohibitively expensive. I’m not sure if I buy into their MTHFR serotonin theory, but it seems to work for some. For me, I would get these weird sensations in my hands and feet, almost like they were heavier or more sensitive, and I felt like my sleep was less restful (even I got 8 hours consistently) because I was always tired. It made me feel off as well, but I assume that is just depression medication in general."

• Ste...
• Taken for 1 to 2 years
• November 6, 2023

For Borderline Personality Disorder "It was recommended to me when a genetic test indicated I had mutations in both sides for the MTHFR gene. I started taking 15 mg/day and within the first two weeks there was a profound improvement. In fact, I'd only filled one two-week pill caddy and forgot to fill the second, so I accidentally stopped taking it after 14 days. On day 16, I had the worst day I'd had in weeks, and on day 17, after realizing what happened and resuming, I felt good again. I have been taking it since January 2022, almost two years, and these have been the most BD symptom-free of my adult life. I think I should stock up enough to last the rest of my life. If the world goes to hell and I can't get meds anymore, LMF is the one I don't ever want to run out of. The only side effects are related to intestinal processes that could just as easily be caused by the Metformin and aren't anywhere near as bad as the positive effects are good."

• sea...
• December 7, 2010

L-methylfolate "I never responded to any medication for anxiety and depression, which was made worse by most medications. Deplin was a miracle for me. I started to use it this summer, and my response was immediate. My response seemed to pop out this summer, but I learned that some people can have this response and need to lower the dose and start and stop the medication. Also, my response could have been due to the Klonopin that I reduced after 20 years of usage. Overall, this medicine was a miracle for me."

• Mur...
• Taken for 1 to 6 months
• January 20, 2021

L-methylfolate for Folate Deficiency "I took a gene test after nearly having no luck with any SSRIs and all the negative side effects. Once I started taking this, I was able to take 5 mg Lexapro and 0.5 mg of Rexulti with no side effects, especially zero sexual side effects. I had depression, anxiety, DP/DR, and it nearly broke me last year. But this stuff, I believe, changed my life and allowed my body to react positively to the medications."

• Not...
• Taken for 1 to 6 months
• January 24, 2022

For Depression "I have a double mutation with the MTHFR situation. It took a long time to get my insurance to cover this. I take 15 mg twice a day, and just like all these other reviews, I am no longer dying. I see that a lot of people are taking 15 mg once a day, so I don't know why I'm on it twice a day, but I went from feeling like somebody who was literally being swallowed up by quicksand to somebody who is alive. I've been on it for 5 months. I have no side effects. It feels crazy to feel normal."

• Jon...
• Taken for less than 1 month
• May 14, 2019

For Depression "I have been struggling with depression and anxiety for 4 years. I used Trintellix, which helped me a lot with memory and anxiety, but I was extremely flat in emotions. I then started modafinil and got a huge improvement. Then I was changed to methylphenidate 20 mg ER, and the Trintellix was reduced to 10 mg. I was using a B vitamin combo that includes methyl folate and methylcobalamin. I suspected it made me anxious, but one of my friends told me that it gives extreme energy at high doses, so I started 10 mg methylfolate. On the first day, I was so happy in the morning, in the afternoon, I was extremely angry, yet felt powerful. A friend recommended that I should use niacin with it, so I added 500 mg niacin. Now I cry when I listen to music or read what I like. It gives a huge boost to methylphenidate, also, the anger went away when I added niacin. I feel emotions so deep and cry with happiness. I am not hyperactive anymore, but I have high energy levels. I can go to work, then to the gym after meeting with friends, and sleep like a baby. I hope this will not change in time."