L-methylfolate User Reviews & Ratings (Page 3)

• Anonymous
• March 21, 2011

L-methylfolate for Depression "I have been on Deplin for six days and I am amazed with the change in my emotions and feelings. I take 7.5mg of Deplin and 60 mg of Prozac, and I am pleased with my increased defenses to deal with my daily life. I feel like myself again for the first time in 10 years. I hope Deplin will continue to provide me with the positive attitude that I am now feeling. I feel like a whole new person."

• Mai...
• Taken for 6 months to 1 year
• August 1, 2017

L-methylfolate for Folate Deficiency "I have suffered from depression for 20+ years. I stumbled across a gene mutation called MTHFR and decided to do more research. Here is what is very important: if you have this gene mutation, then, in some form, your body does not break down folate, aka folic acid. Folic acid is imperative to serotonin levels, which affect your mood and sleeping patterns. If your body cannot produce serotonin, then taking a serotonin-based medication will never work. You are asking your body to produce more serotonin, and it can't do it; it can't produce more because it isn't able to. For people who have this gene mutation, which is a 1:2 ratio, having a supplement is important. Folic acid is broken down 8 times to reach the effective type, and my body cannot break down the first 7, so Deplin is essential for me."

• usa...
• June 11, 2016

For Depression "I have suffered from anxiety and depression for the better part of 60 years. Anxiety was normal for me until a friend told me about Deplin's L-methylfolate. She explained that severe anxiety could be from an inability to absorb folate. I asked my Dr for an Rx and he said it wouldn't hurt to try this, it was a medical food and not a drug. I was on Ativan, Prozac, Doxepin, and Trazodone and still had anxiety 24/7. Within one week of taking L-methylfolate, I had absolutely NO anxiety. It was so quiet in my soul that I almost felt anxiety about not having anxiety! It was foreign to me, the steady drip, drip, drip of adrenaline rushing through my system was shut off. Within six months I was off all other medications. This was a miracle for me."

• Anonymous
• February 20, 2012

L-methylfolate for Depression "I was diagnosed with depression 11 years ago. I can't remember all of the antidepressants I've been on, but for the last 5 years I've been on Wellbutrin 450mg. My psychiatrist prescribed Mirtazapine for its energizing effects when on high doses. It didn't work for me; then he prescribed Deplin 15mg. I took it for 6 weeks. I could not tell a huge difference, so I didn't refill my prescription right away. (It's expensive since insurance won't cover it!) After I stopped, my energy/motivation decreased, so I started taking it again. I've been on it for about a week now and have seen an increase in my energy again, but the motivation is still not as high as it should be. Hopefully, it will get better the longer I'm on it."

• ril...
• Taken for 1 to 2 years
• February 12, 2024

L-methylfolate for Folate Deficiency "If I could rate it a million I would! I have the double MTHFR gene mutation and this has been life-changing for me. I felt better within days of taking this medication. I have been on Lexapro for years, but when I started taking oral birth control pills, I was constantly crying, having panic attacks, and overall so anxious with a constant pit in my stomach. Even when I was still on the birth control pills, I noticed a huge difference from this medication, and even more now that I have stopped taking those. MTHFR shouldn't be ignored like I did for years. I pay $199 for a 90-day supply because it's that important to my quality of life (my insurance doesn't cover it). Seriously, give it a try!"

• Anonymous
• November 17, 2011

L-methylfolate for Depression "I have been on Deplin for over a year now. At first, I was on 7.5 mg and that was helpful, but when that stopped working, the Psych doctor increased the dosage up to 15 mg and it really works. What it does is helps your other antidepressants work better. Deplin will affect each person differently depending on which antidepressant you are taking."

• KQa...
• Taken for 1 to 6 months
• May 5, 2021

L-methylfolate for Depression "My child has been on antidepressants for three years. I read about MTHFR gene mutations and felt this might be the case with my daughter. Her psychiatrist recommended a trial of Deplin rather than testing since Deplin would be the treatment. The results are nothing short of amazing. I have my daughter back!"

• jjo...
• Taken for 5 to 10 years
• March 9, 2014

L-methylfolate for Folate Deficiency "Has changed my life, both physical autoimmune, genetic, hormonal disorders have improved and mental health PTSD, ADHD, RBD-Dyslexia have improved. I wish I had known about my mutation in childbearing years as I lost five pregnancies. My only daughter was the one I had morning sickness with and didn't take prenatal multivitamins."

• Rav...
• Taken for less than 1 month
• January 5, 2020

For Depression "After 40 years of SSRIs and counseling failing, I felt hopeless. Many days were torture. I tired too easily, felt sad, hopeless, unmotivated, and anxious more than I should have most of my life. Finally, I took l-methyl folate at 15 mg and got an immediate rash. Then, based on internet info, I took 1 mg. I noticed an immediate reduction in sadness, improved energy, and interest...but by day 4, I had an unbelievable panic attack with dry heaving and misery. Thankfully, I knew to take niacin and, within the hour, I was normal. This happened 4 times, and I had had enough. But I was beyond despair, so I tried it again at between 0.25 and 0.5 mg and added a small amount of niacin (and will add methyl B12 because I think the problem occurred because I’m building up nitrous oxide). This tiny amount, taken carefully, has completely made me normal. NOTHING else did. I have the MTHFR gene mutation, severe form. To me, it’s like a miracle for which I waited too long."

• Anonymous
• April 30, 2011

L-methylfolate for Depression "I just took my second dose of Deplin. I love the fact that there are no side effects. I went all through the day without getting so angry at someone I would get an anxiety attack. It's a start and I'm hoping I can return to my normal self. Wish me luck."

• Hay...
• Taken for 1 to 6 months
• August 1, 2015

L-methylfolate for Depression "I started taking Deplin 2 months ago in addition to the 300 mg of Wellbutrin I had already been taking for several years. I was experiencing a very low level of chronic depression but generally okay. The doctor recommended I try Deplin to see whether it would increase my level of well-being. I could swear I feel a lot more depressed with the Deplin. Nothing has changed in terms of lifestyle over the past few months, so I can't think of any other explanation. Needless to say, I'm going to stop taking it. I had no idea it might worsen my symptoms."

• lad...
• May 2, 2014

For Depression "Wow. Where to even start? I've been on several cocktails of antidepressants from ages 13 to 28. Finally, my doctor prescribed methylfolate in conjunction with Celexa. Within 10 days, I felt more alive, motivated, energetic, and at peace than I had ever felt in my life. Absolutely a miracle. If you have given up on the endless trial and error, please, please give this a chance."

• Med...
• July 11, 2016

L-methylfolate for Folate Deficiency "MTHFR with some bipolar, previous ADHD, and OCD diagnoses. Started taking Deplin with B12 (methyl folate) - be sure to take both - and seeing great results. Mood improved greatly and performance overall. Couldn't imagine life without it!"

• Jen...
• Taken for less than 1 month
• August 4, 2014

L-methylfolate for Depression "I added Deplin 15 mg to a 150 mg dose of Wellbutrin when the Wellbutrin no longer worked as well. It did help for a few days, but then I developed severe muscle weakness, stiffness, and pain, particularly in my neck and shoulders. It was bad enough that I could not turn my head or look up or down without great discomfort. It kind of felt like I had whiplash. I did some research and found that the muscle pain can be a side effect of both medications. I have not ever had this problem on Wellbutrin alone, so I'm inclined to think the Deplin caused this. I quit taking both medications because I couldn't function with the pain and stiffness any longer, and two days later, the pain is still there but is slowly subsiding."

• Sun...
• Taken for 1 to 2 years
• May 18, 2018

L-methylfolate for Hyperhomocysteinemia "Having the MTHFR C677T double mutation, I started taking Deplin in August of 2016. I had very high homocysteine levels and felt awful for a long time. I started on 15 mg and moved down to 7.5 mg. My homocysteine has balanced out to consistent normal. My energy levels are way up. My B12 came down in huge leaps and bounds and is now stabilized."

• whi...
• Taken for less than 1 month
• July 8, 2013

L-methylfolate for Depression "I have been taking Deplin for 18 days, and I do notice a slight change in my depression, brain fog, and energy levels. I think it is being inhibited by my Adderall withdrawal, but I am hoping it is helpful since I've tried many medications and nothing has really helped."

• chr...
• April 18, 2010

L-methylfolate for Depression "I hope this helps to all the depressed people out there. I have been seeing a psychiatrist for drug-induced depression. I abused meth, Vicodin, coke, and any other drug you can think of for years, and that has left me a basket case. I have tried many antidepressants, but I suffer too many adverse reactions to the stronger stuff. I am currently on 300mg Wellbutrin and 15 mg Deplin, and I have to say I feel GREAT! However, I had taken the Wellbutrin/Deplin combo in the past, and it stopped working for me after 6 months. The results with the antidepressants were a little funny because I went back to abusing Vicodin. Now I am clean of any drugs and just taking what is prescribed by my doctor, 300mg Wellbutrin and 15 mg Deplin."

• Hel...
• Taken for 5 to 10 years
• July 10, 2019

For Depression "I had been prescribed this by the same psychiatrist who gave me Wellbutrin. It was originally covered by my drug plan, and I wasn't sure it was working. But then my plan stopped covering it (because they said it was a 'vitamin'), and I ran out. That's when I found the fog of depression setting in deeply. Deplin is ridiculously overpriced for what it is, and many other manufacturers make l-methylfolate equivalents. I have switched to one of those. I use 15 mg tablets and cut them in half, so a bottle lasts for 180 days. This is much cheaper than Deplin (the generic costs about 40 cents a day, Deplin without a prescription plan is about 4 dollars a day). Honestly, I think the methylfolate helps me, and the generic is affordable, and it works!"

• jer...
• Taken for 1 to 6 months
• July 12, 2019

L-methylfolate for Depression "Have taken Paxil for years, had a poop out with the Paxil, so the doctor added Deplin 15 mg, that did not work, had lots of confusion, out-of-touch feelings. I cut the Deplin back to 7.5 mg, and in three days, it is doing the same thing as the 15 mg. I would assume if you had a folic deficiency, it would work. However, I must have enough, and this just overloads my system. Not for me, cannot get off of it fast enough."

• For...
• Taken for less than 1 month
• July 11, 2016

For Depression "Normally I only peruse these listings, but this time I thought I owed it to all my fellow readers to give a detailed review. I began taking 10 mg methylfolate around 10 days ago at the urging of my father, who, for obvious reasons, shares a very similar genetic predisposition toward depression and anxiety. The results? All I can say is wow. Within 1 day, I felt like my internal motor that had been idling along at a 5 out of 10 had been turned up to a 10 for the first time in a long time. I had more energy, clearer thoughts, a happier disposition, appetite, and libido returned full force. My only regret is not trying this stuff sooner. If it feels like nothing has ever really solved the problem before, please try this. It's a miracle."

• May...
• Taken for less than 1 month
• April 15, 2018

L-methylfolate for Folate Deficiency "I just started Deplin today! I've been reading people's comments, and half say it's helped them, and half have not. I've also researched it and have read so many different articles. From my understanding, you should start off at a low dose, and if that doesn't help, then take more. If the dosage is too high or low and you're not feeling better, adjust it. I personally wouldn't give up after trying it one time at one dose. This medicine has changed people's lives into feeling like a normal, happy person with energy. I personally hope it works for me, and I feel better! I'm not giving up! Try to research it before giving up. I wish everyone good luck with Deplin."

• See...
• September 4, 2018

L-methylfolate for Depression "Update to my previous post: I've now been taking Deplin for close to a year. It serves as an add-on to my antidepressant meds. It hasn't been a magical booster to improve my severe, resistant depression as well as my horrible anxiety. However, over a year's time, Deplin has helped me feel just enough better to justify its cost. A very subtle improvement that is difficult to describe. I'm glad that I stuck with it; not at all noticeable until at least 9 or 10 months. And that time frame (for subtle change) isn't acceptable if you are miserable. But I was improving just enough with my other meds to allow me to continue taking Deplin-just in case it began making a difference ....whenever? Plus, my doctor told me it was good for my overall health, regardless if it touched the depression. This made it easier for me to continue taking it despite feeling no benefit for a long time."

• Mal...
• Taken for 1 to 2 years
• February 15, 2015

For Depression "Depression sufferer my whole life. On Deplin for the last year, and my lows vanished within the first week on 15 mg/day. It's all I'm taking, and the benefit is absolutely profound. Zero side effects. Most psychiatrists downplay the lack of studies, but it definitely works for me better than anything else I've tried. Good luck."

• Mer...
• Taken for 1 to 6 months
• October 17, 2018

L-methylfolate for Folate Deficiency "I also have anxiety disorder. 20 mg Prozac, 0.05 Klonopin. My doctor kept telling me to take it, take it, but I've always resisted. Anyway, I'm taking it. I can't tell you how good I feel, although I didn't really know why. I didn't understand how lacking something in my body could affect the drugs I take or just my overall health. I feel great for the first time in a long time. Don't hesitate."

• Anx...
• Taken for 1 to 6 months
• October 12, 2018

For Depression "L-methylfolate is great. I spent the last 3 years with increasingly crippling anxiety, and it was starting to limit my ability to work and live. At the point of attempting anti-depressants. Luckily, I came across an article for an l-methylfolate product. Given it's just processed folate and B12, I gave it a try because the side effects are so limited. WOW. AMAZING. Within a week (15 mg per day), I had my life back. I still get anxious, but it's like all of a sudden it's not so bad. I can laugh, smile, and be happy. I'm a better husband and father. Anyone who is struggling with thoughts of low self-worth, anxiety, or depression, it is worth considering trialing this drug. I wouldn't say that if the side effects weren't so limited: it's just folate after all!"