L-methylfolate User Reviews & Ratings (Page 3)

• Anonymous
• March 21, 2011

Deplin (l-methylfolate) for Depression "I have been on Deplin for six days and I am amazed with the change in my emotions and feelings. I take 7.5mg of Deplin and 60 mg of Prozac and I am pleased with my increased defenses to deal with my daily life. I feel like myself again for the first time in 10 yrs. I hope Deplin will continue to provide me with the positive attitude that I am now feeling. I feel like a whole new person."

• Anonymous
• February 20, 2012

Deplin (l-methylfolate) for Depression "I was diagnosed with depression 11 years ago. I can't remember all of the anti-depressants I've been on, but for the last 5 years I've been on Welbutrin 450mg. My psychiatrist prescribed Mirtazapine, for it's energizing effects when on high doses. It didn't work for me; then he prescribed Deplin 15mg. I took it for 6 weeks. I could not tell a huge difference, so I didn't refill my prescription right away. (It's expensive since insurance won't cover it!) After I stopped my energy/motivation decreased, so I started taking it again. I've been on it for about a week now and have seen an increase in my energy again, but the motivation is still not as high as I it should be. Hopefully it will get better the longer I'm on it."

• usagr...
• June 11, 2016

For Depression "I have suffered from anxiety and depression for the better part of 60 years. Anxiety was normal for me until a friend told me about Deplin's L-methylfolate. She explained that severe anxiety could be from an inability to absorb folate. I asked my Dr for an Rx and he said it wouldn't hurt to try this it was a medical food and not a drug. I was on Ativan, Prozac, Doxepin and Trazadone and still had anxiety 24/7. Within one week of taking L-methylfolate, I had absolutely NO anxiety. It was so quiet in my soul that I almost felt anxiety about not having anxiety! It was foreign to me; the steady drip, drip, drip of adrenalin rushing through my system was shut off. Within six months I was off all other medications. This was a miracle for me."

• Maide...
• Taken for 6 months to 1 year
• August 1, 2017

Deplin (l-methylfolate) for Folate Deficiency "I have suffered from depression for 20+ years. I stumbled across a gene mutation called MTHFR, and decided to do more research. Here is what is very important; if you have this gene mutation then, in some form, your body does not break down folate aka folic acid. Folic acid is imperative to seratonin levels, which effect your mood and sleeping patterns. IF your body cannot produce serotonin then taking a seratonin based mediation will never work. You are asking your body to produce more seratonin and it can't do it, it can't produce more because it isn't able to. For people who have this gene mutation which is 1:2 ratio having a supplement is important. Folic acid is broken down 8 times to reach the effective type and my body cannot break down the first 7, so Deplin essential for me"

• Hayst...
• Taken for 1 to 6 months
• August 1, 2015

Deplin (l-methylfolate) for Depression "I started taking Deplin 2 months ago in addition to the 300 mg. of Wellbutrin I had already been taking for several years. I was experiencing a very low level of chronic depression but generally okay. The doctor recommended I try Deplin to see whether it would increase my level of well-being. I could swear I feel a lot MORE depressed with the Deplin. Nothing has changed in terms of life style over the past few months, so I can't think of any other explanation. Needless to say, I'm going to stop taking it. I had no idea it might worsen my symptoms."

• jjojjo
• Taken for 5 to 10 years
• March 9, 2014

Deplin (l-methylfolate) for Folate Deficiency "Has changed my life, both physical autoimmune, genetic, hormonal disorders have improved and mental health PTSD, ADHD, RBD-Dyslexia have improved. I wish I had known about my mutation in child bearing years as I lost five pregnancies. My only daughter was the one I had morning sickness with and didn't take prenatal multivitamins."

• Anonymous
• November 17, 2011

Deplin (l-methylfolate) for Depression "I have been on Deplin for over a year now. At first I was on 7.5 mg and that was helpful but when that stopped working the Psych doctor increased the dosage up to 15 mg and it really works. What it does is helps your other antidepressants work better. Deplin will affect each person differently depending on which antidepressant you are taking."

• KQano
• Taken for 1 to 6 months
• May 5, 2021

Deplin (l-methylfolate) for Depression "My child has been on antidepressants for three years. I read about MTHFR gene mutations and felt this might be the case with my daughter. Her psychiatrist recommended a trial of Deplin rather than testing since Deplin would be the treatment. The results are nothing short of amazing. I have my daughter back!"

• Anonymous
• April 30, 2011

Deplin (l-methylfolate) for Depression "I just took my second dose of Deplin. I love the fact that there are no side effects. I went all through the day without getting so angry at someone I would get an anxiety attack. It's a start and I'm hoping I can return to my normal self. Wish me luck."

• just...
• March 26, 2014

Deplin (l-methylfolate) for Depression "I thought I would share my experience as it may be helpful to others. I have been on this for over 2 years now... and depression wise (which is what I'm basing my rating off of because that is what this rating is supposed to pertain to) it hasn't done anything for me at all. At least nothing at all that I have ever noticed. I have stayed on the medication because of the fact IT DOES help bring down my homosistine levels. I have a condition referred to as MTHFR. Basically it's a liver enzyme condition that makes it so the body doesn't convert proteins/peptides very well. Common condition (1/10 americans) but rarely tested for. The lab had to look up what to do for drawing blood and testing for it."

• whizb...
• Taken for less than 1 month
• July 8, 2013

Deplin (l-methylfolate) for Depression "I have been taking Deplin for 18 days and I do notice a slight change in my depression/brain fog and energy levels. I think it is being inhibited by my Adderall withdrawal but am hoping it is helpful since I've tried many medications and nothing has really helped."

• Ravioli
• Taken for less than 1 month
• January 5, 2020

For Depression "After 40 years of SSRIs & counseling failing, I felt hopeless. Many days were torture. I tired too easily, felt sad, hopeless, unmotivated & anxious more than I should have most of my life. Finally I took l methyl folate at 15 mg and got an immediate rash. Then, based on internet info, I took 1mg. I noticed an immediate reduction in sadness, improved energy and interest...but by day 4 I had an unbelievable panic attack with dry heaving and misery. Thankfully, I knew to take niacin and, within the hour, I was normal. This happened 4 times and I had had enough. But I was beyond despair, so I tried it again at between 0.25 and 0.5 mg and added a small amount of niacin (and will add methyl b12 because I think the problem occurred because I’m building up nitrous oxide). This tiny amount, taken carefully, has completely made me normal. NOTHING else did. I have the MTHFR gene mutation, severe form. To me, it’s like a miracle for which I waited too long."

• Jenni...
• Taken for less than 1 month
• August 4, 2014

Deplin (l-methylfolate) for Depression "Added Deplin 15mg to 150 mg dose of Wellbutrin when the Wellbutrin no longer worked as well. It did help for a few days but then I developed severe muscle weakness, stiffness and pain particularly in my neck and shoulders. Bad enough that I could not turn my head or look up or down without great discomfort. Kind of felt like I had whiplash. I did some research and found that the muscle pain can be a side effect of both medications. I have not ever had this problem on Wellbutrin alone, so I'm inclined to think the Deplin caused this. I quit taking both medications because I couldn't function with the pain and stiffness any longer and 2 days later the pain is still there but is slowly subsiding."

• chris...
• April 18, 2010

Deplin (l-methylfolate) for Depression "I hope this helps to all the depressed people out there. I have been seeing a psychiatrist for drug induced depression. I abused meth, Vicodin, coke, and any other drug you can think of for years and that has left me a basket case. I have tried many antidepressants but I suffer too many adverse reactions for the stronger stuff. I am currently on 300mg Wellbutrin and 15 mg Deplin and I have to say I feel GREAT! However I had taken Wellbutrin/Deplin combo in the past and it stopped working for me after 6 months. The results with the antidepressants were a little funny because I went back to abusing Vicodin. Now I am clean of any drugs and just taking what is prescribed by my doctor. 300mg Wellbutrin and 15 mg Deplin. "

• Lskmjk
• Taken for less than 1 month
• July 10, 2016

Deplin (l-methylfolate) for Depression "Terrible! I was on it 3 days while also on Viibryd and it caused me SEVERE anxiety. I was found to have a compound heterozygous gene mutation and the psychiatrist thought this should help. Wrong. I also found out through the gene test I cannot take SSRI's. Viibryd is a hydrid SSRI. The combination was bad news for me and I had to stop the AD cold turkey bc the blast of Deplin apparently caused me serotonin overload. Still struggling 4 weeks later. From what I've researched, l-methyl folate should be started at SMALL doses, like 400mg, NOT 15mg (Deplin).... Lord!"

• ladyk...
• May 2, 2014

For Depression "Wow. Where to even start. I've been on several cocktails of antidepressants from ago 13-28. Finally, my doctor prescribed Methylfolate in conjuction with Celexa. Within 10 days, I felt more alive, motivated, energetic, and at peace then I had EVER felt in my life. Absolutely a miracle. If you have given up on the endless trial and error, please, please give this a chance."

• sprytle
• December 15, 2010

Deplin (l-methylfolate) for Depression "I started taking Deplin yesterday and recently tapered myself off of Cymbalta and Wellbutrin. I still have the Cymbalta withdrawal "brain zaps" but have regained my crying reflex that I lose everytime I get back on medication. I have been pregnant several times and needed to come off all medications for the duration. Today I had more natural energy than I've had in a long time. I had been taking Hydroxycut just to get myself moving and to the gym as I had reached my maximum weight of 188 last week. Now I don't feel like I need it anymore. My OCD is almost non-existent now. I can complete multiple tasks without spending an eternity detailing every aspect of a small task. This is how I feel after day 2, hopeful this will continue."

• MedSt...
• July 11, 2016

Deplin (l-methylfolate) for Folate Deficiency "MTHFR with some bipolar, previous ADHD and OCD diagnoses. Started taking Deplin with B12 (methyl folate)- be sure to take both - and seeing great results. Mood improved greatly and performance overall. Couldn't imagine life without it!"

• jerry...
• Taken for 1 to 6 months
• July 12, 2019

Deplin (l-methylfolate) for Depression "Have taken Paxil for years, had a poop out with the Paxil so the doctor added Deplin 15 MG, that did not work had lots of confusion out of touch feelings. I cut the Deplin back to 7.5 MG and in three days it is doing the same thing as the 15 MG. I would assume if you had a folic deficiency it would work. However, I must have enough and this just overloads my system. Not for me cannot get off of it fast enough."

• skytrex
• Taken for less than 1 month
• June 5, 2017

Deplin (l-methylfolate) for Depression "Like many others I took the Genomind test which told me that SSRI's were not optimal and that SNRI's were a better choice. After 16 years and 20 different meds, I have had MUCH better success with SSRI's than SNRI's. The test results also said that I was deficient in what Deplin could provide. I have been taking 15mg of Deplin for almost 3 weeks now and have been experiencing some of the lowest depression that I have ever felt. Today I woke up feeling just as miserable as I have been for the past 3 weeks so I decided not to take Deplin. As I slumped through he morning I started to feel a wave of happiness and excitement for life come over me around 10:30am and I still feel great. I feel like "my" normal self again. $60 wasted!"

• Seeking
• September 4, 2018

Deplin (l-methylfolate) for Depression "Update to my previous post: I've now been taking Deplin for close to a year. It serves as an add on to my anti depressant meds. It hasn't been a magical booster to improve my severe, resistant depression as well as my horrible anxiety. However, over a year's time, Deplin has helped me feel just enough better to justify its cost. A very subtle improvement that is difficult to describe. I'm glad that I stuck with it; not at all noticeable until at least 9 or 10 months. And that time frame ( for subtle change ) isn't acceptable if you are miserable. But, I was improving just enough with my other meds to allow me to continue taking Deplin--just in case it began making a difference ....whenever? Plus, my dr. told me it was good for my overall health, regardless if it touched the depression. This made it easier for me to continue taking it despite feeling no benefit for a long time."

• Hello...
• Taken for 5 to 10 years
• July 10, 2019

For Depression "I had been prescribed this by the same psychiatrist who gave me Wellbutrin. It was originally covered by my drug plan and I wasn't sure it was working. But then my plan stopped covering it (because they said it was a "vitamin" and I ran out. That's when I found the fog of depression setting in deeply. Deplin is ridiculously overpriced for what it is, and many other manufacturers make l-methylfolate equivalents. I have switched to one of those. I use 15mg tablets and cut them in half, so a bottle lasts for 180 days. This is much cheaper than Deplin (the generic costs about 40 cents a day. Deplin without prescription plan is about 4 dollars a day.) Honestly, I think the methylfolate helps me, and the generic is affordable and it works!"

• Steve
• Taken for 1 to 2 years
• November 6, 2023

For Borderline Personality Disorder "It was recommended to me when a genetic test indicated I had mutations in both sides for the MTHFR gene. I started taking 15 mg/day and within the first two weeks there was a profound improvement. In fact, I'd only filled one two-week pill caddy and forgot to fill the second, so I accidentally stopped taking it after 14 days. On day 16, I had the worst day I'd had in weeks, and on day 17, after realizing what happened and resuming, I felt good again. I have been taking it since January 2022, almost two years, and these have been the most BD symptom-free of my adult life. I think I should stock up enough to last the rest of my life. If the world goes to hell and I can't get meds anymore, LMF is the one I don't ever want to run out of. The only side effects are related to intestinal processes that could just as easily be caused by the Metformin and aren't anywhere near as bad as the positive effects are good."

• Sunset
• Taken for 1 to 2 years
• May 18, 2018

Deplin (l-methylfolate) for Hyperhomocysteinemia "Having the MTHFR C677T double mutation I started taking deplin in August of 2016. I had very high homocysteine levels and felt awful for a long time. I started on 15mg and moved down to 7.5. My homocysteine has balanced out to consistent normal. My energy levels are way up. My B12 came down in huge leaps and bounds and is now stabilized"

• Former...
• Taken for less than 1 month
• July 11, 2016

For Depression "Normally I only peruse these listings, but this time I thought I owed it to all my fellow readers to give a detailed review. I began taking 10mg methyfolate around 10 days ago at the urging of my father, who, for obvious reasons, shares a very similar genetic predisposition toward depression and anxiety. The results? All I can say is wow. Within 1 day, I felt like my internal motor that had been idling along at a 5 out of 10 had been turned up to a 10 for the first time in a long time. I had more energy, clearer thoughts, happier disposition, appetite and libido returned full force. My only regret is not trying this stuff sooner. If it feels like nothing has ever really solved the problem before, please try this. It's a miracle."