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User Reviews for Zyprexa

Zyprexa has an average rating of 6.1 out of 10 from a total of 270 ratings on Drugs.com. 49% of those users who reviewed Zyprexa reported a positive effect, while 28% reported a negative effect.

Condition Avg. Rating Reviews Compare
Bipolar Disorder  
6.5
140 reviews 31 medications
Depression  
5.9
62 reviews 78 medications
Schizophrenia  
5.6
50 reviews 48 medications
Major Depressive Disorder  
4.8
18 reviews 47 medications
Summary of Zyprexa reviews 6.1 270 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Zyprexa

bjohn33 · Taken for 1 to 6 months June 7, 2021

For Schizophrenia: “Like other drugs, zyprexa has different effects on different people. For me, the drug was a life ruining experience. When I was on it, (for a psychotic episode) I had severe side-effects, including sedation, emotional numbing and life threatening metabolic deterioration. With a psychiatrist's help, I cross-titrated from it to Latuda. However, I happened to be in the fraction of people that has severe repercussions from discontinuing Zyprexa. With withdrawal, I had severe insomnia, which half a year later, has only mildly improved. I have had to be on Ativan to get some sleep, and there are many testimonials to the same experience I've had -- Zyprexa can for an indefinite period of time disrupt sleep regulation. Because of this, it should not be tried unless newer antipsychotics with a more focused receptor profile have been attempted.”

1 / 10
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Mahmoud May 11, 2021

For Major Depressive Disorder: “it's a good medicine, I feel me again during one week ! Sure I have gained weight but it is worth it as my depression and anxiety are more under control”

7 / 10
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Bella April 27, 2021

For Schizophrenia: “I am very grateful for Zyprexa. I had a very scary problem of not being able to sleep for a long time, resulting in psychosis. This happened twice in my life within a couple years of each other. The first time they put me on haldol and depakote. I was in so much pain I could not move, and at the same time the depakote gave me horrible shakes and no filter when talking. Worst of all I still had a lot of trouble sleeping. I was lucky enough to taper off them completely eventually and my sleep returned to normal. However two years later I lost my job and could not sleep, the same thing happens. I was put on 5mg Zyprexa and 10mg Lexapro. In less than a week I was stable and sleeping (very) well. Yes I gained weight but I have learned to control it. I am now doing well and down to 2.5mg. I think the key is a smaller dosage. I read some people have 15mg, I think I would have a lot of trouble with side effects too if it was that much. Maybe ask your doctor if you can do 5mg or less.”

9 / 10
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Emero · Taken for 1 to 6 months March 13, 2020

For Depression: “I was put on 17.5mg of zyprexa in 2017. I took this for 6 months before I finally decided to listen to my body and stop listening to the so called experts. Zyprexa made me dull, depressed and robotic. I now lack empathy, emotion, concentration and I no longer get pleasure from things I used to enjoy. Zyprexa zaps the joy from your life basically. There is no upside. Please please avoid this drug. It will steal your personality and nobody will believe you except for the people who have also been victims of this drug.”

1 / 10
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tried everything · Taken for 6 months to 1 year January 10, 2014

For Depression: “Would give this a 10. Have tried every anxiety/depression, SSRIs and MAOIs, etc. out there. One day on this and I felt wonderful, like I woke up as a new normal person. Yes you may gain a lot of weight but only if you eat carbs. You just cannot take this and eat chips, candy, etc. Lean meats, proteins and veg and you will have NO problems, the effect is worth it. If you can put the fork down, it can change your life. My Dr. warned me about the potential for weight gain, but told me he thought I had the willpower to resist the cravings to eat junk, which I did. Try it.”

10 / 10
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mags · Taken for 6 months to 1 year September 23, 2020

For Bipolar Disorder: “This drug Zyprexa has SAVED my life. I take 5mg every night and it keeps me so stable throughout the day! I'm eating again, feeling real happiness, and my head is clearer! It makes me really hungry which is perfect because I need to gain weight. It makes me sleep so deep its amazing. 11/10 love zyprexa. I can't complain.”

10 / 10
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Gigi · Taken for 1 to 6 months April 13, 2020

For Depression: “This medication Zyprexa is a miracle worker ! I was in a very deep depression, suicide thoughts. I started feeling better after just a few weeks.I have been on it 6 weeks now and its keeps getting better. The Doctor is now increase it to 10mg, I feel more tired, but that will lessen as time goes by. I feel like me again !!!”

10 / 10
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TheGoodWife42 March 22, 2015

For Depression: “I am in shock as to the MIRACLE of Olanzipine. A 2 year severe depression, with extreme anxiety, insomnia, and paranoia DISAPEARED the first week on this medicine. Before, my depression was so bad, I stopped brushing my hair, I could barely function, my sadness so profound. After 1 week on Zyprexa, I am finally back to myself, taking good care of myself, sadness is 90% gone, smiling again!”

9 / 10
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Trapped1 · Taken for 2 to 5 years August 15, 2019

For Depression: “Zyprexa made me dull and gain weight, then found its impossible to stop taking. Even with a very, very slow taper, I have terrible withdrawal symptoms that I never ever experienced before olanzapine. I only took 1.25mg, and after 3 years of tapering I'm down to about 0.7mg. Now I have heart arrhythmia, akathisia, insomnia, I feel dazed and out of it, erectile issues, and don't feel pleasure or get excited about anything. Olanzapine has ruined my life. If I could do one thing differently in my life it would be to never ever start taking this horrific drug.”

1 / 10
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j. Daniels · Taken for 1 to 6 months April 7, 2020

For Bipolar Disorder: “Zypresa made my husband a crazy man. He had minor Bipolar. His Pychiatrist prescribed an extremely expensive drug, Zyprexa, then insisted he remain on it for 6 months then left the country. My husband ran track in our house, wore his ski parka even tho 85 degrees, took several family members to help calm him, on and on. He was uncontrollably crazed, When he developed smacking lips about 4 months in, usually permanent, we stopped Zyprexa triggering DT's. His Primary care doc stepped in and tried various meds adding up to 4 that completely incapacitated him. More crazy man, upchucking, couldn't get out of bed when beloved company visited. We traveled to Portland, Or., finding a good Psychiatrist who understood meds, put him on 4 other meds to calm him, then began slowly toggling him off the mess. It took nearly 2 years to detox him. Worse yet, he was never the same again. If you value your health, and the health of those who love you, then grab your hat and RUN FROM ZYPREXA!”

1 / 10
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Mark · Taken for 6 months to 1 year January 24, 2021

For Bipolar Disorder: “It can take your life. You will need to take this for the rest of your life, or your head will be hay wire and thoughts will never stop, it will make you schizophrenic. RUN. I had mild bipolar and my greedy psychiatrist gave me the worst mental illness in a bottle. If you take it don't stop, just taper off and see if you can stop permanently, Most likely you won't be able to.”

1 / 10
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serj · Taken for 2 to 5 years December 18, 2019

For Depression: “This drug is awful, I should've stopped from day 1, now I'm in the 4th year and just started tapering because I'm one of the good boys that always listen to his parents and doctors. Please don't be a fool, don't take this drug it will make you lose years of your precious life. Better be drug free as you know the only winner of your supposed condition is the big pharma that only wants your money every month.”

1 / 10
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Tinkerbel · Taken for 10 years or more September 9, 2020

For Schizophrenia: “Zyprexa saved my life with schizophrenia. It cleared the utter chaos, despair, hallucinations, voices, bipolar mania, accelerated and disruptive thinking, unfocused mental confusion, flat out psychosis - in a matter of a day. I took 15 mg.”

10 / 10
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Josh · Taken for 1 to 2 years October 29, 2019

For Depression: “Hi all, I've been on Zyprexa for about a year and a half at 15mg. I was put on Zyprexa to help with severe treatment resistant depression. I also take 150mg of Effexor and 300mg of Welbutrin. In the past year my depression has slowly gotten worse and I suspect it's the Zyprexa. About 3 months ago I decided to taper myself off Zyprexa. I went from 15mg to 7.5mg for 3 months. I experience moderate sleeping issues (I sleep between 4-8 hours and wake up about 10 times during the night), nausea and a dramatic increase in depression. My highs are lower and my downs are longer and more severe. My two questions are this: 1) Has anyone experienced increased depression as a result of taking Zyprexa 2) Has anyone experienced an increase in depression as a result of Zyprexa withdrawal. ”

6 / 10
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jpurplelady · Taken for less than 1 month May 8, 2016

For Depression: “Started taking 2.5 mg Zyprexia a day 3 days ago. For years have taken 60 mg Celexa, .5 mg Clonazepam, and ( .5 mg Xanax if I need for emergency panic attack) They worked well until 6 years ago, my husband died, a year later my dad died.Two years after my dad passed his wife died, then 4mo. later my son, who had Downs Syndrome died on the operating table. I was really going into a deep black hole by then but it just got worse. A friend of 25 yrs died of cancer not even a year after my son. I can really feel a difference in just 3 days. No crying so far, been outside and to the store without panic attacks. Sleep really well. So far eating hasn't been a problem, have lots of energy, and just feel better. Hoping for a new lease on life!”

10 / 10
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Missy626 · Taken for 6 months to 1 year May 5, 2020

For Depression: “I've been on zyprexa for 9 months now, zyprexa has done wonders for me. No more spontaneous deep dark days ahead of me, my close family can really see a difference, I'm just worried about long term effects of this drug. I have bipolar 1 with psychosis.”

8 / 10
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Vani · Taken for less than 1 month June 13, 2019

For Depression: “Stay away! I took 15 mg Zyprexiafor 2 weeks and I feel so tired, my vision is blurry , weak hand-eye coordination, and its difficult to speak or understand anything. Why is this drug still being prescribed???”

1 / 10
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maddie April 19, 2019

For Depression: “put on this drug for anxiety, loss of weight, not sleeping, all connected with something that happened to me. On it for a month at 10 mg and had pounding blood pressure in ears, sudden headaches, ankles swelled up 2x their size, gained 25 lbs. in a month, huge appetite, foggy thinking, flat personality and dizzy. After I got off, I felt much better. Off it now for 2.5 months and I can't lose any weight, and in fact am still gaining, so can't get it out of my system. How can i get it out of my system? I don't want to become diabetic or get heart disease, but this drug can do that and I'M NOT EVEN ON IT! Doctors are putting people on it that should NOT be given this drug, it should be a last resort if at all. This drug can cause permanent changes chemically, in metabolism and dopamine receptors in brain-is there no antidote?”

2 / 10
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Anonymous December 5, 2019

For Bipolar Disorder: “I have bipolar II and have tried multiple medications. Sadly, I have had to get off this medication because it caused me to gain 20 lbs within a few short months, and also made my thinking slow down. However, this without a doubt was one of the best medications I have tried. I was able to finally get some rest and didn't constantly wake up throughout the night. My depressive thoughts decreased, though they were still there sometimes, they were manageable. I was able to go days without feeling completely poorly. My racing thoughts decreased, and I felt like I could think without having racing thoughts, or having 100 ideas going on in my head at once. My irritation levels almost ceased to exist. I was pleasantly surprised to see after trying several medications, that this is one of the only medications that has worked on me. If you can get around the weight gain, this is definitely a medication that is a must-try. Maybe I will try this medication again in the future if all else fails.”

8 / 10
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Anonymous · Taken for 1 to 6 months October 22, 2019

For Bipolar Disorder: “Zyprexa was a life saver for me. I was diagnosed with bipolar disorder, anxiety, and OCD last year. Took Abilify and became irritated easily, lamictal and kept forgetting things, then I started 30 mg of Prozac and 2.5 mg of Zyprexa combo. It instantly got me out of depression/ mood swings and helped me get back to school & focus a little bit more. I will say that I feel a little dull/ do not want to talk much & gained 25 pounds in one month being on it. No matter how much I workout, I do not lose the weight. I honestly love the pros of this drug, I can smile and laugh again. But I do not want it to effect my confidence and self esteem because I am gaining so much weight. I am now weaning off zyprexa and trying latuda. My advice to anyone trying Zyprexa- give this a try and expect the weight gain to occur, it will help reduce negative thoughts, excessive worrying & mood swings. Have faith, and try it, I really believe Zyprexa will help get someone out of their worst days.”

9 / 10
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Anonymous · Taken for 1 to 6 months March 27, 2019

For Depression: “Zyprexa made me feel very tired and irritable. I almost cussed my boyfriend over a small convenience, My eyesight kept blurring up, always hungry, and then I started getting this uncomfortable drowsy feeling that lasted the whole day. STAY AWAY from this garbage.”

1 / 10
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Holly · Taken for 1 to 6 months March 19, 2021

For Bipolar Disorder: “I have had great luck with this drug. I feel happy and hopeful again. I used to have serious breakdowns every two years but I have a strong feeling Zyprexa is going to reduce or even put a stop to those occurrences. I am able to enjoy activities and feel pleasure and contentment. I feel as close to non-bipolar as I think I ever will. I just hope this drug has longevity and can be used for decades like my prescriber said it could.”

9 / 10
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kestrel28 · Taken for 2 to 5 years May 25, 2013

For Depression: “I started taking Zyprexa over two years ago for intrusive thoughts I was having as a result of Obsessive compulsive disorder/depression. While the Zyprexa helped remove intrusive thinking, it added about thirty pounds onto my slender frame, made me severely tired, and took away my sex drive. In addition to these adverse effects, I was unmotivated/uninterested in many activities that used to give me pleasure. I had a "so what" attitude about life in general. All because of this medicine. What really frightened me about taking this was my cholesterol went sky high, and my blood sugar was also very high, making me an at risk candidate for diabetes. I am finally off of this. ”

2 / 10
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lovemylifeforever December 13, 2014

For Depression: “Had a few psychotic episode few years ago, was hospitalized and was put on Zyprexa and a few other meds. I was diagnosed with BPD (borderline personality disorder), major depression and fibromyalgia. I felt hungry all the time and gained 70lbs, my dose was 20mg a day plus I was on other meds, finally was weaned off all other meds as the months went by. I cannot say my hunger and weight gain was completely due to Zyprexa but I do know that I now take only 5mg a day, at night, sleep well, hunger is normal and I have lost weight with good healthy choices and exercise. I no longer have depression and life has never been better. Zyprexa, therapy, exercise, support and nutrition has saved my life.”

7 / 10
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Lucy · Taken for 1 to 6 months May 31, 2019

For Bipolar Disorder: “My boyfriend suffers from manic bi polar disorder. He was off meds for 2 years and recently became manic again. We go to the Drs and this is what she prescribed him at a dose of 3mg. It worked as to stopping his manic episodes. BUT he legit is a Zombie now. He sleeps all the time. Is always tired. Emotionless. Unsure of himself. Doesn’t talk. Doesn’t eat. Doesn’t laugh. He basically is nothing. It’s really sad to watch, and I’m actually hoping his Dr will change his meds this week because this is NO way to live.”

3 / 10
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ms pimpin thang · Taken for 1 to 2 years June 27, 2013

For Bipolar Disorder: “I have literally been on every medication you can think of. Prozac, Zoloft, Geodon, Haldol, Effexor, Risperdal, Abilify, Xanax, clonazepam and the list doesn't stop but Zyprexa did it! None of them seemed to help until I tried Zyprexa! I do not have to take anxiety medicines anymore because somehow Zyprexa took care of that also and my anxiety used to be so bad.”

10 / 10
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Ed McLendon · Taken for 5 to 10 years September 15, 2017

For Depression: “Zyprexa withdrawal is the worst thing that has ever happened to me in my 55 year old life. I took 2.5 mg for 6 years. Sure it helped me sleep for a few months and that is why I did not know what was causing the terrible grief and over all health problems I was experiencing. I was fainting without warning because of this drug. It ruined my life and I have not touched zyprexa in almost 2 years! It is a drug so terrible it should not be prescribed to anybody. The makers of this drug should be totally ashamed of themselves. They really should be punished for what they have done and continue doing to peoples lives with this drug. No joke.”

1 / 10
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Itel · Taken for 2 to 5 years October 16, 2019

For Bipolar Disorder: “Stay away from Zyprexa. I had a massive weight gain, diabetes cholestrol problems, significantly makes your brain dull unable to think properly , have no emotions, anxiety. Sleep a lot. I think it destroys your brain chemistry. Unable to taper off as the withdrawals extreme.”

1 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.