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Zyprexa User Reviews & Ratings

Zyprexa has an average rating of 5.7 out of 10 from a total of 346 reviews on Drugs.com. 46% of reviewers reported a positive experience, while 33% reported a negative experience.

Reviews for Zyprexa

  • Emero
  • Taken for 1 to 6 months
  • March 13, 2020

For Depression "I was put on 17.5mg of Zyprexa in 2017. I took this for 6 months before I finally decided to listen to my body and stop listening to the so-called experts. Zyprexa made me dull, depressed, and robotic. I now lack empathy, emotion, concentration, and I no longer get pleasure from things I used to enjoy. Zyprexa zaps the joy from your life, basically. There is no upside. Please, please avoid this drug. It will steal your personality, and nobody will believe you except for the people who have also been victims of this drug."

1 / 10
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454 Report
  • Trapped
  • Taken for 2 to 5 years
  • August 15, 2019

For Depression "Zyprexa made me dull and gain weight, then found it's impossible to stop taking. Even with a very, very slow taper, I have terrible withdrawal symptoms that I never ever experienced before olanzapine. I only took 1.25mg, and after 3 years of tapering I'm down to about 0.7mg. Now I have heart arrhythmia, akathisia, insomnia, I feel dazed and out of it, erectile issues, and don't feel pleasure or get excited about anything. Olanzapine has ruined my life. If I could do one thing differently in my life it would be to never ever start taking this horrific drug."

1 / 10
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248 Report
  • mags
  • Taken for 6 months to 1 year
  • September 23, 2020

For Bipolar Disorder "This drug Zyprexa has SAVED my life. I take 5mg every night, and it keeps me so stable throughout the day! I'm eating again, feeling real happiness, and my head is clearer! It makes me really hungry, which is perfect because I need to gain weight. It makes me sleep so deep; it's amazing. 11/10 love Zyprexa. I can't complain."

10 / 10
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188 Report
  • tried...
  • Taken for 6 months to 1 year
  • January 10, 2014

For Depression "Would give this a 10. Have tried every anxiety/depression, SSRIs and MAOIs, etc. out there. One day on this and I felt wonderful, like I woke up as a new normal person. Yes you may gain a lot of weight but only if you eat carbs. You just cannot take this and eat chips, candy, etc. Lean meats, proteins and veg and you will have NO problems, the effect is worth it. If you can put the fork down, it can change your life. My Dr. warned me about the potential for weight gain, but told me he thought I had the willpower to resist the cravings to eat junk, which I did. Try it."

10 / 10
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375 Report
  • TheGo...
  • March 22, 2015

For Depression "I am in shock as to the MIRACLE of Olanzapine. A 2-year severe depression, with extreme anxiety, insomnia, and paranoia DISAPPEARED the first week on this medicine. Before, my depression was so bad; I stopped brushing my hair, I could barely function, my sadness was so profound. After 1 week on Zyprexa, I am finally back to myself, taking good care of myself, sadness is 90% gone, smiling again!"

9 / 10
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322 Report

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  • j Dan...
  • Taken for 1 to 6 months
  • April 7, 2020

For Bipolar Disorder "Zyprexa made my husband a crazy man. He had minor bipolar. His psychiatrist prescribed an extremely expensive drug, Zyprexa, then insisted he remain on it for 6 months then left the country. My husband ran track in our house, wore his ski parka even though it was 85 degrees, took several family members to help calm him, on and on. He was uncontrollably crazed. When he developed smacking lips about 4 months in, usually permanent, we stopped Zyprexa triggering DT's. His primary care doctor stepped in and tried various meds adding up to 4 that completely incapacitated him. More crazy man behavior, upchucking, couldn't get out of bed when beloved company visited. We traveled to Portland, Oregon, finding a good psychiatrist who understood meds, put him on 4 other meds to calm him, then began slowly tapering him off the mess. It took nearly 2 years to detox him. Worse yet, he was never the same again. If you value your health, and the health of those who love you, then grab your hat and RUN FROM ZYPREXA!"

1 / 10
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145 Report
  • serj
  • Taken for 2 to 5 years
  • December 18, 2019

For Depression "This drug is awful. I should've stopped from day 1. Now I'm in the 4th year and just started tapering because I'm one of the good boys that always listen to his parents and doctors. Please don't be a fool. Don't take this drug; it will make you lose years of your precious life. Better be drug-free as you know the only winner of your supposed condition is the big pharma that only wants your money every month."

1 / 10
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151 Report
  • Tinke...
  • Taken for 10 years or more
  • September 9, 2020

For Schizophrenia "Zyprexa saved my life with schizophrenia. It cleared the utter chaos, despair, hallucinations, voices, bipolar mania, accelerated and disruptive thinking, unfocused mental confusion, flat out psychosis - in a matter of a day. I took 15 mg."

10 / 10
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124 Report
  • Vani
  • Taken for less than 1 month
  • June 13, 2019

For Depression "Stay away! I took 15 mg Zyprexa for 2 weeks, and I feel so tired. My vision is blurry, weak hand-eye coordination, and it's difficult to speak or understand anything. Why is this drug still being prescribed?"

1 / 10
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152 Report
  • maddie
  • April 19, 2019

For Depression "Put on this drug for anxiety, loss of weight, not sleeping, all connected with something that happened to me. On it for a month at 10 mg and had pounding blood pressure in ears, sudden headaches, ankles swelled up 2x their size, gained 25 lbs. in a month, huge appetite, foggy thinking, flat personality, and dizzy. After I got off, I felt much better. Off it now for 2.5 months, and I can't lose any weight, and in fact am still gaining, so can't get it out of my system. How can I get it out of my system? I don't want to become diabetic or get heart disease, but this drug can do that and I'm not even on it! Doctors are putting people on it that should not be given this drug; it should be a last resort if at all. This drug can cause permanent changes chemically, in metabolism, and dopamine receptors in the brain. Is there no antidote?"

2 / 10
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146 Report
  • Gigi
  • Taken for 1 to 6 months
  • April 13, 2020

For Depression "This medication Zyprexa is a miracle worker! I was in a very deep depression, suicide thoughts. I started feeling better after just a few weeks. I have been on it 6 weeks now and it keeps getting better. The doctor is now increasing it to 10mg, I feel more tired, but that will lessen as time goes by. I feel like me again!"

10 / 10
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124 Report
  • jpurp...
  • Taken for less than 1 month
  • May 8, 2016

For Depression "Started taking 2.5 mg Zyprexa a day 3 days ago. For years have taken 60 mg Celexa, 0.5 mg Clonazepam, and 0.5 mg Xanax if I need for an emergency panic attack. They worked well until 6 years ago; my husband died. A year later, my dad died. Two years after my dad passed, his wife died. Then, 4 months later, my son, who had Down Syndrome, died on the operating table. I was really going into a deep black hole by then, but it just got worse. A friend of 25 years died of cancer not even a year after my son. I can really feel a difference in just 3 days. No crying so far; been outside and to the store without panic attacks. Sleep really well. So far, eating hasn't been a problem; have lots of energy, and just feel better. Hoping for a new lease on life!"

10 / 10
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202 Report
  • Josh
  • Taken for 1 to 2 years
  • October 29, 2019

For Depression "I've been on Zyprexa for about a year and a half at 15 mg. I was put on Zyprexa to help with severe treatment-resistant depression. I also take 150 mg of Effexor and 300 mg of Wellbutrin. In the past year, my depression has slowly gotten worse, and I suspect it's the Zyprexa. About 3 months ago, I decided to taper myself off Zyprexa. I went from 15 mg to 7.5 mg for 3 months. I experienced moderate sleeping issues (I sleep between 4-8 hours and wake up about 10 times during the night), nausea, and a dramatic increase in depression. My highs are lower, and my lows are longer and more severe. My two questions are this: 1) Has anyone experienced increased depression as a result of taking Zyprexa? 2) Has anyone experienced an increase in depression as a result of Zyprexa withdrawal."

6 / 10
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110 Report
  • Anonymous
  • Taken for 1 to 6 months
  • March 27, 2019

For Depression "Zyprexa made me feel very tired and irritable. I almost cussed my boyfriend over a small inconvenience. My eyesight kept blurring up, always hungry, and then I started getting this uncomfortable drowsy feeling that lasted the whole day. STAY AWAY from this garbage."

1 / 10
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112 Report
  • Anonymous
  • Taken for 1 to 6 months
  • October 22, 2019

For Bipolar Disorder "Zyprexa was a life saver for me. I was diagnosed with bipolar disorder, anxiety, and OCD last year. Took Abilify and became irritated easily, lamictal and kept forgetting things, then I started 30 mg of Prozac and 2.5 mg of Zyprexa combo. It instantly got me out of depression/ mood swings and helped me get back to school & focus a little bit more. I will say that I feel a little dull/ do not want to talk much & gained 25 pounds in one month being on it. No matter how much I workout, I do not lose the weight. I honestly love the pros of this drug, I can smile and laugh again. But I do not want it to effect my confidence and self esteem because I am gaining so much weight. I am now weaning off zyprexa and trying latuda. My advice to anyone trying Zyprexa- give this a try and expect the weight gain to occur, it will help reduce negative thoughts, excessive worrying & mood swings. Have faith, and try it, I really believe Zyprexa will help get someone out of their worst days."

9 / 10
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98 Report
  • Ed Mc...
  • Taken for 5 to 10 years
  • September 15, 2017

For Depression "Zyprexa withdrawal is the worst thing that has ever happened to me in my 55-year-old life. I took 2.5 mg for 6 years. Sure, it helped me sleep for a few months, and that is why I did not know what was causing the terrible grief and overall health problems I was experiencing. I was fainting without warning because of this drug. It ruined my life, and I have not touched Zyprexa in almost 2 years! It is a drug so terrible it should not be prescribed to anybody. The makers of this drug should be totally ashamed of themselves. They really should be punished for what they have done and continue doing to people's lives with this drug. No joke."

1 / 10
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128 Report
  • kestrel
  • Taken for 2 to 5 years
  • May 25, 2013

For Depression "I started taking Zyprexa over two years ago for intrusive thoughts I was having as a result of obsessive-compulsive disorder/depression. While the Zyprexa helped remove intrusive thinking, it added about thirty pounds onto my slender frame, made me severely tired, and took away my sex drive. In addition to these adverse effects, I was unmotivated/uninterested in many activities that used to give me pleasure. I had a 'so what' attitude about life in general. All because of this medicine. What really frightened me about taking this was my cholesterol went sky-high, and my blood sugar was also very high, making me an at-risk candidate for diabetes. I am finally off of this."

2 / 10
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183 Report
  • Mark
  • Taken for 6 months to 1 year
  • January 24, 2021

For Bipolar Disorder "It can take your life. You will need to take this for the rest of your life, or your head will be hay wire and thoughts will never stop, it will make you schizophrenic. RUN. I had mild bipolar and my greedy psychiatrist gave me the worst mental illness in a bottle. If you take it don't stop, just taper off and see if you can stop permanently, Most likely you won't be able to."

1 / 10
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70 Report
  • lovem...
  • December 13, 2014

For Depression "Had a few psychotic episodes a few years ago, was hospitalized and was put on Zyprexa and a few other meds. I was diagnosed with BPD (borderline personality disorder), major depression, and fibromyalgia. I felt hungry all the time and gained 70 lbs. My dose was 20mg a day plus I was on other meds. Finally, I was weaned off all other meds as the months went by. I cannot say my hunger and weight gain were completely due to Zyprexa, but I do know that I now take only 5mg a day at night, sleep well, my hunger is normal, and I have lost weight with good healthy choices and exercise. I no longer have depression, and life has never been better. Zyprexa, therapy, exercise, support, and nutrition have saved my life."

7 / 10
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150 Report
  • audhep
  • Taken for 1 to 6 months
  • February 16, 2021

For Depression "After reading the reviews, I was hesitant to start Zyprexa, but I was at rock bottom with my central nervous system. Let me tell you, 2.5mg has saved my life. I have CRPS and severe anxiety. It calms down the mind, calms the severe anxiety, and makes me sleep at night. I’ve had no side effects from this med. it really is a life saver. Don’t be afraid to start this medicine if you really need it."

10 / 10
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65 Report
  • Geoff
  • November 4, 2019

For Schizophrenia "I was on Zyprexa at 25mg (had Psychosis) for a few months, literally, the worst months of my life, all I wanted to do was eat and sleep so tired and foggy and I had no motivation so glad I ignored doctors and got off it as soon as I possibly could. if there was an option for Zero I would give that this stuff is utter garbage."

1 / 10
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82 Report
  • ms...
  • Taken for 1 to 2 years
  • June 27, 2013

For Bipolar Disorder "I have literally been on every medication you can think of. Prozac, Zoloft, Geodon, Haldol, Effexor, Risperdal, Abilify, Xanax, clonazepam and the list doesn't stop but Zyprexa did it! None of them seemed to help until I tried Zyprexa! I do not have to take anxiety medicines anymore because somehow Zyprexa took care of that also and my anxiety used to be so bad."

10 / 10
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157 Report
  • Lucy
  • Taken for 1 to 6 months
  • May 31, 2019

For Bipolar Disorder "My boyfriend suffers from manic bi polar disorder. He was off meds for 2 years and recently became manic again. We go to the Drs and this is what she prescribed him at a dose of 3mg. It worked as to stopping his manic episodes. BUT he legit is a Zombie now. He sleeps all the time. Is always tired. Emotionless. Unsure of himself. Doesn’t talk. Doesn’t eat. Doesn’t laugh. He basically is nothing. It’s really sad to watch, and I’m actually hoping his Dr will change his meds this week because this is NO way to live."

3 / 10
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83 Report
  • Mel...
  • February 2, 2011

For Bipolar Disorder "I have been on Zyprexa 10mg/day for about 10 years. When I first started taking it in place of Risperdal, I felt out of sorts for a few weeks. My doctor said that I was adjusting to it and that I needed to wait it out. So I waited, and I did adjust. I gained weight on the medicine, which I have since lost. My psychiatrist orders blood work once a year to check my cholesterol, and he says that everything is fine. I don't like that I need a lot of rest, but that is preferable over manic insomnia. I thought that if I stopped taking it, then I could lose more weight, but I know that I need to manage my illness. I'd rather be plump and pleasant than skinny and crazy. I just have to diet and exercise. The world accepts plump better than it accepts crazy."

9 / 10
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172 Report
  • Anonymous
  • Taken for 2 to 5 years
  • December 10, 2014

For Insomnia "This medicine is the best sleep aid I have found. I tried Ambien, and it made me crazy. I can sleep with Zyprexa and wake up the next morning with no side effects. I just have to make sure I take it early in the evening. If I take it too late, it will make me groggy in the morning. Unlike some of the reports I have heard, it doesn't affect my weight at all."

10 / 10
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132 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.