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L-methylfolate Alternatives Compared

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L-methylfolate Remove L-methylfolate from your drug comparison Cymbalta Remove Cymbalta from your drug comparison Zoloft Remove Zoloft from your drug comparison
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L-methylfolate Remove L-methylfolate from your drug comparison Cymbalta duloxetine Remove Cymbalta from your drug comparison Zoloft sertraline Remove Zoloft from your drug comparison

Prescribed for Folic Acid Deficiency, Depression, Hyperhomocysteinemia. May also be prescribed off label for Borderline Personality Disorder.

Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Chronic Pain,... View more

Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Obsessive Compulsive Disorder, Panic Disorder, Major Depressive Disorder,... View more

Prescription only

Prescription only

Prescription only

Ratings & Reviews

View all 143 reviews

View all 1532 reviews

View all 1539 reviews

Drug Class

Side Effects

See the full l-methylfolate side effects document.

Common side effects include: asthenia, constipation, diarrhea, dizziness, drowsiness, fatigue, hypersomnia, insomnia, nausea, sedated state, headache, xerostomia.

See the full Cymbalta side effects document.

Common side effects include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, xerostomia.

See the full Zoloft side effects document.

Pricing and Coupons

* Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 21 delayed release capsule
Dosage 60 mg
Per Unit* $11.61
Cost* $243.73

View all Cymbalta prices and generic prices

Quantity 30 tablet
Dosage 100 mg
Per Unit* $13.13
Cost* $393.84

View all Zoloft prices and generic prices

Get free Discount Card

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Get free Discount Card

Generic Availability

Yes (this medicine)

Yes

Yes

Dosage Form(s) Available
  • Oral capsule
  • Oral tablet
  • Oral delayed release capsule
  • Oral concentrate
  • Oral tablet

Brand Names
Denovo, Deplin, Duleek-DP, Elfolate, L-Methylfolate Forte, XaQuil XR Other duloxetine brands include: Drizalma Sprinkle, Irenka

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

N/A

17 hours

66 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
N
Category N Not classified

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

N/A

FDA Alerts (4)

FDA Alerts (8)

Drug Interactions

A total of 24 drugs are known to interact with l-methylfolate:

  • 2 major drug interactions (4 brand and generic names)
  • 21 moderate drug interactions (138 brand and generic names)
  • 1 minor drug interactions (4 brand and generic names)

A total of 563 drugs are known to interact with Cymbalta:

  • 101 major drug interactions (449 brand and generic names)
  • 439 moderate drug interactions (1908 brand and generic names)
  • 23 minor drug interactions (187 brand and generic names)

A total of 619 drugs are known to interact with Zoloft:

  • 141 major drug interactions (560 brand and generic names)
  • 471 moderate drug interactions (1935 brand and generic names)
  • 7 minor drug interactions (35 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should... View more
  • You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can... View more

Disease Interactions

First Approval Date

N/A

N/A

December 30, 1991

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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