L-methylfolate Compared to Alternatives

For Depression: I have been struggling with depression and anxiety for 4 years. I used trintellix helped me a lot with memory and anxiety but I was extremely flat for emotions, I then started modafinil and got a huge improvement. Then I was changed to methylphenidate 20 mg ER and the trintellix was reduced to 10 mg. I was using B Vit combo includes methyl folate and methylcobalamine, I suspected it make me anxious but one of my friend told me that it gives extreme energy on high dose so I started 10 mg Methylfolate on first day I was so happy in the morning in the afternoon I was extremely angry yet felt powerful. A friend recommended that I should use niacin with it, so I added 500 mg niacin. Now I cry when listen music or reading what I like. It gives huge boost to methylphenidate, also anger went away when I added niacin I feel emotions so deep and cry with happiness. I am not hyperactive anymore but I have high energy levels, I can go work, then the gym after meet with friends and slept like a baby. I hope this will not change in time.

For Depression: I’ve been on so many antidepressants. None made me feel great. Improved the depression for a while then poop out. Or the dose was raised and had no emotions at all. I started Enlyte. I’m in month 3. It’s subtle and gradual for me. But I’m napping less. Back to reading and doing art work again. I feel much less of the “ugh this is too hard” I’m putting one foot in front of the other on automatic instead of such a forced effort. Well worth the $30 a month. I don’t miss any work as work is less of a drag so it pays for itself. I’m living my life for the first time since I was a teenager. At age 60!

For Depression: I started Cymbalta over a month ago. I have been on at least six other Depression medications in the past. Before this medicine, my Depression was so bad I couldn't go to work without losing it. I was unemployed for two months to take time away to get help with Depression. I spent a week in the hospital because I was ready to kill myself and felt like I didn't have a purpose for being here. I learned a lot about myself in the hospital, it was one of the best things I could of done for myself. As of today I am a month free of Depression. Where before I couldn't go minutes without major Depression. I have energy and motivation again. I do have a decreased appetitie on this medication. I take it once in the morning and at night.

For Depression: I took Cymbalta for 1 year. It did help with my depression however, I became very lethargic and gained 25 lbs within 3 months. The weight gain scared me because I had never gained that much in such a short period of time. Also, I did have serious constipation with Cymbalta. If you can handle the wieght gain and constipation, I think Cymbalta is the medication to at least try, it does work-or it at least worked with my depression.

For Depression: Just take these reviews with a grain of salt. A lot of reviews after taking one day, couple weeks etc. you need a full three months for maximum effectiveness. Not that it takes that long to start getting relief. Side effects are common while your body adjusts. Some of them will go away. I had no troublesome side effects with Zoloft. I always have to start out gradually. Maybe even more than they say bc I’m sensitive to meds. I got big relief from depression. Panic attacks went away. OCD went away. The cons are it made me not very motivated, felt kind of numb to strong feelings. Not feeling urgency about my life. I wouldn’t take it again for years bc it blocked my clear perspective. But it was great to get me stabilized. Things that really help but can’t completely replace anti dep is fish oil, vit d, exercise, sunlight, folate like spinach , lentils really good. Also diet really helps. Get a book called the good mood diet. Best wishes

For Depression: I have been on Zoloft for more then 20 yrs. Over the last 6-8 months I have had increased side effects. Diarrhea, loss of appetite, not sleeping, sleeping too much just laying around waiting for the next trip to the bathroom. I had blood work, colonoscopy, endoscopy, you name it. Nothing! I read up on Zoloft side effects. Bingo! I started tapering off. Already...all of my symptoms are improving. It's been only three days Depression is the same.