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L-methylfolate Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
L-methylfolate Bupropion Cymbalta
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
L-methylfolate Bupropion Cymbalta (duloxetine)
Prescription and OTC

Prescribed for Folic Acid Deficiency, Hyperhomocysteinemia, Depression. May also be prescribed off label for Borderline Personality Disorder.

Prescription only

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

Prescription only

Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more

More about L-methylfolate More about Bupropion More about Cymbalta (duloxetine)
Generic Status

Lower-cost generic is available

Lower-cost generic is available

Lower-cost generic is available
Ratings & Reviews

L-methylfolate has an average rating of 7.7 out of 10 from a total of 160 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 17% reported a negative effect.

Bupropion has an average rating of 7.0 out of 10 from a total of 2818 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect.

Cymbalta has an average rating of 6.2 out of 10 from a total of 1861 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect.

View all 160 reviews

View all 2818 reviews

View all 1861 reviews

Drug Class
Side Effects

See also: l-methylfolate side effects in more detail.

Commonly reported side effects include:

  • insomnia
  • nausea
  • pharyngitis
  • weight loss
  • constipation
  • dizziness
  • headache
  • xerostomia

See also: bupropion side effects in more detail.

Common side effects include:

  • asthenia
  • constipation
  • diarrhea
  • dizziness
  • drowsiness
  • fatigue
  • hypersomnia
  • insomnia
  • nausea
  • sedated state
  • headache
  • xerostomia
  • show all 12

See also: Cymbalta side effects in more detail.
Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 30 each
Dosage 150 mg/24 hours
Per Unit* $1.51
Cost* $45.27

View all bupropion prices

Quantity 30 delayed release capsule
Dosage 60 mg
Per Unit* $10.16
Cost* $304.87

View all Cymbalta prices and generic prices

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Dosage Form(s) Available
  • Oral capsule
  • Oral tablet
  • Oral tablet
  • Oral tablet, extended release
  • Oral delayed release capsule
Brand Names
Denovo, Deplin, Duleek-DP, Elfolate, L-Methylfolate Forte, XaQuil XR Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL Other duloxetine brands include: Drizalma Sprinkle, Irenka
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

N/A

30 hours

17 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
N
Category N Not classified

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 25 drugs are known to interact with l-methylfolate:

  • 3 major drug interactions (6 brand and generic names)
  • 21 moderate drug interactions (140 brand and generic names)
  • 1 minor drug interactions (4 brand and generic names)

A total of 491 drugs are known to interact with bupropion:

  • 217 major drug interactions (948 brand and generic names)
  • 269 moderate drug interactions (1254 brand and generic names)
  • 5 minor drug interactions (17 brand and generic names)

A total of 583 drugs are known to interact with Cymbalta:

  • 105 major drug interactions (463 brand and generic names)
  • 455 moderate drug interactions (1985 brand and generic names)
  • 23 minor drug interactions (185 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
  • DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should... View more
Disease Interactions
First Approval Date

N/A

December 30, 1985

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources

N/A
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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