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L-methylfolate and Insomnia: What Users Say

Brand names: Deplin, L-Methylfolate Forte, Denovo, Elfolate, Duleek-DP XaQuil XR

Insomnia: mentioned by 6 users (3.6%)

Based on user experiences from 166 L-methylfolate reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 10.2%
depression 4.2%
insomnia 3.6%
headaches 2.4%

Reviews for L-methylfolate

Commonly mentioned side effects
  • Anonymous
  • April 10, 2013

L-methylfolate for Depression "I'm so happy for you all. It's just pure hell dealing with depression, no sleep, continual thoughts, obsessive compulsive disorder, and not happy at all. Maybe if we all get figured out that this is what we need. Imagine how cheap our health insurance could go to. This is wonderful, I take folic acid and it does make a big difference."

10 / 10
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141 Report
  • Jul...
  • October 24, 2019

For Depression "So, I've been on a litany of meds for 40 years. I have BPD1, major depressive disorder with psychotic features. I sometimes have delusions and hallucinations. Both suicidal and homicidal ideations. This has been utterly unbearable because no antidepressants or antipsychotics have ever helped me. The antidepressants cause me to feel suicidal. About a year ago, a doctor gave me Deplin. I take it when I need to, and it works. Just 3 days ago, I felt suicidal and was hearing the voices inside my head. Day 3 of Deplin, and I feel better again. I only use Deplin and nothing else. Yes, it's tough managing the other symptoms by myself, but they're nothing next to my depressive episodes. All I can say is that L-methylfolate is helping me. It is the only thing that has ever helped. There are some side effects like palpitations, insomnia, and some restlessness, but I don't care."

10 / 10
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23 Report
  • kte...
  • October 27, 2014

L-methylfolate for Depression "For the past several years, I have been trying to find the right balance to deal with the anxiety and depression of Post-Traumatic Stress Disorder. I have been on Citalopram for the depression, and that seems to work well. It has been hard to find an antipsychotic that works, and currently, I'm on Latuda. I'm also on a mood stabilizer, Lamictal. My doctor added Deplin. Long story, I wound up without my Latuda and Deplin for about 6 weeks. In 6 weeks, I was off the charts on the ups, and my old patterns were popping up. Not good. I went back on the Latuda and began evening out, but still had too much up. Now I've been back on the Deplin for a week, and I feel completely numb. Trouble sleeping at the right times, trouble being awake or at least alert at the right times."

7 / 10
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34 Report
  • Amy...
  • Taken for 1 to 6 months
  • October 2, 2022

For Depression "I thought Deplin was helping my depression at first, but soon realized that the severe anxiety and insomnia I was experiencing coincided with when I started taking it. Granted, I take other meds, but I had zero anxiety and practically no trouble sleeping before I added Deplin. It’s a shame because at first I thought it was helping me, but the side effects were intolerable."

1 / 10
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8 Report
  • Jun...
  • Taken for less than 1 month
  • April 10, 2018

For Folate Deficiency "Took for 2-3 weeks due to my body not processing folic acid properly. Worst side effect was I constantly felt overheated. Others were upset stomach, gas, insomnia, and increased anxiety. This drug may work for some, but for me it was not a good experience."

1 / 10
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11 Report
  • Snd...
  • July 3, 2016

For Depression "Two weeks after starting 15 mg, I started having insomnia, increased anxiety, and agitation. Apparently, these can be rare side effects. I am stopping the medication."

2 / 10
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10 Report

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