Amitriptyline / Chlordiazepoxide Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 20, 2024.
Applies to amitriptyline / chlordiazepoxide: oral tablet.
Important warnings
This medicine can cause some serious health issues
Other side effects
Some side effects of amitriptyline / chlordiazepoxide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- bloating
- clumsiness or unsteadiness
- dryness of mouth or unpleasant taste
- weight gain
Less common side effects
- diarrhea
- nausea or vomiting
Serious side effects
Along with its needed effects, amitriptyline / chlordiazepoxide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking amitriptyline / chlordiazepoxide:
Less common side effects
- blurred vision or other changes in vision
- confusion
- constipation
- difficulty in urinating
- dizziness or lightheadedness
- eye pain
- fainting
- irregular heartbeat
- irritability
- mental depression
- nervousness
- seeing, hearing, or feeling things that are not there
- shakiness
- talking, feeling, and acting with excitement
- trouble in sleeping
Incidence not known
- actions that are out of control
- chest pain or discomfort
- decreased interest in sexual intercourse
- false or unusual sense of well-being
- fast, slow, or irregular heartbeat
- inability to have or keep an erection
- increased in sexual ability, desire, drive, or performance
- increased interest in sexual intercourse
- increased sensitivity to sunlight
- loss in sexual ability, desire, drive, or performance
- pain or discomfort in the arms, jaw, back or neck
- redness or other discoloration of skin
- severe sunburn
- shakiness and unsteady walk
- skin rash
- sore throat and fever
- sweating
- swelling of the breasts or breast soreness in males
- swelling of the testicles
- swelling or inflammation of the mouth
- unexpected or excess milk flow from breasts
- unsteadiness, trembling, or other problems with muscle control or coordination
Get emergency help immediately if any of the following symptoms of overdose occur while taking amitriptyline / chlordiazepoxide:
Symptoms of overdose
- agitation
- changes in patterns and rhythms of speech
- confusion
- disorientation
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- hallucinations
- headache
- loss of consciousness
- loss of strength or energy
- mood or other mental changes
- seizures
- shakiness and unsteady walk
- slurred speech
- trouble breathing
- trouble sleeping
- trouble speaking
- unsteadiness, trembling, or other problems with muscle control or coordination
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- unusual excitement, nervousness, restlessness, or irritability
For healthcare professionals
Applies to amitriptyline / chlordiazepoxide: oral tablet.
General adverse events
The most frequently reported side effects included drowsiness, dry mouth, constipation, and blurred vision.[Ref]
Psychiatric
- Frequency not reported: Apprehension, confusion, delusions, drug habituation/dependence, dysphoria, euphoria, hallucinations, hypomania, impotence, increased/decreased libido, insomnia, poor concentration, restlessness, vivid dreams, withdrawal symptoms[Ref]
Nervous system
- Frequency not reported: Ataxia, convulsions, dizziness, drowsiness, EEG pattern changes, extrapyramidal symptoms, extremity numbness/tingling/paresthesia, headache, incoordination, peculiar taste, stroke, syncope, tremor[Ref]
Gastrointestinal
- Frequency not reported: Abdominal cramps, black tongue, bloating, constipation, diarrhea, dry mouth, epigastric distress, nausea, paralytic ileus, parotid swelling, stomatitis, tongue edema, vomiting[Ref]
Dermatologic
- Frequency not reported: Alopecia, face edema, increased perspiration, photosensitization, pruritus, purpura, skin rash, sweating, urticaria[Ref]
Cardiovascular
- Frequency not reported: Arrhythmias, heart block, hypertension, hypotension, myocardial infarction, palpitations, tachycardia[Ref]
Genitourinary
- Frequency not reported: Breast enlargement, galactorrhea, minor menstrual abnormalities, testicular swelling, urinary frequency, urinary retention, urinary tract dilation[Ref]
Hematologic
- Frequency not reported: Agranulocytosis, bone marrow depression, eosinophilia, granulocytopenia, thrombocytopenia
Metabolic
- Frequency not reported: Anorexia, blood sugar level elevation/lowering, weight gain/loss[Ref]
Other
Ocular
- Frequency not reported: Accommodation disturbance, blurred vision, mydriasis[Ref]
Hepatic
- Frequency not reported: Hepatic dysfunction, jaundice[Ref]
Endocrine
- Frequency not reported: Gynecomastia, syndrome of inappropriate antidiuretic hormone (SIADH) secretion[Ref]
Musculoskeletal
- Frequency not reported: Muscle cramps[Ref]
Respiratory
- Frequency not reported: Nasal congestion[Ref]
References
1. (2017) "Product Information. Amitriptyline-Chlordiazepoxide (amitriptyline-chlordiazepoxide)." Mylan Pharmaceuticals Inc
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Further information
Amitriptyline/chlordiazepoxide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.