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Amitriptyline and chlordiazepoxide

Generic Name: amitriptyline and chlordiazepoxide (AM i TRIP ti leen and KLOR dye AZ e POX ide)
Brand Name: Limbitrol, Limbitrol DS

Medically reviewed by Drugs.com on Jun 22, 2020 – Written by Cerner Multum

What is amitriptyline and chlordiazepoxide?

Amitriptyline is a tricyclic antidepressant. Chlordiazepoxide is a benzodiazepine (ben-zoe-dye-AZE-eh-peen).

Amitriptyline and chlordiazepoxide is a combination medicine used to treat moderate to severe depression and anxiety.

Amitriptyline and chlordiazepoxide may also be used for purposes not listed in this medication guide.

Important Information

Fatal side effects can occur if you take amitriptyline and chlordiazepoxide with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.

You should not use this medicine if you have recently had a heart attack.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Before taking this medicine

You should not use this medicine if you are allergic to amitriptyline or chlordiazepoxide, or:

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

Tell your doctor if you have ever had:

  • bipolar disorder (manic depression);

  • suicidal thoughts or actions;

  • drug or alcohol addiction;

  • if you are receiving electroshock treatment;

  • heart disease;

  • a heart attack, stroke, or seizures;

  • a thyroid disorder;

  • liver or kidney disease;

  • glaucoma; or

  • problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

This medicine can harm an unborn baby or cause birth defects. Do not use if you are pregnant, and tell your doctor right away if you become pregnant while taking amitriptyline and chlordiazepoxide.

You should not breastfeed while you are using amitriptyline and chlordiazepoxide.

Do not give this medicine to a child without medical advice.

How should I take amitriptyline and chlordiazepoxide?

Follow the directions on your prescription label and read all medication guides. Never use amitriptyline and chlordiazepoxide in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of amitriptyline and chlordiazepoxide.

This medicine may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.

Do not stop using amitriptyline and chlordiazepoxide suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline and chlordiazepoxide can be fatal, especially if taken with alcohol.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.

What should I avoid while taking amitriptyline and chlordiazepoxide?

Avoid drinking alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how amitriptyline and chlordiazepoxide will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Amitriptyline and chlordiazepoxide side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • severe constipation;

  • confusion, hallucinations, unusual thoughts or behavior;

  • chest pain or heavy feeling, pain spreading to the jaw or shoulder;

  • pounding heartbeats or fluttering in your chest;

  • a light-headed feeling, like you might pass out; or

  • little or no urination.

The sedative effects of this medicine may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury.

Common side effects may include:

  • dizziness, drowsiness;

  • blurred vision; or

  • dry mouth, constipation, bloating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Amitriptyline and chlordiazepoxide dosing information

Usual Adult Dose for Anxiety:

Amitriptyline 25 mg-chlordiazepoxide 10 mg tablets:
-Initial dose: 3 to 4 tablets orally per day, given in divided doses
-Maintenance dose: 2 to 6 tablets orally per day, given in divided doses
Maximum dose: 6 tablets/day

Comments:
-Doses should be reduced to the lowest effective amount once a satisfactory response is obtained.
-The larger portion of the total dose may be given at bedtime.
-A single daily dose (given at bedtime) may be sufficient for some patients.

Use: Treatment of patients with moderate to severe depression associated with moderate to severe anxiety

Usual Adult Dose for Depression:

Amitriptyline 25 mg-chlordiazepoxide 10 mg tablets:
-Initial dose: 3 to 4 tablets orally per day, given in divided doses
-Maintenance dose: 2 to 6 tablets orally per day, given in divided doses
Maximum dose: 6 tablets/day

Comments:
-Doses should be reduced to the lowest effective amount once a satisfactory response is obtained.
-The larger portion of the total dose may be given at bedtime.
-A single daily dose (given at bedtime) may be sufficient for some patients.

Use: Treatment of patients with moderate to severe depression associated with moderate to severe anxiety

What other drugs will affect amitriptyline and chlordiazepoxide?

Taking amitriptyline and chlordiazepoxide with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, prescription cough medicine, or medicine for depression or seizures.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially:

  • any other antidepressants;

  • heart or blood pressure medication; or

  • medicine to treat mental illness.

This list is not complete. Other drugs may affect amitriptyline and chlordiazepoxide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.