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Parnate Side Effects

Generic Name: tranylcypromine

Note: This page contains side effects data for the generic drug tranylcypromine. It is possible that some of the dosage forms included below may not apply to the brand name Parnate.

For the Consumer

Applies to tranylcypromine: oral tablet

As well as its needed effects, tranylcypromine (the active ingredient contained in Parnate) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking tranylcypromine, check with your doctor immediately:

Incidence not known:
  • Absence of or decrease in body movement
  • actions that are out of control
  • agitation
  • anxiety
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • coma
  • confusion
  • confusion about identity, place, and time
  • cough or hoarseness
  • dark urine
  • decrease in frequency of urination
  • decrease in urine volume
  • depression
  • difficulty in passing urine (dribbling)
  • dizziness
  • dry mouth
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • hostility
  • hyperventilation
  • increased need to urinate
  • irregular heartbeats
  • irritability
  • lethargy
  • light-colored stools
  • longer than usual time to ejaculation of semen
  • loss of bladder control
  • lower back or side pain
  • muscle twitching
  • nausea and vomiting
  • nervousness
  • painful or difficult urination
  • pale skin
  • passing urine more often
  • pinpoint red spots on the skin
  • rapid weight gain
  • restlessness
  • seizures
  • shakiness and unsteady walk
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • sudden jerky movements of the body
  • swelling
  • swelling of the face, ankles, or hands
  • swollen glands
  • talking, feeling, and acting with excitement
  • trouble with sleeping
  • troubled breathing with exertion
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal pain
  • yellow eyes and skin

Minor Side Effects

Some tranylcypromine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:
  • Abdominal or stomach pain
  • blurred vision
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased interest in sexual intercourse
  • diarrhea
  • drowsiness
  • dry mouth
  • hair loss or thinning of the hair
  • hearing loss
  • hives or welts
  • inability to have or keep an erection
  • itching
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • memory loss
  • muscle spasm
  • redness of the skin
  • skin rash
  • sleeplessness
  • unable to sleep
  • weakness
  • weight loss

For Healthcare Professionals

Applies to tranylcypromine: oral tablet


The most important adverse event is hypertensive crisis, which may be fatal. The most common adverse event is insomnia, which can frequently be overcome by giving the last dose of the day no later than 3 pm or reducing dosage.[Ref]


Severe hypertensive reactions have occurred, notably with tyramine containing foods, and are sometimes fatal. Symptoms may include pain and stiffness in the neck, multiple extrasystoles, often with substernal pain, sweating and pallor, sometimes followed by flushing, mydriasis, and photophobia.[Ref]

Frequency not reported: Tachycardia, palpitation, postural hypotension, severe hypertensive reaction, hypertensive crisis[Ref]

Nervous system

Frequency not reported: Drowsiness, dizziness, headache, myoclonic jerks, numbness, paresthesia
Postmarketing reports: Ataxia, memory loss, akinesia[Ref]


Frequency not reported: Insomnia, overstimulation (including increased anxiety, agitation, and manic symptoms), restlessness, sleep disturbances, hallucinations, drug dependence, suicidal ideation, suicidal behavior, withdrawal
Postmarketing reports: Confusion, disorientation[Ref]


Frequency not reported: Dry mouth, nausea, diarrhea, abdominal pain, constipation, vomiting
Postmarketing reports: Fissuring in corner of mouth[Ref]


Frequency not reported: Impaired water excretion compatible with syndrome of inappropriate antidiuretic syndrome (SIADH)[Ref]


Frequency not reported: Impotence, urinary retention, retarded ejaculation
Postmarketing reports: Urinary frequency, urinary incontinence[Ref]


Frequency not reported: Anemia, leukopenia, agranulocytosis, thrombocytopenia, blood dyscrasias[Ref]


Frequency not reported: Hepatitis, hepatocellular damage, jaundice[Ref]


Frequency not reported: Chills, muscle spasm
Postmarketing reports: Localized scleroderma[Ref]


Frequency not reported: Weakness, tinnitus, tremors, fatigue[Ref]


Frequency not reported: Blurred vision[Ref]


Frequency not reported: Skin rash, alopecia
Postmarketing reports: Flare up of cystic acne, urticaria[Ref]


Frequency not reported: Significant anorexia, edema[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Parnate (tranylcypromine)." SmithKline Beecham, Philadelphia, PA.

It is possible that some side effects of Parnate may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.