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Parnate Side Effects

Generic Name: tranylcypromine

Note: This document contains side effect information about tranylcypromine. Some of the dosage forms listed on this page may not apply to the brand name Parnate.

For the Consumer

Applies to tranylcypromine: oral tablet

Along with its needed effects, tranylcypromine (the active ingredient contained in Parnate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tranylcypromine:

Incidence not known
  • Absence of or decrease in body movement
  • actions that are out of control
  • agitation
  • anxiety
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • coma
  • confusion
  • confusion about identity, place, and time
  • cough or hoarseness
  • dark urine
  • decrease in frequency of urination
  • decrease in urine volume
  • depression
  • difficulty in passing urine (dribbling)
  • dizziness
  • dry mouth
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • hostility
  • hyperventilation
  • increased need to urinate
  • irregular heartbeats
  • irritability
  • lethargy
  • light-colored stools
  • longer than usual time to ejaculation of semen
  • loss of bladder control
  • lower back or side pain
  • muscle twitching
  • nausea and vomiting
  • nervousness
  • painful or difficult urination
  • pale skin
  • passing urine more often
  • pinpoint red spots on the skin
  • rapid weight gain
  • restlessness
  • seizures
  • shakiness and unsteady walk
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • sudden jerky movements of the body
  • swelling
  • swelling of the face, ankles, or hands
  • swollen glands
  • talking, feeling, and acting with excitement
  • trouble with sleeping
  • troubled breathing with exertion
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal pain
  • yellow eyes and skin

Some side effects of tranylcypromine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Abdominal or stomach pain
  • blurred vision
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased interest in sexual intercourse
  • diarrhea
  • drowsiness
  • dry mouth
  • hair loss or thinning of the hair
  • hearing loss
  • hives or welts
  • inability to have or keep an erection
  • itching
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • memory loss
  • muscle spasm
  • redness of the skin
  • skin rash
  • sleeplessness
  • unable to sleep
  • weakness
  • weight loss

For Healthcare Professionals

Applies to tranylcypromine: oral tablet


The most important adverse event is hypertensive crisis, which may be fatal. The most common adverse event is insomnia, which can frequently be overcome by giving the last dose of the day no later than 3 pm or reducing dosage.[Ref]


Frequency not reported: Edema, flushing, hypertensive crisis, hypotension, multiple extrasystoles, pallor, palpitation, postural hypotension, severe hypertensive reaction, substernal pain, tachycardia[Ref]

Severe hypertensive reactions have occurred, notably with tyramine containing foods, and are sometimes fatal. Symptoms may include pain and stiffness in the neck, multiple extrasystoles, often with substernal pain, sweating and pallor, sometimes followed by flushing, mydriasis, and photophobia.

Hypotension and postural hypotension were usually temporary, but sometimes required discontinuation of treatment. Blood pressure rapidly returned to pretreatment levels once treatment was stopped.[Ref]

Nervous system

Frequency not reported: Drowsiness, dizziness, headache, headache without blood pressure elevation, myoclonic jerks, numbness, paresthesia, syncope, throbbing headache, tremor, unusually frequent headaches
Postmarketing reports: Akinesia, ataxia, memory loss[Ref]


Frequency not reported: Agitation, anxiety, drug dependence, hallucinations, hypomania, insomnia, manic symptoms, overstimulation, restlessness, sleep disturbances, suicidal behavior, suicidal ideation, withdrawal symptoms
Postmarketing reports: Confusion, disorientation[Ref]

Drug dependence with tolerance to high doses may occur in patients without a history of drug dependence.

Overstimulation included increased anxiety, agitation, and manic symptoms, and was usually a sign of excessive therapeutic action.[Ref]


Frequency not reported: Abdominal pain, constipation, diarrhea, dry mouth, nausea, vomiting
Postmarketing reports: Fissuring in corner of mouth[Ref]


Frequency not reported: Syndrome of inappropriate antidiuretic syndrome (SIADH)[Ref]


Frequency not reported: Impotence, retarded ejaculation, urinary retention
Postmarketing reports: Urinary frequency, urinary incontinence[Ref]


Frequency not reported: Agranulocytosis, anemia, blood dyscrasias, leukopenia, thrombocytopenia[Ref]


Frequency not reported: Hepatitis, hepatocellular damage, jaundice[Ref]


Frequency not reported: Muscle spasm, neck stiffness
Postmarketing reports: Localized scleroderma[Ref]


Frequency not reported: Chills, drug tolerance, excessive therapeutic action, fatigue, pain, tinnitus, weakness[Ref]


Frequency not reported: Blurred vision, mydriasis, photophobia[Ref]


Frequency not reported: Alopecia, skin rash/rash, sweating
Postmarketing reports: Flare up of cystic acne, urticaria[Ref]


Frequency not reported: Impaired water excretion, significant anorexia[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Parnate (tranylcypromine)." SmithKline Beecham, Philadelphia, PA.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Parnate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.