Lisdexamfetamine Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 29, 2022.

Summary

Commonly reported side effects of lisdexamfetamine include: insomnia and irritability. Other side effects include: dizziness, weight loss, and xerostomia. Continue reading for a comprehensive list of adverse effects.

Applies to lisdexamfetamine: oral capsule, oral tablet chewable.

Serious side effects of Lisdexamfetamine

Along with its needed effects, lisdexamfetamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lisdexamfetamine:

Less common

• Uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)

Incidence not known

• Agitation
• blistering, peeling, or loosening of the skin
• chest discomfort or pain
• chills
• confusion
• cough
• diarrhea
• difficulty with breathing
• difficulty with swallowing
• discouragement
• dizziness
• faintness
• fast, irregular, pounding, or racing heartbeat or pulse
• feeling sad or empty
• fever
• hives or welts, itching, or skin rash
• irritability
• joint or muscle pain
• lack of appetite
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of interest or pleasure
• overreactive reflexes
• poor coordination
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red skin lesions, often with a purple center
• red, irritated eyes
• redness of the skin
• shivering
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• sweating
• swelling of the feet or lower legs
• talking or acting with excitement you cannot control
• tightness in the chest
• trembling or shaking
• trouble concentrating
• trouble sleeping
• twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
• unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking lisdexamfetamine:

Symptoms of overdose

• Abdominal or stomach cramps
• blurred vision
• change in consciousness
• confusion
• dark-colored urine
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fast breathing
• loss of consciousness
• muscle cramps or spasms
• muscle pain or stiffness
• nervousness
• overactive reflexes
• panic states
• physical attempt to injure yourself
• pounding in the ears
• restlessness
• seeing, hearing, or feeling things that are not there
• seizures
• shakiness in the legs, arms, hands, or feet
• sweating
• trembling or shaking of the hands or feet
• violent actions

Other side effects of Lisdexamfetamine

Some side effects of lisdexamfetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Decreased appetite
• headache
• nausea
• upper abdominal or stomach pain
• vomiting
• weight decreased

Less common

• Crying
• depersonalization
• dry mouth
• dysphoria
• euphoria
• paranoia
• quick to react or overreact emotionally
• rapidly changing moods
• sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to lisdexamfetamine: oral capsule, oral tablet chewable.

Other

Common (1% to 10%): Pyrexia, increased energy, fatigue^[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (36%), upper abdominal pain (12%)

Common (1% to 10%): Vomiting, nausea, diarrhea, constipation, gastroenteritis^[Ref]

Metabolic

Very common (10% or more): Decreased appetite (39%), decreased weight (16.3%)

Common (1% to 10%): Anorexia^[Ref]

Nervous system

Very common (10% or more): Headache (20.3%)

Common (1% to 10%): Dizziness, somnolence, tremor, paresthesia, nightmare, dyskinesia, seizures, psychomotor hyperactivity

Postmarketing reports: Dyskinesia^[Ref]

Psychiatric

Very common (10% or more): Insomnia (27%), irritability (10%)

Common (1% to 10%): Tic, anxiety, agitation, erectile dysfunction, decreased libido, affect lability, feeling jittery, restlessness, aggression, initial insomnia, bruxism

Uncommon (0.1% to 1%): Logorrhea, depression, dysphoria, euphoria, dermatillomania, mania, hallucinations

Postmarketing reports: Libido changes, frequent or prolonged erections, psychotic episodes^[Ref]

Dermatologic

Common (1% to 10%): Rash, hyperhidrosis, pruritus

Uncommon (0.1% to 1%): Urticaria

Postmarketing reports: Stevens-Johnson Syndrome, angioedema^[Ref]

Cardiovascular

Common (1% to 10%): Increased blood pressure, increased heart rate, tachycardia, palpitations

Uncommon (0.1% to 1%): Raynaud's phenomenon

Postmarketing reports: Cardiomyopathy^[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity

Postmarketing reports: Anaphylactic reaction^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection^[Ref]

Ocular

Uncommon (0.1% to 1%): Mydriasis, blurred vision

Postmarketing reports: Diplopia, visual accommodation difficulties^[Ref]

Hepatic

Postmarketing reports: Eosinophilic hepatitis^[Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis^[Ref]

Respiratory

Common (1% to 10%): Dyspnea, oropharyngeal pain^[Ref]

Frequently asked questions

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer