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Lisdexamfetamine Side Effects

In Summary

Commonly reported side effects of lisdexamfetamine include: insomnia and irritability. Other side effects include: dizziness, weight loss, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lisdexamfetamine: oral capsule

In addition to its needed effects, some unwanted effects may be caused by lisdexamfetamine. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking lisdexamfetamine:

Less common:
  • Uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)
Incidence not known:
  • Blistering, peeling, or loosening of the skin
  • chest discomfort or pain
  • chills
  • cough
  • diarrhea
  • difficulty with breathing
  • difficulty with swallowing
  • discouragement
  • dizziness
  • faintness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling sad or empty
  • hives or welts, itching, or skin rash
  • irritability
  • joint or muscle pain
  • lack of appetite
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of interest or pleasure
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the feet or lower legs
  • tightness in the chest
  • trouble concentrating
  • trouble sleeping
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking lisdexamfetamine, get emergency help immediately:

Symptoms of overdose:
  • Abdominal or stomach cramps
  • blurred vision
  • change in consciousness
  • confusion
  • dark-colored urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast breathing
  • loss of consciousness
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nervousness
  • overactive reflexes
  • panic states
  • physical attempt to injure yourself
  • pounding in the ears
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • sweating
  • trembling or shaking of the hands or feet
  • violent actions

Severity: Minor

Some of the side effects that can occur with lisdexamfetamine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Decreased appetite
  • headache
  • nausea
  • upper abdominal or stomach pain
  • vomiting
  • weight decreased
Less common:
  • Crying
  • depersonalization
  • dry mouth
  • dysphoria
  • euphoria
  • fever
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to lisdexamfetamine: oral capsule


All side effects listed, unless otherwise noted, were reported in pediatric patients.[Ref]


Other side effects have included decreased appetite (39%), headache, and pyrexia (2%).


Gastrointestinal side effects have included upper abdominal pain (12%), dry mouth (5%), nausea (6%), and vomiting (9%). Gastrointestinal side effects associated with amphetamine or lisdexamfetamine have included dryness of mouth, unpleasant taste, diarrhea, and constipation.


Metabolic side effects have included weight loss.

Nervous system

Nervous system side effects have included insomnia (19%), dizziness (5%), initial insomnia (4%), and somnolence (2%). Nervous system side effects associated with the use of recommended doses of amphetamine or lisdexamfetamine have included dyskinesia and seizures. Postmarketing reports have included psychotic episodes, mania, hallucination, and aggression.


Psychiatric side effects have included irritability (10%), affect lability (3%), and tic (2%). Psychiatric side effects associated with the use of recommended doses of amphetamine or lisdexamfetamine have included overstimulation, restlessness, euphoria, dysphoria, depression, tremor, and exacerbation of motor and phonic tics and Tourette syndrome. Postmarketing reports have included dermatillomania.


Dermatological side effects have included rash (3%). Dermatological side effects associated with amphetamine or lisdexamfetamine have included serious skin rashes, Stevens Johnson Syndrome, and toxic epidermal necrolysis.


Cardiovascular side effects associated with amphetamine or lisdexamfetamine have included palpitations, tachycardia, increased blood pressure, sudden death, stroke, and myocardial infarction. Cardiomyopathy has been associated with chronic amphetamine use.


Hypersensitivity reactions associated with amphetamine or lisdexamfetamine have included urticaria, angioedema, anaphylaxis, Stevens Johnson Syndrome, and toxic epidermal necrolysis.


Genitourinary side effects associated with amphetamine or lisdexamfetamine have included decreased libido (less than 2%), erectile dysfunction (less than 2%), impotence, and changes in libido. Postmarketing side effects include frequent or prolonged erections.


Ocular side effects including blurred vision have been reported.


1. "Product Information. Vyvanse (lisdexamfetamine)." Shire US Inc, Florence, KY.

Not all side effects for lisdexamfetamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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