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Lisdexamfetamine Side Effects

For the Consumer

Applies to lisdexamfetamine: oral capsule, oral tablet chewable

Along with its needed effects, lisdexamfetamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lisdexamfetamine:

Less common
  • Uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)
Incidence not known
  • Agitation
  • blistering, peeling, or loosening of the skin
  • chest discomfort or pain
  • chills
  • confusion
  • cough
  • diarrhea
  • difficulty with breathing
  • difficulty with swallowing
  • discouragement
  • dizziness
  • faintness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling sad or empty
  • fever
  • hives or welts, itching, or skin rash
  • irritability
  • joint or muscle pain
  • lack of appetite
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of interest or pleasure
  • overreactive reflexes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • shivering
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling of the feet or lower legs
  • talking or acting with excitement you cannot control
  • tightness in the chest
  • trembling or shaking
  • trouble concentrating
  • trouble sleeping
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking lisdexamfetamine:

Symptoms of overdose
  • Abdominal or stomach cramps
  • blurred vision
  • change in consciousness
  • confusion
  • dark-colored urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast breathing
  • loss of consciousness
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nervousness
  • overactive reflexes
  • panic states
  • physical attempt to injure yourself
  • pounding in the ears
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • sweating
  • trembling or shaking of the hands or feet
  • violent actions

Some side effects of lisdexamfetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decreased appetite
  • headache
  • nausea
  • upper abdominal or stomach pain
  • vomiting
  • weight decreased
Less common
  • Crying
  • depersonalization
  • dry mouth
  • dysphoria
  • euphoria
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to lisdexamfetamine: oral capsule, oral tablet chewable

Other

Common (1% to 10%): Pyrexia, increased energy, fatigue[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (36%), upper abdominal pain (12%)
Common (1% to 10%): Vomiting, nausea, diarrhea, constipation, gastroenteritis[Ref]

Metabolic

Very common (10% or more): Decreased appetite (39%), decreased weight (16.3%)
Common (1% to 10%): Anorexia[Ref]

Nervous system

Very common (10% or more): Headache (20.3%)
Common (1% to 10%): Dizziness, somnolence, tremor, paresthesia, nightmare, dyskinesia, seizures, psychomotor hyperactivity
Postmarketing reports: Dyskinesia[Ref]

Psychiatric

Very common (10% or more): Insomnia (27%), irritability (10%)
Common (1% to 10%): Tic, anxiety, agitation, erectile dysfunction, decreased libido, affect lability, feeling jittery, restlessness, aggression, initial insomnia, bruxism
Uncommon (0.1% to 1%): Logorrhea, depression, dysphoria, euphoria, dermatillomania, mania, hallucinations
Postmarketing reports: Libido changes, frequent or prolonged erections, psychotic episodes[Ref]

Dermatologic

Common (1% to 10%): Rash, hyperhidrosis, pruritus
Uncommon (0.1% to 1%): Urticaria
Postmarketing reports: Stevens-Johnson Syndrome, angioedema[Ref]

Cardiovascular

Common (1% to 10%): Increased blood pressure, increased heart rate, tachycardia, palpitations
Uncommon (0.1% to 1%): Raynaud's phenomenon
Postmarketing reports: Cardiomyopathy[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity
Postmarketing reports: Anaphylactic reaction[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Ocular

Uncommon (0.1% to 1%): Mydriasis, blurred vision
Postmarketing reports: Diplopia, visual accommodation difficulties[Ref]

Hepatic

Postmarketing reports: Eosinophilic hepatitis[Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis[Ref]

Respiratory

Common (1% to 10%): Dyspnea, oropharyngeal pain[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Vyvanse (lisdexamfetamine)." Shire US Inc, Florence, KY.

Some side effects of lisdexamfetamine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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