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Lisdexamfetamine Side Effects

In Summary

Commonly reported side effects of lisdexamfetamine include: insomnia and irritability. Other side effects include: dizziness, weight loss, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lisdexamfetamine: oral capsule

In addition to its needed effects, some unwanted effects may be caused by lisdexamfetamine. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking lisdexamfetamine:

Less common:
  • Uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)
Incidence not known:
  • Blistering, peeling, or loosening of the skin
  • chest discomfort or pain
  • chills
  • cough
  • diarrhea
  • difficulty with breathing
  • difficulty with swallowing
  • discouragement
  • dizziness
  • faintness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling sad or empty
  • hives or welts, itching, or skin rash
  • irritability
  • joint or muscle pain
  • lack of appetite
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of interest or pleasure
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the feet or lower legs
  • tightness in the chest
  • trouble concentrating
  • trouble sleeping
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking lisdexamfetamine, get emergency help immediately:

Symptoms of overdose:
  • Abdominal or stomach cramps
  • blurred vision
  • change in consciousness
  • confusion
  • dark-colored urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast breathing
  • loss of consciousness
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nervousness
  • overactive reflexes
  • panic states
  • physical attempt to injure yourself
  • pounding in the ears
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • sweating
  • trembling or shaking of the hands or feet
  • violent actions

Minor Side Effects

Some of the side effects that can occur with lisdexamfetamine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Decreased appetite
  • headache
  • nausea
  • upper abdominal or stomach pain
  • vomiting
  • weight decreased
Less common:
  • Crying
  • depersonalization
  • dry mouth
  • dysphoria
  • euphoria
  • fever
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to lisdexamfetamine: oral capsule

Other

Common (1% to 10%): Pyrexia, increased energy, fatigue[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (36%), upper abdominal pain (12%)
Common (1% to 10%): Vomiting, nausea, diarrhea, constipation, gastroenteritis[Ref]

Metabolic

Very common (10% or more): Decreased appetite (39%), decreased weight (16.3%)
Common (1% to 10%): Anorexia[Ref]

Nervous system

Very common (10% or more): Headache (20.3%)
Common (1% to 10%): Dizziness, somnolence, tremor, paresthesia, nightmare, dyskinesia, seizures, psychomotor hyperactivity
Postmarketing reports: Dyskinesia[Ref]

Psychiatric

Very common (10% or more): Insomnia (27%), irritability (10%)
Common (1% to 10%): Tic, anxiety, agitation, erectile dysfunction, decreased libido, affect lability, feeling jittery, restlessness, aggression, initial insomnia, bruxism
Uncommon (0.1% to 1%): Logorrhea, depression, dysphoria, euphoria, dermatillomania, mania, hallucinations
Postmarketing reports: Libido changes, frequent or prolonged erections, psychotic episodes[Ref]

Dermatologic

Common (1% to 10%): Rash, hyperhidrosis, pruritus
Uncommon (0.1% to 1%): Urticaria
Postmarketing reports: Stevens-Johnson Syndrome, angioedema[Ref]

Cardiovascular

Common (1% to 10%): Increased blood pressure, increased heart rate, tachycardia, palpitations
Uncommon (0.1% to 1%): Raynaud's phenomenon
Postmarketing reports: Cardiomyopathy[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity
Postmarketing reports: Anaphylactic reaction[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Ocular

Uncommon (0.1% to 1%): Mydriasis, blurred vision
Postmarketing reports: Diplopia, visual accommodation difficulties[Ref]

Hepatic

Postmarketing reports: Eosinophilic hepatitis[Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis[Ref]

Respiratory

Common (1% to 10%): Dyspnea, oropharyngeal pain[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Vyvanse (lisdexamfetamine)." Shire US Inc, Florence, KY.

Not all side effects for lisdexamfetamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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