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User Reviews for Niacin to treat Depression

Also known as: Niaspan, Niacor, Slo-Niacin, Niacin SR, Endur-acin, B-3-50 B3-500-Gr HDL Benefit

Niacin has an average rating of 8.7 out of 10 from a total of 44 ratings for the treatment of Depression. 86% of reviewers reported a positive effect, while 11% reported a negative effect.

Niacin Rating Summary

8.7/10 average rating

44 ratings from 55 user reviews.

Compare all 189 medications used in the treatment of Depression.

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Reviews for Niacin

Nick · Taken for 2 to 5 years August 21, 2019

“I am almost 50 years old. I spent most of my life suffering from depression and anxiety. The hard part is the Asian (Eastern) culture do not believe in such ailments. They are signs of weakness and we are taught (expected) to power through it. Mind over matter. I used to use alcohol to medicate myself. Doctors wanted to give me SSRIs, like wellbutrin, zoloft, prozac, and lexapro. I don't wanted any of those drugs. I have plenty of my friends on those medications and I have seen what those meds have done to them. The good news is that three years ago I discovered Niacin. I have been taking them everyday since then. It has lessen my anxiety and depression. I no long drink alcohol. My life took a turn for the better. I am sharing my story because I want others who are suffering depression and anxiety to know of this. Don't give up. Try it.”

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Lisamurry24 January 18, 2017

“Hi everyone I have to share my story with you all on how I cured my depression, anxiety and panic attacks. I was on lexapro 3 years ago then when I came off it I got mania and psychosis then I was on olanzapine for 2 years 10mg I cut down to 1.25 mg and the went off completely this was over a couple of months. When I went off it I had terrible withdrawals, panic attacks, and severe depression I couldn't handle it so I went on cymbalta 60 mg that helped a little and 4 months down I was still feeling the side effects from olanzapine withdrawal. That is until 2 weeks ago I came across a video on YouTube about niacin (flush) and how it cured depression, anxiety and panic attacks, I read lots of online reviews and decided to give it a go! 4 days after taking niacin 500mg. ( it has to be the flushing kind) all my withdrawals were completely gone! I couldn't believe it!! My depression and anxiety and panic attacks gone!!! I'm feeling 100% myself! I am now off the cymbalta too! I had to share my story as I want as many people to know and try it! The best thing about it is that you can try it while your on your Meds as it's just a vitamin! I hope my story will help others!”

10 / 10
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Pete · Taken for less than 1 month April 17, 2021

“Wow! Day 3.... worked up to 2000 mg and flushing has eased right off. My mood has not only done a complete 180, but my energy levels are though the roof . Hope this lasts as I have battled anxiety and depression for 25 years ....”

10 / 10
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Loving niacin · Taken for 1 to 6 months September 23, 2015

“I've suffered from severe major depression for over a decade with little to no relief from countless medications at a variety of doses. I've been using niacin for two months now and I feel fantastic, it has been a trial and error kind of deal but so worth the effort in finding the balance. I recommend this to everyone suffering it does take research and some effort to find what dose will work no two of us are alike so I don't see how what works for someone will work the same for another but it is in my option a cure for depression. I believe our creator created our earth with all the ingredients we'd need to take care of ourselves and niacin is just more proof of that for me!”

10 / 10
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jemmunro · Taken for less than 1 month June 19, 2015

“I have suffered with moderate to severe depression my entire life. Last August, after 9 years on Effexor, I stopped taking it because of the side effects. I tried using supplements as recommended by Julia Ross in her book The Mood Cure, but they were not effective for me. My depression became so severe last Oct. that I had to go back on to an anti-depressant (Bupropion) but this medication made my depression much worse. I was then put onto Trintellix in April. The Trintellix was helpful, but side effects soon began to appear. I happened upon an article about a psychiatrist who had used niacin for treating depression. When I googled niacin and depression, I came upon many other blogs and comments from other people who also found niacin to be effective against their struggles with depression. I was desperate to find an alternative to taking anti-depressants, so 4 weeks ago, I began supplementing with niacin plus vitamin C. (I had already been taking a vitamin B multi, magnesium, fish oil and Vit. D). I started with 100mcg niacin and have been gradually increasing the dose by 25mcg increments each day. I use only the regular niacin, not the timed release nor the non-flushing type. Since I started taking the additional niacin & vitamin C, I find that my depression is/has diminished significantly. I am no longer suffering from that bottomless well of depressive feelings that had been with me since last fall. I stopped taking the Trintellix 3 weeks ago and my depression has continued to lift.”

10 / 10
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Mom of two September 30, 2019

“My daughter, an RN, fell into a severe depression and ended up in the hospital. After taking a multitude of medications, we started her on ketermine infusions and that helped greatly , but didn’t completely rid the negative thoughts quick enough. We started her on niacin - 1500 mg a day, no flush, and her mood and motivation changed instantly!!!!!!! She started going to the gym, out with friends, calmness, and everything became positive within an hour after starting this vitamin. These are facts and I’m grateful to God that we found this information about the Dr that cured depression , just by using niacin daily!”

10 / 10
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Anna C. October 1, 2017

“I'm so excited how niacin has changed my life.. I've suffered from depression and anxiety attacks for years. It started when I was 7th grade.. I'm now 62yr old and been through many drugs and doctors.. When I decided to try niacin it was the last straw for me. With the help and support of my daughter she insisted for me to give it a try. She is taking classes to become nutritionist and came across info on this supplement called niacin and read great testimonies. So I took her advice and began to take it. I'm so amazed how it has lifted my depression, anxiety, and unwanted fear. I feel like a new person, confident , happy and wanting to endeavor in new activities.. Nothing is holding me back!! There is hope for me now..”

10 / 10
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Frequently asked questions

Trish December 14, 2020

“I had slightly elevated cholesterol but didn't want to take statins. My PCP recommended 1200mg of niacin (yes the nasty full-flush kind, the flush does lessen with time). For years I have suffered from depression, antidepressants made me feel worse. By the second day of taking niacin that dark, heavy cloud on my brain just went away. My cat did something goofy and I actually laughed, I can't remember the last time I honestly laughed! It's been two months, the flush effect is minimal. I don't know yet if it's doing anything for my cholesterol but I will keep taking the niacin because I love feeling alive.”

10 / 10
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Melanie567 October 7, 2019

“I recently started using niacin and it completely cured my anxiety depression and alcohol abuse. I really believe that alcoholism is a result of a niacin deficiency. And we are deficient the morning anxiety you have and then you drink to treat that and it's a vicious cycle and creates more deficiency. I am so grateful for this and I'm sharing this with anyone and everyone I can. I was becoming very hopeless and suicidal I had tried everything and nothing was working. This works almost immediately.”

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Cholesterol and depression cur · Taken for 1 to 2 years February 24, 2016

“I began taking niacin 2 years ago for high cholesterol and after 3 months of taking the vitamin at 500mg/day my cholesterol levels dropped from 260 to 210 with improved ldl and hdl also. I upped the dose to 1000mg a day and have taken for 2 years with current chol level of 189. I not only noticed a reduction in cholesterol but began to feel better and happier. I stopped taking niacin last month and after 1 week started to experience previous anxiety and depression problems that I had been plagued by prior to niacin. I had no idea niacin was so effective in helping with depression until I stopped taking it. I'm back on it and have no worries. ”

10 / 10
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Anonymous April 9, 2017

“Really happy it helped me a lot . Severe depression I took it then another dose 2 hours later . I sweated etc felt very chilled then a slight headache . Felt a little tired and sick fell asleep 2 hours. When I woke I felt different I started cleaning my kitchen and bedroom. I lost my daughter Autumn to suicide in Oct . So believe me my depression was severe . Cleaning was a task I could not perform . Thinking more clear with no negative thoughts coming intrusively in my head . I really could not believe it . Gonna try it again tomorrow”

10 / 10
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Tony · Taken for less than 1 month December 14, 2019

“The 12th of December, I woke up like any other day, it felt kind of normal, but as soon as I was on my way to work, I noticed I didn’t have anxiety. My depression was gone as well. And for some reason I felt like smiling. It was a weird feeling. The day before I had took a just about above average dose of niacin and I think that is what made the difference. Everything else in that day and previous were the same as my days with depression and anxiety. So I figured it had to be my diet since I recently changed it, to track my micronutrient intake. I feel great and like I always wanted to feel, the person above said it best. I feel like I am not the way I felt almost my whole life, I can talk to people now without feeling anxious and feel in a Way better positive mood. I thought my whole life was going to be depressing and I was going to try to have to find a way to live like this. It is amazing!”

10 / 10
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Katyy July 22, 2017

“I had severe depression on and off past few years. This time round it was unbearable and I was literally falling apart mentally. Sadness and torment, that would not go away, anxiety and lack of sleep for over a year etc. I refused taking synthethic meds and decided to give niacin a go. it worked pretty much instantly. I started on about 300mg (severe flush like sunburn and itchy skin), then calmness. I was upping the dosage almost each time, and flushes eased eventually. Now (2 weeks later) I take 1500mg 2-3 times a day and the flush is slight with warm face and chest. Sadness is gone and I feel much more "with it". It seems to be blocking unwanted thoughts. hands down- a true depression cure.”

10 / 10
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Akt1 · Taken for 2 to 5 years September 24, 2016

“Been taking nicotinic acid/flushing niacin on and off for about two years. First time i took it, i took 50mg. I Then experienced, to quote My diary " presence, calmness, harmony". I believe 50mg daily is enough for me. If i dont take it, in about three days i become "mentally tortured"; i can not relax, negative thoughts, feel really bad. Maybe some mechanism is wrong somewhere along The line in My serotonin system. If i combine niacin with some tryptophan source (like whey protein) The effects are even better. I would honestly say that niacin has Been a life changer for me, no doubt about that. Have had no side effects that i can think of, maybe decreased appetite in high doses. Also Google niacin and pois if needed. Best Wishes”

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Bigal December 9, 2019

“No need for niacin. Just cake regular nicotinimide b3 and that way no flushing. I take 500mg twice a day after food, this vit is amazing. Stopped 90% of my anxiety and quietened my intrusive thoughts. Love it. Ten dollars for 60 tablets.”

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mia9_28 February 16, 2015

“Niacin has greatly improved my life. My depressive thoughts disappeared right from the start (500mg a day now for 2 weeks. Now going up to 1000mg a day). My girlfriend has also been taking it and we've both been in a greater mood (she's also depressive). Suicidal thoughts are rare now. I no longer flush.”

9 / 10
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Steve'O August 11, 2016

“i have been on and off antidepressants for 18 years. Only after finding out about niacin 3 years ago has there been any significant improvements in my mental health. I am also a alcoholic, witch makes me super hard to treat. " when I take niacin at a high dose, for me is 3.5 4.5g per day it takes only 3-5 days to forget I was ever depressed to start with, and the want for alchohol subsidies "for me anyway" I have discussed this with my doctor he said it could help with my cholesterol. And advised me to take less, when I do in a matter of days I crash :( For me it is a must In my daily routine. I wish more was shared by GP's On this wonderful thing. Rather than pushing pills. I purchase 2.5kg at a time now”

10 / 10
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NJ-Jim July 24, 2019

“It's 7/24/19. I just started this on 7/20. Been taking Viibryd for about 6 months now (40mg). It was working fine for a while, but I started to see the benefits weaning. I bought 1,000 of the 500mg tabs . I took 1,000mg the first day. The flush was little intense for about 45 minutes (itching and flushing of skin). It went away and my depression did too! The next day I took 1,500 mg. The flushing was not as bad as the day before and I felt great. I've been taking 2,000mg a day and I've felt better than I have for 25 years. I think my sweet spot is between 1,500 and 2,000mg per day. As of today, the flushing is VERY minor. I suggest you try this. Now..I'm a type 2 diabetic on medication for control (no insulin). I heard that this can increase sugar in the blood. I hope this doesn't make me have to stop. I'm hoping I can ween off of the Vybriid. This niacin seems like a magical drug, and the best part is it's not a drug...it's a vitamin!!!”

9 / 10
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Banannine April 28, 2017

“2 years ago my step daughter was diagnosed with severe anxiety and depression. She couldn't go to school, she was suicidal and completely dysfunctional. She has been on Zoloft since then. We decided with diet and exercise to spend 6 months weening her off the pills which was hard. I read about Niacin and we came off of Zoloft and immediately into this. 3 pills a day, which would make 1500MG. The flushing subsided very fast for her. On day 3 she went for a run, voluntarily. On day 4 she said she would join soccer. 3 weeks in she was better than ever before. I thought, its a fluke and when her pills ran out I accidentally bought flush free Niacin. It took one day to bring her down. Niacin works, she said it lifted the fog.”

10 / 10
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happypartner June 6, 2017

“I read all of these reviews with much interest after stumbling across a word called niacin while researching some info on depression as my partner was in a very bad place. He had always suffered depression but the last bout was particularly bad and ongoing and he was getting worse, not better. Very glad I found this, he has been taking it for about a month now, and the changes in him were almost immediate. He just takes enough to experience the slight flush which for him seems to be 300mg which he takes immediately after breakfast and another 300mg again after tea. Experiment is the key to finding the right dose for you as everyone is different. I can't speak highly enough of it. So so relieved!!! I was actually fearful for his life!”

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Blushed November 9, 2009

“I recently watched the movie Food Matters and learned that Niacin can be used to treat depression and alcoholism in addition to high cholesterol. I began taking last week, and have noticed a gradual improvement in my mood as I increase the dosage. Make sure you start low and increase gradually, though: the first time I took it I took 100mg with a light snack and ended up stripping down and standing in my kitchen panting, but there were no lasting negative effects.”

9 / 10
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Quando62 · Taken for 10 years or more July 3, 2017

“I am amazed with the mental effects of Niacin. OK, I started taking it 5 weeks ago to lower my high cholesterol and Tryclicerides off the chart!!! I have been having energy like I had 20 years ago, positive attitude, motivated and I have been on every TCA and SSRI and SNRI and none worked. I feel 25 years younger. My fibro and arthritis is less noticeable, and after a heart attack 3 years ago and 3 stents put in, from December till June, I was having heart palpitations every day that concerned me. After a few days of 1gram of Niacin, for 3 weeks, not ONE heart palpitation whatsoever... This stuff is GREAT!!!!”

10 / 10
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Still crazy, but under control! March 13, 2012

“I have suffered from severe anxiety and depression since 2002 when I had cancer and did chemo. The chemotherapy I did saved my life but it messed up my hormones so much that I went into premenopause at the age of 17. I have been on various doses of Effexor XR for the last 8 years ranging from 75-300mg a day. I needed medication to live a normal life. In the last year or two, I had been progressively getting worse until I felt like I was spiraling out of control. I had been working with my doctor to find a solution but nothing was working. Extra meds were not helping. Desperate, I tried niacin. 500mg a day. Flushing is worth it. I am now off Effexor, and on niacin instead and it works better with less side effects, only the flush.”

8 / 10
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Dmarq · Taken for less than 1 month December 17, 2019

“Been suffering from depression and anxiety most of my life. Started taking Solgar Niacin (with the flush) and the change has been like day vs night. Sleeping better, energy in the morning and in the evening (but not affecting sleep), better concentration and mood vastly improved. Started on Solgar Niacin 100mg once a day and moved up to twice a day and feeling great!”

10 / 10
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Benbenben December 4, 2015

“I have been on every ssri and different anti-dep the last 15 years. I started Niacin 8 weeks ago. I am now on 1,5 g. Going up to 3 g. Niacin is wonderful. Has helped me so much. Quite amazing. :) Seriously recommend this. Really strange that this is not more known. Use Niacin only after food. I take the 1.5g after work. 3x500mg. Going to start 1.5g Niacinamide during morning/day-time because it doesnt make you flush. Niacinaminde also work for depression, but not the cholesterol. Probably going over to only Niacinaminde after the Niacin is empty. I live in the winter-darkness of Norway, so I also take vitamin-d.”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.