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Generic name: niacin (nicotinic acid)NYE-a-sin ]
Brand names: B-3-50, B3-500-Gr, Endur-acin, HDL Benefit, Niacin SR, ... show all 8 brands
Drug classes: Miscellaneous antihyperlipidemic agents, Vitamins

Medically reviewed by on Jul 22, 2022. Written by Cerner Multum.

What is B3-500-Gr?

B3-500-Gr is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides, and increase levels of "good" cholesterol (high-density lipoprotein, or HDL).

Niaspan is used to lower the risk of a heart attack in people who have high cholesterol and who have a history of heart attacks. Niaspan can also be used with another cholesterol medicine to slow down the build-up of fatty deposits in your arteries.

B3-500-Gr may also be used for purposes not listed in this medication guide.


You should not take B3-500-Gr if you have severe liver disease, a stomach ulcer, or active bleeding.

Before taking this medicine

You should not take B3-500-Gr if you are allergic to it, or if you have:

  • severe liver disease;

  • a stomach ulcer; or

  • active bleeding.

Tell your doctor if you have ever had:

It is not known whether B3-500-Gr will harm an unborn baby. You may not be able to use B3-500-Gr during pregnancy. Tell your doctor right away if you become pregnant.

Do not breastfeed.

Do not give this medicine to a child without medical advice.

How should I take B3-500-Gr ?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

B3-500-Gr can cause flushing (warmth, itching, redness, or tingly feeling under your skin). These effects should disappear over time as you keep taking the medicine. Flushing may be worse if you drink alcohol or hot beverages shortly after taking this medicine.

Swallow the capsule or tablet whole and do not crush, chew, break, or open it.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the form and strength your doctor prescribes.

If you stop taking B3-500-Gr for any length of time, talk with your doctor before starting the medication again. You may need to restart the medication at a lower dose.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using B3-500-Gr.

B3-500-Gr is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Your doctor may recommend you take aspirin or an NSAID (such as ibuprofen, Advil, or Aleve) to help prevent flushing. Keep using these medicines for as long as your doctor has prescribed.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking B3-500-Gr ?

Avoid drinking alcohol. It may increase your risk of liver damage, and can also worsen the flushing effects of niacin.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid eating foods high in fat or cholesterol, or B3-500-Gr will not be as effective.

B3-500-Gr side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

B3-500-Gr may cause serious side effects. Call your doctor at once if you have:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;

  • unexplained muscle pain, tenderness or weakness;

  • a light-headed feeling, like you might pass out;

  • irregular heartbeats;

  • severe warmth or redness under your skin;

  • vision problems; or

  • jaundice (yellowing of the skin or eyes).

Common side effects of B3-500-Gr may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect B3-500-Gr?

You should not take colesevelam, colestipol, or cholestyramine within 4 hours before or 4 hours after taking B3-500-Gr.

Tell your doctor about all your other medicines, especially:

  • other medicines to lower cholesterol or triglycerides;

  • aspirin;

  • blood pressure medicine; or

  • a blood thinner--warfarin, Coumadin, Jantoven.

This list is not complete. Other drugs may affect B3-500-Gr, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.