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Generic name: niacin (nicotinic acid) (NYE a sin (NIK oh TIN ik AS id))
Brand name: B-3-50, B3-500-Gr, Endur-acin, HDL Benefit, Niacin SR, Niacor, Niaspan ER, Slo-Niacin
Drug class: Miscellaneous antihyperlipidemic agents

Medically reviewed by on Sep 15, 2020. Written by Cerner Multum.

What is Endur-acin?

Endur-acin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides, and increase levels of "good" cholesterol (high-density lipoprotein, or HDL).

Endur-acin may also be used for purposes not listed in this medication guide.


You should not take Endur-acin if you have severe liver disease, a stomach ulcer, or active bleeding.

Before taking this medicine

You should not take Endur-acin if you are allergic to it, or if you have:

  • severe liver disease;

  • a stomach ulcer; or

  • active bleeding.

Tell your doctor if you have ever had:

  • liver disease;

  • heart disease, chest pain (angina);

  • gout; or

  • diabetes.

It is not known whether Endur-acin will harm an unborn baby. You may not be able to use Endur-acin during pregnancy. Tell your doctor right away if you become pregnant.

You should not breastfeed while using Endur-acin.

Endur-acin is not approved for use by anyone younger than 18 years old.

How should I take Endur-acin ?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Endur-acin can cause flushing (warmth, itching, redness, or tingly feeling under your skin). These effects should disappear over time as you keep taking the medicine. Flushing may be worse if you drink alcohol or hot beverages shortly after taking this medicine.

Swallow the capsule or tablet whole and do not crush, chew, break, or open it.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the form and strength your doctor prescribes.

If you stop taking Endur-acin for any length of time, talk with your doctor before starting the medication again. You may need to restart the medication at a lower dose.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Endur-acin.

Endur-acin is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Your doctor may recommend you take aspirin or an NSAID (such as ibuprofen, Advil, or Aleve) to help prevent flushing. Keep using these medicines for as long as your doctor has prescribed.

Store at room temperature away from moisture and heat.

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What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Endur-acin ?

Avoid drinking alcohol. It may increase your risk of liver damage, and can also worsen the flushing effects of niacin.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid eating foods high in fat or cholesterol, or Endur-acin will not be as effective.

Endur-acin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • irregular heartbeats;

  • severe warmth or redness under your skin;

  • vision problems; or

  • jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Endur-acin?

Tell your doctor about all your other medicines, especially:

  • statin cholesterol medication;

  • heart or blood pressure medication; or

  • other medicines that lower blood pressure.

This list is not complete. Other drugs may affect Endur-acin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.