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User Reviews for Tramadol to treat Depression

Also known as: Ultram, Tramadol Hydrochloride ER, ConZip

The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Tramadol Rating Summary

User Ratings
66% (85)
15% (19)
9% (12)
4% (5)
1% (1)
1% (1)
1% (1)
2% (2)
0% (0)
2% (3)
9.1/10 Average Rating
129 ratings from 137 user reviews

Compare all 191 medications used in the treatment of Depression.

Reviews for Tramadol

Sober alcoholic May 22, 2020

“Took first dose 2 years ago. Was 1 year sober (alcohol) and took unprescribed for pain. Took 2 weeks to go 300mg/day. 6 months later at 800mg/day; had 2 seizures. After I maintained at 600mg/day for 8 months. Was happy, energetic, and productive. Wanted out, not willing to give up benefits. Then pandemic came/shut down my source. Self-tapered, now at 100mg/day, can’t taper further without physical withdrawal. Altered mental state to point of suicidal ideations during taper. Works as antidepressant, very addicting. Wish had never taken. I read these forums when I first started experimenting and thought I could manage it. I was wrong. I guess it treats everyone a little differently, but if this post could persuade one person to get out of it before it’s too late then I have my purpose for posting. Please be very careful with this drug, I am still in so much psychological pain unlike anything I’ve experienced since getting sober.”

1 / 10
stephen55 March 2, 2020

“The SNRI metabolite for Tramadol yields most of the anti-depressant action. More mental and emotional energy. Personally, I haven't noticed any addictive quality at all. I have used other hard pain relievers (Oxycontin and Fentanyl) in the past, so I know my Tramadol is not like those. Also I have used Tramadol for 8 years at 400 mg/day; I have experienced NO tolerance-building; I don't have to increase the dose. Psychiatric usefulness definitive.”

10 / 10
CatMom · Taken for 1 to 2 years February 28, 2020

“I have suffered from depression for years, and also have PTSD. Last year my depression became much, much worse. I was in tears most of the day, no positivity with anything and to the point where I was contemplating suicide. I had tried so many medications and CBT , nothing worked. I was given these tramadol for my depression and they worked within hours. I could not believe that one little tablet could have such a drastic effect. I now take 50mg in the morning and 50mg at night, I have never taken more. I have no side effects and can honestly say that Tramadol saved my life. I know that it does and will not work this way for everyone, this is just my experience with them and I am truly grateful.”

10 / 10
Quando62 · Taken for 10 years or more February 17, 2020

“I've been prescribed EVERY anti-depressant known. I have what is knows as Treatment Resistant Depression. I stumbled across Tramadol 7 years ago and WOW, after an hour, energy, happy, feel like I can do things again after 20 years. Haven't had to increase the dosage after 7 years. This medicine has saved my life. After I take it, my wife says my eyes aren't blood shot, my mood is like it was 30 years ago, and now working full time and building a business up on the side! It's helping my Psoratic Arthritis which I had to increase to 300mg's a day since being diagnosed in 2017”

10 / 10
elandem February 6, 2020

“The tramadol helped my depression for a while. I took it on at off (50 mg per day) with various antidepressants. I would feel effects about 2 hours in, but they would fade quickly - and they never fully took away symptoms. I then started taking 2 (50mg) per day - one before getting up to help morning mood and then one later in the day. This was not effective at all. I've now been on the 2X per day dose for a month and am tapering down to 1 per day for a week, then will go to 1/2 per day for a week and stop. I'm going to try pregabalin as my depression has some anxiety and that might help?”

3 / 10
Ramirez · Taken for 1 to 6 months January 31, 2020

“Nothing better for depression at low doses up to 100mg. Best of all it starts working within 60 min. To avoid tolerance and/or addiction just rest 1 or 2 days a week.”

10 / 10
Malan January 13, 2020

“I have been using it for years. It relieves depression. But keep the dose lower because it is addictive.”

Jame583 January 13, 2020

“I actually found tramadol worked for depression while being treated for pain in back. Noticed how great I began to feel. No depression and actually felt like myself for the first time in years. So I actually had a long talk with my psychiatrist and after showing him several articles from various sources, the NEJM for one and much more and telling him of my experience why using it for pain and how it uplifted me he finally agreed to it on a trial bases. I haven’t looked back since. Now I still take my other depression meds. The tramadol is in additional drug. Yes it is addictive and no I don’t care. Your body will start showing signs of tolerance and you made need to adjust your dosage over time. I recommend starting on the lowest dosage that works for this reason. Do not abuse it because it makes you feel high or buzzed. This will increase the quickness in tolerance and you will eventually run in to the ceiling on daily maximum dosage”

9 / 10
gettingBetter · Taken for 1 to 2 years January 9, 2020

“I was prescribed Tramadol 50mg a day for chronic pain and found it also cleared my foggy head and low energy. This has been a life changer for me. I've gone from sitting looking at a pile of work thinking, I just don't have the energy to do this, to wow getting everything done and more. I was not depressed, my foggy head and low energy is from chronic inflammation, arthritis, insomnia and autoimmune disorder. GP does not understand so just keep taking them for the pain with the wonderful side effect of getting my life back.”

10 / 10
Becky28 December 23, 2019

“I am a single mother of 3 boys one who has autism and some days we're soooo hard that I was only just coping. I had anxiety and depression. I was prescribed me some tramadol for a headache I had and let's just say in about 40 mins I went from feeling anxious, stressed and angry to happy, energetic and playing with my children. Complete life changer for me for the better. My quality of life improved along with my families as now they have a mother who is happy, patient and calm. I've been on tramadol for about 7 years with no complications. At most I have gone up to on "bad" days was 800mg but now I taper down or have a couple of days break so my tolerance does not build, because obviously like other pills the withdrawal is awful. But so worth it for me ”

10 / 10
Rachael · Taken for 2 to 5 years December 19, 2019

“Tramadol is the only thing that has ever worked for my depression. However, because of the Opioid crisis every time I tell anyone, including doctors, this fact, they treat me like I am drug addicted. Several have gotten snotty with me and insisted they have never heard of such a thing. Because of this, finding a doctor who will listen is next to impossible. I had one, a very good one, but I had to move away. This drug significantly improves my life. When it wears off in the evenings, I sink back into suicidal depression. I have one refill left and then I am back to life debilitating misery.”

9 / 10
Jake · Taken for 1 to 6 months December 14, 2019

“I’m using tramadol off label for depression as well as chronic back pain, just 50 to 100 mg daily. It doesn't have any of the nasty side effects like all of the typical antidepressants. I virtually have no side effects from it. It’s a godsend for me, it cures anxiety and lifts my mood.”

10 / 10
Alex December 3, 2019

“I've had a mesh implant. It's not getting any better as far as the pain. I've been diagnosed with depression and severe anxiety. I've been on all types of medication , but they had caused way too many side effects. Tiredness was something that I can't deal with, and tramadol doesn't make me feel like that. I've been taking tramadol for pain, but it has totally made my life better. My mood is up, I'm no longer depressed, and I only take 150mg a day. Virtually no side effects. I truly wish that tramadol could be prescribed for my mental issues. It has kept me from relapsing. I've been clean and sober for three years now. I haven't had any cravings since I've started taking tramadol.”

10 / 10
Anonymous · Taken for 5 to 10 years November 22, 2019

“I just wanted to do a follow up , from a previous post about Tram for pain. So let me just say Tram is a depression, anxiety killer. Point blank. There is not another drug like it. The chemical make up is so unique because, yes it does help with pain. But it will absolutely give you a new lease on life if you are depressed. But please, please use with caution, never ever take more than prescribed. Because let me tell you, If you ever have to quit the Tram. The withdrawals are a living hell. And that is putting it mild. There are two classes of people I would recommend Tram too. One with severe depression, that other SSRI did not work. And those who plan on staying on Tram for life. And not conning off. If you ever have to go without for couple days. You will see what I mean. Great drug, lifesaver in some cases. But proceed with caution. Please”

10 / 10
flowerflower · Taken for 1 to 2 years November 20, 2019

“I suffer from depression and I know for a fact Tramadol helps it. I get tramadol once a month for my back pain. It helps a little for the back pain but helps my depression enormously. The only bad thing about it though is like with all opioids you build up a tolerance, and even for depression, you need more. I always run out and my depression always comes back until it's filled again. No other pysch med that I have taken works as well. I also know that even though it takes my depression away that it's too good of a happy mood. So I'm sure it is probably making me high. You know they first made Tramadol for depression. But they noticed exactly what happens to me when I take it. So no I do not think it would make a good depression med, due to the fact people would and do abuse it.”

Gradience · Taken for 1 to 6 months November 16, 2019

“I see a lot of reviews on here saying how much of a wonder drug tramadol is for depression, and I just want to mention why doctors don't want to prescribe it is because it is VERY addictive. Tramadol is an opioid, so taking it daily is not a great idea, even if its a small dose like 50mg. However, it is very effective and works amazingly well for social anxiety, and for me the social effects last even longer than the actual time that the drug is in effect. That said, just watch how often you take it to prevent addiction.”

8 / 10
Ralphy E. November 13, 2019

“This medication is simply perfect. I take one 50 MG dose in the am. One 50 MG dose in the afternoon. If necessary, one 50 mg in the evening. Zero drowsiness. Zero side effects. I’m the happiest human on earth. Cures 100% of anxiety and depression. It even helps with pain related issues too. But for depression and anxiety, it is amazing. It also deters you from wanting other drugs (whether it’s marijuana, alcohol, or anything else) because you naturally don’t want it because you don’t feel anxiety or depression. You are genuinely happy and clear headed. If you want to get high, take something else. If you genuinely want to be happy all the time with no anxiety or depression and want to socialize, this is 10X better than anything else. My doctor stopped prescribing it to me after my surgery after 2 years.”

10 / 10
marty November 7, 2019

“Not only does this drug help me with a herniated disc in my neck and back pain, it also gives me tons of energy and makes me feel happy and more out-going. I feel like I can get so much more done while taking this, this really should be prescribed over anti-depressants. I took Lexapro for a while and Tramadol seems to put you into a good mood instantly. I take one 50mg pill a day, works perfect for me.”

10 / 10
Makpaz · Taken for 5 to 10 years November 1, 2019

“I'm upgrading from 9 to 10. For some reason there is no randomized research comparing tramadol with mainstream antidepressants. Do not be surprised as the realization that tramadol outdoes all the other antidepressants combined has a huge price tag. Tramadol doesn't pay for your psychiatrist to go to Maui and to advertise its near miraculous affect on depression and anxiety within the medical field is sacrilegious. Nevertheless it's an amazing drug. My friend takes 50mg daily without ever needing to raise the dose. Note that different genetics have different liver enzymes. People of Middle Eastern and Southern European descent seem to better process tramadol. Less lucky are people of northern Europeans descent and Orientals descent. Or so I observed.”

10 / 10
El Chico De Miami · Taken for 1 to 6 months October 30, 2019

“Suffered from depression since I was a teen. Nothing helped. In winter and autumn I feel so bad everyday that I literally want to suicide. One of those gloomy, dark and cold days I was prescribed tramadol for another pain that I had. I felt so happy, like I've never been before. It's really a miracle drug. In my experience, taking just 100mg a day makes my mood a lot better, without getting me high, 250mg is too big a dose. It is not addictive at all, I mean physically, psychologically it kind of is. No withdrawal symptoms at all. Can easily take it then take a break for a week and start again. BUT, couldn't accept the fact that I would never take it again. Just can't. Give it 10/10. Don't recommend doing it everyday but it is good for depression”

10 / 10
Tero · Taken for 10 years or more October 23, 2019

“I have experienced depression as long as I can remember. After ineffective treatment with all of the SSRIs/SNRIs available even today, I resigned myself to the fact it was just the way it was. While at my London office, I stopped by a pharmacy for some Advil for a headache. The Pharmacist pointed to an over-the-counter medication. After taking it, my headache went pretty much away, but the "cloud" that was my depression was GONE! Amazing... the OTC med was Tramadol.”

9 / 10
JY · Taken for 5 to 10 years October 7, 2019

“I love tramadol. I use it for both mood and pain. I usually take 50mg a day but some days none and some days 100mg. I like it because I take as needed. Ive been addicted to opioids but this one is different. It’s like a miracle drug for me”

10 / 10
Anonymous · Taken for 1 to 6 months September 28, 2019

“There good for pain.”

6 / 10
Gr September 24, 2019

“This is the best medicine for anxiety and depression. Fast results and no side effects, please fight so doctors prescribe this more. They now treat depression with ketamine - a very dangerous and very illegal drug that I used to take 20 years ago at trance parties. But they say tramadol is addictive..SSRI's are more addictive. I am an ex junkie so I know what I am talking about.”

10 / 10
Karen · Taken for 1 to 2 years August 24, 2019

“I have suffered with Depression for 25 yrs and have tried every medication that has been made! They all either didn't work or had horrible side effects not making it worth taking. I was prescribed Tramadol for chronic headaches and it has changed my life as it got rid of my depression . I take it about an hour before I get up. I get up wanting to live my life and be around people! I have lost 20lbs because I want to do things and exercise. I eat healthy now and have this incredible drive for life! It has saved my life and my marriage. I have recently moved and have to find a new doctor and I am petrified that I won't be able to get my prescription. ”

10 / 10