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User Reviews for Tramadol to treat Depression

Also known as: Ultram, Tramadol Hydrochloride ER, ConZip

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Tramadol Rating Summary

User Ratings
9.1/10 Average Rating
110 Ratings with 108 User Reviews

What next? Compare all 206 medications used in the treatment of Depression.

Reviews for Tramadol

jerry July 10, 2019

"good for very intermittant use -- be careful extremely addicting"

DanDaLion1 · Taken for less than 1 month July 2, 2019

"I suffer from MDD and have taken about 7 different antidepressants which have been, for the most part, ineffective. On the 4 or 5 occasions I have taken tramadol, it has has noticeable effects on my mood. Tramadol doesn't make me drowsy and has powerful antidepressant effects. I feel better for days after a single dose of Tramadol, in which I feel I have more energy, less anxiety and feel oddly clearheaded. I know this drug is not typically indicated for depression or anxiety, but it seems to crush both in one go, at least for me anyways."

Robot1 July 2, 2019

"I was gonna respond to the people saying Tram is a life saver. Well , it can be, but be cautious because it will be the hardest drug you have ever tried to quit. From 8 years of experience. I take 400 mg a day. I have 2 bad vertebrae , stenosis, degenerative disc. Nerve compression . Tram was prescribed for the pain. But it took only a week for me to know something was different After years of Anxiety, depression. Suicidal thoughts. It all ended by the end of that week. There is no other medicine made to do what Tram does. None. Effexor comes the closest. But Tram blows it out of the water. Tram never makes you have that high spacey feeling, just a relief from the panic, depressed. I don’t ever plan on quitting. Like I said earlier, you better plan on being on Tram for the long haul, because their is no going back, once you start. Your depression and Anxiety, pain will be unbearable. So please use caution and count the cost of taking Tram. It is a life saver. Until you go off of it."

Margie · Taken for 2 to 5 years July 1, 2019

"Peripheral Neuropathy slowly but surely stole my mobility. With that came a loss of social contact, and a depression that I had never experienced before. I tried therapy, B12, exercise, health foods and supplements. Still I woke up everyday with the same goals and hopes as always, but a body that was fading. Maybe Tramadol does not bring back mobility. But the energy level increase and the relief from sadness works like nothing else. My neurologist approves....She has seen me function with and without it. I am grateful she prescribes for me to have some quality of life. I know some physicians won't."

Quest July 1, 2019

"I have battled with depression, anxiety and bipolar. I have tried several medications. Some worked for a while then hit a ceiling. Then would switch. After doing research looking for an answer, I read about Tramadol, as I had seen people talking positive about it. I was a little concerned since it is in the Opioid family, but was desperate to find the answer. I have been taking Tramadol 50MG for about a year and a half and along with an anti depressant it absolutely enhances my mood and lifts my depression. Have not had any problem taking break when I feel I need to. Like someone has stated if it helps to make your life better , and it has limited downside then take it"

Trying · Taken for 1 to 2 years June 30, 2019

"I was diagnosed with diabetic neuropathy. I am now 53. The numbness in my legs stopped me from driving. I grew more isolated. My doctor prescribed painkillers, antidepressants, but I kept going down. Then I fell, tore my ACL and was given tramadol. Yes, it helped pain. But for the first time in nine years I was not depressed! Occasionally happy? I thought what is causing this?. Long story short, it was the tramadol working as an antidepressant. It has given me quality of life. And the dependency issues? If dependency means I can experience JOY again, using same daily amount, so be it. It should not be so difficult for doctors to prescribe."

Mb · Taken for less than 1 month June 30, 2019

"I got prescribed Tramadol for Back pain. I have been taking one 50mg pill a day and have seen such an enhancement in my mood. I’ve never wanted to take “antidepressants or anxiety” meds, because I didn’t want it to change my personality or make me a zombie. However, I really enjoy being on Tramadol, it makes my job in retail not such a drag. I don’t have my normal mood swings, and by then end of the night I sleep great! I am afraid to tell my doctor as well that it helped me in that aspect because I don’t want her to think I'm using it as a “high.” But I genuinely love this medication."

DJ June 25, 2019

"I’ve been depressed a good part of life and as I get older the more depressed I seem to get. I’m on two different antidepressants Wellbutrin and Effexor. About 5 years ago I admitted myself in the hospital for depression. While I was there they put me on Tramodal for depression which I always thought was for pain. My physician recently stopped prescribing me Tramadol and since then I’m spiralling out of control. I have to obtain illegally because my physician doesn’t believe it’s for depression. If I go two days without I slump into a deep depression and I don’t care about nothing. Tramadol helps me focus and gives me purpose to be alive. It’s not a high like you get with OxyContin it’s a mellow way to cope with daily living. Some how or another I need to convince my physician to start prescribing them to me"

Sammy · Taken for 2 to 5 years June 24, 2019

"Originally prescribed as a replacement for hydrocodone for headaches, I quickly concluded it lifted me out of a years-long funk most people would call depression. Honestly, this little 50mg tramaol saved my job, and consequently my home life. All the sudden I had the motivation to function as a normal person and not a sleepy-eyed slug trudging through life in a difficult nights job; I take one 50 a day for shift disorder. Now, though, despite taking it less frequently than prescribed (6 weeks to go through a month supply), I think my doctor is about to stop prescribing it. So I'm likely looking for an alternative."

BadDad · Taken for 2 to 5 years June 9, 2019

"This wonder drug appears to have some big fans! I don't have too much to add, just a few things: Dependancy level: I think about dependant as coffee in my opinion. I usually take one 50mg pill a day (which seems a fairly common dose for you commenters, with no craving for more then that)- I think I've been a self medicating kind of guy for most of my life for mild to moderate depression, alcohol mostly. Most mornings with a mild hangover and the depression that came with it. Until I started taking Tramadol for a neck injury that is. Amazing first aid for a hang over and the blues! This fact has been an enabler for drinking too much, but lately I'm using Tramadol to quit drinking and with good results. Sleep super well and wake feeling great!"

apricot · Taken for 1 to 2 years May 23, 2019

"I have always suffered with depression and was using antidepressants which helped somewhat then I ended up with back pain and was prescribed tramadol which has helped me a lot. Lost my husband last year and at times just cannot be bothered with life but if I take tramadol it improves my mood and I get on with my life. It has made a big difference. I want to give it up because I get constipated which I think is a side effect but there are things I can take like fruit and high fibre to get rid of that problem. Every time I try to give it up I get so down that I have decided at the age of 72 why not continue taking it and enjoy life the best I can. I take 50mg in the morning and evening and half at lunch time every day. I still take an antidepressant with it. My dr told me if the pills work thats what it is all about feeling better."

Alice · Taken for 10 years or more May 7, 2019

"I have had the same experience as so many in here. Took tramadol for pain originally then found it gave me quality of life and got rid of depression. My problem is getting a doctor to prescribe it."

Michael hal March 27, 2019

"I have depression my doctor gave me antidepressants , It didn’t work Got sick of it , Went to my cupboard to get panadeine (paracetamol with codeine) forte to knock a headache out so I can rest , Depression was getting to me , While looking for it, I saw an old carton of tramadol , It was for my sister in-law for her tooth pain 2 years back , So I took that instead , And guess what , I felt like never before, Even when I never had depression , I wasn’t sure it was from tramadol I remember walking and saying to myself , the depression is going I was happy Then later I started feeling the depression back it was thesame , Strange , I was curious- was it tramadol? , Mmmmm So I took another 50 mg Wow Felt great Slow release It took around and hour to feel it But went full day It works Control is key I want to live happy Regardless what I read It worked for me Better addicted and happy Than not addicted and miserable Words I told the doctor I’m still no more than 50 mg sometimes 25 mg low dose 4 times a Week"

Klams · Taken for 2 to 5 years March 16, 2019

"Tramadol is life changing for me, all of my depression, and social anxiety vanishes and I want to talk to people, get out of bed, do things and enjoy life. I am 300 lb. I take 50 mg just to stop the worst feelings, 100 mg to be active and totally free of anxiety and depression. The effects last for a full day, and sometimes into the next day. I never take more than a dose a week, so I am often sleepy the next day, but I can get through that easily with caffeine. I don’t know how to get it prescribed. Doctors just don’t care that it has been transformative. It doesn’t seem fair. I have a small supply obtained illegally. I take them only when I absolutely can’t face life as myself any more. I avoid feeling the effects while working. (Even though effects are mild, I don’t want anything to affect my job performance), so I only allow myself relief one day a week or less. Other SSRIs have not helped me much. They just make me not care about anything."

forrin · Taken for 1 to 6 months March 7, 2019

"Doesnt do a thing for me ,"

Wifeofpie · Taken for 1 to 6 months December 9, 2018

"My family has a history of depression. I also have back issues. I took my first dose of 50 mg tramadol tablets. I was so shocked to realize it did little for my back pain but my mood was altered for the better. It helped my depressive issues almost immediately. I was shocked to say the least but also very relieved to fine my spirits lifted without feeling sedated at all. It is amazing."

Pix3L · Taken for less than 1 month November 18, 2018

"I have been on Suboxone for 2 1/2yrs. I've always had issues with Depression/Anxiety. However, the Suboxone has made my Depression/Anxiety 1000x worse and I have been put on different kinds of SSRI/SNRI medications, nothing has worked. I did some research on Suboxone combined with Tramadol and let me tell you, I was my bubbly self again. I felt amazing for the first time in a long time. The opiate side of Tramadol gets blocked by Suboxone so its Tramadol's anti-depressant component that is working its magic on me. The DR will not prescribe this to me since I am on addiction treatment, he won't even prescribe me an anti-depressant that matches Tramadols. I have made my situation even worse now since I got to experience Tramadol's anti-depressant magic knowing I cant get that medication prescribed. Imagine every waking day in mental misery and someone hands you something that makes it all go away but to be told you will never get it."

Julz77 · Taken for 2 to 5 years October 29, 2018

"I LOVE Tramadol. I'm a stay at home mom and I'm over weight, big chest, and my back hurts all the time. Chasing toddlers around and doing house work can be aggravating at times. I've found tramadol to help with quite a few things. Mood, Motivation, pain, depression. I no longer take valium and effexor for my anxiety and depression because tramadol helps everything in my case! It's a wonder pill for me. I usually take 50mg when I get up, 1 later on in the day, then 1 at night. Sometimes I might take 2 in the morning and then 1 later that evening. But regardless tramadol makes me feel normal and able to do my everyday duties without being in a slump. Shame it's a narcotic now bc doctors are hesitant to prescribe and you don't get refills so u have to go every month to your doctor to get it. Hope this helps someone in pain and or depression as I've found it to be of help in both areas!!!"

Taximanlondon · Taken for 2 to 5 years October 11, 2018

"I've had depression since I was very young. I never accepted SSRI and just carried on regardless. My diabetes eventually gave me peripheral neuropathy and my feet hurt. Tramadol was prescribed for the pain. Since taking the tramadol my depression has been virtually non existent. I have not told my GP as he will probably stop the prescription .I do not have euphoria or anything like that, I am though functioning as a real human being with energy and purpose . My life is not perfect but its much much better , it can't just be a coincidence. John Lennon said " Whatever gets you through the night, It's Alright" I wish all you fellow suffers the very best luck x"

Maynard · Taken for 1 to 6 months October 11, 2018

"I have been taking 100mg at once during the morning about every 3 to 4 days and I’m amazed how it calms me down. Unfortunately not taking it for 3 to 4 days makes me a little more depressed. Would love to take it once a day everyday but am afraid to."

BJ · Taken for 5 to 10 years September 30, 2018

"I was at work some years ago I was a welder, and started getting to where I got tired real easy and I couldn't figure it out. And one of my co-workers gave me a Tramadol and it was like wow !! I can make it through the day now. I take one 50 mg a day . If I don't I start to feel run down and tired. I don't know if I had some kind of mild depression or not but that's the way it helps me."

Quando62 · Taken for 5 to 10 years September 6, 2018

"I've been prescribed EVERY anti-depressant known. I have what is knows as Treatment Resistant Depression. I stumbled across Tramadol 7 years ago and WOW, after a hour, energy, happy, feel like I can do things again after 20 years. Haven't had to increase the dosage after 7 years. This medicine has saved my life. After I take it, my wife says my eyes aren't blood shot, my mood is like it was 30 years ago, and now working full time and building a business up on the side!"

Moonflower · Taken for 5 to 10 years September 4, 2018

"The last SSRI I tried put me into a manic episode. After 30 years I discovered Tramadol, the only medication to date that helps with my depression. Then, Tramadol was re-classified and now my psychiatrist wants me to get off the drug. I tried twice in the past to taper back from the 150 mg that I take in divided doses every day. Used the slowest taper schedule I could find online. The withdrawal is bad, I couldn't take the shaking and suicidal thoughts, so continued to take it. I came to peace with taking tramadol, especially after reading about the difference between addiction and dependence. I am dependent on this medication to keep me alive, literally. I don't crave it and I have no desire to increase my dose, both of which are signs of addiction. Am so grateful to read about other people's positive experiences with Tramadol in treating depression. There wasn't much info out there when I started to look into it several years ago."

Tess · Taken for 6 months to 1 year August 23, 2018

"I was given Tramadol for foot pain by my orthopedist. I didn’t particularly notice that it helped my pain, but it certainly improved my mood. And fast. I’m not saying I was hugely depressed and have never been treated for depression, but my improved mood was a surprise. It doesn’t make me feel high or anything like that, and I’m not an overly anxious person, but it just makes me happier and not so grumpy! The only thing is, my doctor hasn’t given me much - guess it’s very controlled. So I got more elsewhere. It only takes about 50 mg a day for me. I did go several months without any and didn’t feel any withdrawal side effects other than some sweating and a return to my normal mood. I certainly would not want to take more than 100mg a day. I have never taken much medication in my life. I have friends on anti-depressants etc., and have mentioned this effect with tramadol. Interesting reading other people comment on this."

Soso · Taken for 1 to 2 years August 15, 2018

"This medication was initially prescribed for back pain. As an unexpected side effect it dealt with my MDD perfectly. Unfortunately I am medication sensitive and started to have negative side effects so had to slowly get off this medication. For some reason the withdrawal was horrible. Everybody responds differently and even though this medication worked with the pain and depression it's side effects made it impossible for me to remain on it and the withdrawal was the worst part "for me.""