Tramadol for Depression User Reviews (Page 4)

• Wif...
• Taken for 1 to 6 months
• December 9, 2018

"My family has a history of depression. I also have back issues. I took my first dose of 50 mg tramadol tablets. I was so shocked to realize it did little for my back pain, but my mood was altered for the better. It helped my depressive issues almost immediately. I was shocked to say the least, but also very relieved to find my spirits lifted without feeling sedated at all. It is amazing."

• tra...
• Taken for 1 to 6 months
• May 15, 2015

"I found by accident that tramadol greatly diminishes my depression. If I knew I could take it daily without building a tolerance against it, I would gladly take it for the rest of my life. As it is, I limit taking it to no more than once a week out of that fear. For just ONE DAY of my life without depression, it is worth it."

• Tan...
• Taken for 5 to 10 years
• February 7, 2024

"I'm so happy to see you all comment here! I have been using 100 mg tramadol twice a day! I can't get up even to smoke a cigarette without it. I lay in bed for days. I have been bedridden for the last 15 years from grief and PTSD. I got things done with tramadol for the last 6 years to secure my future. I stopped alcohol! I thought it was my will to quit."

• kel...
• Taken for less than 1 month
• March 20, 2016

"I have lost 5 pounds on this drug Tramadol. I was on a weight loss journey and had lost 65 pounds on my own, but as of recently, I have struggled with the last 40 until I started taking the Tramadol. It will suppress your appetite and help with food cravings. I believe this drug is a great aid for losing weight if one uses it appropriately. This drug was not prescribed for depression nor weight loss, but it is killing two birds with one stone in my life."

• Joa...
• April 26, 2017

"I have tried almost all antidepressant drugs available in the last 20 years. Fluoxetine, sertraline, paroxetine, citalopram, and escitalopram did not work and destroyed my sex life. Bupropion increased my anxiety a lot. Mirtazapine caused me hallucinations and insomnia. Venlafaxine and desvenlafaxine worked for some time, but affected my libido and erection. Niacin (off-label) did not work for me. The only one that worked and is still working is tramadol (off-label). It starts to work about 1.5 to 2 hours after I take it, and lasts for 8 to 10 hours. I take 1 50mg capsule first in the morning and another at around 4 pm, on an empty stomach. The only drug that works for my depression and anxiety."

• dep...
• Taken for 2 to 5 years
• May 18, 2016

"Been on these pills for 3 years now. Started out for pain relief but soon discovered my depression fading fast. I take 200mg XR in the morning and 200mg at night. It also helps me wake up a lot easier and happier. I went off them, depression came back, and suffered some withdrawals instantly. Getting out of bed was a nightmare. Back on them, life is great. One major downfall is my sex drive, these pills kill it, but it's worth it because I'm happier on these pills with less sex than lots of sex and not happy. Sacrifice I choose to make."

• Rac...
• Taken for 2 to 5 years
• December 19, 2019

"Tramadol is the only thing that has ever worked for my depression. However, because of the opioid crisis, every time I tell anyone, including doctors, this fact, they treat me like I am drug-addicted. Several have gotten snotty with me and insisted they have never heard of such a thing. Because of this, finding a doctor who will listen is next to impossible. I had one, a very good one, but I had to move away. This drug significantly improves my life. When it wears off in the evenings, I sink back into suicidal depression. I have one refill left, and then I am back to life-debilitating misery."

• Ilj...
• Taken for 2 to 5 years
• November 28, 2017

"I am a 65-year-old male and suffer from depression. My psychiatrist prescribed tramadol 50 mg daily. I have been taking it for three years, and it works terrific. I have tried SSRIs in the past but did not have any success. I have heard horror stories about the withdrawal symptoms of tramadol, so I have taken some days off or decreased my dosage to test and experiment with the withdrawal effects, but I am not sure I want to go through the rest of my days bummed out and unproductive. I have heard all the stories about working out, proper diet, self-talk, etc. I am very disciplined in adhering to these principles, but it does not help my depression. Just my two cents. Jerry."

• Das...
• Taken for 2 to 5 years
• July 24, 2024

"I have found that over the course of five years, a dose of 100 mg of IR Tramadol, ranging to 200 mg of ER Tramadol was the fastest acting, most thoroughly effective, and best tolerated medication to treat my severe, treatment-resistant depression. I have tried SNRIs, SSRIs, and a combination. Frequently, my worst bouts of depression have been accompanied by chronic low back pain. This was also effectively relieved. I suffer from anxiety, and the perfect medication combination to make me feel 'normal,' that is, happy and calm, has been alprazolam and tramadol. Perfect combination. Unfortunately, it has been nearly impossible to find physicians to prescribe these medications together or alone. Finally, more scientific literature is emerging to make a case for tramadol for depression. It's long overdue!"

• Ano...
• April 2, 2015

"I have been taking 50 mg Tramadol for three years twice daily (prescribed) for osteoarthritis. It reduces the pain to a tolerable level, allowing me to participate in simple activities again. It has also been a miracle cure for my pain and the depression I have suffered with my entire life. As a child, I was painfully shy, self-conscious, and full of self-doubt. Additionally, I was physically abused. The abuse consisted of being punished by being locked in a dark closet many times, beaten with hangers, beaten with a hairbrush until I bled, slapped. It resulted in BPerD. I was treated with Buspar, Effexor, Prozac, Zoloft, Lexapro, and Clonipin. Nothing worked, many made me worse. Yet, on tramadol, I feel so much better."

• Kla...
• Taken for 2 to 5 years
• March 16, 2019

"Tramadol is life-changing for me, all of my depression and social anxiety vanish, and I want to talk to people, get out of bed, do things, and enjoy life. I am 300 lb. I take 50 mg just to stop the worst feelings, 100 mg to be active and totally free of anxiety and depression. The effects last for a full day, and sometimes into the next day. I never take more than a dose a week, so I am often sleepy the next day, but I can get through that easily with caffeine. I don’t know how to get it prescribed. Doctors just don’t care that it has been transformative. It doesn’t seem fair. I have a small supply obtained illegally. I take them only when I absolutely can’t face life as myself anymore. I avoid feeling the effects while working (even though effects are mild, I don’t want anything to affect my job performance), so I only allow myself relief one day a week or less. Other SSRIs have not helped me much. They just make me not care about anything."

• Amy...
• Taken for 6 months to 1 year
• August 17, 2024

"I had depression diagnosed since I was a teenager. I was prescribed many antidepressants, none helped. I managed to work, but it was hard to get out of bed. My physician gave me tramadol after leg surgery, and something changed! I was smiling! I didn't know why. I told my doctor, and he was kind enough to continue it. It feels like a miracle... I remember how to laugh, enjoy simple things. Hope that it continues."

• DJa...
• June 25, 2019

"I’ve been depressed a good part of life, and as I get older, the more depressed I seem to get. I’m on two different antidepressants, Wellbutrin and Effexor. About five years ago, I admitted myself to the hospital for depression. While I was there, they put me on Tramadol for depression, which I always thought was for pain. My physician recently stopped prescribing me Tramadol, and since then, I’m spiraling out of control. I have to obtain it illegally because my physician doesn’t believe it’s for depression. If I go two days without it, I slump into a deep depression, and I don’t care about anything. Tramadol helps me focus and gives me purpose to be alive. It’s not a high like you get with OxyContin, it’s a mellow way to cope with daily living. Somehow or another, I need to convince my physician to start prescribing them to me."

• Hip...
• Taken for 5 to 10 years
• April 10, 2023

"Imagine studying medicine for years, just to be owned by big Pharma companies. Tramadol has the highest rating for depression on this site! Yet, someone is promoting the notion that it is an 'addictive opioid.' Never mind that my friend has been taking Tramadol for 10 years, 50 mg daily, and never increased the dose. It operates differently than most other opioids and apparently is more effective on some than others (depending on your liver enzymes, your personal DNA). Anyway, there is a whole under-the-radar tramadol dispensing industry, and while I'm not one to argue with the FDA, I think Tramadol should be more available. After all, it got a 9.2/10 rating on drugs.com. Again, it is the best rating for any antidepressant! If you take a reasonable dose daily (under 400 mg), you won't likely get serotonin syndrome! (another argument used to avoid prescribing Tramadol). With Tramadol, my friend feels more alive, motivated, and loses weight."

• Dar...
• March 11, 2017

"I have used tramadol for one year now. First, I was treated for diabetes pain. But every time I took one, I definitely changed. I felt better than ever, with no pain and wanting to get pretty and do things with my family. I told my doctor, and he told me that I was suffering from depression and tramadol was helping me get back together. I swear to God, this medicine is great for depression. I feel better than ever. I do so much in one day, and I sleep wonderfully."

• Syr...
• Taken for 1 to 2 years
• July 31, 2014

"I have been using tramadol with alprazolam for the past 2 years. I take only one 50 mg tablet with one 0.5 mg alprazolam in the morning, and I rarely take more (maybe once a month I take 2). This combination was my savior. Because of it, I am doing very well in my business. I stop taking it sometimes, and I do not have any withdrawal symptoms at all except for the bad mood and fatigue. I am moving to Germany soon, and I am worried that I will not be able to get this medicine there."

• zer...
• Taken for 2 to 5 years
• October 23, 2022

"Tramadol is the single best medication I've known, except for antibiotics, in my 60 years of life. It is labeled as 'a strong pain reliever for moderate to severe pain,' which is a new attack by the medical cartel. The truth is that it is a moderate-level pain reliever at best. It has very, very little addictiveness. It is extremely good at improving concentration, lifting mood, and leveling depression. It is inexpensive. It is an extremely good medication. Press your physician to prescribe it and do not let them off the hook. They must do what is in the patient's interest and not what is in the interest of the money."

• AJD...
• March 21, 2017

"I have suffered from Major Depression since I was 17, or at least that is when I was diagnosed. I believe it started when I was 13. I have been on medication ever since, and I am now 44. I came across tramadol because I have fibromyalgia, and I use it to lessen my pain. I take 50 mg in the morning, and if my pain is unbearable, I will take another 50 mg in the late afternoon. It doesn't take all my pain away, but I can function since I work full time and go to school too. The most miraculous part of all of this is that my depression while on this is completely gone. I have to be careful since I am already on anti-depressants that are a serotonin uptake, that I don't ever overdo it, because of serotonin syndrome. I feel like myself :)"

• Mar...
• Taken for less than 1 month
• May 15, 2025

"AMAZING & UNEXPECTEDLY PHENOMENAL results. Couldn't be happier at how powerfully effective it is for depression & anxiety. Works instantly and obliterates anxiety/depression symptoms within the hour! Tried SNRIs; SSRIs; MAOIs & tricyclic alternatives, but NOTHING comes close to low-dose tramadol. Besides depression/anxiety symptoms, you will feel a much higher improvement in mood!"

• Dan...
• Taken for less than 1 month
• April 8, 2015

"Today I went to my doctor and he shot me in the butt with some Tramadol to help my body pain. For the first time in ages I have been in a good mood, feel extremely relaxed and extremely content. I take Zoloft for depression and it helps to a degree, but this stuff makes me forget what depression even is. I am watching TV and smiling, this is the best mood lifter I have ever had, and so-so for pain relief."

• sad...
• February 22, 2016

"I was prescribed tramadol for a back injury. During the same time period, I was taking Adderall. On a weekend visit with friends, I had forgotten to pack the Adderall. I took my tramadol in the morning and realized I did not need the Adderall. Tramadol was just as effective, if not more so. Its effect on me is a more focused, calmer state of mind. Because my anxiety is silenced, so also is my need to 'angst' eat. I maintain a healthy weight and feel motivated to exercise. Basically, the dark cloud of depression and anxiety is gone. Do I still get moody? Absolutely. The difference now is that I no longer experience random or unexplainable bouts of angst or depression. Life insurance app red flagged it, so I can't get filled at this time."

• Rez...
• Taken for 2 to 5 years
• January 12, 2024

"I suffered 30 years of painful, debilitating, physically destructive depression. No treatment really helped me. Yes, paroxetine just took away the urge to commit suicide. On the other hand, my doctor prescribed this medication for another ailment, and the miracle worked! No more depression, no more lack of motivation, no more procrastination, no more psychological pain, no more insomnia, no more low self-esteem, no more social anxiety, no more debilitating stress, no more feeling of insecurity. And that's not all: my restless legs are over, my irritable bowel syndrome is over. It's a miracle. You can take it as needed. But on the other hand, if you take it every day, you must not forget a dose, otherwise, you will experience withdrawal syndrome. Personally, I will continue until I die if necessary. I have been taking 200 mg extended release 24 hours (Monocrixo) for almost 3 years, without changing dose, with no perceptible drop in effectiveness."

• Que...
• July 1, 2019

"I have battled with depression, anxiety, and bipolar. I have tried several medications. Some worked for a while, then hit a ceiling. Then I would switch. After doing research looking for an answer, I read about Tramadol, as I had seen people talking positively about it. I was a little concerned since it is in the opioid family, but I was desperate to find the answer. I have been taking Tramadol 50MG for about a year and a half, and along with an antidepressant, it absolutely enhances my mood and lifts my depression. I have not had any problem taking a break when I feel I need to. Like someone has stated, if it helps to make your life better, and it has limited downside, then take it."

• Sad...
• Taken for 6 months to 1 year
• June 24, 2018

"I have chronic depression and PTSD. I have tried all the SSRIs and SNRIs. I've tried combinations of supplements and checked into magnetic brain stimulation treatments. Nothing worked. I was in a car accident and hurt my back. I was prescribed tramadol and noticed within a couple of days that I felt 'normal', happy, not anxious. So I talked to my doctor, who is willing to continue prescribing it for me. I still have my negative thoughts, but they don't dominate my day, nor disrupt my life. I keep up on my magnesium L-threonate, magnesium glycinate, and L-theanine, which make a big difference. Everyone's body chemistry is different. This drug works for my chemistry. I understand that I will have to take a medication for the rest of my life, but it's a small price to pay. There are days I almost didn't make it through. And I'm fortunate to have found something that works for me."

• Her...
• March 15, 2015

"Don't let your ignorant physician deprive you of this miracle drug for your depression. They are trained to shun anything narcotic, even if it may be beneficial to the patient. If you have chronic depression, you should definitely try two 50 mg Tramadol (my 90 generic pills cost me $3.99 for 90 pills at a discount pharmacy: no insurance needed) on an empty stomach at 7 am and two more in the late afternoon. Between these doses, walk a lot and drink plenty of water. The results may be astonishingly good. It may not work for all, but I bet it will work for most people who experience moderate levels of depression. Read about the side effects and then decide: it is worth a shot. In contrast to Tramadol, expensive antidepressants may be unnecessary."