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Tramadol for Depression User Reviews (Page 4)

Brand names: Tramadol Hydrochloride ER, ConZip Qdolo

Tramadol has an average rating of 9.3 out of 10 from a total of 212 reviews for the off-label treatment of Depression. 91% of reviewers reported a positive experience, while 3% reported a negative experience.

Reviews for Tramadol

  • Roarski
  • Taken for 1 to 6 months
  • May 14, 2016

"I was prescribed Tramadol for depression a year ago (50 mg, 3x day). I felt like I had the flu so I stopped after 3 days. About 1 1/2 months ago I started to take it again (only 1- 50 mg per day in AM). I currently take adderrall and xanax as they are the only meds that help my depression /anxiety without the terrible side effects. Since on Tramadol I have been more motivated and productive then I can ever remember! I stopped for a couple days and experienced the flu like symptoms again, but I have gone back again on a regular daily schedule. Not sure if I should up the dosage to 100 mg but this has been the best med for me, and I've taken many. Definetly a life changer and I'm optimist about the future for the 1st time in my life."

10 / 10
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  • Tanya
  • Taken for 5 to 10 years
  • February 7, 2024

"I'm so happy to see you all comment here! I have been using 100 mg tramadol twice a day! I can't get up even to smoke a cigarette without it. I lay in bed for days. I have been bedridden for the last 15 years from grief and PTSD. I got things done with tramadol for the last 6 years to secure my future. I stopped alcohol! I thought it was my will to quit."

10 / 10
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  • LifeI...
  • Taken for 6 months to 1 year
  • May 25, 2017

"I lived most of my life feeling terrible and out of place. I was an anxious, low-self esteem, depressed guy. Everything took effort to accomplish, I had few friends because I was afraid of expressing myself and had almost no confidence in myself. I have been taking tramadol daily for about 6 months (100mg in the morning and 100mg after 5-6h), and I feel like a different person. I'm confident, have energy and feel like a normal guy. Keep in mind that at first you may feel some euphoria and you must not chase it by taking more. The anti-depressant and anti-anxiety effects will remain, while the euphoria will disappear. "

10 / 10
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Frequently asked questions

  • Charl...
  • Taken for 2 to 5 years
  • February 4, 2024

"I've been suffering from depression for 15 years. I've tried every antidepressant possible, but nothing worked. I started taking tramadol for pain and it changed my life: no more depression, insomnia, or anxiety. It is a miracle as some of the reviews say! It can be addictive, but it doesn't matter when it allows me to live a normal life. I take 200mg/day. It has been 3 years and I have never increased the dose."

10 / 10
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  • Ralphy...
  • November 13, 2019

"This medication is simply perfect. I take one 50 MG dose in the am. One 50 MG dose in the afternoon. If necessary, one 50 mg in the evening. Zero drowsiness. Zero side effects. I’m the happiest human on earth. Cures 100% of anxiety and depression. It even helps with pain related issues too. But for depression and anxiety, it is amazing. It also deters you from wanting other drugs (whether it’s marijuana, alcohol, or anything else) because you naturally don’t want it because you don’t feel anxiety or depression. You are genuinely happy and clear headed. If you want to get high, take something else. If you genuinely want to be happy all the time with no anxiety or depression and want to socialize, this is 10X better than anything else. My doctor stopped prescribing it to me after my surgery after 2 years."

10 / 10
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Are you taking this medicine?

  • Wifeo...
  • Taken for 1 to 6 months
  • December 9, 2018

"My family has a history of depression. I also have back issues. I took my first dose of 50 mg tramadol tablets. I was so shocked to realize it did little for my back pain but my mood was altered for the better. It helped my depressive issues almost immediately. I was shocked to say the least but also very relieved to fine my spirits lifted without feeling sedated at all. It is amazing."

10 / 10
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  • trama...
  • Taken for 1 to 6 months
  • May 15, 2015

"I found by accident that tramadol greatly diminishes my depression. If I knew I could take it daily without building a tolerance against it I would gladly take it for the rest of my life. As it is, I limit taking it to no more than once a week out of that fear. For just ONE DAY of my life without depression it is worth it."

10 / 10
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More FAQ

  • kel
  • Taken for less than 1 month
  • March 20, 2016

"I have lost 5 pounds on this drug Tramadol. I was on a weight loss journey and had lost 65 pounds on my own but as of recently, I have struggled with the last 40 until I started taking the Tramadol. It will suppress your appetite and help with food cravings. I believe this drug is a great aid for losing weight if one uses it appropriately. This drug was not prescribed for depression nor weight loss but it is killing two birds with one stone in my life."

10 / 10
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  • apricot
  • Taken for 1 to 2 years
  • May 23, 2019

"I have always suffered with depression and was using antidepressants which helped somewhat then I ended up with back pain and was prescribed tramadol which has helped me a lot. Lost my husband last year and at times just cannot be bothered with life but if I take tramadol it improves my mood and I get on with my life. It has made a big difference. I want to give it up because I get constipated which I think is a side effect but there are things I can take like fruit and high fibre to get rid of that problem. Every time I try to give it up I get so down that I have decided at the age of 72 why not continue taking it and enjoy life the best I can. I take 50mg in the morning and evening and half at lunch time every day. I still take an antidepressant with it. My dr told me if the pills work thats what it is all about feeling better."

10 / 10
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  • Klams
  • Taken for 2 to 5 years
  • March 16, 2019

"Tramadol is life changing for me, all of my depression, and social anxiety vanishes and I want to talk to people, get out of bed, do things and enjoy life. I am 300 lb. I take 50 mg just to stop the worst feelings, 100 mg to be active and totally free of anxiety and depression. The effects last for a full day, and sometimes into the next day. I never take more than a dose a week, so I am often sleepy the next day, but I can get through that easily with caffeine. I don’t know how to get it prescribed. Doctors just don’t care that it has been transformative. It doesn’t seem fair. I have a small supply obtained illegally. I take them only when I absolutely can’t face life as myself any more. I avoid feeling the effects while working. (Even though effects are mild, I don’t want anything to affect my job performance), so I only allow myself relief one day a week or less. Other SSRIs have not helped me much. They just make me not care about anything."

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  • depre...
  • Taken for 2 to 5 years
  • May 18, 2016

"Been on these pills for 3 yrs now. Started out for pain relief but soon discovered my depression fading fast. I take 200m xr in am and 200 at night also helps me wake up alot easier and happier. I went off them depression came back and suffered some withdrawals instantly aND geting oit of bed was a nighmare. Back on them life is great one major down fall is my sex drive these pills kill it but it's worth it cause I'm happier on these pills with less sex then lots of sex and not happy. Sacrifice I choose to make."

8 / 10
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  • zeroc...
  • Taken for 2 to 5 years
  • October 23, 2022

"Tramadol is the single best medication I've known, except for antibiotics, in my 60x years of life. It is labelled as "a strong pain reliever for mod-severe pain" which is a new attack by the medical cartel. The truth is that it is a moderate level pain reliever at best. It has very, very little addictiveness. It is extremely good at improving concentration, lifting mood, and levelling depression. It is inexpensive. It is an extremely good medication. Press your physician to prescribe it and do not let them off the hook. They must do what is in the patient's interest and not what is in the interest of the money."

10 / 10
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  • Joao...
  • April 26, 2017

"I have tried almost all antidepressives drugs available in the last 20 years. Fluoxine, sertraline, paroxetina, citalopram and escitalopram did not work and destroyed my sex life. Bupropion increased my anxiety a lot. Mirtazapina caused me hallucinations and insomnia. Venlafaxine and desvenlafaxine worked a for some time, but affected my libido and erection. Niacina (off label) did not work for me. The only one that worked and is still working is Tramadol (off label). It starts to work about 1,5 to 2 hours after I take it, and lasts for 8 to 10 hours. I take 1 50mg capsule first in the morning and another 1 at around 4pm, with empty stomach. The ONLY drug that works for my depression and anxiety."

10 / 10
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  • DJano
  • June 25, 2019

"I’ve been depressed a good part of life and as I get older the more depressed I seem to get. I’m on two different antidepressants Wellbutrin and Effexor. About 5 years ago I admitted myself in the hospital for depression. While I was there they put me on Tramodal for depression which I always thought was for pain. My physician recently stopped prescribing me Tramadol and since then I’m spiralling out of control. I have to obtain illegally because my physician doesn’t believe it’s for depression. If I go two days without I slump into a deep depression and I don’t care about nothing. Tramadol helps me focus and gives me purpose to be alive. It’s not a high like you get with OxyContin it’s a mellow way to cope with daily living. Some how or another I need to convince my physician to start prescribing them to me"

10 / 10
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  • Syrian
  • Taken for 1 to 2 years
  • July 31, 2014

"I have been using tramadol with alprazolam for the past 2 years. I take only one 50 mg tablet with one 0.5 mg alprazolam in the morning and I rarely take more (may be once a month I take 2). This combination was my savior. Because of it, I am doing very good in my business. I stop taking it sometimes and I do not have any withdrawal symptoms at all except for the bad mood and fatigue. I am moving to Germany soon and I am worried that I will not be able to get this medicine there."

10 / 10
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  • ano
  • April 2, 2015

"I have been taking 50 mg Tramadol for three years twice daily (prescribed) for osteoarthritis it reduces the pain to a tolerable level, it allows me to participate in simple activities again. It has also been a miracle cure for my pain and the depression I have suffered with my entire life. As a child a was painfully shy, self conscious and full of self doubt, additionally I was physically abused. The abuse consisted of being punished by being locked in a dark closet many times, beaten with hangars, beaten with a hairbrush till I bled, slapped aIt resulted in BPerD. I was treated with Buspar Effexor Prozac Zoloft lexapro and Clonipin. Nothing worked many made me worse yet on tramadol I feel so much better"

10 / 10
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  • tomdin
  • Taken for 2 to 5 years
  • July 31, 2019

"I placed a post earlier on 2019-07-10 under the name Jerry saying -- I was a 65 year old male that takes Tramadol intermittently to reduce depression. the problem is that when I do take days off -- I am extremely depressed 3 times as much. So you have to be very careful of this medication."

4 / 10
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  • Iljc1...
  • Taken for 2 to 5 years
  • November 28, 2017

"I am a 65 year old Male and suffer from depression. My Psychiatrist prescribed Tramadol 50mg daily.  I have been taking it for three years and it works terrific. I have tried SSRIs in the past but did not have any success. I have heard horror stories about the withdrawal symptoms of Tramadol so I have taken some days off or decreased my dosage to test and experiment the withdrawal effects -- but I am not sure I want to go through the rest of my days bummed out and unproductive. I have heard all the stories about working out, proper diet, self-talk etc... I am very disciplined in adhering to these principles -- but it does not help my depression. Just my two cents. Jerry"

8 / 10
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  • Darling
  • March 11, 2017

"I have used tramadol for one year now. First was treated for diabetes pain. But every time I took one I definitely changed. I felt better than ever no pain and wanting to get pretty and do things with my family. I told my Doctor and he told me that I was suffering from depression and tramadol was helping me get back together. I swear to God this medicine is great for depression. I feel better than ever. I do so much in one day and I sleep lovely."

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  • Pete...
  • Taken for 1 to 6 months
  • May 26, 2016

"Wonderful drug for depression with no weight gain. Had been on it for 12 months and then decided to wean off it - after 18 months it came back (I have suffered from depression since I was 6) Have now been back on it for 3 months and feel "normal" again and motivated. I have never been suicidal but I do lose interest in everything and lose my creativity. Sex drive at times is non existent but I force myself to masturbate (Yes - I am single) because if I don`t masturbate I get an awful ache in my testis so masturbating even just twice a day helps and also I was told it may prevent prostate cancer. To be honest though if losing my sex drive is the worst of it then I don`t care as I`m enjoying life again"

9 / 10
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  • Anonymous
  • Taken for 2 to 5 years
  • April 17, 2023

"I've been using Tramadol for my treatment-resistant depression for about 3 years now, taking 300mg every day, and I feel like my life has improved significantly. I used to barely be able to get out of bed in the mornings. I used to work for just 3 hours a day, and even that felt like too much. Now, I'm working 7 hours a day without any problems. I have no issues waking up at 3:45am each morning, and I spend all day feeling energized and content. I'm honestly amazed at how well this has worked for me. I've also had to stop taking it a few times, and haven't experienced any withdrawal symptoms despite taking it so frequently, nor have I ever had to increase the dosage in three years of use."

10 / 10
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  • GSW
  • Taken for less than 1 month
  • September 22, 2023

"I am a Polio survivor and suffer from PPS. Now degenerative disc. Nothing helped even facet injections. Finally my doctor prescribed Tramadol and it works a lot. But... I didn't realize it was good for depression and anxiety. What a difference, I feel so much better. I read all the scary literature, side effects, etc. Not true. So glad I found this. I am 76 years old and no side effects, plan on taking forever. I take 50mg at night and sometimes another 50 during the day."

10 / 10
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  • sad12...
  • February 22, 2016

"I was prescribed Tramadol for a back injury. During the same time period I was taking Adderall. On a weekend visit with friends I had forgotten to pack the Adderall. I took my Tramadol in the morning and realized I did not need the Adderall. Tramadol was just as effective, if not more so. It's effect on me is a more focused, calmer state of mind. Because my anxiety is silenced, so also is my need to "angst" eat. I maintain a healthy weight and feel motivated to exercise. Basically the dark cloud of depression and anxiety is gone. Do I still get moody. Absolutely. The difference now is that I no longer experience random or unexplainable bouts of angst or depression. Life insurance app. red flagged it so I can't get filled at this time."

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  • AJDG
  • March 21, 2017

"I have suffered from Major Depression since I was 17, or at least that is when I was diagnosed. I believe it started when I was 13. I have been on medication every since and I am now 44. I came across Tramadol because I have Fibromyalgia and I use it to lessen my pain. I take 50 mg in the morning and if my pain is unbearable I will take another 50 mg in the late afternoon. It doesn't take all my pain away but I can function since I work full time and go to school too. The most miraculous part of all of this is that my depression while on this is completely gone. I have to be careful since I am already on anti-depressants that are a serotonin uptake that I don't ever over do it, because of Serotonin Syndrome. Feel like myself :)"

10 / 10
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  • DanDa...
  • Taken for less than 1 month
  • April 8, 2015

"Today I went to my doctor and he shot me in the butt with some Tramadol to help my body pain. For the first time in ages I have been in a good mood, feel extremely relaxed and extremely content. I take Zoloft for depression and it helps to a degree, but this stuff makes me forget what depression even is. I am watching tv and smiling, this is the best mood lifter I have ever had, and so-so for pain relief"

10 / 10
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72 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.