Medically reviewed by Drugs.com. Last updated on Jun 5, 2023.
What is Ryzolt?
Ryzolt is a narcotic-like pain reliever.
Ryzolt extended-release tablets are used to treat moderate to severe chronic pain when treatment is needed around the clock
Ryzolt may also be used for purposes not listed in this medication guide.
You should not take Ryzolt if you have used alcohol, sedatives, tranquilizers, or narcotic medications within the past few hours.
Ryzolt can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take Ryzolt in larger amounts, or for longer than prescribed. Do not crush or break an extended-release tablet. Swallow it whole to avoid exposure to a potentially fatal dose.
Seizures (convulsions) have occurred in some people taking this medicine. Ryzolt may be more likely to cause a seizure if you have a history of seizures or head injury, a metabolic disorder, or if you are taking certain medicines such as antidepressants, muscle relaxers, narcotic, or medicine for nausea and vomiting
Tramadol may be habit-forming, even at regular doses. Take Ryzolt exactly as prescribed by your doctor. Never share the medicine with another person. MISUSE OF NARCOTIC PAIN MEDICATION CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.
Tell your doctor if you are pregnant. Ryzolt may cause life-threatening withdrawal symptoms in a newborn.
Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with Ryzolt.
Do not crush the Ryzolt tablet. This medicine is for oral (by mouth) use only. Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body. Using this medicine by inhalation or injection can cause life-threatening side effects, overdose, or death.
Before taking this medicine
You should not take Ryzolt if you are allergic to tramadol, or if you have:
severe asthma or breathing problems;
a blockage in your stomach or intestines;
if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications.
Seizures have occurred in some people taking tramadol. Talk with your doctor about your seizure risk, which may be higher if you have:
a history of head injury, epilepsy or other seizure disorder;
a history of drug or alcohol addiction;
a metabolic disorder; or
if you are also using certain medicines to treat migraine headaches, muscle spasms, depression, mental illness, or nausea and vomiting.
To make sure Ryzolt is safe for you, tell your doctor if you have:
liver or kidney disease;
a stomach disorder; or
a history of drug abuse, alcohol addiction, mental illness, or suicide attempt.
Ryzolt is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.
Tramadol may be habit forming and should be used only by the person it was prescribed for. Never share Ryzolt with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away Ryzolt to any other person is against the law.
It is not known whether Ryzolt will harm an unborn baby. If you use tramadol while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.
Tramadol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking Ryzolt.
Do not give this medication to anyone younger than 16 years old without the advice of a doctor. Ultram ER should not be given to anyone younger than 18 years old.
How should I take Ryzolt?
Take Ryzolt exactly as prescribed. Follow all directions on your prescription label. Tramadol can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take Ryzolt in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Ryzolt can be taken with or without food, but take it the same way each time.
Do not crush or break an extended-release Ryzolt tablet. Swallow it whole to avoid exposure to a potentially fatal dose.
Never crush or break a Ryzolt pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of tramadol and similar prescription drugs.
The Ryzolt tablet shell may pass into your stools (bowel movements). This is normal and does not mean that you are not receiving enough of the medicine.
Do not stop using Ryzolt suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using tramadol.
Store at room temperature away from moisture and heat.
Keep track of the amount of medicine used from each new bottle. Tramadol is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A tramadol overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, cold and clammy skin, and fainting.
What should I avoid?
Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with Ryzolt. Check your food and medicine labels to be sure these products do not contain alcohol.
Ryzolt may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.
Ryzolt side effects
Get emergency medical help if you have any signs of an allergic reaction to Ryzolt: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
weak or shallow breathing;
high levels of serotonin in the body - agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; or
severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Ryzolt side effects may include:
headache, dizziness, drowsiness, tired feeling;
constipation, diarrhea, nausea, vomiting, stomach pain; or
feeling nervous or anxious.
itching, sweating, flushing (warmth, redness, or tingly feeling).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Ryzolt?
Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking Ryzolt with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Many drugs can interact with tramadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Yes, it is safe for most people to take tramadol with acetaminophen, ibuprofen, or aspirin if they are old enough (aspirin is not recommended for children less than 16 years and tramadol should not be taken by children under the age of 12). Continue reading
Both tramadol and codeine are prescription opioid painkillers, and they seem to be equally effective in terms of pain relief. There is no evidence that tramadol is any stronger than codeine at relieving pain. Continue reading
How much tramadol you give your dog depends on the size of your dog. Smaller dogs do not need as much tramadol as larger dogs need to relieve pain. If you give too much tramadol your dog is likely to have more severe side effects. The tramadol dosage for dogs is usually between 0.45 to 1.8 mg per pound of body weight (1mg to 5 mg/kg). The frequency varies depending on what you are giving it for. For general pain, it is given every 8 to 12 hours, but for cancer-related pain, it can be administered every 6 hours. Continue reading
Symptoms of tramadol withdrawal can start 8-24 hours after the last dose. Untreated, withdrawal symptoms usually last for 4-10 days. Withdrawal is caused by stopping the drug suddenly. Continue reading
Tramadol generally starts to relieve pain within an hour in its fast-acting forms, which are used for short-term pain management. With slow-release or extended-release (ER) forms, the drug may take longer to start because it’s gradually released over 12 or 24 hours, but pain relief lasts longer. Continue reading
Tramadol is eliminated from your system within roughly 2 days of taking the drug, but this does not mean that it can no longer be detected by certain drug tests. Continue reading
Yes, you can take these medications together. Tramadol is safe to take with ibuprofen and may be used to provide additional pain relief. But be aware 800mg ibuprofen is a high dose of ibuprofen that may cause gastrointestinal side effects such as abdominal pain or reflux if taken long term. Continue reading
Any drug that is classified as an "opioid" can cause constipation. Examples of commonly prescribed opioids that may cause this side effect include morphine, tramadol, fentanyl, methadone, hydrocodone, codeine and oxycodone. Continue reading
No, Tramadol is not an anti-inflammatory drug or muscle relaxer. Because it’s not an anti-inflammatory drug, it likely won’t reduce any swelling you have when taken alone. Continue reading
More about Ryzolt (tramadol)
- Check interactions
- Compare alternatives
- Reviews (12)
- Drug images
- Latest FDA alerts (4)
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: Opioids (narcotic analgesics)
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ryzolt only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2024 Cerner Multum, Inc. Version: 14.06.