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Tramadol for Depression User Reviews (Page 5)

Brand names: Tramadol Hydrochloride ER, ConZip Qdolo

Tramadol has an average rating of 9.3 out of 10 from a total of 212 reviews for the off-label treatment of Depression. 91% of reviewers reported a positive experience, while 3% reported a negative experience.

Reviews for Tramadol

  • Carlr...
  • Taken for 10 years or more
  • October 11, 2022

"Without tramadol, my treatment resistant depression would keep me from getting out of the bed each day. I'm able to just function - get up, feed, clothe myself, and to take care of other normal responsibilities. Besides, when I am not on it, my thoughts are abjectly self destructive and even suicidal. I have never taken this drug recreationally, never! I need it, because all other medications made me feel worse, or made me feel like a zombie, spaced-out. Nothing else came close to helping me. For the help that it provides, I'd say that it'd be downright cruel to keep this and other drugs (mushrooms) from people who need them for health not abuse."

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  • Quest
  • July 1, 2019

"I have battled with depression, anxiety and bipolar. I have tried several medications. Some worked for a while then hit a ceiling. Then would switch. After doing research looking for an answer, I read about Tramadol, as I had seen people talking positive about it. I was a little concerned since it is in the Opioid family, but was desperate to find the answer. I have been taking Tramadol 50MG for about a year and a half and along with an anti depressant it absolutely enhances my mood and lifts my depression. Have not had any problem taking break when I feel I need to. Like someone has stated if it helps to make your life better , and it has limited downside then take it"

10 / 10
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  • Trying
  • Taken for 1 to 2 years
  • June 30, 2019

"I was diagnosed with diabetic neuropathy. I am now 53. The numbness in my legs stopped me from driving. I grew more isolated. My doctor prescribed painkillers, antidepressants, but I kept going down. Then I fell, tore my ACL and was given tramadol. Yes, it helped pain. But for the first time in nine years I was not depressed! Occasionally happy? I thought what is causing this?. Long story short, it was the tramadol working as an antidepressant. It has given me quality of life. And the dependency issues? If dependency means I can experience JOY again, using same daily amount, so be it. It should not be so difficult for doctors to prescribe."

9 / 10
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Frequently asked questions

  • BlueM...
  • July 3, 2017

"I originally took Tramadol for pain. I previously had bouts with depression, which totally consumed me. I tried Tramadol (50mg noon time and one at bedtime. ) It pulled me out of the depression before it took me over. Works great."

9 / 10
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55 Report
  • Dreda...
  • October 5, 2016

"So for pain there just alright like a 7 they do last longer than other pain pills- but for my deprssion I feel like a better more capable man when I'm on them. When my supply is gone and I cant find a doc or medical I become suicidal. With them I can live a normal or somewhat normal life"

10 / 10
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Are you taking this medicine?

  • neond...
  • Taken for 2 to 5 years
  • April 7, 2015

"Several years ago I was given tramadol for light pain. I have suffered from bipolar depression for about 40 years and have taken every drug made for depression. I get a little relief using fetzima but the cost is prohibitive. After taking the tramadol I realized that my depression and panic attacks just disappeared. In Mississippi it's almost impossible to get tramadol subscribed so I kept my supply by ordering out of the country which is also very expensive. When you are suicidal much of the time you will seek help wherever you can find it. I finally got a nurse practitioner to prescribe me two 50 mg tablets a day. I have a high tolerance to all drugs and four 50 mg gives me total relief from my mental illness. Side effects decreased sex drv."

10 / 10
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  • Hermes
  • March 15, 2015

"Don't let your ignorant physian deprive you of this miracle drug for your depression. They are trained to shun anything narcotic, even if it may be beneficial to the patient. If you have chronic depression, you should definitely try two 50 mg Tramadol (my 90 generic pills cost me 3.99 for 90 pills at a discount pharmacy: no insurance needed) on an empty stomach at 7 am and two more in the late afternoon. Between these doses walk a lot and drink plenty of water. The results may be astonishingly good. It may not work for all, but I bet it will work for most people who experience moderate levels of depression. Read about the side effects and then decide: it is worth a shot. In contrast to Tramadol, expensive anti-depressants may unnecessarily."

10 / 10
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More FAQ

  • Sad...
  • Taken for 6 months to 1 year
  • June 24, 2018

"I have chronic depression and PTSD. I have tried all the SSRIs and SNRIs. I've tried combinations of supplements, and checked into magnetic brain stimulation treatments. Nothing worked. I was in a car accident and hurt my back. I was prescribed Tramadol and noticed within a couple of day that I felt "normal", happy, not anxious. So I talked to my doctor who is willing to continue prescribing it for me. I still have my negative thoughts but they don't dominate my day, nor disrupt my life. I keep up on my magnesium L-threonate, magnesium glycate and L-theanine which make a big difference. Everyone's body chemistry is different. This drug works for my chemistry. I understand that I will have to take a medication for the test of my life, but it's a small price to pay. There are days I almost didn't make it through. And I'm fortunate to have found something that works for me."

9 / 10
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  • mrstc
  • December 29, 2015

"I have had major health issues all year. 3 bulging discs in my neck. Got the pain somewhat masked with multiple rounds of injections, and finally burning the nerve endings in my neck so that I am no longer waking every morning in pain. I subsequently tore a ligament in my shoulder and am now having to start physical therapy and see an orthopedic doctor. I have been taking muscle relaxers as well as Hydrocodone . Having constant pain issues for so long has made me feel depressed, all I want to do is work and sleep. Today I went to my medicine pantry and pulled out a bottle of Tramadol that I had been prescribed previously. I took one and within an hour the fog lifted and I feel 100% better! Will be taking this daily now"

10 / 10
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  • Notwell
  • October 4, 2015

"Given to me for pain, didn't work for that but, it worked great for my restless leg syndrome and my depression. I take 4 at once a day in the afternoon. I never take more than that. I am addicted, tried to stop taking them for 2 weeks and I felt sooo sick and weak. I also started getting these weird tings in my head, like a rubberband snap sensation. I can't stop taking them. If I do I cant function well."

10 / 10
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61 Report
  • Sunny
  • Taken for 2 to 5 years
  • May 28, 2021

"This medicine is a miracle. I swear. Low dosage tramado taken as a regular antidepressant has saved my life. I used to be able to not drive and have almost seizure like problems. I wasn’t able to go out of my house or do anything. I have major social anxiety as well. This medication changed my life!!!! I mean it! I have tried every single anti depressant out there and they all make me ill. Like a zombie. They make me sad. And if you missed a dose watch out. I was on tramadol for 2 years and when I got off of it I had zero issues as well. I was on Xanax for a couple of years awhile ago and it’s what ruined me. Tramadol saved my life. Please look more into this! I’m so healthy because of this medication."

10 / 10
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  • Pix3L
  • Taken for less than 1 month
  • November 18, 2018

"I have been on Suboxone for 2 1/2yrs. I've always had issues with Depression/Anxiety. However, the Suboxone has made my Depression/Anxiety 1000x worse and I have been put on different kinds of SSRI/SNRI medications, nothing has worked. I did some research on Suboxone combined with Tramadol and let me tell you, I was my bubbly self again. I felt amazing for the first time in a long time. The opiate side of Tramadol gets blocked by Suboxone so its Tramadol's anti-depressant component that is working its magic on me. The DR will not prescribe this to me since I am on addiction treatment, he won't even prescribe me an anti-depressant that matches Tramadols. I have made my situation even worse now since I got to experience Tramadol's anti-depressant magic knowing I cant get that medication prescribed. Imagine every waking day in mental misery and someone hands you something that makes it all go away but to be told you will never get it."

10 / 10
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  • Jimmix
  • November 10, 2015

"I found this drug to be very useful for pain. I have crohns disease, degenerative disc disease, migraines, bipolar disorder , ptsd, anxiety disorder. I take tramadol 3 pills a day. 150mg total. The only thing i dont like is when i skip doses i get awful side effects like a buzzing or vibration in my head. So i am unable to skip days of taking it or i feel very awful."

9 / 10
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  • HardL...
  • Taken for 1 to 6 months
  • May 19, 2015

"Tramadol is about the most effective drug in the world for depression - for immediate, short term relief ONLY though. During the initial dosing period, 100mg twice a day utterly obliterates any negative thinking or depression symptoms. It delivers results immediately, vs the necessary patience of waiting a few days or weeks with traditional SSRI drugs. However, tolerance DOES build to tramadaol at a pace far more rapidly then with traditional anti-depressants. I had 2 months of solid relief from 100mg 2x daily, but by the third month this does barely made a difference and my mood continued to sink. Instead of upping my dose, I went back on Zoloft which delivers less immediate, but more consistent long term results for me."

7 / 10
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  • HikeM...
  • Taken for 6 months to 1 year
  • March 16, 2017

"Hello everyone. I, as many of you, have struggled with major depression for a long time. For me, it comes and goes - with a terrible onset towards the end of the winter month's. I've tried 4 different antidepressants with no success. Actually, Wellbutrin did help - but I ended up being allergic to it. Go figure. I was prescribed Tramadol for pain last year during a hip problem I was having and wow did it help my mood. I didn't feel so broken. This year I am suffering from depression again but haven't started on Tramadol yet. I am nervous because of it's addictive qualities, but I cannot keep calling out of work and risk losing my job. It is a terrible feeling. All your posts have been very encouraging so thank you for sharing!"

8 / 10
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  • marty
  • November 7, 2019

"Not only does this drug help me with a herniated disc in my neck and back pain, it also gives me tons of energy and makes me feel happy and more out-going. I feel like I can get so much more done while taking this, this really should be prescribed over anti-depressants. I took Lexapro for a while and Tramadol seems to put you into a good mood instantly. I take one 50mg pill a day, works perfect for me."

10 / 10
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  • Margie
  • Taken for 2 to 5 years
  • July 1, 2019

"Peripheral Neuropathy slowly but surely stole my mobility. With that came a loss of social contact, and a depression that I had never experienced before. I tried therapy, B12, exercise, health foods and supplements. Still I woke up everyday with the same goals and hopes as always, but a body that was fading. Maybe Tramadol does not bring back mobility. But the energy level increase and the relief from sadness works like nothing else. My neurologist approves....She has seen me function with and without it. I am grateful she prescribes for me to have some quality of life. I know some physicians won't."

10 / 10
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  • Jude
  • Taken for 2 to 5 years
  • December 9, 2023

"I was prescribed Tramadol [50 mg 1-2x a day] for severe knee pain from osteoarthritis. Long before any studies came out, I noticed that it significantly improved my mood. No ill effects -- it's wonderful and unlike a drug I took years ago that made me fuzzy headed."

10 / 10
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  • Dallas...
  • Taken for less than 1 month
  • June 9, 2017

"I have treatment resistant Major Depression and as a result, I've taken so many drugs over the years that I can't list them all. I got kidney stones a while back and got tramadol to help me with the pain. It didn't help much for that, but it sure helped treat my depression. I talked with my primary care doctor about this and she's reluctant to prescribe it if it isn't for pain. As the result, I'm going to find a new doctor... One who knows a bit more about psychiatry."

10 / 10
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  • BadDad
  • Taken for 2 to 5 years
  • June 9, 2019

"This wonder drug appears to have some big fans! I don't have too much to add, just a few things: Dependancy level: I think about dependant as coffee in my opinion. I usually take one 50mg pill a day (which seems a fairly common dose for you commenters, with no craving for more then that)- I think I've been a self medicating kind of guy for most of my life for mild to moderate depression, alcohol mostly. Most mornings with a mild hangover and the depression that came with it. Until I started taking Tramadol for a neck injury that is. Amazing first aid for a hang over and the blues! This fact has been an enabler for drinking too much, but lately I'm using Tramadol to quit drinking and with good results. Sleep super well and wake feeling great!"

10 / 10
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  • ALEX...
  • Taken for 1 to 2 years
  • November 14, 2021

"Tramadol is worse medication you can take for your depression or anxiety for a long term; at the beginning, it makes you happy and energetic, but eventually, you are a drug addict and can not function without it, you will be so relaxed that you don't care about anything or anyone; you want to sleep all day long and day by day losing your short memory. I used it myself for two years and sober from it now for about two years; withdrawal symptom is like you go to hell and back. I am not recommending this drug at all. Take my feedback seriously. Good Luck"

1 / 10
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  • Evilm...
  • Taken for 1 to 6 months
  • May 31, 2015

"If you decide to take this med, or your doctor wants you to, ask for the XR version. It truly is 24 hours of pain relief, I take 100mg XR every night and the best part is that you get to wake up mostly pain free. The mild pain relief all day that can be enhanced easily with tylenol. I have tried muscle relaxers, creams, injections, opiates, and this is the only med to be side effect free and mixes well with over the counter pain meds well to manage. Last thing is the mood elevation that accompanies the XR version, I actually stopped taking my anti-depressant. This works better than anything I have ever taken for my depression, though anxiety is not helped that much."

8 / 10
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  • shepa...
  • October 4, 2016

"I've suffered from chronic depression for over 20 years. I've been on a number of antidepressants and nothing has worked long term. I was put on this drug to ease the pain of a back injury and quite surprisingly and unexpectedly my depression symptoms disappeared completely. I became a happy productive individual overnight. Amazing! Too bad it's an addictive opiate, and I imagine that, over time, the benefit would wane."

10 / 10
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  • Makpaz
  • Taken for 5 to 10 years
  • November 1, 2019

"I'm upgrading from 9 to 10. For some reason there is no randomized research comparing tramadol with mainstream antidepressants. Do not be surprised as the realization that tramadol outdoes all the other antidepressants combined has a huge price tag. Tramadol doesn't pay for your psychiatrist to go to Maui and to advertise its near miraculous affect on depression and anxiety within the medical field is sacrilegious. Nevertheless it's an amazing drug. My friend takes 50mg daily without ever needing to raise the dose. Note that different genetics have different liver enzymes. People of Middle Eastern and Southern European descent seem to better process tramadol. Less lucky are people of northern Europeans descent and Orientals descent. Or so I observed."

10 / 10
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  • Angel
  • Taken for 5 to 10 years
  • December 21, 2016

"I have manic depression and anxiety disorder an I also have fibromyalgia and chronic pain this medicine an I also take 600 gabapentin it works for me also help with menopause symptoms but for my depression it really helps keeps me from crying all day and helps me feel better,"

10 / 10
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48 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.