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Tramadol for Depression User Reviews (Page 5)

Brand names: Tramadol Hydrochloride ER, ConZip Qdolo

Tramadol has an average rating of 9.3 out of 10 from a total of 220 reviews for the off-label treatment of Depression. 91% of reviewers reported a positive experience, while 3% reported a negative experience.

Reviews for Tramadol

  • sad12...
  • February 22, 2016

"I was prescribed tramadol for a back injury. During the same time period, I was taking Adderall. On a weekend visit with friends, I had forgotten to pack the Adderall. I took my tramadol in the morning and realized I did not need the Adderall. Tramadol was just as effective, if not more so. Its effect on me is a more focused, calmer state of mind. Because my anxiety is silenced, so also is my need to 'angst' eat. I maintain a healthy weight and feel motivated to exercise. Basically, the dark cloud of depression and anxiety is gone. Do I still get moody? Absolutely. The difference now is that I no longer experience random or unexplainable bouts of angst or depression. Life insurance app red flagged it, so I can't get filled at this time."

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  • AJDG
  • March 21, 2017

"I have suffered from Major Depression since I was 17, or at least that is when I was diagnosed. I believe it started when I was 13. I have been on medication ever since, and I am now 44. I came across tramadol because I have fibromyalgia, and I use it to lessen my pain. I take 50 mg in the morning, and if my pain is unbearable, I will take another 50 mg in the late afternoon. It doesn't take all my pain away, but I can function since I work full time and go to school too. The most miraculous part of all of this is that my depression while on this is completely gone. I have to be careful since I am already on anti-depressants that are a serotonin uptake, that I don't ever overdo it, because of serotonin syndrome. I feel like myself :)"

10 / 10
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  • DanDa...
  • Taken for less than 1 month
  • April 8, 2015

"Today I went to my doctor and he shot me in the butt with some Tramadol to help my body pain. For the first time in ages I have been in a good mood, feel extremely relaxed and extremely content. I take Zoloft for depression and it helps to a degree, but this stuff makes me forget what depression even is. I am watching TV and smiling, this is the best mood lifter I have ever had, and so-so for pain relief."

10 / 10
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Frequently asked questions

  • Quest
  • July 1, 2019

"I have battled with depression, anxiety, and bipolar. I have tried several medications. Some worked for a while, then hit a ceiling. Then I would switch. After doing research looking for an answer, I read about Tramadol, as I had seen people talking positively about it. I was a little concerned since it is in the opioid family, but I was desperate to find the answer. I have been taking Tramadol 50MG for about a year and a half, and along with an antidepressant, it absolutely enhances my mood and lifts my depression. I have not had any problem taking a break when I feel I need to. Like someone has stated, if it helps to make your life better, and it has limited downside, then take it."

10 / 10
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  • Sad...
  • Taken for 6 months to 1 year
  • June 24, 2018

"I have chronic depression and PTSD. I have tried all the SSRIs and SNRIs. I've tried combinations of supplements and checked into magnetic brain stimulation treatments. Nothing worked. I was in a car accident and hurt my back. I was prescribed tramadol and noticed within a couple of days that I felt 'normal', happy, not anxious. So I talked to my doctor, who is willing to continue prescribing it for me. I still have my negative thoughts, but they don't dominate my day, nor disrupt my life. I keep up on my magnesium L-threonate, magnesium glycinate, and L-theanine, which make a big difference. Everyone's body chemistry is different. This drug works for my chemistry. I understand that I will have to take a medication for the rest of my life, but it's a small price to pay. There are days I almost didn't make it through. And I'm fortunate to have found something that works for me."

9 / 10
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Are you taking this medicine?

  • Hermes
  • March 15, 2015

"Don't let your ignorant physician deprive you of this miracle drug for your depression. They are trained to shun anything narcotic, even if it may be beneficial to the patient. If you have chronic depression, you should definitely try two 50 mg Tramadol (my 90 generic pills cost me $3.99 for 90 pills at a discount pharmacy: no insurance needed) on an empty stomach at 7 am and two more in the late afternoon. Between these doses, walk a lot and drink plenty of water. The results may be astonishingly good. It may not work for all, but I bet it will work for most people who experience moderate levels of depression. Read about the side effects and then decide: it is worth a shot. In contrast to Tramadol, expensive antidepressants may be unnecessary."

10 / 10
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  • neond...
  • Taken for 2 to 5 years
  • April 7, 2015

"Several years ago I was given tramadol for light pain. I have suffered from bipolar depression for about 40 years and have taken every drug made for depression. I get a little relief using fetzima but the cost is prohibitive. After taking the tramadol I realized that my depression and panic attacks just disappeared. In Mississippi it's almost impossible to get tramadol prescribed so I kept my supply by ordering out of the country which is also very expensive. When you are suicidal much of the time you will seek help wherever you can find it. I finally got a nurse practitioner to prescribe me two 50 mg tablets a day. I have a high tolerance to all drugs and four 50 mg gives me total relief from my mental illness. Side effects decreased sex drive."

10 / 10
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More FAQ

  • Trying
  • Taken for 1 to 2 years
  • June 30, 2019

"I was diagnosed with diabetic neuropathy. I am now 53. The numbness in my legs stopped me from driving. I grew more isolated. My doctor prescribed painkillers, antidepressants, but I kept going down. Then I fell, tore my ACL, and was given tramadol. Yes, it helped with pain. But for the first time in nine years, I was not depressed! Occasionally happy? I thought, what is causing this? Long story short, it was the tramadol working as an antidepressant. It has given me quality of life. And the dependency issues? If dependency means I can experience joy again, using the same daily amount, so be it. It should not be so difficult for doctors to prescribe."

9 / 10
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  • Dreda...
  • October 5, 2016

"So for pain they're just alright, like a 7. They do last longer than other pain pills, but for my depression, I feel like a better, more capable man when I'm on them. When my supply is gone and I can't find a doc or medical help, I become suicidal. With them, I can live a normal or somewhat normal life."

10 / 10
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  • mrstc
  • December 29, 2015

"I have had major health issues all year: three bulging discs in my neck. I got the pain somewhat masked with multiple rounds of injections and finally burning the nerve endings in my neck, so that I am no longer waking every morning in pain. I subsequently tore a ligament in my shoulder and am now having to start physical therapy and see an orthopedic doctor. I have been taking muscle relaxers as well as hydrocodone. Having constant pain issues for so long has made me feel depressed, all I want to do is work and sleep. Today, I went to my medicine pantry and pulled out a bottle of tramadol that I had been prescribed previously. I took one, and within an hour, the fog lifted, and I feel 100% better! I will be taking this daily now."

10 / 10
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  • BlueM...
  • July 3, 2017

"I originally took Tramadol for pain. I previously had bouts with depression, which totally consumed me. I tried Tramadol (50 mg noon time and one at bedtime.) It pulled me out of the depression before it took me over. Works great."

9 / 10
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  • Anonymous
  • Taken for 2 to 5 years
  • April 17, 2023

"I've been using Tramadol for my treatment-resistant depression for about 3 years now, taking 300mg every day, and I feel like my life has improved significantly. I used to barely be able to get out of bed in the mornings. I used to work for just 3 hours a day, and even that felt like too much. Now, I'm working 7 hours a day without any problems. I have no issues waking up at 3:45am each morning, and I spend all day feeling energized and content. I'm honestly amazed at how well this has worked for me. I've also had to stop taking it a few times, and haven't experienced any withdrawal symptoms despite taking it so frequently, nor have I ever had to increase the dosage in three years of use."

10 / 10
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  • Carlr...
  • Taken for 10 years or more
  • October 11, 2022

"Without tramadol, my treatment resistant depression would keep me from getting out of the bed each day. I'm able to just function - get up, feed, clothe myself, and to take care of other normal responsibilities. Besides, when I am not on it, my thoughts are abjectly self destructive and even suicidal. I have never taken this drug recreationally, never! I need it, because all other medications made me feel worse, or made me feel like a zombie, spaced-out. Nothing else came close to helping me. For the help that it provides, I'd say that it'd be downright cruel to keep this and other drugs (mushrooms) from people who need them for health not abuse."

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  • Notwell
  • October 4, 2015

"Given to me for pain, didn't work for that but it worked great for my restless leg syndrome and my depression. I take 4 at once a day in the afternoon. I never take more than that. I am addicted, tried to stop taking them for 2 weeks and I felt so sick and weak. I also started getting these weird tings in my head, like a rubber band snap sensation. I can't stop taking them. If I do I can't function well."

10 / 10
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  • GSW
  • Taken for less than 1 month
  • September 22, 2023

"I am a Polio survivor and suffer from PPS. Now degenerative disc. Nothing helped even facet injections. Finally my doctor prescribed Tramadol and it works a lot. But... I didn't realize it was good for depression and anxiety. What a difference, I feel so much better. I read all the scary literature, side effects, etc. Not true. So glad I found this. I am 76 years old and no side effects, plan on taking forever. I take 50mg at night and sometimes another 50 during the day."

10 / 10
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  • Pix3L
  • Taken for less than 1 month
  • November 18, 2018

"I have been on Suboxone for 2 1/2 years. I've always had issues with depression/anxiety. However, the Suboxone has made my depression/anxiety 1000 times worse, and I have been put on different kinds of SSRI/SNRI medications, nothing has worked. I did some research on Suboxone combined with tramadol, and let me tell you, I was my bubbly self again. I felt amazing for the first time in a long time. The opiate side of tramadol gets blocked by Suboxone, so it's tramadol's anti-depressant component that is working its magic on me. The doctor will not prescribe this to me since I am in addiction treatment, he won't even prescribe me an anti-depressant that matches tramadol's. I have made my situation even worse now since I got to experience tramadol's anti-depressant magic knowing I can't get that medication prescribed. Imagine every waking day in mental misery and someone hands you something that makes it all go away but to be told you will never get it."

10 / 10
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  • Margie
  • Taken for 2 to 5 years
  • July 1, 2019

"Peripheral neuropathy slowly but surely stole my mobility. With that came a loss of social contact and a depression that I had never experienced before. I tried therapy, B12, exercise, health foods, and supplements. Still, I woke up every day with the same goals and hopes as always, but a body that was fading. Maybe tramadol does not bring back mobility. But the energy level increase and the relief from sadness works like nothing else. My neurologist approves. She has seen me function with and without it. I am grateful she prescribes for me to have some quality of life. I know some physicians won't."

10 / 10
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  • Jimmix
  • November 10, 2015

"I found this drug to be very useful for pain. I have Crohn's disease, degenerative disc disease, migraines, bipolar disorder, PTSD, and anxiety disorder. I take tramadol, 3 pills a day, 150 mg total. The only thing I don't like is that when I skip doses, I get awful side effects like a buzzing or vibration in my head. So I am unable to skip days of taking it, or I feel very awful."

9 / 10
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  • Sunny
  • Taken for 2 to 5 years
  • May 28, 2021

"This medicine is a miracle. I swear. Low-dose tramadol taken as a regular antidepressant has saved my life. I used to be able to not drive and have almost seizure-like problems. I wasn’t able to go out of my house or do anything. I have major social anxiety as well. This medication changed my life!!!! I mean it! I have tried every single antidepressant out there, and they all make me ill. Like a zombie. They make me sad. And if you miss a dose, watch out. I was on tramadol for 2 years, and when I got off of it, I had zero issues as well. I was on Xanax for a couple of years a while ago, and it’s what ruined me. Tramadol saved my life. Please look more into this! I’m so healthy because of this medication."

10 / 10
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  • HardL...
  • Taken for 1 to 6 months
  • May 19, 2015

"Tramadol is about the most effective drug in the world for depression - for immediate, short-term relief ONLY though. During the initial dosing period, 100 mg twice a day utterly obliterates any negative thinking or depression symptoms. It delivers results immediately, vs. the necessary patience of waiting a few days or weeks with traditional SSRI drugs. However, tolerance DOES build to tramadol at a pace far more rapidly than with traditional anti-depressants. I had 2 months of solid relief from 100 mg 2x daily, but by the third month this dose barely made a difference and my mood continued to sink. Instead of upping my dose, I went back on Zoloft, which delivers less immediate, but more consistent long-term results for me."

7 / 10
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  • Dallas...
  • Taken for less than 1 month
  • June 9, 2017

"I have treatment-resistant major depression, and as a result, I've taken so many drugs over the years that I can't list them all. I got kidney stones a while back and got tramadol to help me with the pain. It didn't help much for that, but it sure helped treat my depression. I talked with my primary care doctor about this, and she's reluctant to prescribe it if it isn't for pain. As a result, I'm going to find a new doctor... one who knows a bit more about psychiatry."

10 / 10
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  • HikeM...
  • Taken for 6 months to 1 year
  • March 16, 2017

"I, as many of you, have struggled with major depression for a long time. For me, it comes and goes - with a terrible onset towards the end of the winter months. I've tried 4 different antidepressants with no success. Actually, Wellbutrin did help - but I ended up being allergic to it. Go figure. I was prescribed Tramadol for pain last year during a hip problem I was having, and wow, did it help my mood. I didn't feel so broken. This year I am suffering from depression again but haven't started on Tramadol yet. I am nervous because of its addictive qualities, but I cannot keep calling out of work and risk losing my job. It is a terrible feeling. All your posts have been very encouraging, so thank you for sharing!"

8 / 10
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  • BadDad
  • Taken for 2 to 5 years
  • June 9, 2019

"This wonder drug appears to have some big fans! I don't have too much to add, just a few things: Dependency level: I think about dependency as coffee in my opinion. I usually take one 50 mg pill a day (which seems a fairly common dose for you commenters, with no craving for more than that) - I think I've been a self-medicating kind of guy for most of my life for mild to moderate depression, alcohol mostly. Most mornings with a mild hangover and the depression that came with it. Until I started taking Tramadol for a neck injury that is. Amazing first aid for a hangover and the blues! This fact has been an enabler for drinking too much, but lately I'm using Tramadol to quit drinking and with good results. Sleep super well and wake feeling great!"

10 / 10
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  • Evilm...
  • Taken for 1 to 6 months
  • May 31, 2015

"If you decide to take this med, or your doctor wants you to, ask for the XR version. It truly is 24 hours of pain relief. I take 100 mg XR every night, and the best part is that you get to wake up mostly pain-free. The mild pain relief all day can be enhanced easily with Tylenol. I have tried muscle relaxers, creams, injections, opiates, and this is the only med to be side-effect-free and mixes well with over-the-counter pain meds to manage. The last thing is the mood elevation that accompanies the XR version, I actually stopped taking my antidepressant. This works better than anything I have ever taken for my depression, though anxiety is not helped that much."

8 / 10
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  • marty
  • November 7, 2019

"Not only does this drug help me with a herniated disc in my neck and back pain, it also gives me tons of energy and makes me feel happy and more outgoing. I feel like I can get so much more done while taking this, this really should be prescribed over antidepressants. I took Lexapro for a while, and tramadol seems to put you into a good mood instantly. I take one 50 mg pill a day, it works perfect for me."

10 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.