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User Reviews for Desvenlafaxine to treat Depression

Also known as: Pristiq

Desvenlafaxine has an average rating of 6.9 out of 10 from a total of 750 ratings for the treatment of Depression. 59% of users who reviewed this medication reported a positive effect, while 23% reported a negative effect.

Desvenlafaxine Rating Summary

6.9/10 average rating

750 ratings from 805 user reviews.

Compare all 189 medications used in the treatment of Depression.

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Reviews for Desvenlafaxine

omr2012 · Taken for less than 1 month July 22, 2021

Pristiq (desvenlafaxine): “Pristiq took away my depression in 5 days and I don't think I have any side effects. Best anti depressant I've been on. I've taken Lexapro which helped the suicidal thoughts but I couldn't grasp happiness. Then Cymbalta but I got suicidal sometimes. This one is the best of both.”

10 / 10
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Aljo · Taken for 1 to 6 months July 17, 2021

Pristiq (desvenlafaxine): “I've recently come off lexapro due to some side effects, loss of sex drive and ejaculations without orgasms. How weird is that? Anyway I'm now on Pristiq and the fog has lifted. You forget how good life can be when you're in the spirals of depression. But be active in your care and keep trying different meds because one day you'll succeed. I think Pristiq is my 6th attempt at finding my happy place. For some of us there is a family history and a very real reason we are depressed. If your brain is constantly reuptaking your feel good hormones then it's out of your control til you can balance that out. I wanted to write this to give some hope and to keep trying. You are important and you deserve the best health you can achieve. Good luck and keep being brave.”

10 / 10
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oddcabinet · Taken for 1 to 6 months July 16, 2021

Pristiq (desvenlafaxine): “Pristiq made me even more depressed and anxious. I had to check myself into the hospital because of suicidal thoughts because I was on this medication. I'm sure this helps many people, but it hurt me. Once I came off it and went on Lexapro, I started doing much better.”

1 / 10
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No_more_denial August 18, 2020

Pristiq (desvenlafaxine): “Picture this: I am dressed and ready to sell someone’s house and before I can open the door and leave I freeze. I feel impending doom. I can’t move. I can not leave the house. So I undress with tears in my eyes, cancel my appointments and creep into bed. Completely ashamed and disappointed in myself. This has affected so many aspects of my life. Everyone sees a happy, confident person... which triggers the depression.... and denial. They don’t know the mental illness I hide. I couldn’t hide it any longer.I went on Pristiq 50mg two years ago. I would take it at night and sleep well & after 6 months I got off of... slowly but surely it came back. This time my dose is 100mg. I was in complete denial but I’ve been humbled and won’t take my mental health for granted. No more hiding in bed. No more fear of the mail man or someone knocking at my door. No more panic attacks. Don’t suffer. Live better and be well.”

10 / 10
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rbc123 · Taken for 6 months to 1 year February 16, 2020

Pristiq (desvenlafaxine): “I never write reviews on ANYTHING online but after being precribed Pristiq for anxiety and reading multiple negative reviews I thought I'd write about my positive experiencing with this medication. I am 31 years old and have been experiencing moderate to severe anxiety my entire life. Last summer I began taking this medication and I won't lie... the first 4 weeks were rough. Decreased appetite, increased anxiety and just very spaced out. Saying this, once you get passed the 4-6 week adjustment period this medication is LIFE CHANGING. And yes I know that this medication does not help everyone who takes it but I encourage people to tough through the adjustment period. I honestly wish I knew about this medication earlier. And yes there are still lows you will feel, this is life. And this is not a magic pill... but completely takes the edge off. I wake up feeling great most days, I have increased motivation, little to no self doubt, increased appetite, increased sex drive, etc.... the list goes on.”

10 / 10
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Crazybananas February 12, 2020

Pristiq (desvenlafaxine): “So I had to share my experience because I’ve read so many reviews of so many different drugs. I was on every possible SSRI from primary care dr. The side effects were horrible. I mean HORRIBLE. Zoloft, lexapro, celexa, Prozac.....you name it I tried it. Finally got smart and went to a psychiatrist at the advice of my therapist. Hallelujah! He put me on pristiq and within days I felt better. It’s been two weeks now and he just doubled my dose. I take 25 mg at 7 pm and noticed by the next day around 2 I was getting anxious, clenching my teeth, etc. so he has upped it to 50mg. He also gave me Ativan for when my anxiety is at full tilt. I’ve had no side effects. I just want to give people hope. You can’t go by the reviews because we all react differently to medicine, but don’t give up. See the right professional. I also did the mouth swab thing to see what medicines might be a good fit. With the $$$$$. Good luck to whoever is reading this and stay strong”

9 / 10
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munik July 9, 2010

Pristiq (desvenlafaxine): “Give Pristiq time. I've been on Pristiq for 3 and 1/2 weeks and the first 2 weeks I had hot sweats, nightmares, irritability and increased anxiety. I wanted to quit but I resisted, and then WOW the 3rd week I started feeling WONDERFUL! Side effects disappeared, lost 7 pounds, and have sex drive again. As a mother of 3 little kids and working, I felt more optimistic, energetic and enthusiastic! I love my work again, which I did a long time ago and I am much more loving with my kids and husband and show much more affection to everyone. This is who I really am and was 5 years ago! It has made me want to exercise and play with my kids again! Dont quit early give it TIME to Work. I thank God and pray for all of you that you find peace , happiness”

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Frequently asked questions

Johney · Taken for 1 to 6 months February 23, 2020

Pristiq (desvenlafaxine): “I found this drug to be extremely helpful. I haven't felt this good in years. I started with 25mg and it took approximately 4 weeks to start noticing the benefits. My therapist recommended I take the medication after having a serious panic attack that left me anxious and worried for my own personal safety. Never been that low before. Now about 5 weeks in, I'm feeling great and we decided to up my dosage to 50mg. I've had zero side effects as of yet. My advice to anyone on here who's curious about the drug to give it a try. And give the medicine time. It takes time to fully take effect. Like I said, it was weeks on end for me. Felt like an eternity. I'm more optimistic, motivated to accomplish goals, less anxiety, etc. Medications are like shoes; not every shoe is well suited for every single person on Earth. The same could be said with regard to medication. Take care all. Feel better.”

10 / 10
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Billy · Taken for 5 to 10 years March 10, 2020

Pristiq (desvenlafaxine): “Pristiq 50 mg is the ONLY medication which has worked for my depression. Good sleep Good appetite Upbeat, consistently good mood. I have tried everything else and nothing Worked OR I had bad experiences. This is my fifth year on Pristiq. If you’re without hope, ask your doctor. It’s been a lifesaver for me.”

9 / 10
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Mylifeisruined · Taken for less than 1 month June 19, 2021

Pristiq (desvenlafaxine): “I have never wanted to take any SSRI or SNRI, but I became very depressed and was desperate, so I listened to my doctor who told me to try pristiq and give it 4 weeks. I suffered almost every side effect, yawning, insomnia, increased anxiety, tinnitus, sweating, incapable of having an orgasm, vivid nightmares. I took pristiq 50mg for 4 weeks and I only had 1 day that I was not depressed. I quit taking it after 4 weeks of sleepless nights and a very loud high pitched ringing in my head. 2 weeks of feeling dizzy and extreme headaches, then 2 months of bad headaches and extreme anxiety. Now 4 months off prisitq I have very high anxiety, headaches, and the worst is tinnitus. Pristiq ruined my life. After researching I realize that this tinnitus is probably not going away, since it has been 4 months, and I am devastated. The ringing is intruding my brain every second and my anxiety has grown uncontrollable along side the tinnitus. I wish I never took pristiq.”

1 / 10
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Munzkay May 25, 2021

Pristiq (desvenlafaxine): “I have been taking generic Pristiq for several years and it has really helped. Got a refill and the bottle looked different. The pill was also different. After about 5 days, I began to get dizzy, light-headed, has problems sleeping and very anxious. It was from a different manufacturer. Stopped taking it and the dizziness has stopped, been able to sleep but have been having anxiety. I had no problems until different the pharmacy got the supply from different manufacturer.”

9 / 10
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ecalho01 June 24, 2008

Pristiq (desvenlafaxine): “After trying several of the top ten antidepressants and never feeling exactly right - and gaining at least 30 pounds per episode - after only 2 weeks on Pristiq I have never felt better and have energy and the desire to live and exercise.”

10 / 10
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mtl222 · Taken for 1 to 6 months February 21, 2020

Pristiq (desvenlafaxine): “I have been on Pristiq for 1 month and a half. The first week felt weird : I had headaches, anxiety, couldn't eat, difficulty to sleep. Then the physical side effect went away and I started to feel better but it was very subtle and slow but steady change. After 1 month and a half I can say that I feel a lot better. I have more energy, more sense of control on my life. One thing that stays is that I have to drink a lot of water to stay hydrated. I have skipped a dose once and it wasn't bad, I didn't cry or felt horrible.”

9 / 10
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Full of Life again March 10, 2010

Pristiq (desvenlafaxine): “I suffer from Dysthymic Depression and had been on Prozac until it stopped working and I started having suicidal thoughts. I've been on Pristiq for 3 months and it has changed my life for the better. I take it in the morning so I sleep at night. I am no longer tired. I have tons of energy and have a zest for living again. I have dropped 12 lbs and it does not affect my energy levels for running, biking and weight training. I can focus better at work and my sex drive has returned after being dulled for the past 7 years. My husband is thrilled. This drug has been a positive step for me.”

10 / 10
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ombrelle · Taken for 1 to 2 years April 9, 2021

Pristiq (desvenlafaxine): “I have been taking Pristiq for more than a year now for anxiety and depression. The first month wasn't great, my anxiety increased, had trouble falling asleep, feeling nauseous. After that, these were the side effects that stuck : sweats, it takes more time to orgasm, brain zap when I forget a dose. I definitely feel better, I have a better feeling of control over my life. I don't have suicidal thoughts anymore. It gave me hope that change is possible and we don't have to accept feeling that way for our whole life.”

9 / 10
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Mutaza · Taken for less than 1 month May 11, 2019

Pristiq (desvenlafaxine): “Update on my experience with Pristiq, I’ve been taking 50mg for over 2 weeks now for depression and I am incredibly happy with the results no negative thoughts or depressing thoughts, so it is working. I can honestly say if I didn’t find this drug I would be dead In 5 years. Sad but true. I have everything anyone could ask for but my mind tells me otherwise, so selfish considering others in this world have to deal with a hell of a lot more!”

10 / 10
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LeTronique · Taken for 2 to 5 years June 22, 2021

Pristiq (desvenlafaxine): “3 years ago, I started taking Pristiq. Had to stop for a year after new job insurance declined to pay for it. Just got back on it and now I realize how useful it was as a med. Immediately, I noticed muscle pain all over including my chest when I started taking it 3 years ago. I was much more emotional and positive after taking Pristiq for about a week or so, but I'm sure the lamotrigine was preventing any mood swings. Pristiq makes me sweat like crazy! It was harder to achieve orgasm if you take a higher dose. However, my BuSpar negates the effect considerably so my sex life is still (thankfully) intact. It beats Effexor in this regard. The muscle pain goes away in a month or so. The teeth grinding goes to a minimum with time. After one week starting at 100mg (terrible idea BTW but really didn't want to taper off of Cymbalta) I still have the muscle pain but I'm kissing my spouse a lot more and I'm looking toward the future positively. So, I guess it's a win for me.”

8 / 10
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Niko · Taken for 6 months to 1 year February 13, 2020

Pristiq (desvenlafaxine): “I'm on Pristiq 50 for 9 months. I have had no negative side effects except brain drain when missing a dose. I like it so much that I want to try a higher dose. I've been depressed for decades. I've tried most other SSRIs antidepressants with mixed results. Pristiq is for me the best of the lot. I'm very surprised to read so many reports of adverse reactions.”

9 / 10
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butterfly72 · Taken for 1 to 6 months May 27, 2019

Pristiq (desvenlafaxine): “Don’t be too scared to try Pristiq. Give it a chance. Everyone comes here to write horror stories but for me this really helped with my anxiety. If it works really well for people they don't tend to return to review as they are busy enjoying there lives. It also really helped me sleep and made me sleep feel more restful. The first few days taking it I had kind of migraine like symptoms, very tired, but just plan accordingly and know that will all most likely pass. Any antidepressant will have an adjustment period. The only lingering side effects I have are dry eyes and mouth especially in the morning. Good luck!”

7 / 10
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Anonymous February 15, 2010

Pristiq (desvenlafaxine): “I am a 77 year old male. My Grandfather and my Father suffered from Depression. I have suffered from depression all of my life. I was first diagnosed with severe clinical depression about 1975. I was put on ELAVIL and the results were very good and I took it for about 12 years. At that time the ELAVIL stopped working and my Doctor put me on NORTRIPTYLINE. That seemed to stop the depression and worked for a long time. When it stopped working, my Doctor put me on PAXCIL. Then, a Psychiatrist added WELLBUTRIN XL. Then my PDOC replaced the generic PAXCIL with PRISTIQ. For the first time in 40 years, my depression has gone!”

7 / 10
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JanLeigh October 4, 2008

Pristiq (desvenlafaxine): “I just started Pristiq Exrelease 50mg about 6 days ago. I am just learning more about this drug. All these comments are very helpful, I have much, much hope. I have anxiety issues, panic disorder, and some depression. I have also noticed decreased hunger. Please continue writing in it can make a big difference to people like me. Thank you!”

8 / 10
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Anonymous January 31, 2010

Pristiq (desvenlafaxine): “Started with Wellbutrin 300mg - I was way to agitated -- went to Cymbalta - loved it except for the lack of ability in the sack. Went to Celexa - worked okay stayed on it for 3 months but never felt anything. So during the 3 months doctor added Wellbutrin - does not help. Celexa made me feel - no sorry it didn't make me feel anything but overall in some ways I kind of liked not feeling but that is not life. So the doctor changed to Pristiq -- WOW I feel alive, energetic, really great. I hope this continues. Oh yea .. no lack in the sack on this one. My real message here is that I hope each of you continues to work with you doctor and find the right medicine.”

9 / 10
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F*ckpristiq February 14, 2020

Pristiq (desvenlafaxine): “I would not wish upon my worst enemy the hell I went through with this drug. My doctor at the time suggested this antidepressant to help maintain my growth & help my energy... this was the first year it existed and of course was expensive because there wasn’t a generic brand, it ruined my life. Everything in the small print happened to me. I slept on average 2 hours on my bathroom or kitchen floor because I felt suffocated in my bed. Everything irritated me physically. All I did was clean as if I was trying to get rid of something so toxic (pristiq) that my life depended on it (it did..) I lost a lot of my hair/eyebrows and I was going crazy, literally. Eventually I got off it, which was like detoxing from a hard drug, such as heroin or meth. I was on it for 6 months- I have been off it for many years, but I still struggle with the reality of what it took away from my life- so many years trying to pick up the pieces of the horrific reality I lived while on Pristiq.”

1 / 10
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Kay · Taken for 1 to 6 months February 19, 2020

Pristiq (desvenlafaxine): “Had a DNA test to recommend what type of anti-depressant I should be taking....I had been on Venlafaxine for years after refusing others. Pristiq was recommended by this test for me to take. I did notice a number of positive changes taking Pristiq......Generic "Desvenlafax." I am more alert, Have somewhat more interest in life. No longer think about dying. It doesn't control my anxiety so therefore I take a mild dose of klonopin when needed. It did not give me energy but helps making me get up and around. I take 50 mg's a day. I do sleep 10 to 12 hours a day....sometimes not waking up during that time but I know that's the depression.I do take Amitriptyline for pain from Spinal Disk Degeneration pain.”

8 / 10
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Hdgmomma April 25, 2021

Pristiq (desvenlafaxine): “I FINALLY was able to wean off of this awful drug! I should have stopped taking it the first week when I couldn’t sleep and had zero appetite from stomach pains. I began taking it in the fall of 2018 when Lamictal started giving me mood swings. Once I got past the first month, I thought all was good. Since then, I have been out of work three different times for weeks with severe dizziness and fatigue. Come to find out this medication was causing my blood pressure to significantly drop! Apparently with this you have to increase your sodium intake because this can happen (if you already run on the low side). I’ve put on weight from the lack of energy, and weaning off of it is like no other because you can NOT cut it. It took me over a month to get here (disclaimer: I did talk to my therapist and doctor). It is now April 2021 and I wish I would have gone with my gut instinct and been more persistent about not taking this.”

2 / 10
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NYC GIRL November 17, 2008

Pristiq (desvenlafaxine): “This drug is amazing. Before taking it I would eat non-stop and obsess about food because of my depression. Now I only eat when it's meal time and don't even think about it any other time. I sleep great, have more energy and the only side effects were mild nausea the first couple days. The depression is gone and I feel so much better. I'm taking 50 mgs once per day.”

10 / 10
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TMc · Taken for 1 to 2 years January 10, 2020

Pristiq (desvenlafaxine): “I tried many meds over the years that would only work for a short time. Started Pristiq one year ago. Iv'e stayed on 25mg which is normally a step-in dose. It works great for me. I was very tired the first three days but since that time I haven't had any side effects at all. This med has given me my life back!”

10 / 10
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Gratefulmeduser · Taken for 6 months to 1 year November 25, 2019

Pristiq (desvenlafaxine): “After 20+ years on SSRIs, I have a new lease on life with only 25mg pf Pristiq. I’m alert, in a positive mood, and have lots of energy. This has lasted for 6+ months. This drug is so much better for me than were any of the SSRIs (I tried probably all of them). The only reason I give 9 stars is because of low appetite and constipation side effects.”

9 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.