Skip to Content

User Reviews for Lamotrigine to treat Depression

Also known as: Lamictal, Lamictal XR, Subvenite, Lamictal ODT, Lamictal CD

Lamotrigine has an average rating of 7.1 out of 10 from a total of 138 ratings for the treatment of Depression. 64% of those users who reviewed Lamotrigine reported a positive effect, while 25% reported a negative effect.

Lamotrigine Rating Summary

7.1/10 average rating

138 ratings from 141 user reviews.

Compare all 189 medications used in the treatment of Depression.

10
38%
9
17%
8
9%
7
2%
6
1%
5
4%
4
3%
3
5%
2
4%
1
15%

Reviews for Lamotrigine

FramptonZ · Taken for 1 to 6 months June 19, 2021

“I suffer from depression and severe anxiety. I have tried many many antidepressants, nine of which worked. I have been on Venlafaxine and Mirtazapine to no avail. Psychiatrist then recommended adding Lamotrigine to those two as a last stop before Lithium. No side effects noted and raging hunger has gone. Almost from Day 1 I started feeling a bit better. Now 3 months down the line taking 50 mg a day I feel like my old self. Anxiety is virtually gone and I enjoy my life after months of misery. It has worked for me, I hope it works for you.”

10 / 10
Was this helpful?YesNo
dmy25 June 4, 2021

“I’ve been on many SSRI’s and anxiety medications, & this has 100% been the most helpful one I’ve ever taken. I’m diagnosed major depressive, GAD, OCD, PMDD, & agoraphobic & this medication has saved my life. It’s the first med I’ve taken that had minimal side effects. When I first started I would get a bit of nausea after about an hour & then get really hungry. When I took it after a meal or with a snack it stopped happening. I can’t take it at night because it will give me some crazy dreams so I usually take it around lunch. My anxiety has decreased dramatically, I have a range of emotions now instead of just sad or angry & they’re very even, I’m getting housework done, I’ve stopped waking up in the middle of the night at 3am every night, & I’m enjoying time with my family. If you’ve been prescribed this medication and are nervous, please try it. It is a slow build up so don’t go into it expecting the process to be quick. It’s definitely worth it though.”

10 / 10
Was this helpful?YesNo
backtome May 4, 2021

“I have drug resistant severe clinical depression. Since 1982 I’ve tried every drug possible all with side effects. I’ve taken Lamictal for the past 20 years and I have to say it has, without any doubt whatsoever, saved my life including giving me a quality life. Lamictal for me is a godsend and I’ll never stop taking it -Back To Being Me”

9 / 10
Was this helpful?YesNo

Frequently asked questions

Jay · Taken for 1 to 6 months February 10, 2020

“the first day on lamitrogine has been an absolute life changer! I was having severe hopeless depression paired with anxiety. My moods seemed to shift from one to another triggered by hormones or stress. It developed into eating disorder over time untreated. I've tried every SSRI and off label blood pressure meds etc. I always have them a good run and they always had a lot of side effects and made my original symptoms worse. Then after research I asked my psychiatrist for lamictal. I had 0 side effects!! I started at a dose of 25mg for 2 weeks and am at the end of 2 weeks on 50mg. I felt the difference by the second week of 25mg and even more at 50mg. I have felt so hopeful and excited at times in perfectly healthy ways and depression and anxiety is all but gone. I don't feel doped up at all just a better version of me than I have ever felt. Also unlike SSRIs this doesn't impact sex drive and if I get pregnant it's safe. Love and plan to stay on it for a long time. It's worth it!”

10 / 10
Was this helpful?YesNo
DeeB · Taken for 6 months to 1 year August 24, 2019

“Lamictal has changed my life!!! I have had medication resistant depression for over 30 years. I am now 60. Have been on every med out there only to keep from being suicidal at best. Was on abilify for 3 or 4 years with Viibryd. Gained 30 lbs and cholesterol went sky high. So as a last resort decided to try lamictal. I am on 150mg and 30mg of Viibryd. It has totally changed my life. I am no longer depressed at ALL! My friends and family are amazed at the difference they see in me. I am socializing with people and taking care of myself again. I think I feel better than I did before being diagnosed with depression. Now I know we all react to meds differently but if you are having trouble finding something that works this is worth a try. I have major depression, not bipolar. I say that because most things I read about using lamictal was to help with bipolar. But it can also help as an add on to your antidepressant. I thank GOD I found out about it.”

10 / 10
Was this helpful?YesNo
E · Taken for 1 to 6 months October 30, 2019

“I'm diagnosed ADHD, anxiety, depression and PTSD and have been in a very dark place for months and very depressed and anxious and suicidal thoughts. I'm on several medications for months, Venlafaxine, Wellbutrin and Vyvanse which are little to no help. Lamictal was added and I'm now on 100 mg daily in the morning and my depression is entirely gone and so is my anxiety. I don't get mood swings anymore, I am calmer and less pessimistic. I've had no side effects except some minor itching upon dose increases lasting for a day or so. I don't feel emotionally numb. I just feel like a calmer, more logical, happier version of myself. I've tried so many medications over the years for my depression and anxiety (over 20) and this is the first one to truly help. A miracle medication for me. It can take time to find the right medications for you but don't give up hope.”

10 / 10
Was this helpful?YesNo
MT Gal · Taken for 1 to 6 months November 16, 2019

“I’ve been on Lamotrigine since mid-August. I titrated up slowly and am at maintenance dose of 200mg daily. I was on every depression/anxiety medication you can think of for the past 20 years. I had to wean off those as lamotrigine was introduced. So far it has made a remarkable difference in my moods, my depression, my motivation. I love not laying in bed all day. Going on it was not easy however. My anxiety was high, migraines, fatigue, insomnia. These have resolved but it’s taken 3 months. I’m thrilled at the difference it made in me and pray it continues to work! Remember it took months and 200 mg dose until I felt better.”

9 / 10
Was this helpful?YesNo

More FAQ

Leela · Taken for 6 months to 1 year October 14, 2019

“I believe I’ve been misdiagnosed with bipolar disorder. I’ve never had a manic or hypomanic episode. Ever. I was put on 200mg of Lamictal, along with other meds. I feel completely flat and I think it’s the Lamictal. I have no emotions and my motivation is extremely low. I KNOW I love my daughter but I don’t FEEL that love. This is an example of having no emotions. And I hate it. I WANT to feel that love. I want to feel ANYTHING. I’m just flat.”

2 / 10
Was this helpful?YesNo
CaliforniaPrison · Taken for less than 1 month August 24, 2020

“I was telling my doctor about my severe depression, anxiety, panic attacks, ADHD/restlessness and he prescribed me this drug lamotrigine. After 4/5 days of taking it, I had extreme anxiety, could not stand being at work and my thoughts convinced me that if I just drove to the golden gate bridge and finally did it, all my problems would be solved. I have never been actively suicidal, so as I noticed these thoughts I looked it up and apparently its a rare side effect from this drug. That is something my doctor never told me before taking it. IT CAN MAKE YOU FEEL WORSE!”

1 / 10
Was this helpful?YesNo
Hot_Potato · Taken for 6 months to 1 year August 27, 2020

“When I first started Lamotrigine, I was having crazy nightmares for for the duration of the "starter kit". Once my dose got adjusted to 300mg, the nightmares stopped and I started making progress on getting my life together. I know it's working in some subtle way... At least I can look at nature and appreciate its beauty, again.”

8 / 10
Was this helpful?YesNo
Jason · Taken for 2 to 5 years May 21, 2019

“I started lamictal during a life upheaval leading to acute, severe depression and after a bad reaction to lexapro (worsening depression and suicidal). Starting at Lamotrigine 25mg within 1 to 2 days I felt immediate relief. I worked up to 75mg and stuck with that for several months. Circumstance lead to worsening depression and went to 150mg once daily and now at 200mg and holding steady. I have stopped years of benzo, Ativan, Klonopin, Xanax. Now only take Lamictal. This medication provides a wall against depressive thoughts, behaviors. Also mood swings and rage issues that I suffered most of my life are almost completely absent. This med has given me a chance to live happily even during times of great change and struggle. Time to time I consider going off, but I'm afraid of relapse. Have been taking 3 years.”

10 / 10
Was this helpful?YesNo
Mysfyt · Taken for 6 months to 1 year September 30, 2014

“Tried everything from Depakote to Lithium and every antidepressant with them. Finally paired Lamictal (Lamotrigine) with Lexapro (Escitalopram,) and hit the jackpot! I'm Unipolar (severe depressive,) and the 300mg ER Lamotrigine with 20mg Lexapro has kept me totally mood-balanced and low-anxiety. After 20 years of different meds, I finally feel like myself.”

10 / 10
Was this helpful?YesNo
Katy G · Taken for 6 months to 1 year July 17, 2015

“This medication saved my life at a time when I was severely suicidal. I finally feel "normal" after 5 years battling MDD and GAD. Tired citalopram, vibryd, Zoloft, Effexor, Xanax and some others I can't remember. Tried holistic and homeopathic remedies. I just kept getting worse and worse. I have no side effects, my depression and anxiety is completely manageable and I feel like I have my life back.”

10 / 10
Was this helpful?YesNo
Becky · Taken for 1 to 6 months January 11, 2021

“I’ve been titrating up slowly on Lamotrigine. I’ve been taking it for about six weeks now and am up to 100mg a day. I have had no side effects, but I’ve also had no relief from depression or anxiety yet. In fact, I believe that my depression may be getting worse. I’m getting very discouraged and losing hope.”

1 / 10
Was this helpful?YesNo
Angie · Taken for 2 to 5 years December 20, 2019

“Lamictal has been a live-saver for me. I began taking it as an inpatient at 16 years old for very severe depression, and now after two and a half years I feel like my mood has completely leveled out. I don't experience extreme highs and lows anymore, I just feel normal. That doesn't mean I never get sad or never feel happy, just not to the extremes that I used to, which I'm totally fine with. The only problems I've had were that it took a really long time for it to start working for me; I still found myself experiencing depressive episodes six months after beginning taking it. However, they weren't as bad as they were before, and after another several months the depressive episodes were pretty much nonexistent. Also, it didn't help much for anxiety like I was told it would, but it didn't increase anxiety for me either.”

9 / 10
Was this helpful?YesNo
Rick23 September 20, 2015

“I have had depression episodes all my life and had never been medicated. Three years ago, I had a huge burnout and finally opted for meds. I have tried Celexa, Effexor, Abilify & Cipralex. All of them helped to some extent but not to completely stop the depression in the long term. My psychiatrist recommended Lamotrigine. I had seen on this site so many positive reviews that I decided to try it. Like many others, it has been a miracle drug for me. I have been on it for 3 months now and aside for 2 or 3 small bumps on the road, I feel great! Except for dry mouth (not that bad), I have had no side effects. Don't give up! Good luck :-)”

10 / 10
Was this helpful?YesNo
Stacie331 · Taken for 6 months to 1 year January 18, 2016

“I am currently on a 150mg maintenance dosage. I do take this in combination with other medications because I also have Panic/Anxiety Disorder with Agoraphobia. A year ago I was in such a deep depression (for months). I was not exactly suicidal but often prayed I would go to sleep & not wake up. I began seeing a new psychiatrist & he immediately started me on Lamictal. Literally within weeks I noticed my depression was now under control! I truly believe this medication saved my life. I am definitely still a work in progress, but I am in a much better place. I can actually see the future.”

10 / 10
Was this helpful?YesNo
TippyKanoe · Taken for 6 months to 1 year February 21, 2016

“I have had anxiety since I was 18. Paxil worked wonders for me until after I had kids. From then on no SSRI's worked much any more. I found an amazing lady who helped me figure out what was going on. We agreed that I have mood disorder not otherwise specified. I don't fit the criteria for bipolar because I don't get manic and my depression showed up more as anxiety. Any how, I started taxing lamotrigine XR and it has changed my life! I get nervous I am going to jinx it by admitting out loud how much it has helped me:) I used to read these posts and pray I had the same positive experiences. I am glad to say lamotrigine XR has given me that experience! The firing in my brain is finally calm!!!!”

10 / 10
Was this helpful?YesNo
Wes · Taken for 1 to 6 months August 20, 2018

“I have fought anxiety and depression all my life. I am 38 now and on Lamictal. I thought that their was no hope after trying virtually every antidepressant on the market. Lamictal has me feeling the best in my entire life. Depression and anxiety are 95% gone. Truly unbelievable.”

10 / 10
Was this helpful?YesNo
notfine October 1, 2014

“I've been taking Lamotrigine for a few years. When I first started it, I was amazed. They gave it to me as a mood stabilizer. It helped tremendously. And still does. I've been afraid they'd try to change it. That was one of my first medicines for severe depression. It doesn't make you a zombie at all. I do struggle with the making you tired or sleepy side effect. But everything makes me tired and sleepy. I have a couple other meds and they all make you sleepy. I had no other side effects. I would highly recommend trying this medication if it's offered or suggested. Give it a couple months if you're not sure if it's working. Especially if you're trying it along with other newer medications.”

9 / 10
Was this helpful?YesNo
Wings · Taken for 1 to 6 months March 7, 2021

“I suffer from drug resistant major depressive disorder and generalized anxiety disorder. I titrated up slowly over a one month period to 125 mg per day, and stayed on 125 mg per day for 3 weeks. Lamotrigine made my depression much worse. I became completely hopeless, and suicidal. After discontinuing the Lamotrigine, I still feel persistently sad and filled with worry, but I no longer feel suicidal. Lamotrigine was not a good drug for me. I found zero benefit from this medication.”

1 / 10
Was this helpful?YesNo
whatsup1234 February 28, 2015

“generic, inexpensive, the best medication i have ever taken...thank goodness for lamictal/lamotragine....zero side effects....normal stable mental life without deep depression and ruminations...wish i had this in my twenties...would have made life so much more enjoyable....the only drawback (is temporary) which is the slow titration...some anxiety, night sweats especially as dose is upped...taking 150 now which is pretty mild...at night...makes sleep perfect...no benzo's...another bad med imo....u can also take a little more lamictal to deal with any serious anxiety stress episode...i don't understand why this is not first line... and as far as SSRI's....for most people a big mistake to go down this road in my opinion and experience.”

10 / 10
Was this helpful?YesNo
Love · Taken for 10 years or more September 30, 2019

“I've been on lamictal for over ten years. I changed psychiatrist due to moving. I told him that it helps with depression and bipolar. Now he wants me to go off of it. I tried to and became suicidal each time. I will not go off of it! It is a wonder drug! I highly recommend it.”

10 / 10
Was this helpful?YesNo
Anonymous · Taken for 1 to 2 years December 8, 2012

“This has been my savior, no longer flying off the handle at people, and my children not being afraid of me. I take this for several things migriane, anxiety, depression. I use this along with Zoloft, and amitriptyline for sleep.”

10 / 10
Was this helpful?YesNo
Anonymous · Taken for less than 1 month October 31, 2015

“The first day of taking (50 mg) I feel better then I have in YEARS! I have suffered with depression, anxiety, PTSD, insomnia, and BPD (a mess I know). I have been on every antidepressant and antianxiety med over the past 10 years and I have to say it has done wonders! Looking forward to many more good days.”

8 / 10
Was this helpful?YesNo
tried_it · Taken for 1 to 6 months February 11, 2020

“Everyone will have a different reaction to this, or any medicine, but for me, lamotrigine really worsened my depression. I felt emotionally unstable, and it was giving me bipolar symptoms of feeling like I had excess energy, which I never had before. I feel much better now after discontinuing it.”

1 / 10
Was this helpful?YesNo
DianaAtlanta June 5, 2015

“I suffer from major depression and was a little skeptical when my doctor prescribed as I am not bipolar. It really works great and I have been on everything. There have been a few times that I did not refill my prescription right away and if I went without for a week I went into major depressive state. Within a day of going back on it, the depression subsided a great deal.”

9 / 10
Was this helpful?YesNo
mamakitty3 · Taken for less than 1 month June 11, 2015

“I have went many yrs thinking I was not depressed. My symptoms were anxiety, mood swings and irritability and low energy. Other Drs tried antidepressant s and they always made me tired. Lamotrigine has truly shown me that it was depression. I have a much better mood and sense og calmness plus a little motivation boost!”

10 / 10
Was this helpful?YesNo

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.