Lamotrigine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Lamotrigine	Vraylar (cariprazine)	Caplyta (lumateperone)	Enter another drug to compare

Lamotrigine

Vraylar (cariprazine)

Caplyta (lumateperone)

Prescription only

Lamotrigine is used to decrease the frequency and severity of seizures in some types of epilepsy and also to stabilize mood in bipolar I disorder. It is an oral tablet that is taken once or twice a... View more

Prescription only

Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar I disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to... View more

Prescription only

Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more

More about Lamotrigine

More about Vraylar (cariprazine)

More about Caplyta (lumateperone)

Ratings & Reviews

Lamotrigine has an average rating of 7.8 out of 10 from a total of 1845 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 15% reported a negative effect.

Vraylar has an average rating of 6.1 out of 10 from a total of 530 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 32% reported a negative effect.

Caplyta has an average rating of 6.6 out of 10 from a total of 189 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 28% reported a negative effect.

View all 1845 reviews

View all 530 reviews

View all 189 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (7.3%)
Depression (6.7%)
Rash (5.6%)
Insomnia (4.8%)
Headaches (4.6%)
Memory loss (3.9%)
Weight gain (3.8%)

View all Lamotrigine side effects

Restlessness (16.4%)
Insomnia (14.7%)
Weight gain (12.3%)
Nausea (9.8%)
Anxiety (8.9%)
Tiredness (5.8%)
Hallucinations (5.5%)

View all Vraylar side effects

Headaches (14.8%)
Nausea (10.6%)
Dizziness (10.1%)
Dry mouth (10.1%)
Drowsiness (9.5%)
Tiredness (9.0%)
Weight gain (6.9%)

View all Caplyta side effects

Drug Class

Triazine anticonvulsants

Atypical antipsychotics

Atypical antipsychotics

Generic Availability

Lower cost generic

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	100 mg
Per unit^*	$0.22
Cost^*	$21.63

View all Lamotrigine prices

Quantity	20 each
Strength	1.5 mg
Per unit^*	$54.55
Cost^*	$1,090.96

View all Vraylar prices

Quantity	30 each
Strength	42 mg
Per unit^*	$61.18
Cost^*	$1,835.40

View all Caplyta prices

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Dosage Forms

Oral tablet
Oral tablet, disintegrating
Oral tablet, dispersible
Oral tablet, extended release

Oral capsule

Oral capsule

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

25.7 hours

504 hours

18 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 287 drugs are known to interact with Lamotrigine:

38 major drug interactions (272 brand and generic names)
237 moderate drug interactions (1620 brand and generic names)
12 minor drug interactions (47 brand and generic names)

A total of 578 drugs are known to interact with Vraylar:

94 major drug interactions (385 brand and generic names)
482 moderate drug interactions (1837 brand and generic names)
2 minor drug interactions (5 brand and generic names)

A total of 606 drugs are known to interact with Caplyta:

167 major drug interactions (620 brand and generic names)
437 moderate drug interactions (1726 brand and generic names)
2 minor drug interactions (5 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of lamoTRIgine such as dizziness, drowsiness... View more

Grapefruit juice can increase the blood levels of cariprazine. This may increase side effects such... View more
Using cariprazine together with alcohol may increase side effects such as dizziness, drowsiness... View more

Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this... View more
Using lumateperone together with alcohol may increase side effects such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

December 27, 1994

September 17, 2015

December 20, 2019

WADA Class View classifications

N/A

More Information

Patient Resources

Lamotrigine uses

Vraylar uses

Caplyta uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Lamotrigine Alternatives Compared

See also:

Vraylar

Abilify

Caplyta

Seroquel

Lamictal

Depakote

Divalproex sodium

Lithium

Carbamazepine

Risperidone

Further information

Lamotrigine Alternatives Compared

See also:

Further information

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