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Modafinil Drug Interactions

A total of 583 drugs are known to interact with modafinil.

  • 84 major drug interactions
  • 258 moderate drug interactions
  • 241 minor drug interactions

Show all medications in the database that may interact with modafinil.

Check for interactions

Type in a drug name to check for interactions with modafinil.

Most frequently checked interactions

View interaction reports for modafinil and the medicines listed below.

  • Adderall (amphetamine / dextroamphetamine)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Arthritis Pain, Bufferin, Ascriptin, Easprin, Fasprin, Aspergum, Empirin, Aspiritab, Bayer Children's Aspirin, Durlaza, Ascriptin Enteric, Entercote, Acuprin 81, Aspirin Lite Coat, Aspi-Cor, Aspirtab, Halfprin, Ecotrin Adult Low Strength, Buffered Aspirin, St. Joseph Aspirin, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Ecotrin Maximum Strength, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Bayer Aspirin Regimen, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Aspirin Low Strength (aspirin)
  • caffeine (Vivarin, Diurex Ultra, Caffedrine, Jet Alert Regular Strength, Jet Alert Maximum Strength, Stay Awake, Alert, 357 HR Magnum, Overtime, Valentine, NoDoz, Jet Alert Double Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Verv, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Pep-Back Ultra, Cafcit, Enerjets, Fastlene, Keep Going, Molie)
  • Cialis (tadalafil)
  • citalopram (Celexa)
  • Cymbalta (duloxetine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Motrin IB, Proprinal, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Motrin Childrens, Rufen, Ibuprofen PMR, Ibu-8, Motrin Pediatric, Menadol, Nuprin, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, NeoProfen, Ibu-Tab, Genpril, Haltran, IBU-200, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lyrica (pregabalin)
  • methadone (Dolophine, Methadose, Methadone Diskets, Methadose Sugar-Free)
  • Prozac (fluoxetine)
  • Ritalin (methylphenidate)
  • Suboxone (buprenorphine / naloxone)
  • Synthroid (levothyroxine)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Vyvanse (lisdexamfetamine)
  • Wellbutrin (bupropion)
  • Xanax (alprazolam)
  • Zoloft (sertraline)

Modafinil alcohol/food interactions

There are 2 alcohol/food interactions with modafinil

Modafinil disease interactions

There are 7 disease interactions with modafinil which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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