Modafinil Drug Interactions
A total of 529 drugs (2494 brand and generic names) are known to interact with modafinil.
- 59 major drug interactions (485 brand and generic names)
- 236 moderate drug interactions (1075 brand and generic names)
- 234 minor drug interactions (934 brand and generic names)
Check for interactions with modafinil
Common medications checked in combination with modafinil
- Abilify (aripiprazole)
- Adderall (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Aspirin Low Strength (aspirin)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Lamictal (lamotrigine)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Nexium (esomeprazole)
- Prozac (fluoxetine)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Wellbutrin XL (bupropion)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
modafinil alcohol/food Interactions
There are 3 alcohol/food interactions with modafinil
modafinil disease Interactions
There are 7 disease interactions with modafinil which include:
- Cardiac Disease
- Hypertension
- Liver Disease
- Seizure Disorders
- Psychiatric Disorders
- Renal Dysfunction
- Cardiovascular
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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