Generic Name: amphetamine (am FET a meen)
Brand Name: Adzenys XR-ODT, Adzenys ER, Dyanavel XR, Evekeo
Medically reviewed by Kaci Durbin, MD. Last updated on Dec 28, 2020.
What is amphetamine?
Amphetamine is used to treat attention deficit hyperactivity disorder (ADHD).
The Evekeo brand of amphetamine is used to treat ADHD and also narcolepsy. Evekeo is sometimes used to treat obesity in people who have not lost weight with diets or other treatments.
Amphetamine is not approved for use in children less than 6 years of age, with the exception of Evekeo (approved for children age 3 and older).
Amphetamine may be habit-forming, and this medicine is a drug of abuse. Tell your doctor if you have had problems with drug or alcohol abuse.
Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect.
Do not use amphetamine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine or have received a methylene blue injection.
Amphetamine may cause new or worsening psychosis (unusual thoughts or behavior), especially if you have a history of depression, mental illness, or bipolar disorder.
Amphetamine may cause blood circulation problems that can cause numbness, pain, or discoloration in your fingers or toes.
Call your doctor right away if you have: signs of heart problems - chest pain, feeling light-headed or short of breath; signs of psychosis - paranoia, aggression, new behavior problems, seeing or hearing things that are not real; signs of circulation problems - unexplained wounds on your fingers or toes.
Before taking this medicine
You should not use amphetamine if you are allergic to any stimulant medicine, or if you have:
heart disease or a heart defect;
moderate to severe high blood pressure;
severe anxiety, tension, or agitation (stimulant medicine can make these symptoms worse); or
a history of drug or alcohol abuse.
Do not use amphetamine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Some medicines can interact with amphetamine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
Stimulants have caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have:
heart problems or a congenital heart defect;
high blood pressure or high heart rate; or
a family history of heart disease or sudden death.
To make sure amphetamine is safe for you, tell your doctor if you or anyone in your family has ever had:
depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions;
problems with drug or alcohol abuse;
motor tics (muscle twitches) or Tourette's syndrome;
a thyroid disorder;
seizures or epilepsy;
an abnormal brain wave test (EEG);
coronary artery disease (clogged arteries); or
blood circulation problems in the hands or feet.
Taking this medicine during pregnancy can cause premature birth, low birth weight, or withdrawal symptoms in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Amphetamine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Amphetamine is not approved for use by anyone younger than 6 years old.
How should I take amphetamine?Using amphetamine improperly can cause death or serious side effects on the heart.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
This medicine may be habit-forming. Never share amphetamine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.
Take amphetamine with or without food, first thing in the morning. If taken too late in the day, you may have trouble sleeping.
If your doctor changes your brand, strength, or type of stimulant medicine, your dosage needs may change. Use only the brand of this medicine your doctor has prescribed.
Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon (not a kitchen spoon) or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
To take the orally disintegrating tablet (Adzenys XR-ODT):
Keep the tablet in its blister pack until you are ready to take it. Using dry hands open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
Use dry hands to remove the tablet and place it in your mouth.
Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may sip liquid to help swallow the dissolved tablet.
While using amphetamine, your doctor will need to check your progress at regular visits. Tell any doctor who treats you that you are using this medicine.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Keep track of your medicine. Amphetamine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
What happens if I miss a dose?
Take the missed dose as soon as you remember, but not late in the day. Skip the missed dose if it is almost evening. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amphetamine could be fatal.
Overdose symptoms may include restlessness, tremor, muscle twitches, rapid breathing, hostility, violence, panic, muscle pain or weakness, and dark colored urine. These symptoms may be followed by depression and tiredness. Overdose may also cause seizure or coma.
What to avoid
Avoid drinking alcohol while you are taking this medicine.
Avoid drinking fruit juices or taking vitamin C at the same time you take amphetamine. These can make your body absorb less of the medicine.
Avoid driving or hazardous activity until you know how amphetamine will affect you. Your reactions could be impaired.
Amphetamine side effects
Get emergency medical help if you have signs of an allergic reaction to amphetamine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
signs of heart problems - chest pain, trouble breathing, feeling like you might pass out;
signs of psychosis - hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;
signs of circulation problems - numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;
a seizure (convulsions);
muscle twitches (tics); or
changes in your vision.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Amphetamine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.
Common amphetamine side effects may include:
- dry mouth, unusual or unpleasant taste in the mouth
- loss of appetite, weight loss;
- stomach pain, nausea, diarrhea;
- feeling restless or nervous;
- sleep problems (insomnia);
- mood changes;
- dizziness or headaches; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect amphetamine?
Ask your doctor before using a stomach acid medicine (including Alka-Seltzer or sodium bicarbonate). Some of these medicines can change the way your body absorbs amphetamine, and may increase side effects.
Many drugs can interact with amphetamine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor if you are taking an anti-depressant or any other medication for mental illness; an antihistamine such as allergy medication; seizure drugs, or any over the counter medications. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.
The main difference between Adderall and Vyvanse is that Adderall is a mixture of four different kinds of amphetamine salts (one of which is dextroamphetamine) while Vyvanse only contains one type of amphetamine salt, called lisdexamfetamine. Lisdexamfetamine gets converted into dexamphetamine once it is in the body. One advantage of Vyvanse is that it may be less likely to be abused; however, there is no generic form available so it is more costly than Adderall. Because both drugs contain amphetamines, they work in a similar way. Studies have shown that Vyvanse is just as effective as Adderall, and side effects, including the risk of dependence, are similar.
Adzenys ER is an extended-release 1.25mg/mL liquid suspension compared to most other brands of amphetamine which are tablet and capsule formulations. Dyanavel XR is also an amphetamine extended-release liquid suspension, but with a strength of 2.5mg/mL. Continue reading
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More about amphetamine
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- Drug class: CNS stimulants
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amphetamine only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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