Skip to Content

Amphetamine Side Effects

For the Consumer

Applies to amphetamine: oral suspension extended release, oral tablet, oral tablet extended release disintegrating

Along with its needed effects, amphetamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amphetamine:

Rare
  • Seeing, hearing, or feeling things that are not there
  • severe mental changes
Incidence not known
  • Agitation
  • blurred vision
  • confusion
  • diarrhea
  • dizziness
  • false or unusual sense of well-being
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • headache
  • nervousness
  • overactive reflexes
  • pounding in the ears
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • shivering
  • slow or fast heartbeat
  • sweating
  • talking or acting with excitement you cannot control
  • trouble sleeping
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)

Get emergency help immediately if any of the following symptoms of overdose occur while taking amphetamine:

Symptoms of overdose
  • Abdominal or stomach cramps
  • dark-colored urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nausea
  • seizures
  • sweating
  • unusual tiredness or weakness
  • vomiting

Some side effects of amphetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • dry mouth
  • hives or welts, itching, or skin rash
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • redness of the skin
  • unpleasant taste
  • weight loss

For Healthcare Professionals

Applies to amphetamine: oral suspension extended release, oral tablet, oral tablet disintegrating extended release

Cardiovascular

Frequency not reported: Palpitations, tachycardia, elevated blood pressure, cardiomyopathy
Postmarketing reports: Peripheral vasculopathy[Ref]

Psychiatric

Rare (less than 0.1%): Psychotic episodes
Frequency not reported: Euphoria, dysphoria, insomnia, restlessness[Ref]

Nervous system

Frequency not reported: Overstimulation, dizziness, dyskinesia, tremor, headache, exacerbation of motor/phonic tics and Tourette's syndrome[Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis[Ref]

Gastrointestinal

Common (1% to 10%): Upper abdominal pain
Frequency not reported: Dry mouth, unpleasant taste, diarrhea, constipation, other GI disturbances[Ref]

Endocrine

Frequency not reported: Impotence, libido changes, frequent or prolonged erections[Ref]

Immunologic

Frequency not reported: Urticaria[Ref]

Metabolic

Frequency not reported: Anorexia, weight loss[Ref]

Respiratory

Common (1% to 10%): Epistaxis, allergic rhinitis[Ref]

References

1. "Product Information. Evekeo (amphetamine)." Arbor Pharmaceuticals, Atlanta, GA.

2. "Product Information. Dyanavel XR (amphetamine)." Tris Pharma Inc, Monmouth Junction, NJ.

Some side effects of amphetamine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide