How is Adzenys ER different to other brands of amphetamine?
Adzenys ER is an extended-release 1.25mg/mL liquid suspension compared to most other brands of amphetamine which are tablet and capsule formulations. Dyanavel XR is also an amphetamine extended-release liquid suspension, but with a strength of 2.5mg/mL.
- In September 2017, the FDA approved Adzenys ER (amphetamine), a once-daily, 1.25mg/mL extended-release liquid suspension formulation indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in patients 6 years and older.
- Adzenys ER is available in an orange-flavored suspension that requires no refrigeration or reconstitution.
- All amphetamine products for ADHD are schedule CII controlled substances.
Adzenys ER vs other amphetamine brands
Before the approval of Adzenys ER, the FDA approved once-daily Adzenys XR-ODT (amphetamine) in January 2016 for the treatment of ADHD in patients 6 years and older.
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Adzenys XR-ODT was the first extended-release orally disintegrating tablet (ODT) available for ADHD.
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Adzenys XR-ODT is available in the same six dosage strengths as Adderall XR (ranging from 3.1 mg to 18.8 mg per tablet), but is patented and not a generic of amphetamine mixed salts XR capsules.
- Allow tablet to disintegrate in saliva then swallow. It may be taken with or without food.
Adzenys XR-ODT utilizes the same proprietary modified-release drug delivery technology as Adzenys ER suspension, thereby providing health care providers the option to transition patients from liquid to ODT formulations. Both Adzenys ER and Adzenys XR-ODT are manufactured by Neos Therapeutics and are bioequivalent to Adderall XR.
Dyanavel XR is a suspension form of extended-release amphetamine for ADHD. Dyanavel XR 2.5 mg/mL suspension, approved in October 2015, was the first, extended-release amphetamine-based oral liquid for the treatment of ADHD. It is given once per day in the morning in children 6 years and older and is bubblegum flavored. Take with or without food.
The Evekeo brand of amphetamine is an immediate-release tablet used to treat ADHD, narcolepsy, and for short-term use in weight loss (obesity).
- In ADHD, it is used for treatment of children 3 years of age and older. It comes as a 5 mg or 10 mg oral tablet, and is usually dosed once per day, but can be used in twice daily increments in children 6 of years of age or older. Children 3 to 5 years of age to start with 2.5 mg daily.
- Evekeo is not for use as a weight loss medicine for obesity in children less than 12 years of age.
- It is also available an orally disintegrating tablet (ODT) formulation approved for the treatment of ADHD in children 3 to 17 years of age.
Generic amphetamine and generic amphetamine salt combinations for treatment of ADHD are also available which may yield cost-savings.
This is not all the information you need to know about Adzenys ER for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full product information here, and discuss this information and any questions you have with your doctor or other health care provider.
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References
- Adzenys ER [product information]. Drugs@FDA. Accessed Sept. 9, 2021 at https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204325s000lbl.pdf
- Evekeo (amphetamine sulfate tablets). Arbor Pharmaceuticals, LLC
Atlanta, GA. Accessed Sept. 9, 2021 at https://www.evekeo.com/pdfs/evekeo-pi.pdf
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