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How is Adzenys ER different to other brands of amphetamine?

Medically reviewed by Last updated on Sep 30, 2020.

Official Answer


Adzenys ER is an extended-release 1.25mg/mL liquid suspension compared to other brands of amphetamine which are tablet and capsule formulations. Dyanavel XR is another extended-release liquid suspension with a strength of 2.5mg/mL.

In September 2017, the FDA approved Adzenys ER (amphetamine), a once-daily, 1.25mg/mL extended-release liquid suspension formulation indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in patients 6 years and older. Adzenys ER will be available in an orange-flavored suspension that requires no refrigeration or reconstitution. All amphetamine products for ADHD are schedule CII controlled substances.

Before the approval of Adzenys ER, the FDA approved once-daily Adzenys XR-ODT (amphetamine) in January 2016 for the treatment of ADHD in patients 6 years and older. Adzenys XR-ODT is the first extended-release orally disintegrating tablet (ODT) available for ADHD. Adzenys XR-ODT is available in the same six dosage strengths as Adderall XR (ranging from 3.1 mg to 18.8 mg per tablet), but is patented and not a generic of amphetamine mixed salts XR capsules. Adzenys ER suspension utilizes the same proprietary modified-release drug delivery technology as Adzenys XR-ODT, thereby providing health care providers the option to transition patients from liquid to ODT formulations. Both Adzenys ER and Adzenys XR-ODT are manufactured by Neos Therapeutics and are bioequivalent to Adderall XR.

Dyanavel XR is another suspension form of extended-release amphetamine for ADHD. Dyanavel XR 2.5 mg/mL suspension, approved in October 2015, was the first, extended-release amphetamine-based oral liquid for the treatment of ADHD. It is dosed once per day in children 6 years and older, and is bubblegum flavored.

The Evekeo brand of amphetamine is an immediate-release tablet used to treat ADHD, narcolepsy, and for short-term use in weight loss (obesity). In ADHD, it is used for treatment of children 3 years of age and older. It comes as a 5 mg oral tablet, and is usually dosed once per day, but can be used in twice daily increments in children 6 of years of age or older.

Generic amphetamine for treatment of ADHD is also available in immediate-release tablets and extended-release capsule formulations, which may yield cost-savings for the patient.

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