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Dexedrine Spansule

Generic name: dextroamphetamineDEX-tro-am-FET-a-meen ]
Brand names: Dexedrine Spansule, ProCentra, Xelstrym, Zenzedi
Drug class: CNS stimulants

Medically reviewed by on Jun 22, 2023. Written by Cerner Multum.

What is Dexedrine Spansule?

Dexedrine Spansule tablets and oral solution (liquid) are used to treat attention deficit hyperactivity disorder (ADHD) in children who are 3 to 16 years old.

Dexedrine Spansule extended-release capsules are used to treat attention deficit hyperactivity disorder (ADHD) in children who are 6 to 16 years old.

Dexedrine Spansule skin patch is used to treat attention deficit hyperactivity disorder (ADHD) in adults and children at least 6 years old.

Dexedrine Spansule tablets, oral solution (liquid) and extended-release capsules are also used in the treatment of a sleep disorder called narcolepsy.

Dexedrine Spansule may also be used for purposes not listed in this medication guide.

Dexedrine Spansule side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stimulants have caused stroke, heart attack, and sudden death in certain people. Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, or feeling short of breath.

Dexedrine Spansule may cause serious side effects. Call your doctor at once if you have:

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Dexedrine Spansule can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using Dexedrine Spansule.

Common side effects of Dexedrine Spansule may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not use this medicine if you have glaucoma, overactive thyroid, severe agitation, moderate to severe high blood pressure, heart disease or coronary artery disease, or a history of drug or alcohol addiction.

Dexedrine Spansule may be habit-forming. Misuse can cause addiction, serious heart problems, or death.

Call your doctor right away if you have: chest pain, seeing or hearing things that are not real, decreased need for sleep, being agitated, unexplained wounds on your fingers or toes.

Before taking this medicine

You should not use Dexedrine Spansule if you are allergic to any stimulant medicine, or if you have:

Do not use Dexedrine Spansule if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you also use opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with Dexedrine Spansule could cause a serious condition called serotonin syndrome.

Tell your doctor if you or a family member has ever had:

Tell your doctor if you are pregnant or plan to become pregnant. Using Dexedrine Spansule during pregnancy may increase the risk of premature birth, withdrawal symptoms or low birth weight.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of dextroamphetamine skin patch on the baby.

You should not breastfeed while using Dexedrine Spansule.

How should I use Dexedrine Spansule?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Dexedrine Spansule may be habit-forming. Misuse can cause addiction, overdose, serious heart problems or death. Keep the medication where others cannot get to it. Selling or giving away this medicine is against the law.

Dexedrine Spansule is sometimes taken 2 or 3 times per day. Extended-release this medicine is taken only once per day.

Apply the patch to clean, dry, hairless skin. Press firmly into place for about 10 seconds. Leave the patch on while bathing, showering, or swimming. Apply the patch 2 hours before the effect is needed and remove the patch within 9 hours after application.

Choose a different place on your body each time you apply a new patch. Do not apply to the same skin twice in 7 days. Do not wear more than one patch at a time. Use only 1 patch per day. Never cut a skin patch.

Swallow the Dexedrine Spansule extended release capsule whole and do not crush, chew, break, or open it.

Measure liquid medicine with the supplied measuring device (not a kitchen spoon).

Your doctor will need to check your progress on a regular basis. You may need medical tests. Tell any doctor who treats you that you are using this medicine.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes.

Store at room temperature away from moisture, heat, and light.

Read and carefully follow the instructions provided with this medicine about how to safely dispose of any unused portion. Do not flush Dexedrine Spansule skin patch down the toilet.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Dexedrine Spansule can be fatal.

Overdose symptoms may include restlessness, rapid breathing, hallucinations, aggressiveness, vomiting, diarrhea, uneven heartbeats, fainting, seizures, or coma.

What should I avoid while using dextroamphetamine?

Dexedrine Spansule may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Avoid external heat sources like hair dryers, heat lamps or saunas while wearing Dexedrine Spansule skin patch.

Avoid drinking fruit juices or taking vitamin C while you take Dexedrine Spansule. These can make your body absorb less of the medicine.

What other drugs will affect Dexedrine Spansule?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your current medicines. Many drugs can affect Dexedrine Spansule, especially:

This list is not complete and many other drugs may affect Dexedrine Spansule. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.