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Dextroamphetamine Pregnancy and Breastfeeding Warnings

Dextroamphetamine is also known as: Dexedrine, Dextrostat, Liquadd, ProCentra, Zenzedi

Dextroamphetamine Pregnancy Warnings

Infants born to mothers dependent on amphetamines have an increased risk of premature delivery and low birth weight. These infants may experience symptoms of withdrawal including dysphoria, agitation, weakness, and exhaustion. One study on the affects of methamphetamine abuse on pregnancy outcome reported that body weight, length, and head circumference were significantly decreased in neonates born to mothers who abused methamphetamines during pregnancy. The study also noted that the frequency of congenital anomalies was not significantly increased.

Dextroamphetamine has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryotoxicity and teratogenicity. There are no controlled data in human pregnancy. There has been one report of a case of severe congenital bony deformity, tracheoesophageal fistula, and anal atresia (vater association) in a baby born to a woman using dextroamphetamine during the first trimester of pregnancy. Dextroamphetamine should only be given during pregnancy when benefits outweigh risks.

See references

Dextroamphetamine Breastfeeding Warnings

Dextroamphetamine is excreted into human milk. Dextroamphetamine is considered contraindicated during breast-feeding by the manufacturer.

See references

References for pregnancy information

  1. Little BB, Snell LM, Gilstrap LC 3d "Methamphetamine abuse during pregnancy: outcome and fetal effects." Obstet Gynecol 72 (1988): 541-4
  2. "Product Information. Dexedrine (dextroamphetamine)" SmithKline Beecham, Philadelphia, PA.

References for breastfeeding information

  1. Steiner E, Villen T, Hallberg M, Rane A "Amphetamine secretion in breast milk." Eur J Clin Pharmacol 27 (1984): 123-4
  2. Ilett KF, Hackett LP, Kristensen JH, Kohan R "Transfer of dexamphetamine into breast milk during treatment for attention deficit hyperactivity disorder." Br J Clin Pharmacol 63 (2007): 371-5
  3. "Product Information. Dexedrine (dextroamphetamine)" SmithKline Beecham, Philadelphia, PA.

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