Modafinil Alternatives Compared
| Modafinil | Bupropion | Cymbalta |
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| Modafinil | Bupropion | Cymbalta (duloxetine) |
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Prescription only
Prescribed for ADHD, Chronic Fatigue Syndrome, Depression, Fatigue, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, Shift Work Sleep Disorder, Idiopathic Hypersomnia. modafinil may also be... View more |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Prescription only
Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more |
Related suggestions |
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| More about Modafinil | More about Bupropion | More about Cymbalta (duloxetine) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Modafinil has an average rating of 7.2 out of 10 from a total of 510 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2825 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
Cymbalta has an average rating of 6.2 out of 10 from a total of 1865 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: modafinil side effects in more detail. |
See also: bupropion side effects in more detail. |
See also: Cymbalta side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all modafinil prices |
View all bupropion prices |
View all Cymbalta prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Provigil | Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | Other duloxetine brands include: Drizalma Sprinkle, Irenka | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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15 hours |
30 hours |
17 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 463 drugs are known to interact with modafinil:
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A total of 492 drugs are known to interact with bupropion:
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A total of 585 drugs are known to interact with Cymbalta:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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December 24, 1998 |
December 30, 1985 |
N/A |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.