Comparing Methylphenidate vs Modafinil
| Methylphenidate | Modafinil |
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| Methylphenidate | Modafinil |
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Prescription only
Methylphenidate is a CNS stimulant used to treat ADHD in adults and children aged 6 and older, and narcolepsy. It works by blocking the reuptake of dopamine and norepinephrine, increasing their... View more |
Prescription only
Prescribed for Chronic Fatigue Syndrome, ADHD, Fatigue, Narcolepsy, Shift Work Sleep Disorder, Depression, Idiopathic Hypersomnia, Obstructive Sleep Apnea/Hypopnea Syndrome. Modafinil may also be... View more |
Related suggestionsDepressionADHD (Attention Deficit Hyperactivity Disorder)Popular Comparisons |
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| More about Methylphenidate | More about Modafinil | ||||||||||||||||||||
| Ratings & Reviews | |||||||||||||||||||||
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Methylphenidate has an average rating of 7.2 out of 10 from a total of 1131 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 17% reported a negative effect. |
Modafinil has an average rating of 7.2 out of 10 from a total of 547 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 18% reported a negative effect. |
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View all 1131 reviews |
View all 547 reviews |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||||||
View all side effects |
View all side effects |
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| Boxed Warnings A boxed warning is the most serious warning from the Food and Drug Administration (FDA) about drug effects that may be dangerous. | |||||||||||||||||||||
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View boxed warnings |
N/A |
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| Drug Class | |||||||||||||||||||||
| Generic Availability Learn more about brand vs generic drugs. | |||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance. | |||||||||||||||||||||
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| Dosage Forms | |||||||||||||||||||||
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| Brand Names | |||||||||||||||||||||
| Aptensio XR, Concerta, Cotempla XR-ODT, Daytrana, Jornay PM, Metadate CD, Methylin, Methylin ER, QuilliChew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA View more | Provigil | ||||||||||||||||||||
| Half Life Learn about the half-life of a drug and how it is calculated. | |||||||||||||||||||||
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4 hours |
15 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||||||
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High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
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| Pregnancy Category | |||||||||||||||||||||
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Category C
See the full pregnancy warnings document. |
Category C
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||||||
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A total of 216 drugs are known to interact with Methylphenidate:
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A total of 553 drugs are known to interact with Modafinil:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||||||
| First Approval Date | |||||||||||||||||||||
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December 5, 1955 |
December 24, 1998 |
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| WADA Class View classifications | |||||||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.