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Medications for Helicobacter Pylori Infection

What is Helicobacter Pylori Infection?

Helicobacter pylori (H.pylori) is a type of bacteria that can infect your stomach and digestive tract. Infection is common, and more than two-thirds of the world’s population is infected, although the rate of infection is declining as more people get access to clean water and sanitation.

Most people with H. pylori become infected as a child and most don’t know they are infected as it can live harmlessly in your body, without causing any symptoms.

In other people, H. pylori slowly attacks the lining of the stomach and is a common cause of dyspepsia (indigestion).

Continued damage can lead to the development of gastric ulcers, which are sores or erosions in the lining of your stomach. For some people, an infection can lead to stomach cancer.
 

How do you get infected with H. pylori?

H. pylori is more common in countries or areas that lack clean water or are without a good sewerage system. You can easily pick up the bacteria from food, water, utensils, or through contact with the saliva or other body fluids of infected people.

There is a greater risk of spreading the infection in overcrowded living areas.

What are the symptoms of H. pylori?

The symptoms of H. pylori reflect those of dyspepsia (indigestion) or an ulcer and may include:

  • A dull or burning pain in your stomach that is worse if you haven't eaten
  • Bloating
  • Indigestion or heartburn
  • Nausea
  • Low appetite
  • Frequent burping
  • Acid burps
  • Weight loss.

How is H. pylori diagnosed?

Doctors do not usually go looking for H. pylori unless you develop ongoing or frequent dyspepsia (indigestion) or gastric ulcers.

Your doctor will ask you about your medical history, any symptoms, and what medications you take. They will perform a physical examination where they will press on your stomach to feel for any swelling, tenderness, or pain.

They may also conduct:

  • Blood or stool tests to look for evidence of infection or other anomalies (such as anemia or the presence of blood in the stool)
  • An urea breath test. This detects H. pylori in the stomach
  • An upper gastrointestinal endoscopy to look into your stomach and small intestine and to collect a sample which can be tested for the presence of bacteria
  • An X-ray
  • A computed tomography (CT) scan.

How is H.pylori infection treated?

If H. pylori is found, it can be treated using eradication therapy, which usually consists of two antibiotics and another type of medicine called proton pump inhibitor (PPI).

The antibiotics kill H.pylori and the PPI reduces the production of acid in the stomach, allowing the ulcer to heal. Treatment is usually for 7 days and is effective in approximately 90% of people. The chances of reinfection are low because most H. pylori infections occur in childhood.

 

Drugs Used to Treat Helicobacter Pylori Infection

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
clarithromycin C N 63 reviews
5.7

Generic name: clarithromycin systemic

Brand name:  Biaxin XL

Drug class: macrolides

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

omeprazole C N 3 reviews
5.0

Generic name: omeprazole systemic

Brand name:  Prilosec

Drug class: proton pump inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

amoxicillin B N 3 reviews
10

Generic name: amoxicillin systemic

Brand names:  Amoxil, Apo-Amoxi

Drug class: aminopenicillins

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

metronidazole B N X 34 reviews
5.3

Generic name: metronidazole systemic

Brand names:  Flagyl, Flagyl IV, Flagyl 375

Drug class: amebicides, miscellaneous antibiotics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Pylera D N X 185 reviews
5.9

Generic name: bismuth subcitrate potassium / metronidazole / tetracycline systemic

Drug class: H. pylori eradication agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Amoxil B N 1 review
10

Generic name: amoxicillin systemic

Drug class: aminopenicillins

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Prevpac C N 70 reviews
7.4

Generic name: amoxicillin / clarithromycin / lansoprazole systemic

Drug class: H. pylori eradication agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Nexium C N 5 reviews
7.3

Generic name: esomeprazole systemic

Drug class: proton pump inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Aciphex B N 4 reviews
9.5

Generic name: rabeprazole systemic

Drug class: proton pump inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

amoxicillin / clarithromycin / lansoprazole C N 139 reviews
6.8

Generic name: amoxicillin / clarithromycin / lansoprazole systemic

Brand name:  Prevpac

Drug class: H. pylori eradication agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

Flagyl B N X 6 reviews
7.2

Generic name: metronidazole systemic

Drug class: amebicides, miscellaneous antibiotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

pantoprazole B N 5 reviews
4.5

Generic name: pantoprazole systemic

Brand names:  Protonix, Protonix IV

Drug class: proton pump inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Prilosec C N 2 reviews
4.5

Generic name: omeprazole systemic

Drug class: proton pump inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

tetracycline D N 1 review
10

Generic name: tetracycline systemic

Brand names:  Achromycin V, Ala-Tet, Brodspec

Drug class: tetracyclines

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

bismuth subcitrate potassium / metronidazole / tetracycline D N X 193 reviews
5.9

Generic name: bismuth subcitrate potassium / metronidazole / tetracycline systemic

Brand name:  Pylera

Drug class: H. pylori eradication agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts

Protonix B N Add review
0.0

Generic name: pantoprazole systemic

Drug class: proton pump inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

lansoprazole B N 1 review
8.0

Generic name: lansoprazole systemic

Brand names:  Prevacid, Prevacid SoluTab, Prevacid OTC

Drug class: proton pump inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Pepto-Bismol N N Add review
0.0

Generic name: bismuth subsalicylate systemic

Drug class: antidiarrheals

For consumers: dosage, interactions, side effects

bismuth subsalicylate N N Add review
0.0

Generic name: bismuth subsalicylate systemic

Brand names:  Pepto-Bismol, Kaopectate, Bismarex, Bismatrol, Peptic Relief, Pink Bismuth, Bismatrol Maximum Strength …show all

Drug class: antidiarrheals

For consumers: dosage, interactions,

For professionals: Prescribing Information

esomeprazole C N 6 reviews
6.0

Generic name: esomeprazole systemic

Brand names:  Nexium, Nexium IV

Drug class: proton pump inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

amoxicillin / clarithromycin / omeprazole C N 1 review
5.0

Generic name: amoxicillin / clarithromycin / omeprazole systemic

Brand name:  Omeclamox-Pak

Drug class: H. pylori eradication agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts

Prevacid B N Add review
0.0

Generic name: lansoprazole systemic

Drug class: proton pump inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

rabeprazole B N 5 reviews
9.6

Generic name: rabeprazole systemic

Brand name:  Aciphex

Drug class: proton pump inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Omeclamox-Pak C N 1 review
5.0

Generic name: amoxicillin / clarithromycin / omeprazole systemic

Drug class: H. pylori eradication agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Biaxin XL C N Add review
0.0

Generic name: clarithromycin systemic

Drug class: macrolides

For consumers: dosage, interactions, side effects

Learn more about Helicobacter Pylori Infection

IBM Watson Micromedex

ICD-10 CM Clinical Codes (External)

Legend

Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Off Label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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