Amoxicillin / Clarithromycin / Lansoprazole Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 1, 2025.

Applies to amoxicillin / clarithromycin / lansoprazole: oral capsule, oral capsule delayed release, oral tablet.

Precautions

It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects. If your condition does not improve, or if it becomes worse, talk with your doctor.

Do not use this medicine if you are also using astemizole (Hismanal®), atazanavir (Reyataz®), cisapride (Propulsid®), lovastatin (Mevacor®), pimozide (Orap®), simvastatin (Zocor®), terfenadine (Seldane®), certain ergot medicines (such as dihydroergotamine, ergotamine, D.H.E. 45®, Ergomar®, Ergostat®, or Migranal®), or medicines containing rilpivirine. If you have kidney or liver disease, do not take this medicine together with colchicine (Colcrys®). Using these medicines together may increase risk for more serious side effects.

This medicine may cause serious allergic reactions, including anaphylaxis. This can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, fever or chills, hoarseness, sores or ulcers on the skin, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine.

Make sure your doctor knows if you are pregnant or planning to become pregnant. If you become pregnant while using this medicine, tell your doctor right away.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Check with your doctor right away if you have a fever, joint pain, skin rash, swelling of the body, feet, or ankles, or unusual weight gain after receiving this medicine. These could be symptoms of serious kidney problem called acute interstitial nephritis.

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you Stop taking amoxicillin / clarithromycin / lansoprazole. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Cutaneous or systemic lupus erythematosus may occur or get worse in patients receiving a PPI. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Other side effects

Some side effects of amoxicillin / clarithromycin / lansoprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects

Along with its needed effects, amoxicillin / clarithromycin / lansoprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin / clarithromycin / lansoprazole:

For healthcare professionals

Applies to amoxicillin / clarithromycin / lansoprazole: oral kit.

General adverse events

The most commonly reported side effects included diarrhea, headache, and taste perversion.

Amoxicillin: The most commonly reported side effects included nausea, diarrhea, rash, and vomiting.

Clarithromycin: The most commonly reported side effects included abdominal pain, diarrhea, nausea/vomiting, and dysgeusia.

Lansoprazole: The most commonly reported side effects included abdominal pain, diarrhea, and nausea.^[Ref]

Nervous system

• Common (1% to 10%): Headache, taste perversion
• Frequency not reported: Dizziness

Amoxicillin:

• Common (1% to 10%): Headache, taste perversion
• Frequency not reported: Dizziness, hyperactivity/reversible hyperactivity

Clarithromycin:

• Common (1% to 10%): Dysgeusia, headache
• Frequency not reported: Dizziness, dyskinesia, loss of consciousness, somnolence, tremor, vertigo
• Postmarketing reports: Ageusia, anosmia, convulsion, paresthesia, parosmia

Lansoprazole:

• Frequency not reported: Amnesia, cerebrovascular accident/cerebral infarction, convulsion, dementia, dizziness, headache, hemiplegia, hyperkinesia, hypertonia, hypesthesia, migraine, paresthesia, parosmia, somnolence, syncope, taste loss/perversion, tremor, vertigo
• Postmarketing reports: Speech disorder^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea
• Frequency not reported: Abdominal pain, dark stools, dry mouth, glossitis, nausea, oral moniliasis, rectal itching, stomatitis, tongue discoloration/disorder, vomiting

Amoxicillin:

• Common (1% to 10%): Diarrhea, nausea, vomiting
• Frequency not reported: Black hairy tongue, hemorrhagic/pseudomembranous colitis, tooth discoloration/brown, yellow or gray staining of teeth

Clarithromycin:

• Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, nausea, vomiting
• Frequency not reported: Abdominal distension, constipation, dry mouth, eructation, esophagitis, flatulence, gastritis, gastroenteritis, gastroesophageal reflux disease, glossitis, proctalgia, stomatitis
• Postmarketing reports: Acute pancreatitis, pseudomembranous colitis, tongue/tooth discoloration

Lansoprazole:

• Common (1% to 10%): Abdominal pain, constipation, diarrhea, nausea
• Frequency not reported: Abnormal stools, bezoar, cardiospasm, colitis, dry mouth, dyspepsia, dysphagia, enlarged abdomen, enteritis, eructation, esophageal stenosis, esophageal ulcer, esophagitis, fecal discoloration, flatulence, gastric nodules/fundic gland polyps, gastritis, gastroenteritis, gastrointestinal anomaly, gastrointestinal disorder, gastrointestinal hemorrhage, gastrointestinal moniliasis, glossitis, gum hemorrhage, halitosis, hematemesis, increased salivation, melena, mouth ulceration, rectal disorder/hemorrhage, stomatitis, tenesmus, tongue disorder, ulcerative colitis/stomatitis, vomiting
• Postmarketing reports: Clostridium difficile-associated diarrhea, pancreatitis, positive fecal occult blood^[Ref]

Genitourinary

• Frequency not reported: Vaginal moniliasis, vaginitis

Amoxicillin:

• Frequency not reported: Crystalluria

Clarithromycin:

• Frequency not reported: Vaginal infection
• Postmarketing reports: Abnormal urine color

Lansoprazole:

• Frequency not reported: Abnormal menses, breast enlargement/pain/tenderness, dysmenorrhea, dysuria, impaired urination, impotence, leukorrhea, menorrhagia, menstrual disorder, pelvic pain, penis disorder, polyuria, testis disorder, urethral pain, urinary frequency, urinary retention, urinary tract infection, urinary urgency, vaginitis
• Postmarketing reports: Albuminuria, hematuria, presence of crystal urine, urine abnormalities^[Ref]

Dermatologic

• Frequency not reported: Skin reactions

Amoxicillin:

• Common (1% to 10%): Rash
• Frequency not reported: Acute generalized exanthematous pustulosis, erythematous maculopapular rashes, erythema multiforme, exfoliative dermatitis, hypersensitivity vasculitis, mucocutaneous candidiasis, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria

Clarithromycin:

• Common (1% to 10%): Rash
• Frequency not reported: Cellulitis, dermatitis bollus, hyperhidrosis, maculopapular rash, pruritus, urticaria
• Postmarketing reports: Acne, drug rash with eosinophilia and systemic symptoms (DRESS), Henoch-Schonlein purpura, Stevens-Johnson syndrome, toxic epidermal necrolysis

Lansoprazole:

• Frequency not reported: Acne, alopecia, contact dermatitis, dry skin, fixed eruption, hair disorder, maculopapular rash, nail disorder, pruritus, rash, skin disorder, sweating, urticaria
• Postmarketing reports: Cutaneous lupus erythematosus, erythema multiforme, severe dermatologic reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)/fatal TEN^[Ref]

Psychiatric

• Frequency not reported: Confusion

Amoxicillin:

• Frequency not reported: Agitation, anxiety, behavioral change, confusion, insomnia

Clarithromycin:

• Common (1% to 10%): Insomnia
• Frequency not reported: Anxiety, nervousness
• Postmarketing reports: Abnormal behavior/dreams, confusion, confusional state, depersonalization, depression, disorientation, hallucination, manic behavior, psychotic disorder

Lansoprazole:

• Frequency not reported: Abnormal dreams/thinking, aggravated hostility, agitation, anxiety, apathy, confusion, depersonalization, depression, emotional lability, hallucinations, insomnia, increased/decreased libido, nervousness, neurosis, sleep disorders^[Ref]

Musculoskeletal

• Frequency not reported: Myalgia

Clarithromycin:

• Frequency not reported: Muscle spasms, myalgia, nuchal rigidity
• Postmarketing reports: Myopathy, rhabdomyolysis

Lansoprazole:

• Frequency not reported: Arthralgia, arthritis, back pain, bone disorder, joint disorder, leg cramps, musculoskeletal pain, myalgia, myasthenia, neck pain/rigidity, synovitis
• Postmarketing reports: Bone fracture, myositis, systemic lupus erythematosus^[Ref]

Other

• Frequency not reported: Thirst

Clarithromycin:

• Frequency not reported: Chills, fatigue, hearing loss, malaise, pyrexia, tinnitus
• Postmarketing reports: Deafness, death

Lansoprazole:

• Frequency not reported: Asthenia, chills, deafness, ear disorder, fever, malaise, otitis media, pain, thirst, tinnitus
• Postmarketing reports: Increased globulins^[Ref]

Respiratory

• Frequency not reported: Respiratory disorders

Clarithromycin:

• Frequency not reported: Asthma, epistaxis, pulmonary embolism

Lansoprazole:

• Frequency not reported: Asthma, bronchitis, cough increased, dyspnea, epistaxis, hemoptysis, hiccup, lung fibrosis, pharyngitis, pleural disorder, pneumonia, respiratory disorder, upper respiratory inflammation/infection, rhinitis, sinusitis, stridor^[Ref]

Hematologic

Amoxicillin:

• Frequency not reported: Agranulocytosis, anemia, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura

Clarithromycin:

• Frequency not reported: Abnormal albumin globulin ratio, eosinophilia, leukopenia, neutropenia, thrombocythemia
• Postmarketing reports: Agranulocytosis, decreased white blood cell count, increased INR, prolonged prothrombin time, thrombocytopenia

Lansoprazole:

• Frequency not reported: Anemia, hemolysis, lymphadenopathy
• Postmarketing reports: Abnormal AG ratio/red blood cells, abnormal/increased/decreased white blood cells/platelets, agranulocytosis, aplastic anemia, decreased hemoglobin, eosinophilia, hemolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura^[Ref]

Hepatic

Amoxicillin:

• Frequency not reported: Acute cytolytic hepatitis, cholestatic jaundice, hepatic dysfunction/cholestasis, moderate AST/ALT elevation

Clarithromycin:

• Common (1% to 10%): Abnormal liver function tests
• Frequency not reported: Cholestasis, hepatitis, increased blood bilirubin
• Postmarketing reports: Hepatic dysfunction/failure, hepatocellular jaundice

Lansoprazole:

• Frequency not reported: Cholelithiasis
• Postmarketing reports: Abnormal liver function tests, bilirubinemia, hepatotoxicity, increased AST/ALT/gamma glutamyl transpeptidase^[Ref]

Hypersensitivity

Amoxicillin:

• Frequency not reported: Anaphylaxis, hypersensitivity phenomena

Clarithromycin:

• Common (1% to 10%): Anaphylactoid reaction
• Frequency not reported: Hypersensitivity
• Postmarketing reports: Anaphylactic reaction

Lansoprazole:

• Frequency not reported: Allergic reaction
• Postmarketing reports: Anaphylactic/anaphylactoid reactions^[Ref]

Metabolic

Clarithromycin:

• Frequency not reported: Anorexia, decreased appetite, increased blood alkaline phosphatase/lactate dehydrogenase
• Postmarketing reports: Hypoglycemia

Lansoprazole:

• Frequency not reported: Anorexia, avitaminosis, dehydration, diabetes mellitus, gout, hyperglycemia, hypoglycemia, increased appetite, weight gain/loss
• Postmarketing reports: Hyperlipemia, hypomagnesemia, increased alkaline phosphatase/blood potassium/lactate dehydrogenase, increased/decreased electrolytes/cholesterol^[Ref]

Cardiovascular

Clarithromycin:

• Frequency not reported: Atrial fibrillation, cardiac arrest, chest pains, electrocardiogram QT prolonged, extrasystoles, palpitations
• Postmarketing reports: Hemorrhage, torsade de pointes, ventricular arrhythmia/tachycardia

Lansoprazole:

• Frequency not reported: Angina, arrhythmia, bradycardia, chest pain (not otherwise specified), edema, hypertension/hypotension, myocardial infarction, palpitations, peripheral edema, shock/circulatory failure, tachycardia, vasodilation^[Ref]

Renal

Clarithromycin:

• Frequency not reported: Increased blood creatinine/urea
• Postmarketing reports: Interstitial nephritis, renal failure

Lansoprazole:

• Frequency not reported: Kidney calculus, kidney pain
• Postmarketing reports: Glycosuria, increased creatinine/blood urea, interstitial nephritis^[Ref]

Ocular

Lansoprazole:

• Frequency not reported: Abnormal vision, amblyopia, blepharitis, blurred vision, cataracts, conjunctivitis, diplopia, dry eyes, eye disorder, eye pain, glaucoma, photophobia, ptosis, retinal degeneration/disorder, visual field defect^[Ref]

Endocrine

Lansoprazole:

• Frequency not reported: Goiter, gynecomastia, hypothyroidism
• Postmarketing reports: Increased glucocorticoids/gastrin levels^[Ref]

Oncologic

Lansoprazole:

• Frequency not reported: Carcinoma, laryngeal neoplasia, skin carcinoma^[Ref]

Immunologic

Amoxicillin:

• Frequency not reported: Serum sickness-like reaction

Clarithromycin:

• Common (1% to 10%): Candidiasis
• Frequency not reported: Infection

Lansoprazole:

• Frequency not reported: Candidiasis, flu syndrome, infection (not otherwise specified)^[Ref]

See also:

Further information

Amoxicillin/clarithromycin/lansoprazole side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer