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Amoxicillin / Clarithromycin / Lansoprazole Dosage

Medically reviewed by Last updated on Mar 18, 2022.

Applies to the following strengths: 500 mg-500 mg-30 mg

Usual Adult Dose for Helicobacter pylori Infection

Amoxicillin 1000 mg-clarithromycin 500 mg-lansoprazole 30 mg orally 2 times a day

  • Duration of therapy: 10 to 14 days

Comment: This drug should be taken in the morning and evening.

Use: Treatment of patients with Helicobacter pylori infection and duodenal ulcer disease to eradicate H pylori

Renal Dose Adjustments

Mild to moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended.

Acute interstitial nephritis (AIN): Discontinue treatment in patients who develop AIN.

Liver Dose Adjustments

Liver dysfunction and normal renal function: No adjustment recommended.
Liver dysfunction with severe renal dysfunction (CrCl less than 30 mL/min): Not recommended.

Signs/symptoms of hepatitis: Discontinue clarithromycin immediately



  • Hypersensitivity to the active components, erythromycin, any macrolide antibiotic, or any of the ingredients
  • Patients using astemizole, cisapride, ergotamine/dihydroergotamine, HMG-CoA reductase inhibitors extensively metabolized by CYP450 3A4 (e.g. lovastatin, simvastatin), pimozide, and/or terfenadine concomitantly
  • Patients with a history of clarithromycin-associated cholestatic jaundice/hepatic dysfunction
  • Patients with a history of QT prolongation or ventricular cardiac arrhythmia, including Torsade de pointes
  • Patients with a history of severe hypersensitivity reactions to beta-lactam antibiotics (e.g., penicillins, cephalosporins)
  • Patients with liver/renal dysfunction who are receiving concomitant administration of colchicine
  • Use with rilpivirine-containing products

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

  • Patients should take each dose before meals.
  • This drug combination should be swallowed whole.

Storage requirements:
  • Protect from light and moisture.

  • Eradication of H pylori reduces the risk of duodenal ulcer recurrence.
  • This drug may be used in patients with active or a one-year history of duodenal ulcer.
  • LIMITATION OF USE: Some manufacturers recommend limiting use of combination products to their intended use; the use of the individual products to treat other conditions alone or in combination should be avoided.

  • HEPATIC: Hepatic function tests
  • HEMATOLOGIC: Hematopoietic function tests
  • RENAL: Renal function tests

Patient advice:
  • Patients should be advised to avoid missing doses and to complete the entire course of therapy.
  • Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile-associated diarrhea, hypomagnesemia, or systemic cutaneous lupus erythematosus occur.
  • Inform patients that this drug may cause drowsiness, dizziness, vertigo, and/or visual disturbances. They should avoid driving or operating machinery until the full effects of the drug are seen.
  • Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.