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Amoxicillin / Clarithromycin / Lansoprazole Dosage

Medically reviewed by Last updated on Mar 28, 2019.

Applies to the following strengths: 500 mg-500 mg-30 mg

Usual Adult Dose for Helicobacter pylori Infection

Amoxicillin 1000 mg-clarithromycin 500 mg-lansoprazole 30 mg orally 2 times a day
-Duration of therapy: 10 to 14 days

Comment: This drug should be taken in the morning and evening.

Use: Treatment of patients with Helicobacter pylori infection and duodenal ulcer disease to eradicate H pylori

Renal Dose Adjustments

Mild to moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction (less than 30 mL/min): Not recommended.

Acute interstitial nephritis (AIN): Discontinue treatment in patients who develop AIN.

Liver Dose Adjustments

Liver dysfunction and normal renal function: No adjustment recommended.
Liver dysfunction with renal dysfunction: Decrease the dose and/or prolong the dosing interval.

Signs/symptoms of hepatitis: Discontinue clarithromycin immediately


Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:
-Patients should take each dose before meals.
-The pills should be swallowed whole.

Storage requirements: Protect from light and moisture.

-Eradication of H pylori reduces the risk of duodenal ulcer recurrence.
-This drug may be used in patients with active or a one-year history of duodenal ulcer.

-Hepatic: Hepatic function tests
-Hematologic: Hematopoietic function tests
-Renal: Renal function tests

Patient advice:
-Tell patients that it is important to complete the full regimen.
-Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile-associated diarrhea, hypomagnesemia, or systemic cutaneous lupus erythematosus occur.
-Inform patients that this drug may cause drowsiness, dizziness, vertigo, and/or visual disturbances. They should avoid driving or operating machinery until the full effects of the drug are seen.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.