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Amoxicillin / Clarithromycin / Lansoprazole Dosage

Applies to the following strength(s): 500 mg-500 mg-30 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Helicobacter pylori Infection

Amoxicillin 1000 mg-clarithromycin 500 mg-lansoprazole 30 mg orally 2 times a day
-Duration of therapy: 10 to 14 days

Comment: This drug should be taken in the morning and evening.

Use: Treatment of patients with Helicobacter pylori infection and duodenal ulcer disease to eradicate H pylori

Renal Dose Adjustments

Mild to moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction (less than 30 mL/min): Not recommended.

Liver Dose Adjustments

Liver dysfunction and normal renal function: No adjustment recommended.
Liver dysfunction with renal dysfunction: Decrease the dose and/or prolong the dosing interval.

Precautions

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Patients should take each dose before meals.
-The pills should be swallowed whole.

Storage requirements: Protect from light and moisture.

General:
-Eradication of H pylori reduces the risk of duodenal ulcer recurrence.
-This drug may be used in patients with active or a one-year history of duodenal ulcer.

Monitoring:
-Hepatic: Hepatic function tests
-Hematologic: Hematopoietic function tests
-Renal: Renal function tests

Patient advice:
-Tell patients that it is important to complete the full regimen.
-Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile-associated diarrhea, hypomagnesemia, or systemic cutaneous lupus erythematosus occur.
-Inform patients that this drug may cause drowsiness, dizziness, vertigo, and/or visual disturbances. They should avoid driving or operating machinery until the full effects of the drug are seen.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

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