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Amoxicillin / Clarithromycin / Lansoprazole Dosage

Applies to the following strength(s): 500 mg-500 mg-30 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Helicobacter pylori Infection

Amoxicillin 1000 mg-clarithromycin 500 mg-lansoprazole 30 mg orally 2 times a day
-Duration of therapy: 10 to 14 days

Comment: This drug should be taken in the morning and evening.

Use: Treatment of patients with Helicobacter pylori infection and duodenal ulcer disease to eradicate H pylori

Renal Dose Adjustments

Mild to moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction (less than 30 mL/min): Not recommended.

Liver Dose Adjustments

Liver dysfunction and normal renal function: No adjustment recommended.
Liver dysfunction with renal dysfunction: Decrease the dose and/or prolong the dosing interval.

Precautions

US BOXED WARNINGS:
Use in Pregnancy:
-Clarithromycin should not be used in pregnant women except in clinical circumstances where no alternative therapy is appropriate.
-If pregnancy occurs while taking clarithromycin, the patient should be informed of the potential hazard to the fetus.
-Clarithromycin has demonstrated adverse effects of pregnancy outcome and/or embryofetal development in monkeys, rats, mice, and rabbits at doses that produced plasma levels 2 to 17 times the serum levels achieved in humans treated at the maximum recommended human doses.

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Patients should take each dose before meals.
-The pills should be swallowed whole.

Storage requirements: Protect from light and moisture.

General:
-Eradication of H pylori reduces the risk of duodenal ulcer recurrence.
-This drug may be used in patients with active or a one-year history of duodenal ulcer.

Monitoring:
-Hepatic: Hepatic function tests
-Hematologic: Hematopoietic function tests
-Renal: Renal function tests

Patient advice:
-Tell patients that it is important to complete the full regimen.
-Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile-associated diarrhea, hypomagnesemia, or systemic cutaneous lupus erythematosus occur.
-Inform patients that this drug may cause drowsiness, dizziness, vertigo, and/or visual disturbances. They should avoid driving or operating machinery until the full effects of the drug are seen.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

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