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User Reviews for Esomeprazole

Also known as: Nexium, Nexium 24HR, Nexium IV

Esomeprazole has an average rating of 6.2 out of 10 from a total of 223 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 32% reported a negative effect.

Condition Avg. Rating Reviews Compare
GERD  
5.8
167 reviews 220 medications
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Helicobacter Pylori Infection  
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NSAID-Induced Gastric Ulcer  
10.0
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Gastritis/Duodenitis  
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2 reviews 4 medications
Summary of Esomeprazole reviews 6.2 223 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Esomeprazole

Bud January 15, 2020

Nexium (esomeprazole) for GERD: “Omagh let me start by saying I've only been on this for 14 days. Since then I've been to nine doctors appointments, 3 of these were different ER's because I was having heart/panic attacks! I'm 27 years young healthy as a lark. Every doctor swore that this wasn't the problem, that I had nothing at all wrong with me that anxiety, twitching, sweating/freezing, very moody, VERY bad Gas, sharp pains in chest and upper and lower back, abdomen hurting, confusion, foggy vision. This is insane I had to figure it out on my own. Guys I have never had any side effects from any medications. I have never ever felt this awful in my life. Just imagining me being as young and healthy as I am what this is doing to others. Just know your doctors/nurses will tell you that you're crazy and causing panic attacks and anxiety on your own. It's a lie. This medication was UNBELIEVABLY TOXIC for me. It did stop my heart burn 100% but I'd rather have heartburn than 100,000 dollars in Medical Bill's.”

1 / 10
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HW · Taken for 1 to 6 months May 2, 2021

Nexium (esomeprazole) for GERD: “Thank you, thank you!! I thought I was going crazy!!!!! Massive anxiety attacks, high blood pressure, heart palpitations, massive headaches, worst cramps ever... so many ED visits, so many doctors visits, ultrasounds, stress tests! My doctors thought I was a hypochondriac, that I was faking it... they put me on soo many prescriptions! So I decided to go off all my medications. I have felt the best for the last few weeks until yesterday when I got heartburn, so I took my nexium tablet... within 30-40mins I was laying in bed so bloody sick! Blood pressure was up, headaches kicked back in, massive fatigue. So I googled and found this review pages! I have now chucked out my tablets and I'll find something else to stop the heartburn! Thank you, thank you!!”

1 / 10
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Shoe Queen · Taken for 10 years or more March 2, 2020

Nexium (esomeprazole) for GERD: “I suffered for years with GERD and hiatus hernia. Ten years ago I was prescribed Nexium 40 mg which worked, Then reduced to 20 mg. After four years my Ferritin levels dropped to between 5 and seven and now are at level 2 !!! I had reduced B12/ B6 and Vitamin D . Finally I have osteoporosis because of lack of Vitamin D . All because Nexium blocks these from being absorbed into the bloodstream -Nexium is available over the counter without a prescription here in the UK and as such I continued to take it ! Nexium has side effects that are dangerous and life threatening - there are many ways to treat GERD without taking Nexium. Nexium will drain your body of all the required nutrients and vitamins needed for a healthy life and will block B12 absorption . NEXIUM is dangerous and should be available only on prescription for short term relief only .”

4 / 10
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Pete71 November 18, 2020

Nexium (esomeprazole) for GERD: “Glad that I have found this site. Got prescribed these meds from ER with suspected gastritis. Used them for 8 days (40mg x 2 times a day). Like everyone else, after 2 days use, I was severely debilitated - the only thing I could do was to lie down all day, every day whilst using them. Got all the regular symptoms described by others - shortness of breath, anxiety attacks, palpitations, light headedness, constant bloated feeling etc etc. 3 visits to ER - nil issues found with heart, bloods/xrays done all clear. Had gastroscopy done - all clear - nil issues at all - shouldn't have taken these meds to begin with. 5 days on after stopping them, I'm still feeling weak, anxious and consistently burping/feeling bloated. Research has shown these effects (even for short term use) can last up to 2 weeks - I've gone cold turkey and will never take these meds again. Previous to this, I never had these symptoms.”

1 / 10
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M2020 · Taken for 1 to 6 months March 9, 2020

Nexium (esomeprazole) for GERD: “I  have been on Nexium for a few months (almost 4 months) then I stopped taking it without medical advice. Although it can help reduce the acidity of stomach, however, its side effects are very annoying: I was feeling stomach cramps all day and constipation was a must no matter how much water you drink. I had a weird feeling of melancholy for no apparent reason and dark thoughts and self-flagellation, especially the time when I wake up in the morning. After I stopped taking Nexium, my psychology has immediately recovered in a few days and felt that was a nightmare.”

7 / 10
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Kekkie · Taken for 2 to 5 years February 20, 2020

Nexium (esomeprazole) for GERD: “I have been on Nexium for four years for GERD and just recently stopped. I have recently come to realize that Nexium is no longer helping me and instead is creating whole other set of problems such as low B12, intermittent low iron, upset stomach, dizziness, rash, etc. Now with studies showing dementia as another possible side effect, it's a drug I wouldn't recommend anyone be on. Honestly, do yourself a favor - if you have GERD like me, change your diet, exercise a bit more, don't eat after six, and have a tums for heartburn instead of using this garbage. Plus, a three-month supply is $442.00 where I live. NEVER again. Big pharma is just a crime.”

1 / 10
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RJN305 · Taken for less than 1 month December 17, 2019

Nexium (esomeprazole) for GERD: “I developed terrible GERD and acid reflux where I had chest pressure and the feeling of a giant golf ball stuck in my throat. I was started on Omeprazole for about a week with no improvement. I was sleeping almost sitting down because laying down made the chest pressure so much worse. I was switched to Nexium 40 mg, which I took for 2 weeks. I had terrible nausea, diarrhea, sweating, and anxiety every day. I also developed a fear of suicidal ideations. Fear of dying and fear that something would make me jump from my balcony. I had to lock all my sliding doors and I currently moved to my mom's house. I also had moments where my mind would not stop racing and I would be in a daze. Everyone was talking around me and I would not be present. I stopped the Nexium for 1 day already. The nausea has stopped and so has the diarrhea. I also have not had any dazed our moments today and my thoughts of dying were much less today. I also developed crazy depression.”

1 / 10
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Frequently asked questions

chunkymaw · Taken for less than 1 month June 25, 2021

Nexium (esomeprazole) for GERD: “I have taken Nexium a few times in the past and didn't realize that it was causing so many side effects until recently. I went back on it last week and started having terrible shakes, anxiety, nervousness, I felt like I was going to jump out of my skin. I stopped taking the Nexium, after I knew that's what was causing my mood changes and anxiety. I had the same symptoms a few Summer's ago from taking it. I will find something else for GERD, Nexium is not worth it. I just wondering how long this anxiety will last? it's not going away in a few days as it did before. UGHHHHHH”

1 / 10
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Yoshi · Taken for 1 to 6 months February 20, 2020

Nexium (esomeprazole) for GERD: “I feel much better, thanks to this website. I have been on Nexium for 2 months and started to develop brain fog, dizziness and involuntary muscle twitches. I am glad to read I'm not the only one. I will be weaning myself off of this medication. Great for acid but not worth it. Thanks!”

10 / 10
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Never again · Taken for 1 to 2 years February 9, 2020

Nexium (esomeprazole) for GERD: “I have used nexium on and off for several years. I didn't put 2 and 2 together until yesterday. My reaction to this drug has been horrific. Chest pain, anxiety, numb swollen tongue, arm and leg bone pain, bloating. I need to find a better solution because this drug is dangerous for me.”

1 / 10
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jay · Taken for 1 to 6 months December 30, 2020

Nexium (esomeprazole) for GERD: “I bought Nexium after the Zantac warning. It helped with reflux but caused constipation fairly quickly. Next I noticed dizziness, then feelings of nausea, followed by extreme tiredness during the day but insomnia causing me to wake in the early hours and be unable to fall asleep again. I became extremely depressed and lost interest in everything. The final straw was noticing that my legs have started to swell and feel tight and my feet are tingling and uncomfortable when I want to relax. The first few symptoms I could live with but the swelling and twitching of my feet and legs is not acceptable, neither is the aching I am experiencing. I am concerned about this to the extent I will be contacting my doctor. I will not be taking any more Nexium, I will try and control acid with diet from now on.”

1 / 10
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Swan · Taken for 6 months to 1 year August 5, 2018

Nexium (esomeprazole) for GERD: “I was put on nexium 40 mg daily 8 months ago for gastroesophageal reflux disease (GERD). It has nearly killed me. I thought I was developing MS as every muscle twitches and spasms, my skin itches, I have involuntary movements and worst of all I've got such an acutely dry mouth that I can no longer even eat. I've gone from a healthy person with GERD to an invalid. Finally my now critical illness has been found to be a reaction to the build up of nexium in my body over 8 months. I've been told to stop it immediately. Now I can no longer take any PPI and have such increased acid flow that I don't know what will become of me. How come this killer drug doesn't come with a strong warning? And why don't the doctors warn you?”

1 / 10
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YL · Taken for less than 1 month December 12, 2018

Nexium (esomeprazole) for GERD: “My doctor prescribe Nexium 40mg after endoscopy result that I've hiatus hinea and gastritis. The next day work up feeling terrible, stomach discomfort burping the whole time. I don't even have this symptoms before taking Nexium. By evening I felt my whole body so weak, can't sleep , anxiety, heart palpitation. Next morning, were slightly better but because I did not know it was the effect of the medicine I continue to take. By evening I felt like dying, the next morning admitted to hospital for IV drip . Stay a night and the doctor said which probably could be viral infection. But after discharge , I took Nexium again. True enough the whole attack happen again. I did not take today, but the side effect is still there. Hopefully it will go off soon. Not bearable. This drugs done more damage to me and not helping at all.”

1 / 10
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EDSuscMOM · Taken for 1 to 6 months January 23, 2020

Nexium (esomeprazole) for GERD: “Ill with GERD for years, unknowingly. Sore throat, itchy ears, no energy. An ear, nose throat specialist recognized the symptoms in 10 min. Was on Priolesec for 3 months. Started to have stomach ache. I switched to Nexium 24 hour slow release - great. Month 7, am down to only 3x per week and regulate on diet of the day. However, I do take with Greek Yogurt and am on a restrictive diet by choice. Yogurt, 3 tbs per meal. soothes tummy. if one does not follow a GERD diet, no medication will help. GERD diets are available online and very helpful. Lifestyle change is positive / significant. I am thankful for Nexium 24 hour slow release.”

10 / 10
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ME · Taken for 1 to 6 months January 15, 2020

Nexium (esomeprazole) for GERD: “I had been taking this medication Nexium for 4 months. I didn’t realize it at first, but it slowly sucked away my energy. Near the end of the 4 months, I began to feel nauseous and dizzy, with pain in my back. I had labs done, and am borderline anemic, low potassium, and kidney function is no longer optimal. I stopped the drug immediately and started to feel better - aside from the return of my gastritis. Three days ago I began taking it again: same symptoms, except this time with diarrhea, too. Make sure your vitamin and electrolytes are measured before and during use of this drug! It has been awful for me.”

1 / 10
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Another Anon · Taken for 10 years or more November 28, 2014

Nexium (esomeprazole) for GERD: “I've been taking Nexium for about 18 years now. I suffered bad heartburn/reflux etc,, that was partly to do with 'trigger' foods I ate. Over the years I learned to avoid those foods, & I started on Nexium. This medicine reduced my severe heartburn/reflux from maybe each second night when I wasn't taking it, to only about 2 times a month when I was taking it, so overall, over 18 years, Nexium made a huge difference to my life. From having to sit upright till 4am in bed till the pain went away & I could finally lie down (without Nexium) to getting a good sleep most nights (with Nexium). I do thoroughly recommend Nexium to anyone who can take it. Tip - AVOID Trigger foods! some are - chocolate, cream, oily foods, chickpeas, horseradish, mustard.”

9 / 10
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Bill · Taken for 1 to 6 months June 8, 2019

Nexium (esomeprazole) for GERD: “This drug is dangerous. I was given an 8 month prescription for acid reflux. At first I didn't notice any bad side effects, but after about 3 months things have really deteriorated. At first I thought I was tired from pushing myself hard with my work, and workout routine. But then a started feeling nauseous and it persisted for three days, then I began having severe joint pains to the point where I could hardly walk. Also feeling of panic, insomnia, and blood when I go to the toilet. But the worst has been MY HAIR FALLING OUT!!! I thought I was imagining it at first, but now my whole head has gone flaky/scabbing and I've lost about a third of my hair. I'm going straight to my doctor on Monday for a blood test. Current I'm bed ridden. Stay well away from this medication it's not worth the risks.”

1 / 10
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AndeA April 2, 2016

Nexium (esomeprazole) for GERD: “Wake up people. Google Nexium deaths for a real eye opener. I admit I took Nexium too long, over a year. The bad side effects came along gradually, and worsened as time went on. That is the only daily pharmaceutical drug I took. I did take vitamins frequently. First, pressure to go to the bathroom was noticed. I was checked for a UTI which was negative. I developed screaming migraine headaches which at 64 I had never had. When acute mouth dryness occurred, I thought I was diabetic for sure. I developed both dull pain in the kidney areas, and an aching under the shoulder blades. Bowel movements were slow, and difficult. I developed puffy spots under the eyes, and several doctors told me it was allergies which was frustrating. It was Nexium.”

1 / 10
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Vercetti October 28, 2019

Nexium (esomeprazole) for GERD: “I jumped onto Nexium just this past Friday since I needed a substitute for the Zantac recall. It was NOT a good choice but by the 3rd day, I had what I thought was either a heart or panic attack. I was having severe pressure behind the sternum and almost a twisting or spasmatic feeling there and in my stomach. It was difficult to breath and then my face and extremities began to tingle. It lasted for an hour and then finally subsided a bit but my chest remained uncomfortable. Here we are on day 4 and I have not taken it today nor will I. My dull chest pains are still off and on. I've gone and picked up some Magnesium Glycinate to rule this out based on what Nexium does with Magnesium though I doubt 3 doses would suck up my Magnesium. I also picked up some Pepcid which seems to be one the closest equivalents to Zantac. RECAP: I haven't gotten so much relief with regards to my GERD BUT it's sure as hell not worth these symptoms. Use at your own risk!”

2 / 10
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sally February 25, 2020

Nexium (esomeprazole) for GERD: “I have been on Nexium for a number of years. After eating too much fiber I got my stomach irritated. The Doctor put me on 40 mg of Nexium instead of the 20 mg that I had taken. Well, the 40 mg caused my blood pressure to go up and my heart to race. Will not take the 40 mg anymore.”

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Kaydee · Taken for less than 1 month April 18, 2019

Nexium (esomeprazole) for GERD: “I took one Nexium and had some frightening neurological or central nervous system response. I was trembling uncontrollably, broke out in a cold sweat, was weak, and nauseous. It terrified me! The only other time I have had a reaction like this was to a flu shot. I will never take either, again!”

1 / 10
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PFP · Taken for less than 1 month May 25, 2016

Nexium (esomeprazole) for GERD: “I can only speak FOR Nexium. It has literally changed my life for the better. I was fighting with GERD now for the past three years of my life. Terrible years, constant heartburn, increasing chest pains, I would wake up in the middle of the night and have my lungs full of acid. Then I could not lay back down because the acid taste would just make me even sicker. I was taking all kinds of acid blockers and nothing really worked. Then I finally tried Nexium and from day one it has changed EVERYTHING for the better. My heartburn is gone, completely. No more reflux, heartburn, chest pains, nothing. It is amazing. I had only slight side effects on day 2 but they went away and now I am just perfectly well. Amazing. Thank you!!”

10 / 10
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Anonymous · Taken for less than 1 month October 28, 2018

Nexium (esomeprazole) for GERD: “Absolutely awful drug.... I took it for 3 days.. yes it worked by removing the incessant burning...However...the side effects were horrific and take quite some time to get rid of... day 4 chest pain out of the blue lasting for several minutes ended up in the emergency room..ecg normal...lethargy ,anxiety, terrible stomach cramps, diarrhoea, back pain, limb weakness, neck pain and cramps, swaying.... this drug is SO toxic....it took a week or two for it to all subside.”

1 / 10
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Micha · Taken for 1 to 2 years May 12, 2020

Nexium (esomeprazole) for GERD: “I was prescribed the generic brand if Nexium, it worked once I was taking properly. I thought I could stop after a while but I would truly not be able to eat or sleep thru the nite if I was not taking this pill. Though I take daily on rare occasion I have an episode of running to bathroom to throw up at nite. I have noticed no side effects and have been talking for a year or a little longer.”

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Mia August 14, 2019

Nexium (esomeprazole) for GERD: “I had gastritis and was put on NEXIUM. After 2 months, still lot of pain due to diary, sugar etc.(tasty foods) So I assumed that I still have gastritis! Soon after I had a gastroscopy, and they found nothing. The doctor's msdiagnosed me with IBS. So I took matters into my own hands. So I read online about the interaction nexium could be causing. I hypothesised that perhaps this pain from foods is because of LOW ACIDITY because proton pumps REDUCE ACIDITY. It made sense! How can I eat chunky foods, when my body does not have enough juices in my body to break it down due to NEXIUM! So, I got off nexium the next morning, felt BURNING sensation (takes time for your stomach to adjust). Instead of Nexium, I reached for bicarbonate soda and water. The acidity went away. I reached for the milk and tomato sauce, and was able to drink and digest is like a boss! I could not believe what I was experiencing! The problem was nexium! FACT: Nexium causes hypersensitivity to the stomach to some people.”

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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.