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AcipHex

Generic Name: rabeprazole (ra BEP ra zole)
Brand Names: AcipHex, AcipHex Sprinkle

Medically reviewed on Aug 9, 2018

What is AcipHex?

AcipHex (rabeprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

AcipHex is used short-term to treat symptoms of gastroesophageal reflux disease (GERD) in adults and children who are at least 1 year old.

AcipHex is used only in adults to treat conditions involving excessive stomach acid, such as Zollinger-Ellison syndrome. It is also used in adults to promote healing of duodenal ulcers or erosive esophagitis (damage to your esophagus caused by stomach acid).

AcipHex may also be given with an antibiotic to prevent duodenal ulcer caused by infection with Helicobacter pylori (H. pylori).

AcipHex is not for immediate relief of heartburn symptoms.

Important Information

You should not use AcipHex if you are allergic to rabeprazole or to similar medicines such as lansoprazole (Prevacid), esomeprazole (Nexium), omeprazole (Prilosec, Zegerid), or pantoprazole (Protonix). AcipHex is not for immediate relief of heartburn symptoms.

Rabeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

AcipHex may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

Taking AcipHex may increase your risk of bone fracture in the hip, wrist, or spine, especially if you take the medicine long term or more than once per day.

Before taking this medicine

Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed.

You should not use AcipHex if you are allergic to rabeprazole or:

Tell your doctor if you have ever had:

You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Do not give AcipHex to a child without without medical advice. Certain forms and strengths of rabeprazole should not be given to a child younger than 12 years old.

How should I take AcipHex?

AcipHex is usually taken once per day. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

AcipHex is for short-term use only, usually 4 to 8 weeks. Your doctor may recommend a second course of treatment if you need additional healing time.

AcipHex Sprinkle should not be given to a child younger than 1 year old.

Take this medicine with a full glass of water.

If you take AcipHex to treat duodenal ulcers, take the medicine after a meal. If you take AcipHex to prevent ulcers caused by Helicobacter pylori, take the medicine with food. If you take this medicine for any other condition, you may take it with or without food.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Swallow the tablet whole and do not crush, chew, or break it.

Do not swallow a delayed-release capsule (AcipHex Sprinkle) whole. Open it and sprinkle the medicine into a spoonful of soft food such as applesauce, yogurt, or baby food made from fruit or vegetable. You may also mix the medicine with apple juice, Pedialyte, or infant formula. Swallow the mixture right away without chewing. Do not save it for later use.

Rabeprazole can affect the results of certain medical tests. Tell any doctor who treats you that you are using rabeprazole.

Some conditions are treated with a combination of rabeprazole and antibiotics. Use all medications as directed.

Take AcipHex for the full prescribed length of time, even if your symptoms quickly improve.

Call your doctor if your symptoms do not improve, or if they get worse while using AcipHex.

Store at room temperature away from moisture and heat.

AcipHex Dosing Information

Usual Adult Dose for Duodenal Ulcer:

20 mg orally once a day
-Duration of therapy: 4 weeks

Comment: While most patients achieve ulcer healing after 4 weeks, some patients may need an additional course of therapy to achieve ulcer healing.

Use: Healing and symptomatic relief of duodenal ulcers

Usual Adult Dose for Erosive Esophagitis:

20 mg orally once a day
-Duration of therapy: 4 to 8 weeks

Comment: If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.

Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)

Usual Adult Dose for Gastric Ulcer:

20 mg orally once a day
-Duration of therapy: 4 to 8 weeks

Comment: If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.

Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)

Usual Adult Dose for Duodenal Ulcer Prophylaxis:

20 mg orally once a day
-Duration of therapy: Up to 12 months

Comment: Controlled studies for maintenance therapy have not extended beyond 12 months.

Use: Maintenance of healing and reduction in relapse rates of heartburn symptoms in patients with erosive or ulcerative GERD

Usual Adult Dose for Gastroesophageal Reflux Disease:

20 mg orally once a day
-Duration of therapy: Up to 4 weeks

Comment: If symptoms do not resolve after 4 weeks of therapy, an additional course of treatment may be considered.

Use: Treatment of daytime and nighttime heartburn and other symptoms associated with GERD

Usual Adult Dose for Helicobacter pylori Infection:

20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin
-Duration of therapy: 7 days

Comments:
-Refer to the manufacturer product information for dosing for amoxicillin and clarithromycin.
-All medications should be taken with morning and evening meals.
-Eradication of Helicobacter pylori has been shown to decrease the risk of duodenal ulcer recurrence.
-Patients who fail therapy should undergo susceptibility testing and/or begin alternative antimicrobial therapy.

Use: Treatment and eradication of H pylori and active/history of duodenal ulcer disease within 5 years

Usual Adult Dose for Zollinger-Ellison Syndrome:

Initial dose: 60 mg orally once a day
Maintenance dose: 60 mg orally 2 times a day or 100 mg orally once a day
Duration of therapy: Up to 1 year

Comments:
-Doses should be patient-specific and should continue for as long as clinically necessary.
-Divided dosing may be required in some patients.

Use: Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome)

Usual Pediatric Dose for Gastroesophageal Reflux Disease:

1 to 11 years:
Less than 15 kg: 5 mg orally once a day, with the option to increase to 10 mg if inadequate response
15 kg or more: 10 mg orally once a day
Duration of therapy: Up to 12 weeks

12 years or older: 20 mg orally once a day
-Duration of therapy: Up to 8 weeks

Uses:
-Treatment of GERD
-Treatment of symptomatic GERD

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking AcipHex?

This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

AcipHex side effects

Get emergency medical help if you have signs of an allergic reaction to AcipHex: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • sudden pain or trouble moving your hip, wrist, or back;

  • seizure (convulsions);

  • kidney problems--urinating less than usual, blood in your urine, swelling, rapid weight gain;

  • new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight;

  • low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or

  • signs of bleeding (if you also take warfarin)--headaches, dizziness, weakness; pain or swelling; bruising, unusual bleeding (nosebleeds, bleeding gums); red or pink urine; heavy menstrual flow; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or any bleeding that will not stop.

Taking AcipHex long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

If you use AcipHex for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Common AcipHex side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect AcipHex?

Tell your doctor about all your current medicines. Many drugs can interact with rabeprazole, especially:

This list is not complete and many other drugs may interact with rabeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use AcipHex only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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