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AcipHex

Generic Name: rabeprazole (ra BEP ra zole)
Brand Names: AcipHex, AcipHex Sprinkle

Medically reviewed on January 11, 2018

What is AcipHex?

AcipHex (rabeprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

AcipHex is used short-term to treat symptoms of gastroesophageal reflux disease (GERD) in adults and children who are at least 1 year old.

AcipHex is used only in adults to treat conditions involving excessive stomach acid, such as Zollinger-Ellison syndrome. Rabeprazole is also used in adults to promote healing of duodenal ulcers or erosive esophagitis (damage to your esophagus caused by stomach acid).

AcipHex may also be given with an antibiotic to prevent duodenal ulcer caused by infection with Helicobacter pylori (H. pylori).

This medicine is not for immediate relief of heartburn symptoms.

Important information

You should not use AcipHex if you are allergic to rabeprazole or to similar medicines such as lansoprazole (Prevacid), esomeprazole (Nexium), omeprazole (Prilosec, Zegerid), or pantoprazole (Protonix). AcipHex is not for immediate relief of heartburn symptoms.

Some conditions are treated with a combination of AcipHex and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Rabeprazole can cause kidney problems, an intestinal infection, or lupus (an autoimmune disorder).

Call your doctor right away if you have new or worsening joint pain, a skin rash that gets worse in sunlight, severe stomach pain, watery or bloody diarrhea, blood in your urine, or little or no urination.

Taking AcipHex may increase your risk of bone fracture in the hip, wrist, or spine, especially if you take the medicine long term or more than once per day.

Before taking this medicine

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

You should not use AcipHex if you are allergic to rabeprazole or:

  • if you also take any medicine that contains rilpivirine, such as Edurant or Complera; or

  • if you also allergic to medicines like rabeprazole, such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), or pantoprazole (Protonix).

To make sure AcipHex is safe for you, tell your doctor if you have ever had:

  • liver disease;

  • osteoporosis or low bone mineral density (osteopenia);

  • lupus (an autoimmune disorder); or

  • low levels of magnesium in your blood.

Taking a proton pump inhibitor such as AcipHex may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medicine long term or more than once per day, and in those who are age 50 and older. It is not clear whether AcipHex is the actual cause of an increased risk of fracture.

It is not known whether AcipHex will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether rabeprazole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take AcipHex?

AcipHex is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

AcipHex is for short-term use only, usually 4 to 8 weeks. Your doctor may recommend a second course of treatment if you need additional healing time.

Do not give this medicine to a child without medical advice. Certain forms and strengths of rabeprazole should not be given to a child younger than 12 years old.

AcipHex Sprinkle should not be given to a child younger than 1 year old.

When treating H. pylori infection, AcipHex may be needed for only 7 days. Follow your doctor's dosing instructions very carefully.

Take this medicine with a full glass of water.

If you take AcipHex to treat duodenal ulcers, take the medicine after a meal. If you take AcipHex to prevent ulcers caused by Helicobacter pylori, take the medicine with food. If you take this medicine for any other condition, you may take rabeprazole with or without food.

AcipHex Sprinkle delayed-release capsules should be taken 30 minutes before a meal.

Do not crush, break, or chew the tablet form of this medicine. Swallow the tablet whole.

To take AcipHex Sprinkle, open the capsule and sprinkle the medicine into a spoonful of soft food such as applesauce, yogurt, or baby food made from fruit or vegetable. You may also mix the medicine with apple juice, Pedialyte, or infant formula. Swallow right away without chewing. Do not save the mixture for later use; it will go bad after 15 minutes.

Some conditions are treated with a combination of rabeprazole and antibiotics. Use all medications as directed by your doctor. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Do not change your doses or medication schedule without your doctor's advice.

Take your medicine for the full prescribed length of time. Your symptoms may improve before your condition is completely cleared.

Rabeprazole can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.

Call your doctor if your symptoms do not improve, or if they get worse while using AcipHex.

If you use AcipHex for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Store at room temperature away from moisture and heat.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking AcipHex?

This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Rabeprazole side effects

Get emergency medical help if you have signs of an allergic reaction to AcipHex: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • sudden pain or trouble moving your hip, wrist, or back;

  • seizure (convulsions);

  • kidney problems - urinating less than usual, blood in your urine, swelling, rapid weight gain;

  • symptoms of lupus - new or worsening joint pain, skin rash on your cheeks and arms (worsens in sunlight);

  • symptoms of low magnesium - dizziness, irregular heart rate, feeling jittery, muscle pain or weakness, muscle spasms in your hands and feet, choking feeling, hoarse voice, seizure;

  • symptoms of low vitamin B - pale skin, tiredness, muscle weakness, irregular heartbeats, feeling light-headed or short of breath; or

  • signs of bleeding (if you also take warfarin) - headaches, dizziness, weakness; pain or swelling; bruising, unusual bleeding, nosebleeds, bleeding gums); red or pink urine; heavy menstrual flow; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or any bleeding that will not stop.

Common AcipHex side effects may include:

  • headache;

  • sore throat;

  • diarrhea, constipation; or

  • stomach pain, gas, nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect AcipHex?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • methotrexate (Otrexup, Rasuvo,Trexall); or

  • warfarin (Coumadin, Jantoven).

This list is not complete. Other drugs may interact with rabeprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use AcipHex only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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