Aciphex Side Effects
Generic name: rabeprazole
Medically reviewed by Drugs.com. Last updated on Feb 6, 2023.
Note: This document contains side effect information about rabeprazole. Some dosage forms listed on this page may not apply to the brand name Aciphex.
Summary
Common side effects of Aciphex include: atrophic gastritis. Continue reading for a comprehensive list of adverse effects.
Applies to rabeprazole: oral tablets.
Side effects include:
Pain, pharyngitis, flatulence, infection, constipation.
For Healthcare Professionals
Applies to rabeprazole: oral delayed release capsule, oral delayed release tablet, oral tablet extended release.
General
The most commonly reported side effects are headache, diarrhea, and abdominal pain.[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (up to 21%), abdominal pain (up to 16%), vomiting (up to 14%)
Common (1% to 10%): Benign fundic gland polyps, constipation, flatulence, nausea
Uncommon (0.1% to 1%): Dry mouth, dyspepsia, eructation
Rare (0.01% to 0.1%): Gastritis, stomatitis
Frequency not reported: Microscopic colitis
Postmarketing reports: Clostridium difficile-associated diarrhea[Ref]
Other
Common (1% to 10%): Asthenia, non-specific pain, pain
Uncommon (0.1% to 1%): Chills, pyrexia/fever
Postmarketing reports: Sudden death[Ref]
Respiratory
Common (1% to 10%): Cough, pharyngitis, rhinitis
Uncommon (0.1% to 1%): Bronchitis, sinusitis
Postmarketing reports: Dyspnea, interstitial pneumonia[Ref]
Nervous system
Hepatic encephalopathy occurred in patients with underlying cirrhosis.[Ref]
Common (1% to 10%): Dizziness, headache, taste disturbance/perversion
Uncommon (0.1% to 1%): Somnolence
Rare (0.01% to 0.1%): Hepatic encephalopathy
Postmarketing reports: Coma, vertigo[Ref]
Immunologic
Common (1% to 10%): Flu-like syndrome/ influenza-like illness, infection[Ref]
Musculoskeletal
Common (1% to 10%): Back pain, myalgia
Uncommon (0.1% to 1%): Arthralgia, fracture of hip/wrist/spine, leg cramps
Postmarketing reports: Bone fractures, rhabdomyolysis[Ref]
Dermatologic
Erythema and bullous reactions usually resolved after discontinuation.[Ref]
Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Erythema
Rare (0.01% to 0.1%): Bullous reactions, pruritus, sweating
Very rare (less than 0.01%): Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)
Frequency not reported: Facial swelling, subacute cutaneous lupus erythematosus
Postmarketing reports: fatal TEN, other drug eruptions, severe dermatological reactions, systemic lupus erythematosus, urticarial skin eruptions[Ref]
Psychiatric
Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Nervousness
Rare (0.01% to 0.1%): Depression
Frequency not reported: Confusion
Postmarketing reports: Delirium, disorientation[Ref]
Cardiovascular
Common (1% to 10%): Chest pain
Uncommon (0.1% to 1%): Peripheral edema
Postmarketing reports: Hypotension[Ref]
Hepatic
Uncommon (0.1% to 1%): Increased hepatic enzymes
Rare (0.01% to 0.1%): Hepatitis, jaundice, serious hepatic dysfunction[Ref]
Increased hepatic enzymes occurred in patients with underlying cirrhosis.[Ref]
Genitourinary
Uncommon (0.1% to 1%): Urinary tract infection[Ref]
Hematologic
Rare (0.01% to 0.1%): Leukocytosis, leukopenia, neutropenia, thrombocytopenia
Postmarketing reports: Agranulocytosis, bicytopenia, blood dyscrasias, hemolytic anemia, increase in prothrombin time/INR, pancytopenia[Ref]
Increased prothrombin time/INR occurred in patients taking warfarin concomitantly.[Ref]
Metabolic
Rare (0.01% to 0.1%): Anorexia, weight gain
Frequency not reported: Cyanocobalamin (Vitamin B-12) deficiency, hypomagnesemia, hyponatremia
Postmarketing reports: Hyperammonemia[Ref]
Renal
Rare (0.01% to 0.1%): Interstitial nephritis[Ref]
Ocular
Rare (0.01% to 0.1%): Visual disturbance
Postmarketing reports: Blurred vision[Ref]
Endocrine
Frequency not reported: Gynecomastia
Postmarketing reports: Thyroid stimulating hormone (TSH) elevations[Ref]
Hypersensitivity
Hypersensitivity reactions included facial swelling, hypotension, dyspnea, erythema, and bullous reactions; these reactions typically resolved after discontinuation.[Ref]
Rare (0.01% to 0.1%): Hypersensitivity
Postmarketing reports: Acute systemic allergic reactions, anaphylaxis/anaphylactic reactions, angioedema, potential allergic reactions[Ref]
More about Aciphex (rabeprazole)
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Patient resources
- Aciphex drug information
- Aciphex (Rabeprazole Delayed-Release Tablets)
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Other brands
Professional resources
Related treatment guides
References
1. Product Information. Aciphex (rabeprazole). Janssen Pharmaceuticals. 2001.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
3. Cerner Multum, Inc. Australian Product Information.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.