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Aciphex Side Effects

Generic name: rabeprazole

Medically reviewed by Last updated on Feb 6, 2023.

Note: This document contains side effect information about rabeprazole. Some dosage forms listed on this page may not apply to the brand name Aciphex.


Common side effects of Aciphex include: atrophic gastritis. Continue reading for a comprehensive list of adverse effects.

Applies to rabeprazole: oral tablets.

Side effects include:

Pain, pharyngitis, flatulence, infection, constipation.

For Healthcare Professionals

Applies to rabeprazole: oral delayed release capsule, oral delayed release tablet, oral tablet extended release.


The most commonly reported side effects are headache, diarrhea, and abdominal pain.[Ref]


Very common (10% or more): Diarrhea (up to 21%), abdominal pain (up to 16%), vomiting (up to 14%)

Common (1% to 10%): Benign fundic gland polyps, constipation, flatulence, nausea

Uncommon (0.1% to 1%): Dry mouth, dyspepsia, eructation

Rare (0.01% to 0.1%): Gastritis, stomatitis

Frequency not reported: Microscopic colitis

Postmarketing reports: Clostridium difficile-associated diarrhea[Ref]


Common (1% to 10%): Asthenia, non-specific pain, pain

Uncommon (0.1% to 1%): Chills, pyrexia/fever

Postmarketing reports: Sudden death[Ref]


Common (1% to 10%): Cough, pharyngitis, rhinitis

Uncommon (0.1% to 1%): Bronchitis, sinusitis

Postmarketing reports: Dyspnea, interstitial pneumonia[Ref]

Nervous system

Hepatic encephalopathy occurred in patients with underlying cirrhosis.[Ref]

Common (1% to 10%): Dizziness, headache, taste disturbance/perversion

Uncommon (0.1% to 1%): Somnolence

Rare (0.01% to 0.1%): Hepatic encephalopathy

Postmarketing reports: Coma, vertigo[Ref]


Common (1% to 10%): Flu-like syndrome/ influenza-like illness, infection[Ref]


Common (1% to 10%): Back pain, myalgia

Uncommon (0.1% to 1%): Arthralgia, fracture of hip/wrist/spine, leg cramps

Postmarketing reports: Bone fractures, rhabdomyolysis[Ref]


Erythema and bullous reactions usually resolved after discontinuation.[Ref]

Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Erythema

Rare (0.01% to 0.1%): Bullous reactions, pruritus, sweating

Very rare (less than 0.01%): Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)

Frequency not reported: Facial swelling, subacute cutaneous lupus erythematosus

Postmarketing reports: fatal TEN, other drug eruptions, severe dermatological reactions, systemic lupus erythematosus, urticarial skin eruptions[Ref]


Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Nervousness

Rare (0.01% to 0.1%): Depression

Frequency not reported: Confusion

Postmarketing reports: Delirium, disorientation[Ref]


Common (1% to 10%): Chest pain

Uncommon (0.1% to 1%): Peripheral edema

Postmarketing reports: Hypotension[Ref]


Uncommon (0.1% to 1%): Increased hepatic enzymes

Rare (0.01% to 0.1%): Hepatitis, jaundice, serious hepatic dysfunction[Ref]

Increased hepatic enzymes occurred in patients with underlying cirrhosis.[Ref]


Uncommon (0.1% to 1%): Urinary tract infection[Ref]


Rare (0.01% to 0.1%): Leukocytosis, leukopenia, neutropenia, thrombocytopenia

Postmarketing reports: Agranulocytosis, bicytopenia, blood dyscrasias, hemolytic anemia, increase in prothrombin time/INR, pancytopenia[Ref]

Increased prothrombin time/INR occurred in patients taking warfarin concomitantly.[Ref]


Rare (0.01% to 0.1%): Anorexia, weight gain

Frequency not reported: Cyanocobalamin (Vitamin B-12) deficiency, hypomagnesemia, hyponatremia

Postmarketing reports: Hyperammonemia[Ref]


Rare (0.01% to 0.1%): Interstitial nephritis[Ref]


Rare (0.01% to 0.1%): Visual disturbance

Postmarketing reports: Blurred vision[Ref]


Frequency not reported: Gynecomastia

Postmarketing reports: Thyroid stimulating hormone (TSH) elevations[Ref]


Hypersensitivity reactions included facial swelling, hypotension, dyspnea, erythema, and bullous reactions; these reactions typically resolved after discontinuation.[Ref]

Rare (0.01% to 0.1%): Hypersensitivity

Postmarketing reports: Acute systemic allergic reactions, anaphylaxis/anaphylactic reactions, angioedema, potential allergic reactions[Ref]


1. Product Information. Aciphex (rabeprazole). Janssen Pharmaceuticals. 2001.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.