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Aciphex Side Effects

Generic Name: rabeprazole

Note: This page contains information about the side effects of rabeprazole. Some of the dosage forms included on this document may not apply to the brand name Aciphex.

In Summary

Common side effects of Aciphex include: atrophic gastritis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rabeprazole: oral capsule delayed release, oral tablet enteric coated

In addition to its needed effects, some unwanted effects may be caused by rabeprazole (the active ingredient contained in Aciphex). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking rabeprazole:

Less common:
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • cough or hoarseness
  • dark urine
  • dry mouth
  • fever or chills
  • general tiredness and weakness
  • light-colored stools
  • lower back or side pain
  • nausea and vomiting
  • painful or difficult urination
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss
  • yellow eyes and skin
  • Bloody urine
  • continuing ulcers or sores in the mouth
  • convulsions (seizures)
  • difficulty with breathing
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Incidence not known:
  • Back, leg, or stomach pains
  • bleeding gums
  • blood in the urine or stools
  • bloody, black, or tarry stools
  • change in consciousness
  • clay-colored stools
  • cloudy urine
  • confusion about identity, place, person, and time
  • continuing nausea or vomiting
  • difficulty with swallowing
  • dizziness
  • drowsiness
  • fast heartbeat
  • general body swelling
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination or amount of urine
  • headache
  • high fever
  • hives
  • holding false beliefs that cannot be changed by fact
  • increase in the frequency of seizures
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • loss of consciousness
  • mood or mental changes
  • muscle cramps
  • muscle pain or stiffness
  • muscle spasms (tetany) or twitching
  • no blood pressure
  • no breathing
  • no pulse
  • nosebleeds
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seeing, hearing, or feeling things that are not there
  • seizures
  • skin blisters
  • skin rash
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tightness in the chest
  • trembling
  • unpleasant breath odor
  • unusual excitement, nervousness, or restlessness
  • vomiting of blood

Minor Side Effects

Some of the side effects that can occur with rabeprazole may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
Less common
  • Body aches or pain
  • congestion
  • constipation
  • diarrhea
  • excess air or gas in the stomach or intestines
  • feeling weak
  • full feeling
  • heartburn
  • numbness, tingling, pain, or weakness in the hands or feet
  • pain
  • passing gas
  • runny nose
  • sleepiness
  • swollen joints
  • tender, swollen glands in the neck
  • voice changes
Incidence not known:
  • Blistering, peeling, or loosening of the skin
  • red, irritated eyes
  • red skin lesions, often with a purple center

For Healthcare Professionals

Applies to rabeprazole: oral delayed release capsule, oral delayed release tablet, oral tablet extended release


The most commonly reported side effects are headache, diarrhea, and abdominal pain.[Ref]


Common (1% to 10%): Diarrhea, vomiting, nausea, abdominal pain, constipation, flatulence
Uncommon (0.1% to 1%): Dyspepsia, dry mouth, eructation
Rare (0.01% to 0.1%): Gastritis, stomatitis
Postmarketing reports: Clostridium difficile-associated diarrhea[Ref]


Common (1% to 10%): Infection, non-specific pain, influenza-like illness, asthenia
Uncommon (0.1% to 1%): Chills, pyrexia/fever
Postmarketing reports: Sudden death[Ref]


Common (1% to 10%): Cough, pharyngitis, rhinitis
Uncommon (0.1% to 1%): Bronchitis, sinusitis
Postmarketing reports: Dyspnea, interstitial pneumonia[Ref]

Nervous system

Hepatic encephalopathy occurred in patients with underlying cirrhosis.[Ref]

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Somnolence, hepatic encephalopathy
Rare (0.01% to 0.1%): Taste disturbance/perversion
Postmarketing reports: Coma[Ref]


Common (1% to 10%): Back pain, myalgia
Uncommon (0.1% to 1%): Leg cramps, arthralgia, fracture of hip/wrist/spine
Postmarketing reports: Rhabdomyolysis[Ref]


Erythema and bullous reactions usually resolved after discontinuation.[Ref]

Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Erythema
Rare (0.01% to 0.1%): Pruritus, sweating, bullous reactions
Very rare (less than 0.01%): Erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome
Frequency not reported: Subacute cutaneous lupus erythematosus
Postmarketing reports: Urticarial skin eruptions, other drug eruptions[Ref]


Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Nervousness
Rare (0.01% to 0.1%): Depression
Frequency not reported: Confusion
Postmarketing reports: Disorientation, delirium[Ref]


Common (1% to 10%): Chest pain
Uncommon (0.1% to 1%): Peripheral edema
Postmarketing reports: Hypotension[Ref]


Uncommon (0.1% to 1%): Increased hepatic enzymes
Rare (0.01% to 0.1%): Hepatitis, jaundice[Ref]

Increased hepatic enzymes occurred in patients with underlying cirrhosis.[Ref]


Uncommon (0.1% to 1%): Urinary tract infection[Ref]


Rare (0.01% to 0.1%): Neutropenia, leukopenia, thrombocytopenia, leukocytosis
Postmarketing reports: Pancytopenia, agranulocytosis, bicytopenia, hemolytic anemia, increase in prothrombin time/INR[Ref]

Increased prothrombin time/INR occurred in patients taking warfarin concomitantly.[Ref]


Rare (0.01% to 0.1%): Anorexia, weight gain
Frequency not reported: Hypomagnesemia, hyponatremia
Postmarketing reports: Hyperammonemia[Ref]


Hypersensitivity reactions included facial swelling, hypotension, dyspnea, erythema, and bullous reactions; these reactions typically resolved after discontinuation.[Ref]

Rare (0.01% to 0.1%): Hypersensitivity[Ref]


Rare (0.01% to 0.1%): Interstitial nephritis[Ref]


Rare (0.01% to 0.1%): Visual disturbance[Ref]


Frequency not reported: Gynecomastia
Postmarketing reports: TSH elevations[Ref]


Postmarketing reports: Acute systemic allergic reactions, anaphylaxis/anaphylactic reactions, angioedema[Ref]


1. "Product Information. Aciphex (rabeprazole)" Janssen Pharmaceuticals, Titusville, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Aciphex may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.