Aciphex Side Effects

Generic name: rabeprazole

Medically reviewed by Drugs.com. Last updated on Feb 6, 2023.

Note: This document contains side effect information about rabeprazole. Some dosage forms listed on this page may not apply to the brand name Aciphex.

Summary

Common side effects of Aciphex include: atrophic gastritis. Continue reading for a comprehensive list of adverse effects.

Applies to rabeprazole: oral tablets.

Side effects include:

Pain, pharyngitis, flatulence, infection, constipation.

For Healthcare Professionals

Applies to rabeprazole: oral delayed release capsule, oral delayed release tablet, oral tablet extended release.

General

The most commonly reported side effects are headache, diarrhea, and abdominal pain.^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 21%), abdominal pain (up to 16%), vomiting (up to 14%)

Common (1% to 10%): Benign fundic gland polyps, constipation, flatulence, nausea

Uncommon (0.1% to 1%): Dry mouth, dyspepsia, eructation

Rare (0.01% to 0.1%): Gastritis, stomatitis

Frequency not reported: Microscopic colitis

Postmarketing reports: Clostridium difficile-associated diarrhea^[Ref]

Other

Common (1% to 10%): Asthenia, non-specific pain, pain

Uncommon (0.1% to 1%): Chills, pyrexia/fever

Postmarketing reports: Sudden death^[Ref]

Respiratory

Common (1% to 10%): Cough, pharyngitis, rhinitis

Uncommon (0.1% to 1%): Bronchitis, sinusitis

Postmarketing reports: Dyspnea, interstitial pneumonia^[Ref]

Nervous system

Hepatic encephalopathy occurred in patients with underlying cirrhosis.^[Ref]

Common (1% to 10%): Dizziness, headache, taste disturbance/perversion

Uncommon (0.1% to 1%): Somnolence

Rare (0.01% to 0.1%): Hepatic encephalopathy

Postmarketing reports: Coma, vertigo^[Ref]

Immunologic

Common (1% to 10%): Flu-like syndrome/ influenza-like illness, infection^[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, myalgia

Uncommon (0.1% to 1%): Arthralgia, fracture of hip/wrist/spine, leg cramps

Postmarketing reports: Bone fractures, rhabdomyolysis^[Ref]

Dermatologic

Erythema and bullous reactions usually resolved after discontinuation.^[Ref]

Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Erythema

Rare (0.01% to 0.1%): Bullous reactions, pruritus, sweating

Very rare (less than 0.01%): Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)

Frequency not reported: Facial swelling, subacute cutaneous lupus erythematosus

Postmarketing reports: fatal TEN, other drug eruptions, severe dermatological reactions, systemic lupus erythematosus, urticarial skin eruptions^[Ref]

Psychiatric

Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Nervousness

Rare (0.01% to 0.1%): Depression

Frequency not reported: Confusion

Postmarketing reports: Delirium, disorientation^[Ref]

Cardiovascular

Common (1% to 10%): Chest pain

Uncommon (0.1% to 1%): Peripheral edema

Postmarketing reports: Hypotension^[Ref]

Hepatic

Uncommon (0.1% to 1%): Increased hepatic enzymes

Rare (0.01% to 0.1%): Hepatitis, jaundice, serious hepatic dysfunction^[Ref]

Increased hepatic enzymes occurred in patients with underlying cirrhosis.^[Ref]

Genitourinary

Uncommon (0.1% to 1%): Urinary tract infection^[Ref]

Hematologic

Rare (0.01% to 0.1%): Leukocytosis, leukopenia, neutropenia, thrombocytopenia

Postmarketing reports: Agranulocytosis, bicytopenia, blood dyscrasias, hemolytic anemia, increase in prothrombin time/INR, pancytopenia^[Ref]

Increased prothrombin time/INR occurred in patients taking warfarin concomitantly.^[Ref]

Metabolic

Rare (0.01% to 0.1%): Anorexia, weight gain

Frequency not reported: Cyanocobalamin (Vitamin B-12) deficiency, hypomagnesemia, hyponatremia

Postmarketing reports: Hyperammonemia^[Ref]

Renal

Rare (0.01% to 0.1%): Interstitial nephritis^[Ref]

Ocular

Rare (0.01% to 0.1%): Visual disturbance

Postmarketing reports: Blurred vision^[Ref]

Endocrine

Frequency not reported: Gynecomastia

Postmarketing reports: Thyroid stimulating hormone (TSH) elevations^[Ref]

Hypersensitivity

Hypersensitivity reactions included facial swelling, hypotension, dyspnea, erythema, and bullous reactions; these reactions typically resolved after discontinuation.^[Ref]

Rare (0.01% to 0.1%): Hypersensitivity

Postmarketing reports: Acute systemic allergic reactions, anaphylaxis/anaphylactic reactions, angioedema, potential allergic reactions^[Ref]