Medically reviewed on January 11, 2018.
What is rabeprazole?
Rabeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.
Rabeprazole is used only in adults to treat conditions involving excessive stomach acid, such as Zollinger-Ellison syndrome. Rabeprazole is also used in adults to promote healing of duodenal ulcers or erosive esophagitis (damage to your esophagus caused by stomach acid).
Rabeprazole is not for immediate relief of heartburn symptoms.
Rabeprazole may also be used for purposes not listed in this medication guide.
Rabeprazole can cause kidney problems, an intestinal infection, or lupus (an autoimmune disorder).
Call your doctor right away if you have new or worsening joint pain, a skin rash that gets worse in sunlight, severe stomach pain, watery or bloody diarrhea, blood in your urine, or little or no urination.
Taking rabeprazole may increase your risk of bone fracture in the hip, wrist, or spine, especially if you take the medicine long term or more than once per day.
Before taking this medicine
Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.
You should not use this medicine if you are allergic to rabeprazole or:
To make sure rabeprazole is safe for you, tell your doctor if you have ever had:
lupus (an autoimmune disorder); or
low levels of magnesium in your blood.
Taking a proton pump inhibitor such as rabeprazole may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medicine long term or more than once per day, and in those who are age 50 and older. It is not clear whether rabeprazole is the actual cause of an increased risk of fracture.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether rabeprazole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take rabeprazole?
Rabeprazole is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Rabeprazole is for short-term use only, usually 4 to 8 weeks. Your doctor may recommend a second course of treatment if you need additional healing time.
Do not give this medicine to a child without medical advice. Certain forms and strengths of rabeprazole should not be given to a child younger than 12 years old.
AcipHex Sprinkle should not be given to a child younger than 1 year old.
When treating H. pylori infection, rabeprazole may be needed for only 7 days. Follow your doctor's dosing instructions very carefully.
Take this medicine with a full glass of water.
If you take rabeprazole to treat duodenal ulcers, take the medicine after a meal. If you take rabeprazole to prevent ulcers caused by Helicobacter pylori, take the medicine with food. If you take rabeprazole for any other condition, you may take the medicine with or without food.
The rabeprazole delayed-release capsule (AcipHex Sprinkle) should be taken 30 minutes before a meal.
Do not crush, break, or chew a rabeprazole tablet. Swallow it whole.
To take delayed-release rabeprazole (AcipHex Sprinkle), open the capsule and sprinkle the medicine into a spoonful of soft food such as applesauce, yogurt, or baby food made from fruit or vegetable. You may also mix the medicine with apple juice, Pedialyte, or infant formula. Swallow right away without chewing. Do not save the mixture for later use; it will go bad after 15 minutes.
Some conditions are treated with a combination of rabeprazole and antibiotics. Use all medications as directed by your doctor. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Do not change your doses or medication schedule without your doctor's advice.
Take your medicine for the full prescribed length of time. Your symptoms may improve before your condition is completely cleared.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using rabeprazole.
Call your doctor if your symptoms do not improve, or if they get worse while using rabeprazole.
If you use rabeprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking rabeprazole?
This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Rabeprazole side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody;
sudden pain or trouble moving your hip, wrist, or back;
kidney problems--urinating less than usual, blood in your urine, swelling, rapid weight gain;
symptoms of lupus--new or worsening joint pain, skin rash on your cheeks and arms (worsens in sunlight);
symptoms of low vitamin B--pale skin, tiredness, muscle weakness, irregular heartbeats, feeling light-headed or short of breath; or
signs of bleeding (if you also take warfarin)--headaches, dizziness, weakness; pain or swelling; bruising, unusual bleeding (nosebleeds, bleeding gums); red or pink urine; heavy menstrual flow; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or any bleeding that will not stop.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect rabeprazole?
Tell your doctor about all your current medicines and any you start or stop using, especially:
This list is not complete. Other drugs may interact with rabeprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 11.02.
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- Drug class: proton pump inhibitors