Rabeprazole Dosage
Medically reviewed by Drugs.com. Last updated on Dec 25, 2024.
Applies to the following strengths: 20 mg; 5 mg; 10 mg
Usual Adult Dose for:
- Duodenal Ulcer
- Erosive Esophagitis
- Gastric Ulcer
- Duodenal Ulcer Prophylaxis
- Gastroesophageal Reflux Disease
- Helicobacter pylori Infection
- Zollinger-Ellison Syndrome
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Duodenal Ulcer
20 mg orally once a day
- Duration of therapy: 4 weeks
Comments:
- While most patients achieve ulcer healing after 4 weeks, some patients may need an additional course of therapy to achieve ulcer healing.
- The dose should be taken after the morning meal.
Use: Short-term treatment for the healing and symptomatic relief of duodenal ulcers
Usual Adult Dose for Erosive Esophagitis
20 mg orally once a day
- Duration of therapy: 4 to 8 weeks
Comment: If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.
Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)
Usual Adult Dose for Gastric Ulcer
20 mg orally once a day
- Duration of therapy: 4 to 8 weeks
Comment: If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.
Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)
Usual Adult Dose for Duodenal Ulcer Prophylaxis
20 mg orally once a day
- Duration of therapy: Up to 12 months
Comment: Controlled studies for maintenance therapy have not extended beyond 12 months.
Use: Maintenance of healing and reduction in relapse rates of heartburn symptoms in patients with erosive or ulcerative GERD
Usual Adult Dose for Gastroesophageal Reflux Disease
20 mg orally once a day
- Duration of therapy: Up to 4 weeks
Comment: If symptoms do not resolve after 4 weeks of therapy, an additional course of treatment may be considered.
Uses:
- Treatment of daytime and nighttime heartburn and other symptoms associated with GERD
- Treatment of symptomatic GERD
Usual Adult Dose for Helicobacter pylori Infection
20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin
- Duration of therapy: 7 days
Comments:
- Refer to the manufacturer product information for dosing for amoxicillin and clarithromycin.
- All medications should be taken with morning and evening meals.
- Eradication of Helicobacter pylori has decreased the risk of duodenal ulcer recurrence.
- Patients who fail therapy should undergo susceptibility testing and/or begin alternative antimicrobial therapy. If susceptibility studies are unavailable OR patients have resistance to clarithromycin, clarithromycin, alternative antimicrobial treatment should be selected.
Use: Treatment and eradication of H pylori and active/history of duodenal ulcer disease within 5 years
Usual Adult Dose for Zollinger-Ellison Syndrome
Initial dose: 60 mg orally once a day
Maintenance dose: 60 mg orally 2 times a day or 100 mg orally once a day
Duration of therapy: Up to 1 year
Comments:
- Doses should be patient-specific and should continue for as long as clinically necessary.
- Divided dosing may be required in some patients.
Use: Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome)
Usual Pediatric Dose for Gastroesophageal Reflux Disease
1 to 11 years:
Less than 15 kg: 5 mg orally once a day, with the option to increase to 10 mg if inadequate response
15 kg or more: 10 mg orally once a day
Duration of therapy: Up to 12 weeks
12 years or older: 20 mg orally once a day
- Duration of therapy: Up to 8 weeks
Uses:
- Treatment of GERD
- Treatment of symptomatic GERD
Renal Dose Adjustments
No adjustment recommended.
Liver Dose Adjustments
Mild to moderate hepatic impairment (Child-Pugh A and B): No adjustment recommended.
Severe hepatic impairment (Child-Pugh C): Not recommended. If treatment is necessary, patients should be monitored for adverse reactions.
Precautions
CONTRAINDICATIONS:
- Hypersensitivity to the active component, substituted benzimidazoles, or any of the ingredients
- Rilpivirine-containing products
For the treatment of H pylori (as combination therapy): Refer to the contraindications section of the other antibacterial agents for further information.
Safety and efficacy have not been established in patients younger than 1 year (sprinkle formulations) OR 12 years (tablet formulations).
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Avoid chewing/crushing/splitting the dose form.
- Tablets may be taken without regard to food.
- Capsule/granules should be taken 30 minutes before a meal.
Storage requirements: The manufacturer product information should be consulted.
General:
- Patients on long-term therapy should be evaluated regularly for the continued need of this drug.
- Compliance for once a day dosing may improve if this drug is taken in the morning before eating.
- There are no data for use with antibiotic therapy in patients with renal or hepatic impairment.
- Patients using this drug to treat gastroesophageal reflux disease symptoms for longer than 6 months should be further reevaluated.
Monitoring:
- HEMATOLOGIC: INR and prothrombin time in patients receiving concomitant treatment with warfarin
- METABOLIC: Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy; calcium, vitamin D, and vitamin B12 levels, especially in patients on long-term therapy
- MUSCULOSKELETAL: Bone fractures, especially in patients at high risk for osteoporosis-related events
Patient advice:
- Capsules may be opened and sprinkled onto room temperature or colder soft food or into a small amount of liquid. Patients should consume the whole dose within 15 minutes of preparation.
- If using this drug to treat Helicobacter pylori, tell patients that it is important to complete the 7-day regimen.
- Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile, or systemic cutaneous lupus erythematosus occur.
- Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
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