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Rabeprazole Dosage

Applies to the following strength(s): 20 mg5 mg10 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Duodenal Ulcer

Recommended dose: 20 mg orally once a day
Duration of therapy: 4 weeks

Comments:
-While most patients achieve ulcer healing after 4 weeks, some patients may need an additional course of therapy to achieve ulcer healing.

Use: Healing and symptomatic relief of duodenal ulcers

Usual Adult Dose for Erosive Esophagitis

Recommended dose: 20 mg orally once a day
Duration of therapy: 4 to 8 weeks

Comment:
-If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.

Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)

Usual Adult Dose for Gastric Ulcer

Recommended dose: 20 mg orally once a day
Duration of therapy: 4 to 8 weeks

Comment:
-If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.

Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)

Usual Adult Dose for Duodenal Ulcer Prophylaxis

Recommended dose: 20 mg orally once a day
Duration of therapy: 12 months

Comment:
-Controlled studies for maintenance therapy have not extended beyond 12 months.

Use: Maintenance of healing and reduction in relapse rates of heartburn symptoms in patients with erosive or ulcerative gastroesophageal reflux disease (GERD)

Usual Adult Dose for Gastroesophageal Reflux Disease

Recommended dose: 20 mg orally once a day
Duration of therapy: Up to 4 weeks

Comment:
-If symptoms do not resolve after 4 weeks of therapy, an additional course of treatment may be considered.

Use: Treatment of daytime and nighttime heartburn and other symptoms associated with Gastroesophageal Reflux Disease (GERD)

Usual Adult Dose for Helicobacter pylori Infection

Recommended dose: 20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin
Duration of therapy: 7 days

Comments:
-Refer to the manufacturer product information for dosing for amoxicillin and clarithromycin.
-All medications should be taken with morning and evening meals.
-Eradication of Helicobacter pylori (H pylori) has been shown to decrease the risk of duodenal ulcer recurrence.
-Patients who fail therapy should undergo susceptibility testing and/or begin alternative antimicrobial therapy.

Use: Treatment and eradication of Helicobacter pylori (H pylori) and active/history of duodenal ulcer disease within 5 years

Usual Adult Dose for Zollinger-Ellison Syndrome

Initial dose: 60 mg orally once a day
Maintenance dose: 60 mg orally 2 times a day or 100 mg orally once a day
Duration of therapy: Up to 1 year

Comments:
-Doses should be patient-specific and should continue for as long as clinically necessary.
-Divided dosing may be required in some patients.

Use: Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome)

Usual Pediatric Dose for Gastroesophageal Reflux Disease

1 to 11 years:
Less than 15 kg: 5 mg orally once a day for up to 12 weeks with the option to increase to 10 mg if inadequate response
15 kg or more: 10 mg orally once a day for up to 12 weeks

12 years or older:
20 mg orally once a day for up to 8 weeks

Uses: Treatment of gastroesophageal reflux disease (GERD); treatment of symptomatic GERD

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild to moderate hepatic impairment: No adjustment recommended.
Severe hepatic impairment: Use with caution.

Precautions

Safety and efficacy have not been established in patients younger than 1 year.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Avoid chewing/crushing/splitting the dose form.
-Tablets may be taken without regard to food.
-Capsule/granules should be taken 30 minutes before a meal.

Storage requirements:
-The manufacturer product information should be consulted.

General:
-Patients on long-term therapy should be evaluated regularly for the continued need of this drug.
-Compliance for once a day dosing may improve if this drug is taken in the morning before eating.
-There are no data for use with antibiotic therapy in patients with renal or hepatic impairment.
-Patients using this drug to treat gastroesophageal reflux disease symptoms for longer than 6 months should be further reevaluated.

Monitoring:
-Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy
-Vitamin B12 levels, especially in patients on long-term therapy
-Bone fractures, especially in patients at high risk for osteoporosis-related events
-Calcium and vitamin D levels, especially in patients on long-term therapy

Patient advice:
-Capsules may be opened and sprinkled onto room temperature or colder soft food or into a small amount of liquid. Patients should consume the whole dose within 15 minutes of preparation.
-If using this drug to treat Helicobacter pylori, tell patients that it is important to complete the 7-day regimen.
-Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile, or systemic cutaneous lupus erythematosus occur.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

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