Skip to Content

Rabeprazole Dosage

Medically reviewed on June 28, 2018.

Applies to the following strengths: 20 mg; 5 mg; 10 mg

Usual Adult Dose for Duodenal Ulcer

20 mg orally once a day
-Duration of therapy: 4 weeks

Comments:
-While most patients achieve ulcer healing after 4 weeks, some patients may need an additional course of therapy to achieve ulcer healing.
-The dose should be taken after the morning meal.

Use: Short-term treatment for the healing and symptomatic relief of duodenal ulcers

Usual Adult Dose for Erosive Esophagitis

20 mg orally once a day
-Duration of therapy: 4 to 8 weeks

Comment: If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.

Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)

Usual Adult Dose for Gastric Ulcer

20 mg orally once a day
-Duration of therapy: 4 to 8 weeks

Comment: If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.

Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)

Usual Adult Dose for Duodenal Ulcer Prophylaxis

20 mg orally once a day
-Duration of therapy: Up to 12 months

Comment: Controlled studies for maintenance therapy have not extended beyond 12 months.

Use: Maintenance of healing and reduction in relapse rates of heartburn symptoms in patients with erosive or ulcerative GERD

Usual Adult Dose for Gastroesophageal Reflux Disease

20 mg orally once a day
-Duration of therapy: Up to 4 weeks

Comment: If symptoms do not resolve after 4 weeks of therapy, an additional course of treatment may be considered.

Uses:
-Treatment of daytime and nighttime heartburn and other symptoms associated with GERD
-Treatment of symptomatic GERD

Usual Adult Dose for Helicobacter pylori Infection

20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin
-Duration of therapy: 7 days

Comments:
-Refer to the manufacturer product information for dosing for amoxicillin and clarithromycin.
-All medications should be taken with morning and evening meals.
-Eradication of Helicobacter pylori has decreased the risk of duodenal ulcer recurrence.
-Patients who fail therapy should undergo susceptibility testing and/or begin alternative antimicrobial therapy. If susceptibility studies are unavailable OR patients have resistance to clarithromycin, clarithromycin, alternative antimicrobial treatment should be selected.

Use: Treatment and eradication of H pylori and active/history of duodenal ulcer disease within 5 years

Usual Adult Dose for Zollinger-Ellison Syndrome

Initial dose: 60 mg orally once a day
Maintenance dose: 60 mg orally 2 times a day or 100 mg orally once a day
Duration of therapy: Up to 1 year

Comments:
-Doses should be patient-specific and should continue for as long as clinically necessary.
-Divided dosing may be required in some patients.

Use: Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome)

Usual Pediatric Dose for Gastroesophageal Reflux Disease

1 to 11 years:
Less than 15 kg: 5 mg orally once a day, with the option to increase to 10 mg if inadequate response
15 kg or more: 10 mg orally once a day
Duration of therapy: Up to 12 weeks

12 years or older: 20 mg orally once a day
-Duration of therapy: Up to 8 weeks

Uses:
-Treatment of GERD
-Treatment of symptomatic GERD

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild to moderate hepatic impairment (Child-Pugh A and B): No adjustment recommended.
Severe hepatic impairment (Child-Pugh C): Not recommended. If treatment is necessary, patients should be monitored for adverse reactions.

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component, substituted benzimidazoles, or any of the ingredients
-Rilpivirine-containing products

For the treatment of H pylori (as combination therapy): Refer to the contraindications section of the other antibacterial agents for further information.

Safety and efficacy have not been established in patients younger than 1 year (sprinkle formulations) OR 12 years (tablet formulations).

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Avoid chewing/crushing/splitting the dose form.
-Tablets may be taken without regard to food.
-Capsule/granules should be taken 30 minutes before a meal.

Storage requirements: The manufacturer product information should be consulted.

General:
-Patients on long-term therapy should be evaluated regularly for the continued need of this drug.
-Compliance for once a day dosing may improve if this drug is taken in the morning before eating.
-There are no data for use with antibiotic therapy in patients with renal or hepatic impairment.
-Patients using this drug to treat gastroesophageal reflux disease symptoms for longer than 6 months should be further reevaluated.

Monitoring:
-HEMATOLOGIC: INR and prothrombin time in patients receiving concomitant treatment with warfarin
-METABOLIC: Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy; calcium, vitamin D, and vitamin B12 levels, especially in patients on long-term therapy
-MUSCULOSKELETAL: Bone fractures, especially in patients at high risk for osteoporosis-related events

Patient advice:
-Capsules may be opened and sprinkled onto room temperature or colder soft food or into a small amount of liquid. Patients should consume the whole dose within 15 minutes of preparation.
-If using this drug to treat Helicobacter pylori, tell patients that it is important to complete the 7-day regimen.
-Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile, or systemic cutaneous lupus erythematosus occur.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide