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Rabeprazole Side Effects

In Summary

Commonly reported side effects of rabeprazole include: atrophic gastritis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rabeprazole: oral capsule delayed release, oral tablet enteric coated

Side effects requiring immediate medical attention

Along with its needed effects, rabeprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rabeprazole:

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • chills
  • cough
  • dark urine
  • dry mouth
  • fever
  • general feeling of tiredness and weakness
  • hoarseness
  • light-colored stools
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss
  • vomiting
  • yellow eyes and skin

Rare

  • Bloody urine
  • continuing ulcers or sores in the mouth
  • difficulty with breathing
  • seizures
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence not known

  • Back, leg, or stomach pains
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • bloody, black, or tarry stools
  • change in consciousness
  • clay-colored stools
  • cloudy urine
  • confusion about identity, place, person, and time
  • continuing nausea or vomiting
  • difficulty with swallowing
  • dizziness
  • drowsiness
  • fast heartbeat
  • general body swelling
  • greatly decreased frequency of urination or amount of urine
  • headache
  • high fever
  • hives, itching, or skin rash
  • holding false beliefs that cannot be changed by fact
  • increase in the frequency of seizures
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • loss of appetite
  • loss of consciousness
  • mood or mental changes
  • muscle cramp, pain, or stiffness
  • muscle spasms (tetany) or twitching
  • no blood pressure
  • no breathing
  • no pulse
  • nosebleeds
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seeing, hearing, or feeling things that are not there
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tightness in the chest
  • trembling
  • unpleasant breath odor
  • unusual excitement, nervousness, or restlessness
  • vomiting of blood

Side effects not requiring immediate medical attention

Some side effects of rabeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bad, unusual, or unpleasant (after) taste
  • change in taste

Less common

  • Body aches or pain
  • congestion
  • constipation
  • diarrhea
  • excess air or gas in the stomach or bowels
  • full feeling
  • heartburn
  • numbness, tingling, pain, or weakness in the hands or feet
  • passing gas
  • runny nose
  • sleepiness
  • swollen joints
  • tender, swollen glands in the neck
  • voice changes

For Healthcare Professionals

Applies to rabeprazole: oral delayed release capsule, oral delayed release tablet, oral tablet extended release

General

The most commonly reported side effects are headache, diarrhea, and abdominal pain.[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 21%), abdominal pain (up to 16%), vomiting (up to 14%)

Common (1% to 10%): Benign fundic gland polyps, constipation, flatulence, nausea

Uncommon (0.1% to 1%): Dry mouth, dyspepsia, eructation

Rare (0.01% to 0.1%): Gastritis, stomatitis

Frequency not reported: Microscopic colitis

Postmarketing reports: Clostridium difficile-associated diarrhea[Ref]

Other

Common (1% to 10%): Asthenia, non-specific pain, pain

Uncommon (0.1% to 1%): Chills, pyrexia/fever

Postmarketing reports: Sudden death[Ref]

Respiratory

Common (1% to 10%): Cough, pharyngitis, rhinitis

Uncommon (0.1% to 1%): Bronchitis, sinusitis

Postmarketing reports: Dyspnea, interstitial pneumonia[Ref]

Nervous system

Hepatic encephalopathy occurred in patients with underlying cirrhosis.[Ref]

Common (1% to 10%): Dizziness, headache, taste disturbance/perversion

Uncommon (0.1% to 1%): Somnolence

Rare (0.01% to 0.1%): Hepatic encephalopathy

Postmarketing reports: Coma, vertigo[Ref]

Immunologic

Common (1% to 10%): Flu-like syndrome/ influenza-like illness, infection[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, myalgia

Uncommon (0.1% to 1%): Arthralgia, fracture of hip/wrist/spine, leg cramps

Postmarketing reports: Bone fractures, rhabdomyolysis[Ref]

Dermatologic

Erythema and bullous reactions usually resolved after discontinuation.[Ref]

Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Erythema

Rare (0.01% to 0.1%): Bullous reactions, pruritus, sweating

Very rare (less than 0.01%): Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)

Frequency not reported: Facial swelling, subacute cutaneous lupus erythematosus

Postmarketing reports: fatal TEN, other drug eruptions, severe dermatological reactions, systemic lupus erythematosus, urticarial skin eruptions[Ref]

Psychiatric

Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Nervousness

Rare (0.01% to 0.1%): Depression

Frequency not reported: Confusion

Postmarketing reports: Delirium, disorientation[Ref]

Cardiovascular

Common (1% to 10%): Chest pain

Uncommon (0.1% to 1%): Peripheral edema

Postmarketing reports: Hypotension[Ref]

Hepatic

Uncommon (0.1% to 1%): Increased hepatic enzymes

Rare (0.01% to 0.1%): Hepatitis, jaundice, serious hepatic dysfunction[Ref]

Increased hepatic enzymes occurred in patients with underlying cirrhosis.[Ref]

Genitourinary

Uncommon (0.1% to 1%): Urinary tract infection[Ref]

Hematologic

Rare (0.01% to 0.1%): Leukocytosis, leukopenia, neutropenia, thrombocytopenia

Postmarketing reports: Agranulocytosis, bicytopenia, blood dyscrasias, hemolytic anemia, increase in prothrombin time/INR, pancytopenia[Ref]

Increased prothrombin time/INR occurred in patients taking warfarin concomitantly.[Ref]

Metabolic

Rare (0.01% to 0.1%): Anorexia, weight gain

Frequency not reported: Cyanocobalamin (Vitamin B-12) deficiency, hypomagnesemia, hyponatremia

Postmarketing reports: Hyperammonemia[Ref]

Renal

Rare (0.01% to 0.1%): Interstitial nephritis[Ref]

Ocular

Rare (0.01% to 0.1%): Visual disturbance

Postmarketing reports: Blurred vision[Ref]

Endocrine

Frequency not reported: Gynecomastia

Postmarketing reports: Thyroid stimulating hormone (TSH) elevations[Ref]

Hypersensitivity

Hypersensitivity reactions included facial swelling, hypotension, dyspnea, erythema, and bullous reactions; these reactions typically resolved after discontinuation.[Ref]

Rare (0.01% to 0.1%): Hypersensitivity

Postmarketing reports: Acute systemic allergic reactions, anaphylaxis/anaphylactic reactions, angioedema, potential allergic reactions[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Aciphex (rabeprazole)" Janssen Pharmaceuticals, Titusville, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.