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Esomeprazole Delayed-Release Tablets

Generic Name: Esomeprazole Delayed-Release Tablets (es oh ME pray zol)
Brand Name: NexIUM 24HR

Medically reviewed on September 5, 2018

Uses of Esomeprazole Delayed-Release Tablets:

  • It is used to treat gastroesophageal reflux disease (GERD; acid reflux).
  • It is used to treat or prevent GI (gastrointestinal) ulcers caused by infection.
  • It is used to treat or prevent ulcers of the swallowing tube (esophagus).
  • It is used to treat syndromes caused by lots of stomach acid.
  • It is used to treat or prevent NSAID-associated gastric ulcers in patients with a history of ulcers.
  • It is used to treat heartburn.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Esomeprazole Delayed-Release Tablets?

  • If you have an allergy to esomeprazole or any other part of this medicine (esomeprazole delayed-release tablets).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are taking any of these drugs: Atazanavir, clopidogrel, nelfinavir, rifampin, rilpivirine, or St. John's wort.
  • If you have any of these health problems: Black or bloody stools; heartburn with light-headedness, sweating, or dizziness; chest pain; shoulder pain with shortness of breath; pain that spreads to the arms, neck, or shoulders; light-headedness; sweating a lot; throwing up blood; or trouble or pain swallowing food.

This is not a list of all drugs or health problems that interact with this medicine (esomeprazole delayed-release tablets).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (esomeprazole delayed-release tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Esomeprazole Delayed-Release Tablets?

  • Tell all of your health care providers that you take this medicine (esomeprazole delayed-release tablets). This includes your doctors, nurses, pharmacists, and dentists.
  • Use care if you have risks for soft, brittle bones (osteoporosis). Some of these risks include drinking alcohol, smoking, taking steroids, taking drugs to treat seizures, or having family members with osteoporosis. Talk with your doctor about your risks of osteoporosis.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine (esomeprazole delayed-release tablets).
  • This medicine may raise the chance of hip, spine, and wrist fractures in people with weak bones (osteoporosis). The chance may be higher if you take this medicine (esomeprazole delayed-release tablets) in high doses or for longer than a year, or if you are older than 50 years old. Talk with your doctor.
  • Low magnesium levels have rarely happened in people taking drugs like this one for at least 3 months. Most of the time, this has happened after 1 year of care. You will need to have your blood work checked if you will be taking this medicine (esomeprazole delayed-release tablets) for a long time or if you take certain other drugs like digoxin or water pills. Talk with your doctor.
  • Long-term treatment (for instance longer than 3 years) with drugs like this one has rarely caused low vitamin B-12 levels. Talk with the doctor.
  • Lupus has happened with this medicine (esomeprazole delayed-release tablets), as well as lupus that has gotten worse in people who already have it. Tell your doctor if you have lupus. Call your doctor right away if you have signs of lupus like a rash on the cheeks or other body parts, sunburn easy, muscle or joint pain, chest pain or shortness of breath, or swelling in the arms or legs.
  • This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking this medicine (esomeprazole delayed-release tablets) with your other drugs.
  • Do not use more than what your doctor told you to use. Do not use more often or longer than what you were told. Doing any of these things may raise the chance of very bad side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine (esomeprazole delayed-release tablets) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Esomeprazole Delayed-Release Tablets) best taken?

Use this medicine (esomeprazole delayed-release tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take 1 hour before a meal.
  • Take with a full glass of water.
  • Swallow whole. Do not chew, break, or crush.
  • To gain the most benefit, do not miss doses.
  • Keep taking this medicine (esomeprazole delayed-release tablets) as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low magnesium levels like mood changes, muscle pain or weakness, muscle cramps or spasms, seizures, shakiness, not hungry, very bad upset stomach or throwing up, or a heartbeat that does not feel normal.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Very bad dizziness or passing out.
  • Very bad belly pain.
  • Bone pain.
  • Fever or chills.
  • Sore throat.
  • Shortness of breath.
  • A big weight loss.
  • This medicine may raise the chance of a very bad form of diarrhea called Clostridium difficile (C diff)-associated diarrhea. Call your doctor right away if you have stomach pain or cramps, very loose or watery stools, or bloody stools. Do not try to treat loose stools without first checking with your doctor.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Injection:

  • Irritation where the shot is given.

What are some other side effects of Esomeprazole Delayed-Release Tablets?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Feeling sleepy.
  • Belly pain.
  • Loose stools (diarrhea).
  • Hard stools (constipation).
  • Gas.
  • Dry mouth.
  • Upset stomach.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Esomeprazole Delayed-Release Tablets?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep lid tightly closed.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine (esomeprazole delayed-release tablets), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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