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lansoprazole, amoxicillin, and clarithromycin (Oral route)

lan-SOE-pra-zole, a-mox-i-SIL-in, kla-rith-roe-MYE-sin

Commonly used brand name(s)

In the U.S.

  • Prevpac
  • Triple Therapy

Available Dosage Forms:

  • Tablet
  • Capsule
  • Capsule, Delayed Release

Uses For lansoprazole, amoxicillin, and clarithromycin

Prevpac™ is a product containing three components: lansoprazole, amoxicillin, and clarithromycin. lansoprazole, amoxicillin, and clarithromycin is used to treat patients with H. pylori infection and duodenal ulcers caused by H. pylori bacteria.

Lansoprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach. Amoxicillin and clarithromycin both belong to the class of medicines known as antibiotics. They work by killing bacteria or preventing their growth. However, lansoprazole, amoxicillin, and clarithromycin will not work for colds, flu, or other virus infections.

lansoprazole, amoxicillin, and clarithromycin is available only with your doctor's prescription.

Before Using lansoprazole, amoxicillin, and clarithromycin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lansoprazole, amoxicillin, and clarithromycin, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to lansoprazole, amoxicillin, and clarithromycin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of Prevpac™ in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Prevpac™ in the elderly. However, elderly patients are more likely to have kidney or liver problems, which may require caution and an adjustment in the dose for patients receiving lansoprazole, amoxicillin, and clarithromycin.


Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking lansoprazole, amoxicillin, and clarithromycin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using lansoprazole, amoxicillin, and clarithromycin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Alfuzosin
  • Amifampridine
  • Astemizole
  • Bepridil
  • Cisapride
  • Colchicine
  • Conivaptan
  • Dihydroergotamine
  • Dronedarone
  • Eletriptan
  • Eliglustat
  • Eplerenone
  • Ergoloid Mesylates
  • Ergonovine
  • Ergotamine
  • Fluconazole
  • Isavuconazonium Sulfate
  • Ivabradine
  • Ketoconazole
  • Lomitapide
  • Lovastatin
  • Lurasidone
  • Maraviroc
  • Mesoridazine
  • Methylergonovine
  • Methysergide
  • Naloxegol
  • Nelfinavir
  • Nimodipine
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Ranolazine
  • Rilpivirine
  • Saquinavir
  • Silodosin
  • Simvastatin
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Tolvaptan
  • Ziprasidone

Using lansoprazole, amoxicillin, and clarithromycin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ado-Trastuzumab Emtansine
  • Afatinib
  • Ajmaline
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amlodipine
  • Amobarbital
  • Amprenavir
  • Anagrelide
  • Apixaban
  • Apomorphine
  • Aprepitant
  • Aprindine
  • Aprobarbital
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Atazanavir
  • Atorvastatin
  • Avanafil
  • Axitinib
  • Azithromycin
  • Bedaquiline
  • Bosutinib
  • Brentuximab Vedotin
  • Bretylium
  • Bupropion
  • Buserelin
  • Butabarbital
  • Butalbital
  • Cabazitaxel
  • Cabozantinib
  • Carbamazepine
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Chlortetracycline
  • Cilostazol
  • Ciprofloxacin
  • Citalopram
  • Clomipramine
  • Clonazepam
  • Clozapine
  • Cobicistat
  • Crizotinib
  • Cyclobenzaprine
  • Dabigatran Etexilate
  • Dabrafenib
  • Daclatasvir
  • Dasabuvir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Delavirdine
  • Demeclocycline
  • Desipramine
  • Deslorelin
  • Dexamethasone
  • Digoxin
  • Diltiazem
  • Disopyramide
  • Docetaxel
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Doxycycline
  • Droperidol
  • Dutasteride
  • Ebastine
  • Efavirenz
  • Enzalutamide
  • Eribulin
  • Erlotinib
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Estazolam
  • Eszopiclone
  • Etravirine
  • Everolimus
  • Famotidine
  • Felbamate
  • Felodipine
  • Fentanyl
  • Fingolimod
  • Flecainide
  • Fluoxetine
  • Fluticasone
  • Formoterol
  • Foscarnet
  • Fosphenytoin
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydrocodone
  • Hydroquinidine
  • Hydroxychloroquine
  • Ibrutinib
  • Ibutilide
  • Idelalisib
  • Ifosfamide
  • Iloperidone
  • Imipramine
  • Irinotecan
  • Isoflurane
  • Isradipine
  • Itraconazole
  • Ivacaftor
  • Ixabepilone
  • Ketoconazole
  • Lapatinib
  • Ledipasvir
  • Letrozole
  • Leuprolide
  • Levofloxacin
  • Levomilnacipran
  • Lopinavir
  • Lorcainide
  • Losartan
  • Lumefantrine
  • Lymecycline
  • Macitentan
  • Meclocycline
  • Mefloquine
  • Mephobarbital
  • Methacycline
  • Methadone
  • Methohexital
  • Methotrexate
  • Metronidazole
  • Midazolam
  • Mifepristone
  • Minocycline
  • Mitotane
  • Mizolastine
  • Modafinil
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Mycophenolate Mofetil
  • Nafarelin
  • Nafcillin
  • Nelfinavir
  • Nicardipine
  • Nilotinib
  • Nintedanib
  • Nisoldipine
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olaparib
  • Ombitasvir
  • Ondansetron
  • Ospemifene
  • Oxcarbazepine
  • Oxycodone
  • Oxytetracycline
  • Palbociclib
  • Paliperidone
  • Panobinostat
  • Paritaprevir
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Pentobarbital
  • Perampanel
  • Perflutren Lipid Microsphere
  • Perphenazine
  • Phenobarbital
  • Phenytoin
  • Pipamperone
  • Pirmenol
  • Pixantrone
  • Pomalidomide
  • Ponatinib
  • Primidone
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Regorafenib
  • Retapamulin
  • Rifabutin
  • Rifapentine
  • Rilpivirine
  • Risperidone
  • Ritonavir
  • Roflumilast
  • Rolitetracycline
  • Romidepsin
  • Ruxolitinib
  • Salmeterol
  • Saquinavir
  • Secobarbital
  • Sertindole
  • Sevoflurane
  • Sildenafil
  • Siltuximab
  • Simeprevir
  • Sirolimus
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • St John's Wort
  • Sulfamethoxazole
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tadalafil
  • Tamoxifen
  • Tamsulosin
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Temsirolimus
  • Tetrabenazine
  • Tetracycline
  • Thiopental
  • Ticagrelor
  • Tizanidine
  • Tolterodine
  • Topotecan
  • Toremifene
  • Trabectedin
  • Tramadol
  • Trazodone
  • Triazolam
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vilanterol
  • Vilazodone
  • Vinblastine
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Vinorelbine
  • Vismodegib
  • Vorapaxar
  • Voriconazole
  • Vorinostat
  • Warfarin
  • Zaleplon
  • Zidovudine
  • Zileuton
  • Zolpidem

Using lansoprazole, amoxicillin, and clarithromycin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Alfentanil
  • Bromocriptine
  • Conjugated Estrogens
  • Cranberry
  • Cyclosporine
  • Darunavir
  • Delavirdine
  • Diazepam
  • Dicumarol
  • Esterified Estrogens
  • Estradiol
  • Estriol
  • Estrone
  • Estropipate
  • Ethinyl Estradiol
  • Glipizide
  • Glyburide
  • Hexobarbital
  • Indinavir
  • Khat
  • Levothyroxine
  • Linezolid
  • Methylprednisolone
  • Nevirapine
  • Phenprocoumon
  • Pravastatin
  • Prednisone
  • Probenecid
  • Repaglinide
  • Rifampin
  • Rivaroxaban
  • Tipranavir
  • Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of lansoprazole, amoxicillin, and clarithromycin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to amoxicillin or penicillins or cephalosporins, history of or
  • Allergy to clarithromycin, erythromycin, or macrolide antibiotics or
  • Allergy to lansoprazole—Should not be used in patients with these conditions.
  • Cholestatic jaundice, history of or
  • Heart rhythm problems (eg, QT prolongation, torsades de pointes, ventricular arrhythmia), history of or
  • Liver disease, history of—Should not be used in patients with a history of these conditions caused by clarithromycin.
  • Diarrhea or
  • Kidney disease or
  • Liver disease or
  • Myasthenia gravis (severe muscle weakness)—Use with caution. May make these conditions worse.
  • Hypokalemia (low potassium in the blood), uncorrected or
  • Hypomagnesemia (low magnesium in the blood), uncorrected—Should be corrected first before using lansoprazole, amoxicillin, and clarithromycin.
  • Kidney disease, severe—Use is not recommended in patients with this condition.

Proper Use of lansoprazole, amoxicillin, and clarithromycin

Take lansoprazole, amoxicillin, and clarithromycin only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Prevpac™ comes with an individual daily administration card that contains: 2 pink and black capsules of lansoprazole, 4 opaque, yellow capsules of amoxicillin, and 2 yellow tablets of clarithromycin.

Swallow the capsules and tablet whole. Do not crush, break, chew, or open any of them. Take each dose on an empty stomach, before a meal.

Keep using lansoprazole, amoxicillin, and clarithromycin for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.


The dose of lansoprazole, amoxicillin, and clarithromycin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of lansoprazole, amoxicillin, and clarithromycin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (kit):
    • For treatment of duodenal ulcers and H. pylori infections:
      • Adults—30 milligrams (mg) or 1 capsule of lansoprazole, 1000 mg or 2 capsules of amoxicillin, and 500 mg or 1 tablet of clarithromycin taken as a single dose two times per day before meals.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of lansoprazole, amoxicillin, and clarithromycin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using lansoprazole, amoxicillin, and clarithromycin

It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects. If your condition does not improve, or if it becomes worse, discuss this with your doctor.

Do not use lansoprazole, amoxicillin, and clarithromycin if you are also using astemizole (Hismanal®), atazanavir (Reyataz®), cisapride (Propulsid®), lovastatin (Mevacor®), pimozide (Orap®), simvastatin (Zocor®), terfenadine (Seldane®), or certain ergot medicines (such as dihydroergotamine, ergotamine, D.H.E. 45®, Ergomar®, Ergostat®, or Migranal®). If you have kidney or liver disease, do not take both lansoprazole, amoxicillin, and clarithromycin and colchicine (Colcrys®). Using these medicines together may increase risk for more serious side effects.

lansoprazole, amoxicillin, and clarithromycin may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, fever or chills, hoarseness, sores or ulcers on the skin, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you are using lansoprazole, amoxicillin, and clarithromycin.

Make sure your doctor knows if you are pregnant or planning to become pregnant. If you become pregnant while using lansoprazole, amoxicillin, and clarithromycin, tell your doctor right away.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Check with your doctor right away if you have a fever, joint pain, skin rash, swelling of the body, feet, or ankles, or unusual weight gain after receiving lansoprazole, amoxicillin, and clarithromycin. These could be symptoms of acute interstitial nephritis.

lansoprazole, amoxicillin, and clarithromycin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking lansoprazole, amoxicillin, and clarithromycin. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Make sure any doctor or dentist who treats you knows that you are using lansoprazole, amoxicillin, and clarithromycin. lansoprazole, amoxicillin, and clarithromycin may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

lansoprazole, amoxicillin, and clarithromycin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known
  • Abdominal or stomach pain or tenderness
  • blistering, peeling, or loosening of the skin
  • clay colored stools
  • dark urine
  • diarrhea
  • difficulty with swallowing
  • dizziness or fainting
  • fast, slow, or irregular heartbeat
  • fever or chills
  • headache
  • hives, itching, or skin rash
  • joint or muscle pain
  • loss of appetite
  • nausea and vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the body, feet, and ankles
  • tightness in the chest
  • unusual tiredness or weakness
  • unusual weight gain
  • watery and severe diarrhea, which may also be bloody
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Bad, unusual or unpleasant (after) taste
  • change in taste
Less common or rare
  • Confusion
  • discoloration of the tongue
  • itching of the vagina or genital area
  • pain during sexual intercourse
  • redness, swelling, or soreness of the tongue
  • sore mouth or tongue
  • thick, white vaginal discharge with no odor or with a mild odor
  • white patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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