Bismuth subcitrate potassium, metronidazole, and tetracycline
Generic Name: bismuth subcitrate potassium, metronidazole, and tetracycline (BIZ muth sub SIT rate poe TASS ee um, MET roe NYE da zole, TET ra SYE kleen)
Brand Name: Pylera
Dosage Forms: oral capsule (140 mg-125 mg-125 mg)
What is bismuth subcitrate potassium, metronidazole, and tetracycline (Pylera)?
Bismuth subcitrate potassium, metronidazole, and tetracycline (Pylera) is a combination medicine used to treat peptic ulcer (duodenal ulcer) with Helicobacter pylori infection. Pylera is usually given together with omeprazole (Prilosec).
Pylera may also be used for purposes not listed in this medication guide.
Do not use this medicine if you are pregnant or breastfeeding.
Do not drink alcohol or consume foods or medicines that contain propylene glycol while you are taking Pylera and for at least 3 days after you stop taking it.
Before taking this medicine
You should not use Pylera if you are allergic to bismuth subcitrate potassium, metronidazole, or tetracycline, or if:
you have severe kidney disease; or
you drink alcohol daily.
Some medicines can cause unwanted or dangerous effects when used with Pylera. Your doctor may change your treatment plan if you also use:
disulfiram (Antabuse), especially if you have taken it in the past 14 days;
any medicine that contains propylene glycol.
Do not use if you are pregnant. Taking Pylera during pregnancy may affect tooth and bone development in the unborn baby. Taking Pylera during the last half of pregnancy can cause permanent tooth discoloration later in the baby's life.
You should not breastfeed within 2 days after using Pylera. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.
Tell your doctor if you have ever had:
Cockayne syndrome (a rare genetic disorder);
a blood cell disorder; or
any type of infection.
Metronidazole has caused cancer in animal studies. However, it is not known whether this would occur in humans. Ask your doctor about your risk.
Pylera is not approved for use by anyone younger than 18 years old.
How should I take Pylera?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take your medicine with a full glass (8 ounces) of water. Swallow the capsule whole.
Pylera is usually taken after meals and at bedtime. If you also take omeprazole (Prilosec), take it after your morning and evening meals.
Use bismuth subcitrate potassium, metronidazole, and tetracycline for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Pylera will not treat a viral infection such as the flu or a common cold.
You will need frequent blood tests to check your liver function.
Metronidazole can affect the results of certain x-rays or medical tests. Tell any doctor who treats you that you are using Pylera.
Store at room temperature away from moisture and heat. If you use the 10-day Pylera package, keep each capsule in the blister pack until you are ready to take a dose.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
If you miss more than 4 doses, call your doctor for instructions.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Pylera?
Do not drink alcohol or consume food or medicines that contain propylene glycol while you are taking Pylera. You may have unpleasant side effects such as headaches, stomach cramps, nausea, vomiting, and flushing (warmth, redness, or tingly feeling).
Avoid alcohol or propylene glycol for at least 3 days after you stop taking Pylera. Check the labels of any medicines or food products you use to make sure they do not contain alcohol or propylene glycol.
Avoid exposure to sunlight or tanning beds. Pylera can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Avoid taking Pylera with milk or other dairy products. Also avoid taking Pylera at the same time you take any multivitamins, mineral supplements, or antacids. These products can make it harder for your body to absorb the medicine.
Pylera side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
dizziness, problems with speech or coordination;
fever, chills, sore throat, flu symptoms;
neck stiffness, increased sensitivity to light, purple spots on the skin;
numbness or tingling in your arms and legs;
a seizure; or
increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.
If you have Cockayne syndrome, stop taking Pylera and call your doctor right away if you have signs of liver problems such as stomach pain, nausea, clay-colored stools, or yellowing of your skin or eyes.
Pylera may cause your tongue to become darker in color. It may also cause your stools to appear black in color. These are harmless and temporary side effects.
Common side effects may include:
diarrhea or other changes in your stools;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Bismuth subcitrate potassium, metronidazole, and tetracycline dosing information
Usual Adult Dose for Helicobacter pylori Infection:
Bismuth subcitrate potassium 420 mg-metronidazole 375 mg-tetracycline 375 mg orally 4 times a day (after meals and at bedtime)
-Duration of therapy: 10 days
-Omeprazole 20 mg should be given orally 2 times a day during treatment (after morning and evening meals).
-Helicobacter pylori eradication has been shown to reduce duodenal ulcer recurrence risk.
Use: Eradication of H pylori infection in patients with active or a history (e.g., within 5 years) of duodenal ulcer infection and/or disease
What other drugs will affect Pylera?
Tell your doctor about all your other medicines, especially:
More about bismuth subcitrate potassium / metronidazole / tetracycline
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 209 Reviews
- Drug class: H. pylori eradication agents
- Other brands
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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