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Omeprazole Dosage

Applies to the following strength(s): 20 mg ; 10 mg ; 40 mg ; 2.5 mg ; 2 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Duodenal Ulcer

Recommended dose: 20 mg orally once a day
Duration of therapy: 4 weeks

Comment:
-If patients are not fully healed after 4 weeks, treatment may continue for another 4 weeks.

Use:
-Treatment of active duodenal ulcer

Usual Adult Dose for Helicobacter pylori Infection

Dual therapy:
-Recommended dose: 40 mg orally once a day, taken concomitantly with clarithromycin
-Duration of therapy: 14 days

Triple therapy:
-Recommended dose: 20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin
-Duration of therapy: 10 days

Comments:
-Patients presenting with an ulcer at the time of treatment should continue treatment with a 20 mg dose orally once a day for 14 days (dual therapy) or 18 days (triple therapy).
-Antibiotic selection should be determined by local bacterial resistance, duration of treatment, and appropriate use.
-Refer to the manufacturer product information for dosing for amoxicillin and/or clarithromycin.

Use:
-Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence

Usual Adult Dose for Gastric Ulcer

Recommended dose: 40 mg orally once a day
Duration of therapy: 4 to 8 weeks

Use:
-Active benign gastric ulcer

Usual Adult Dose for Erosive Esophagitis

Treatment:
-Recommended dose: 20 mg orally once a day
-Duration of therapy: 4 to 8 weeks

Maintenance:
-Recommended dose: 20 mg orally once a day

Comments:
-Controlled studies for maintenance therapy did not extend past 12 months.
-Patients who do not respond after 8 weeks of treatment may continue for an additional 4 weeks.
-If there is a recurrence of erosive esophagitis (EE) or gastroesophageal reflux disease (GERD) symptoms, an additional 4 to 8 week course of treatment should be considered.

Uses:
-Treatment of EE due to acid-mediated GERD
-Maintenance of healing of EE due to acid-mediated GERD

Usual Adult Dose for Multiple Endocrine Adenomas

Initial dose: 60 mg orally once a day
Maximum dose: 360 mg/day (as 120 mg orally 3 times a day)

Comments:
-Doses higher than 80 mg should be given in divided doses.
-The treatment duration should be for as long as clinically necessary. Some patients with Zollinger-Ellison Syndrome have been treated for longer than 5 years.

Use:
-Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis)

Usual Adult Dose for Systemic Mastocytosis

Initial dose: 60 mg orally once a day
Maximum dose: 360 mg/day (as 120 mg orally 3 times a day)

Comments:
-Doses higher than 80 mg should be given in divided doses.
-The treatment duration should be for as long as clinically necessary. Some patients with Zollinger-Ellison Syndrome have been treated for longer than 5 years.

Use:
-Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis)

Usual Adult Dose for Zollinger-Ellison Syndrome

Initial dose: 60 mg orally once a day
Maximum dose: 360 mg/day (as 120 mg orally 3 times a day)

Comments:
-Doses higher than 80 mg should be given in divided doses.
-The treatment duration should be for as long as clinically necessary. Some patients with Zollinger-Ellison Syndrome have been treated for longer than 5 years.

Use:
-Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis)

Usual Adult Dose for Hypersecretory Conditions

Initial dose: 60 mg orally once a day
Maximum dose: 360 mg/day (as 120 mg orally 3 times a day)

Comments:
-Doses higher than 80 mg should be given in divided doses.
-The treatment duration should be for as long as clinically necessary. Some patients with Zollinger-Ellison Syndrome have been treated for longer than 5 years.

Use:
-Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis)

Usual Adult Dose for Gastroesophageal Reflux Disease

Recommended dose: 20 mg orally once a day
Duration of therapy: Up to 4 weeks

Use:
-Treatment of symptomatic gastroesophageal reflux disease (GERD)

Usual Adult Dose for Dyspepsia

Over-the-Counter (OTC) formulations:
-Recommended dose: 20 mg orally once a day in the morning
-Duration of therapy: 14 days

Comments:
-A 14-day course of treatment may be repeated every 4 months.
-This drug should be taken with a full glass of water prior to eating.

Use:
-Treatment for frequent heartburn (occurring 2 or more days a week)

Usual Pediatric Dose for Gastroesophageal Reflux Disease

1 to 16 years:
5 to less than 10 kg: 5 mg orally once a day
10 to less than 20 kg: 10 mg orally once a day
20 kg and greater: 20 mg orally once a day
Duration of therapy: Up to 4 weeks

16 to 18 years:
Recommended dose: 20 mg orally once a day
Duration of therapy: Up to 4 weeks

Use: Treatment of symptomatic gastroesophageal reflux disease (GERD)

Usual Pediatric Dose for Erosive Esophagitis

TREATMENT:
1 month to less than 1 year:
3 to less than 5 kg: 2.5 mg orally once a day
5 to less than 10 kg: 5 mg orally once a day
10 kg and greater: 10 mg orally once a day

1 to 16 years:
5 to less than 10 kg: 5 mg orally once a day
10 to less than 20 kg: 10 mg orally once a day
20 kg and greater: 20 mg orally once a day

16 to 18 years:
Recommended dose: 20 mg orally once a day

Duration of therapy: 4 to 8 weeks

MAINTENANCE:
1 to 16 years:
5 to less than 10 kg: 5 mg orally once a day
10 to less than 20 kg: 10 mg orally once a day
20 kg and greater: 20 mg orally once a day

16 to 18 years:
Recommended dose: 20 mg orally once a day

Comments:
-Patients who do not respond after 8 weeks of treatment may continue for an additional 4 weeks.
-If there is a recurrence of erosive esophagitis (EE) or gastroesophageal reflux disease (GERD) symptoms, an additional 4 to 8 week course of treatment should be considered.
-Controlled studies for maintenance therapy did not extend past 8 weeks.

Uses:
-Treatment of EE due to acid-mediated GERD
-Maintenance of healing of EE due to acid-mediated GERD

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Combination therapy with clarithromycin: Avoid use
Maintenance of healing of erosive esophagitis: 10 mg orally once a day

Dose Adjustments

Maintenance of healing of erosive esophagitis in Asian patients:
-Recommended dose: 10 mg orally once a day

Precautions

Safety and efficacy of prescription formulations have not been established in patients younger than 1 year (prescription formulations) or 18 years (over-the-counter formulations).

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Tablet and capsule formulations should be swallowed whole, without crushing/chewing.
-The delayed-release capsule may be opened and sprinkled onto a tablespoon of applesauce and swallowed immediately. Do not chew or crush granules.
-The delayed-release oral suspension may be emptied into a small volume of water, allowed to thicken (approximately 2 to 3 minutes), and swallowed within 30 minutes. Remaining material should be mixed with more water and swallowed immediately.
-The suspension may be mixed with water and administered via nasogastric tube.

Storage requirements:
-The manufacturer product information should be consulted.

Reconstitution/preparation techniques:
-The manufacturer product information should be consulted.

IV compatibility:
-The manufacturer product information should be consulted.

General:
-The IV formulation should be used when oral formulations are inappropriate; IV use should be discontinued as soon as treatment with an oral formulation is possible. A single 10 mg IV dose was shown to be equivalent to a single 20 mg oral tablet dose.
-Antacids may be used concomitantly during treatment.

Monitoring:
-Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy
-Vitamin B12 levels, especially in patients on long-term therapy
-Bone fractures, especially in patients at high risk for osteoporosis-related events

Patient advice:
-Patients should be advised that use is not intended for immediate relief. Patients may not experience full effects for up to 4 days.
-If using this drug to treat H pylori, tell patients that it is important to complete the full regimen.
-Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile, or systemic cutaneous lupus erythematosus occur.
-Inform patients that this drug may cause drowsiness, dizziness, vertigo, and/or visual disturbances. They should avoid driving or operating machinery until the full effects of the drug are seen.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

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